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1. 发明授权

US07632921B2 Site-directed modification of FVIII 有权
标题翻译： FVIII的定点修饰
公开(公告)号：US07632921B2
公开(公告)日：2009-12-15
申请号：US11273896
申请日：2005-11-14
申请人： Clark Q. Pan , John E. Murphy , Baisong Mei , Jonathan S. Strauss , Hendri Tjandra , Jianmin Chen , Thomas Barnett , Liang Tang , Deqian Wang
发明人： Clark Q. Pan , John E. Murphy , Baisong Mei , Jonathan S. Strauss , Hendri Tjandra , Jianmin Chen , Thomas Barnett , Liang Tang , Deqian Wang
IPC分类号： A16K38/00 , C12P21/04
CPC分类号： A61K38/37 , A61K38/00 , A61K47/60 , C07K14/755 , C07K17/08 , C07K2319/00
摘要： This invention relates to Factor VIII muteins that are covalently bound, at one or more predefined sites that are not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity, are capable of correcting human factor VIII deficiencies and have improved pharmacokinetic properties.
摘要翻译：本发明涉及在一个或多个不是N-末端胺的预定位点上与一种或多种生物相容性聚合物如聚乙二醇共价结合的因子VIII突变蛋白。突变蛋白偶联物保留FVIII促凝血活性，能够校正人因子VIII缺乏并具有改善的药代动力学性质。

2. 发明申请

US20100081615A1 CONTINUATION - SITE DIRECTED MODIFICATION OF FVIII 有权
标题翻译：连续性 - FVIII的现场指导性修改
公开(公告)号：US20100081615A1
公开(公告)日：2010-04-01
申请号：US12540703
申请日：2009-08-13
申请人： Clark Q. Pan , John E. Murphy , Baisong Mei , Jonathan S. Strauss , Hendri Tjandra , Jianmin Chen , Thomas Barnett , Liang Tang , Deqian Wang
发明人： Clark Q. Pan , John E. Murphy , Baisong Mei , Jonathan S. Strauss , Hendri Tjandra , Jianmin Chen , Thomas Barnett , Liang Tang , Deqian Wang
IPC分类号： C07K14/755 , A61K38/37 , C12P21/02
CPC分类号： A61K38/37 , A61K38/00 , A61K47/60 , C07K14/755 , C07K17/08 , C07K2319/00
摘要： This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
摘要翻译：本发明涉及在一个或多个生物相容性聚合物例如聚乙二醇上共价结合在不是N-末端胺的预定位点上的因子VIII突变蛋白。突变蛋白偶联物保留FVIII促凝血活性并具有改善的药代动力学性质。

3. 发明授权

US09364520B2 Factor VIII conjugates 有权
公开(公告)号：US09364520B2
公开(公告)日：2016-06-14
申请号：US12540703
申请日：2009-08-13
申请人： Clark Q. Pan , John E. Murphy , Baisong Mei , Jonathan S. Strauss , Hendri Tjandra , Jianmin Chen , Thomas Barnett , Liang Tang , Deqian Wang
发明人： Clark Q. Pan , John E. Murphy , Baisong Mei , Jonathan S. Strauss , Hendri Tjandra , Jianmin Chen , Thomas Barnett , Liang Tang , Deqian Wang
IPC分类号： A61K38/37 , A61K47/48 , C07K14/755 , C07K17/08 , A61K38/00
CPC分类号： A61K38/37 , A61K38/00 , A61K47/60 , C07K14/755 , C07K17/08 , C07K2319/00
摘要： This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.

4. 发明申请

US20060115876A1 Site-directed modification of FVIII 有权
标题翻译： FVIII的定点修饰
公开(公告)号：US20060115876A1
公开(公告)日：2006-06-01
申请号：US11273896
申请日：2005-11-14
申请人： Clark Pan , John Murphy , Baisong Mei , Jonathan Strauss , Hendri Tjandra , Jianmin Chen , Thomas Barnett , Liang Tang , Deqian Wang
发明人： Clark Pan , John Murphy , Baisong Mei , Jonathan Strauss , Hendri Tjandra , Jianmin Chen , Thomas Barnett , Liang Tang , Deqian Wang
IPC分类号： C12P21/06 , C07H21/04 , C07K14/745
CPC分类号： A61K38/37 , A61K38/00 , A61K47/60 , C07K14/755 , C07K17/08 , C07K2319/00
摘要： This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
摘要翻译：本发明涉及在一个或多个生物相容性聚合物例如聚乙二醇上共价结合在不是N-末端胺的预定位点上的因子VIII突变蛋白。突变蛋白偶联物保留FVIII促凝血活性并具有改善的药代动力学性质。

5. 发明申请

US20120121613A1 PROTEIN CONJUGATE HAVING AN ENDOPEPTIDASE- CLEAVABLE BIOPROTECTIVE MOIETY 审中-公开
标题翻译：具有内切酶 - 可清除的生物保护性环境的蛋白质结合
公开(公告)号：US20120121613A1
公开(公告)日：2012-05-17
申请号：US13145335
申请日：2010-01-19
申请人： Liang Tang , Jun Wang , Baisong Mei , John E. Murphy
发明人： Liang Tang , Jun Wang , Baisong Mei , John E. Murphy
IPC分类号： A61K38/36 , C12N9/96 , A61K38/48 , C07K17/08 , A61K38/37 , A61K38/38 , C07K17/10 , C07K17/00 , A61P7/04
CPC分类号： A61K38/4846 , A61K38/37 , A61K38/4833 , A61K47/60 , A61K47/65 , C07K7/06 , C07K7/08
摘要： The invention is directed to a procoagulant conjugate having an endopeptidase-activatable procoagulant protein moiety and one or more bioprotective moieties, which are conjugated to one another by a linker that is cleaved by an endopeptidase in situ to release the bioprotective moiety. The invention is also directed to therapeutic uses of the procoagulant conjugate and methods of making the conjugate.
摘要翻译：本发明涉及具有内肽酶活化的促凝血蛋白部分和一个或多个生物保护性部分的促凝血剂缀合物，其通过由内肽酶原位切割以释放生物保护性部分的接头彼此缀合。本发明还涉及促凝血剂缀合物的治疗用途和制备缀合物的方法。

6. 发明授权

US08609602B2 Cleaning solution 有权
标题翻译：清洁液
公开(公告)号：US08609602B2
公开(公告)日：2013-12-17
申请号：US13183282
申请日：2011-07-14
申请人： Benjamin R. Travis , Ritesh Mittal , Seth M. Huff , Lijun M. Huang , Liang Tang
发明人： Benjamin R. Travis , Ritesh Mittal , Seth M. Huff , Lijun M. Huang , Liang Tang
IPC分类号： C11D1/75 , C11D3/26 , C11D3/43 , C11D3/44
CPC分类号： C11D1/75 , C11D3/04 , C11D3/044 , C11D3/2003 , C11D3/2006 , C11D3/43
摘要： Disclosed are cleaning solutions. More particularly, non-toxic solutions of base, water, alcohol and detergent, that effectively and surprisingly eliminate contaminating aliphatic acids in aqueous solutions. When present as a foam or even a contaminating film remaining on various parts and surfaces, aliphatic acid contaminants can be present a large and costly problem in manufacturing operations, cleaning tasks, personal hygiene. The need to remove such contaminants arises in a myriad environments and situations, such as during the manufacture of detergents, pharmaceuticals, consumer products, coring and core analysis, manipulation of oils, fuels, fermentation applications, manufacture of emollients, moisturizers, liquors, foods such as seafood, milk, butter and other dairy products, water processing, paper products, tissue culture, reusable clinical equipment, and the like. Presented are cleaning compositions and methods that effectively eliminate and prevent build up of such dangerous and costly contaminants in aqueous solutions.
摘要翻译：披露的是清洁解决方案。更具体地，碱，水，醇和洗涤剂的无毒溶液有效且令人惊奇的消除了水溶液中的污染性脂肪酸。当作为泡沫或甚至残留在各种部件和表面上的污染膜存在时，脂肪族酸污染物在制造操作，清洁任务，个人卫生中可能存在大而昂贵的问题。在无数的环境和情况下，例如在制造洗涤剂，药物，消费品，取芯和核心分析，操作油，燃料，发酵应用，润肤剂，保湿剂，液体，食品的制造如海鲜，牛奶，黄油等乳制品，水处理，纸制品，组织培养，可重复利用的临床设备等。提出了清洁组合物和方法，其有效地消除并防止在水溶液中积累这种危险且昂贵的污染物。

7. 发明授权

US08146093B2 Computer multiple operation system switching method 有权
标题翻译：计算机多操作系统切换方法
公开(公告)号：US08146093B2
公开(公告)日：2012-03-27
申请号：US11793463
申请日：2005-07-11
申请人： Zhongqing Li , Liang Tang
发明人： Zhongqing Li , Liang Tang
IPC分类号： G06F9/46 , G06F15/76 , G06F7/38 , G06F9/00
CPC分类号： G06F9/441
摘要： A computer multi-OS switching method, in which a data exchange region for storing OS running environment information is provided, wherein the method includes: A. saving running information of computer hardware devices in a random access memory (RAM) by the computer after receiving a command for switching OS; B. obtaining OS running environment information of OS to be switched to from the data exchange region and storing the obtained OS running environment information in the RAM by the computer; C. restoring running state of the computer hardware devices based on its running information stored in the RAM, obtaining a preset OS to be switched to, starting the OS and subsequently executing the OS running environment information in the RAM by the computer. The method reduces the time for switching between multi-OSs in a computer.
摘要翻译：一种计算机多OS切换方法，其中提供了用于存储OS运行环境信息的数据交换区域，其中所述方法包括：A.接收之后由计算机在计算机中存储随机存取存储器（RAM）中的计算机硬件设备的运行信息用于切换OS的命令; B.从数据交换区域获取要切换的OS的OS运行环境信息，并通过计算机将所获得的OS运行环境信息存储在RAM中; C.基于其存储在RAM中的运行信息来恢复计算机硬件设备的运行状态，获得要切换到的预设OS，启动OS并随后由计算机执行RAM中的OS运行环境信息。该方法减少了在计算机中多操作系统之间切换的时间。

8. 发明申请

US20120015501A1 Silicon Surface Modification for the Electrochemical Synthesis of Silicon Particles in Suspension 失效
标题翻译：用于悬浮液中硅颗粒的电化学合成的硅表面改性
公开(公告)号：US20120015501A1
公开(公告)日：2012-01-19
申请号：US12836030
申请日：2010-07-14
申请人： Chang-Ching Tu , Liang Tang , Apostolos T. Voutsas
发明人： Chang-Ching Tu , Liang Tang , Apostolos T. Voutsas
IPC分类号： H01L21/20 , B32B43/00
CPC分类号： H01L21/02422 , C23C24/00 , C23C26/02 , C25F3/12 , H01L21/02532 , H01L21/02601 , H01L21/02628
摘要： A process of silicon (Si) surface modification is provided for the electrochemical synthesis of Si particles in suspension. The process begins with a Si first substrate with a surface, and forms Si particles attached to the surface. Hydrogen-terminated Si particles are created and the first substrate is immersed in a hexane/1-octene (1/1 volume ratio) solution with a catalytic amount of chloroplatinic acid (H2PtCl6). 1-octene is bonded with the hydrogen-terminated Si particles, creating modified Si particles, with octane capping ligands, attached to the substrate surface. The first substrate is then exposed to ultrasonication, separating the modified Si particles from the first substrate. After removing the first substrate, a suspension is created of modified Si particles suspended in excess hexane/1-octene.
摘要翻译：提供硅（Si）表面改性的方法用于悬浮液中的Si颗粒的电化学合成。该方法开始于具有表面的Si第一衬底，并且形成附着在表面上的Si颗粒。产生氢封端的Si颗粒，并将第一衬底浸入具有催化量的氯铂酸（H 2 PtCl 6）的己烷/ 1-辛烯（1/1体积比））溶液中。 1-辛烯与氢封端的Si颗粒结合，产生改性的Si颗粒，与辛基封端配体连接在基材表面上。然后将第一衬底暴露于超声波处理，将改性的Si颗粒与第一衬底分离。在除去第一衬底之后，产生悬浮在过量己烷/ 1-辛烯中的改性Si颗粒的悬浮液。

9. 发明授权

US08037210B2 Computer and method for directly accessing computer hardware by virtual system 有权
标题翻译：通过虚拟系统直接访问计算机硬件的计算机和方法
公开(公告)号：US08037210B2
公开(公告)日：2011-10-11
申请号：US12623076
申请日：2009-11-20
申请人： Liang Tang , Chunyu Song , Ke Ke
发明人： Liang Tang , Chunyu Song , Ke Ke
IPC分类号： G06F3/00 , G06F9/455
CPC分类号： G06F9/4411
摘要： A computer and method for directly accessing computer hardware by a virtual system are provided. The computer comprises a hardware platform having a first-type device, a second-type device and a third-type device provided thereon; a virtual machine managing module; a first operating module; a second operating module; wherein the virtual machine managing module comprises a first-type device configuration module for directly configuring the first type device to be used by the main operating system; a second-type device configuration module for directly configuring the second-type device to be used by the guest operating system; and a third-type device configuration module for virtualizing the third-type device on the hardware platform to generate a virtualized third-type device and configuring the virtualized third-type device to be used by the main operating system and the guest operating system, respectively. The present invention considers the distribution and use of the devices as a whole in combination with the use of BIOS in the main board. Therefore, the incompatibility problem between hardware and software of the virtual system can be solved.
摘要翻译：提供了一种由虚拟系统直接访问计算机硬件的计算机和方法。计算机包括具有第一类型设备，第二类型设备和设置在其上的第三类型设备的硬件平台; 虚拟机管理模块; 第一操作模块; 第二操作模块; 其中所述虚拟机管理模块包括用于直接配置要由所述主操作系统使用的所述第一类型设备的第一类型设备配置模块; 用于直接配置由客户操作系统使用的第二类型设备的第二类型设备配置模块; 以及第三类设备配置模块，用于在硬件平台上虚拟化第三类设备，以生成虚拟化的第三类设备，并分别配置主操作系统和客户操作系统使用的虚拟化第三类设备。本发明结合在主板中使用BIOS来考虑设备的整体分布和使用。因此，可以解决虚拟系统硬件与软件之间的不兼容性问题。

10. 发明申请

US20110032743A1 Colloidal-Processed Silicon Particle Device 失效
标题翻译：胶体加工硅粒子装置
公开(公告)号：US20110032743A1
公开(公告)日：2011-02-10
申请号：US12835974
申请日：2010-07-14
申请人： Jiandong Huang , Liang Tang , Changqing Zhan , Chang-Ching Tu
发明人： Jiandong Huang , Liang Tang , Changqing Zhan , Chang-Ching Tu
IPC分类号： G11C13/04 , G11C11/34 , H01L45/00 , H01L21/20 , B82Y10/00 , B82Y15/00
CPC分类号： H01L21/02532 , H01L21/02601 , H01L21/02628 , H01L33/18
摘要： Colloidal-processed Si particle devices, device fabrication, and device uses have been presented. The generic device includes a substrate, a first electrode overlying the substrate, a second electrode overlying the substrate, laterally adjacent the first electrode, and separated from the first electrode by a spacing. A colloidal-processed Si particle layer overlies the first electrode, the second electrode, and the spacing between the electrodes. The Si particle layer includes a first plurality of nano-sized Si particles and a second plurality of micro-sized Si particles.
摘要翻译：已经提出了胶体加工的Si粒子装置，器件制造和器件用途。通用器件包括衬底，覆盖衬底的第一电极，覆盖衬底的第二电极，与第一电极横向相邻，并且与第一电极间隔开。胶体处理的Si颗粒层覆盖第一电极，第二电极和电极之间的间隔。 Si颗粒层包括第一多个纳米尺寸的Si颗粒和第二多个微尺寸的Si颗粒。

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