专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2008001726A Rapidly dissolving robust dosage form 有权
标题翻译：快速解散稳健剂量形式
公开(公告)号：JP2008001726A
公开(公告)日：2008-01-10
申请号：JP2007249399
申请日：2007-09-26
申请人： Cima Labs Inc , シーマ・ラブス、インコーポレイテッド
发明人： KHANKARI RAJENDRA K , HONTZ JOHN , CHASTAIN SARA J , KATZNER LEO
IPC分类号： A61K9/20 , A61K9/26 , A61K9/00 , A61K9/46
CPC分类号： A61K9/0007 , A61K9/0056 , A61K9/2018 , Y10S514/951 , Y10S514/96
摘要： PROBLEM TO BE SOLVED: To provide a hard tablet that can be stored, packaged and processed in bulk. SOLUTION: The present invention provides the tablet created from an active ingredient mixed into a matrix of an indirect compression filler and a relatively high lubricant content. The tablet also contains a matrix comprising the indirect compression filler, a wicking agent, and a hydrophobic lubricant. The matrix of the tablet contains a quick water-soluble ingredient in at least about 60% based on the total weight of the tablet. It is preferable that the tablet dissolves rapidly in the mouth of the patient with a minimum of grit. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供可以批量储存，包装和加工的硬片。解决方案：本发明提供了由混合成间接压缩填料的基质的活性成分和相对高的润滑剂含量产生的片剂。片剂还含有包含间接压缩填料，芯吸剂和疏水润滑剂的基质。基于片剂的总重量，片剂的基质含有至少约60％的快速水溶性成分。优选的是，片剂以最小的砂砾迅速溶解在患者的口中。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2012162558A Rapidly dissolving robust dosage form 审中-公开
标题翻译：快速解散稳健剂量形式
公开(公告)号：JP2012162558A
公开(公告)日：2012-08-30
申请号：JP2012092155
申请日：2012-04-13
申请人： Cima Labs Inc , シーマ・ラブス、インコーポレイテッド
发明人： KHANKARI RAJENDRA K , HONTZ JOHN , CHASTAIN SARA J , KATZNER LEO
IPC分类号： A61K9/20 , A61K9/26 , A61K9/00 , A61K9/46 , A61K47/12 , A61K47/26
CPC分类号： A61K9/0007 , A61K9/0056 , A61K9/2018 , Y10S514/951 , Y10S514/96
摘要： PROBLEM TO BE SOLVED: To provide a hard tablet that can be stored, packaged and processed in bulk.SOLUTION: The tablet is created from an active ingredient mixed into a matrix of an indirect compression filler and a relatively high lubricant content. Preferably, the tablet also contains a matrix having the indirect compression filler, a wicking agent, and a hydrophobic lubricant. The matrix of the tablet contains a rapid water-soluble ingredient in at least about 60% based on the total weight of the matrix material. It is preferable that the tablet dissolves rapidly in the mouth of the patient with a minimum of grit.
摘要翻译：要解决的问题：提供可以批量储存，包装和加工的硬片。解决方案：片剂由混合成间接压缩填料的基质和较高润滑剂含量的活性成分制成。优选地，片剂还含有具有间接压缩填料，芯吸剂和疏水性润滑剂的基质。基于基质材料的总重量，片剂的基质含有至少约60％的快速水溶性成分。优选的是，片剂以最小的砂砾迅速溶解在患者的口中。版权所有（C）2012，JPO＆INPIT

3. 发明专利

HK1137654A1 RAPIDLY DISSOLVING ROBUST DOSAGE FORM 未知
公开(公告)号：HK1137654A1
公开(公告)日：2010-08-06
申请号：HK10102664
申请日：2010-03-15
申请人： CIMA LABS INC
发明人： KHANKARI RAJENDRA K , HONTZ JOHN , CHASTAIN SARA J , KATZNER LEO
IPC分类号： A61K20060101 , A61K9/20 , A61K9/00 , A61K9/46
摘要： The invention relates to an organoleptically pleasant, orally dissolving compressed tablet comprising: an active pharmaceutical ingredient wherein the active pharmaceutical ingredient is uncoated and ungranulated; a non-direct compression sugar alcohol consisting of mannitol; and a hydrophobic lubricant, wherein upon dissolving a non-gritty suspension forms in the oral cavity.

4. 发明专利

AU726336B2 Rapidly dissolving robust dosage form 未知
公开(公告)号：AU726336B2
公开(公告)日：2000-11-02
申请号：AU6896998
申请日：1998-04-13
申请人： CIMA LABS INC
发明人： KHANKARI RAJENDRA K , HONTZ JOHN , CHASTAIN SARA J , KATZNER LEO
IPC分类号： A61K9/20 , A61K9/00 , A61K9/46 , A61K9/26
摘要： The invention relates to an organoleptically pleasant, orally dissolving compressed tablet comprising: an active pharmaceutical ingredient wherein the active pharmaceutical ingredient is uncoated and ungranulated; a non-direct compression sugar alcohol consisting of mannitol; and a hydrophobic lubricant, wherein upon dissolving a non-gritty suspension forms in the oral cavity.

5. 发明专利

DK2147669T4 Hurtigt opløsende, robust doseringsform 未知
公开(公告)号：DK2147669T4
公开(公告)日：2018-03-12
申请号：DK09013477
申请日：1998-04-13
申请人： CIMA LABS INC
发明人： KHANKARI RAJENDRA K , HONTZ JOHN , CHASTAIN SARA J , KATZNER LEO
IPC分类号： A61K9/20 , A61K9/00 , A61K9/26 , A61K9/46

6. 发明专利

CA2284663A1 RAPIDLY DISSOLVING ROBUST DOSAGE FORM 未知
公开(公告)号：CA2284663A1
公开(公告)日：1998-10-22
申请号：CA2284663
申请日：1998-04-13
申请人： CIMA LABS INC
发明人： HONTZ JOHN , KATZNER LEO , CHASTAIN SARA J , KHANKARI RAJENDRA K
IPC分类号： A61K9/20 , A61K9/00 , A61K9/46 , A61K31/135 , A61K31/16 , A61K9/26 , A61K31/415 , A61K31/44
摘要： The invention is directed to a hard tablet that can be stored, packaged and processed in bulk. Yet the tablet dissolves rapidly in the mouth of the patient with a minimum of grit. The tablet is created from an active ingredient mixed into a matrix of a non-direct compression filler and a relatively high lubricant content.

7. 发明专利

DK2266538T3 Hurtigt opløsende, robust doseringsform 未知
公开(公告)号：DK2266538T3
公开(公告)日：2017-10-23
申请号：DK10011802
申请日：1998-04-13
申请人： CIMA LABS INC
发明人： KHANKARI RAJENDRA , HONTZ JOHN , CHASTAIN SARA , KATZNER LEO
IPC分类号： A61K9/20 , A61K9/00 , A61K9/26 , A61K9/46

8. 发明专利

ES2525720T3 Forma de dosificación robusta de disolución rápida 未知
公开(公告)号：ES2525720T3
公开(公告)日：2014-12-29
申请号：ES09013477
申请日：1998-04-13
申请人： CIMA LABS INC
发明人： KHANKARI RAJENDRA K , HONTZ JOHN , CHASTAIN SARA J , KATZNER LEO
IPC分类号： A61K9/20 , A61K9/00 , A61K9/26 , A61K9/46
摘要： Un procedimiento de fabricación de una forma de dosificación oralmente disgregable envasada, adaptada para una dosificación oral directa, que tiene una dureza de al menos 15 Newtons y una friabilidad del 2 % o menos cuando se ensaya de acuerdo con la Farmacopea de Estados Unidos, comprendiendo dicho procedimiento las etapas de: (a) formar una mezcla que incluye un ingrediente activo y una matriz que incluye una carga de compresión no directa y un lubricante; (b) comprimir dicha mezcla mediante compresión directa para formar una pluralidad de formas de dosificación rápidamente disgregables, duras y comprimidas que tienen dicho ingrediente activo distribuido en dicha matriz que se disuelve oralmente, estando adaptadas dichas formas de dosificación para disolverse espontáneamente en la boca de un paciente en menos de 60 segundos y liberar, por tanto, dicho ingrediente activo; y en el que dicha carga de compresión no directa es un azúcar o un alcohol de azúcar presente en una cantidad del 25 al 95 % en peso; dicho lubricante está presente en una cantidad de entre el 1 y el 2,5 % en peso; y el 85 % de las partículas de la carga de no compresión son de menos de 100 μm; en el que dicha carga de compresión no directa no está modificada físicamente para impartirle una mayor fluidez y compresibilidad antes de la compresión.

9. 发明专利

CA2284663C RAPIDLY DISSOLVING ROBUST DOSAGE FORM 未知
公开(公告)号：CA2284663C
公开(公告)日：2003-06-17
申请号：CA2284663
申请日：1998-04-13
申请人： CIMA LABS INC
发明人： KHANKARI RAJENDRA K , KATZNER LEO , HONTZ JOHN , CHASTAIN SARA J
IPC分类号： A61K9/20 , A61K9/00 , A61K9/46 , A61K31/135 , A61K31/16 , A61K9/26 , A61K31/415 , A61K31/44
摘要： The invention is directed to a hard tablet that can be stored, packaged and processed in bulk. Yet the tablet dissolves rapidly in the mouth of the patient with a minimum of grit. The tablet is created from an active ingredient mixed into a matrix of a non-direct compression filler and a relatively high lubricant content.

10. 发明专利

AU6896998A Rapidly dissolving robust dosage form 未知
公开(公告)号：AU6896998A
公开(公告)日：1998-11-11
申请号：AU6896998
申请日：1998-04-13
申请人： CIMA LABS INC
发明人： KHANKARI RAJENDRA K , HONTZ JOHN , CHASTAIN SARA J , KATZNER LEO
IPC分类号： A61K9/20 , A61K9/00 , A61K9/46 , A61K9/26
摘要： The invention relates to an organoleptically pleasant, orally dissolving compressed tablet comprising: an active pharmaceutical ingredient wherein the active pharmaceutical ingredient is uncoated and ungranulated; a non-direct compression sugar alcohol consisting of mannitol; and a hydrophobic lubricant, wherein upon dissolving a non-gritty suspension forms in the oral cavity.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式