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1. 发明公开

EP0753735A2 Specimen testing apparatus 失效
标题翻译：标本检测仪器
公开(公告)号：EP0753735A2
公开(公告)日：1997-01-15
申请号：EP96305122.2
申请日：1996-07-11
申请人： Ciba Corning Diagnostics Corp.
发明人： Malek, Michael L. , Coghlan, Gregory A. , Carey, Glen A.
IPC分类号： G01N21/76 , G01N35/02 , G01J1/04
CPC分类号： G01N21/76 , G01N21/13 , G01N2035/0448 , Y10T436/114165
摘要： A luminometer for determining the composition of a specimen sample includes an annular guide path for sample containing cuvettes within a light tight housing. A rotor moves spaced segments through the guide path with the cuvettes positioned between the segments. The luminometer further includes one or two detector assemblies (110,112) coupled to the housing and positioned to view and detect light emitted by cuvettes as they pass along the guide path between segments. A cuvette is advanced around the housing via the rotor and rotor segments and when the cuvette reaches a predetermined position on the housing, a reagent, such as a base, is added to the cuvette to initiate a chemiluminescent reaction within the cuvette and provide an emission of light energy in a predetermined spectral range. The luminometer has a waste aspiration probe to remove the contents of the cuvette after it passes the detector. A cuvette elevator moves a sample containing cuvette into the guide path between segments and an exit chute removes cuvettes after their contents have been aspirated. The luminometer permits continuous uninterrupted sample testing when coupled to an incubation chamber in which the cuvettes receive samples and test specific reagents before they are moved into the luminometer by the elevator.
The luminometer has a temperature detection and control circuit coupled to the detector (PMT) (110) with thermal insulating sleeve (126). A TED (132) is coupled to the PMT thermal sleeve. The PMT comprises a lens cap (128) and a seal.
摘要翻译：用于确定样本组成的发光计包括用于包含在不透光外壳内的比色皿的样本的环形导向路径。转子将间隔开的部分移动通过引导路径，反应杯定位在部分之间。发光计还包括一个或两个检测器组件（110,112），所述检测器组件耦合到壳体并定位成当它们沿着区段之间的引导路径通过时观察和检测由比色管发射的光。试管通过转子和转子区段在壳体周围推进，并且当试管到达壳体上的预定位置时，向试管添加诸如基座的试剂以在试管内引发化学发光反应并提供发射的光能在预定的光谱范围内。光度计有一个废物吸取探针，以在通过检测器后移除比色杯的内容物。比色杯升降器将含有比色皿的样品移动到区段之间的引导路径中，并且出口溜槽在其内容物已经被抽吸之后移除比色皿。该光度计在连接到孵育室时允许连续不间断的样品测试，在该孵育室中比色杯接收样品并且在特定试剂被电梯移入发光计之前测试特定试剂。该发光计具有与检测器（PMT）（110）耦合的具有热绝缘套筒（126）的温度检测和控制电路。 TED（132）耦合到PMT热套筒。 PMT包括镜头盖（128）和密封件。

2. 发明公开

EP0753735A3 Specimen testing apparatus 失效
标题翻译：抽样监测设备
公开(公告)号：EP0753735A3
公开(公告)日：1997-05-07
申请号：EP96305122.2
申请日：1996-07-11
申请人： Ciba Corning Diagnostics Corp.
发明人： Malek, Michael L. , Coghlan, Gregory A. , Carey, Glen A.
IPC分类号： G01N21/76 , G01N35/02 , G01J1/04
CPC分类号： G01N21/76 , G01N21/13 , G01N2035/0448 , Y10T436/114165
摘要： A luminometer for determining the composition of a specimen sample includes an annular guide path for sample containing cuvettes within a light tight housing. A rotor moves spaced segments through the guide path with the cuvettes positioned between the segments. The luminometer further includes one or two detector assemblies (110,112) coupled to the housing and positioned to view and detect light emitted by cuvettes as they pass along the guide path between segments. A cuvette is advanced around the housing via the rotor and rotor segments and when the cuvette reaches a predetermined position on the housing, a reagent, such as a base, is added to the cuvette to initiate a chemiluminescent reaction within the cuvette and provide an emission of light energy in a predetermined spectral range. The luminometer has a waste aspiration probe to remove the contents of the cuvette after it passes the detector. A cuvette elevator moves a sample containing cuvette into the guide path between segments and an exit chute removes cuvettes after their contents have been aspirated. The luminometer permits continuous uninterrupted sample testing when coupled to an incubation chamber in which the cuvettes receive samples and test specific reagents before they are moved into the luminometer by the elevator. The luminometer has a temperature detection and control circuit coupled to the detector (PMT) (110) with thermal insulating sleeve (126). A TED (132) is coupled to the PMT thermal sleeve. The PMT comprises a lens cap (128) and a seal.

3. 发明公开

EP0712000A3 Incubation chamber in automated immunoassay analyser 失效转让
标题翻译：自动免疫分析仪中的孵育室
公开(公告)号：EP0712000A3
公开(公告)日：1996-06-26
申请号：EP95306882.2
申请日：1995-09-29
申请人： Ciba Corning Diagnostics Corp.
发明人： Carey, Glen A. , Malek, Michael L.
IPC分类号： G01N35/02 , G01N33/543
CPC分类号： B01L3/50853 , G01N35/0092 , G01N35/0098 , G01N35/025 , G01N2035/0455 , Y10T436/11 , Y10T436/113332 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/25 , Y10T436/25125 , Y10T436/2575
摘要： Method and apparatus for transportation and processing of multiple protocol assays within an automated immunoassay analyzer instrument (10). The apparatus includes a cuvette ring (32) movably coupled to a magnet ring (30). In one embodiment, the magnet ring (30) and cuvette ring (32) are provided having circular shapes. A temperature controlled housing (28) is disposed about the cuvette and magnet rings to provide a rotary incubation and particle separation chamber (12). The cuvette ring (32) holds a plurality of cuvettes each of which may have a different assay disposed therein. The cuvette ring (32) advances the cuvettes around the circumference of the incubation chamber. A plurality of discrete processing centers for aspiration and dispensing fluid samples, reagents and wash fluids are disposed at predetermined positions about the incubation chamber (12). The cuvette ring (32) moves cuvettes in both clockwise and counter clockwise directions around the incubation chamber (12) to position particular cuvettes at particular ones of the plurality of discrete processing centers to thus accomodate different protocols of each of the assays. By controlling the manner in which the cuvette ring (32) moves within the incubation chamber (12), a plurality of different protocol assays each of which require different incubation times, can be simultaneously processed in the analyzer instrument.
摘要翻译：用于在自动化免疫分析分析仪器（10）内运输和处理多方案分析的方法和装置。该设备包括可移动地联接到磁环（30）的比色皿环（32）。在一个实施例中，磁环（30）和比色皿环（32）被提供为具有圆形形状。温控外壳（28）围绕比色皿和磁环设置，以提供旋转培养和颗粒分离室（12）。比色杯环（32）容纳多个比色杯，每个比色杯可以具有设置在其中的不同化验。比色杯环（32）围绕孵育室的圆周推进比色杯。用于抽吸和分配流体样品，试剂和洗涤流体的多个离散处理中心设置在围绕孵育室（12）的预定位置处。比色皿环（32）围绕孵育室（12）沿顺时针和逆时针方向移动比色杯以将特定比色杯定位在多个离散处理中心中的特定比色杯中，从而适应每种测定的不同方案。通过控制比色皿环（32）在孵育室（12）内移动的方式，可以在分析仪器中同时处理多个不同的方案测定，其中每一个需要不同的温育时间。

4. 发明公开

EP0712000A2 Incubation chamber in automated immunoassay analyser 失效转让
标题翻译： Inkubationskammer einer automatischen immunologischen Analysevorrichtung
公开(公告)号：EP0712000A2
公开(公告)日：1996-05-15
申请号：EP95306882.2
申请日：1995-09-29
申请人： Ciba Corning Diagnostics Corp.
发明人： Carey, Glen A. , Malek, Michael L.
IPC分类号： G01N35/02 , G01N33/543
CPC分类号： B01L3/50853 , G01N35/0092 , G01N35/0098 , G01N35/025 , G01N2035/0455 , Y10T436/11 , Y10T436/113332 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/25 , Y10T436/25125 , Y10T436/2575
摘要： Method and apparatus for transportation and processing of multiple protocol assays within an automated immunoassay analyzer instrument (10). The apparatus includes a cuvette ring (32) movably coupled to a magnet ring (30). In one embodiment, the magnet ring (30) and cuvette ring (32) are provided having circular shapes. A temperature controlled housing (28) is disposed about the cuvette and magnet rings to provide a rotary incubation and particle separation chamber (12). The cuvette ring (32) holds a plurality of cuvettes each of which may have a different assay disposed therein. The cuvette ring (32) advances the cuvettes around the circumference of the incubation chamber. A plurality of discrete processing centers for aspiration and dispensing fluid samples, reagents and wash fluids are disposed at predetermined positions about the incubation chamber (12). The cuvette ring (32) moves cuvettes in both clockwise and counter clockwise directions around the incubation chamber (12) to position particular cuvettes at particular ones of the plurality of discrete processing centers to thus accomodate different protocols of each of the assays. By controlling the manner in which the cuvette ring (32) moves within the incubation chamber (12), a plurality of different protocol assays each of which require different incubation times, can be simultaneously processed in the analyzer instrument.
摘要翻译：用于在自动免疫分析仪器（10）内运输和处理多种方案测定的方法和装置。该装置包括可移动地联接到磁环（30）的比色皿环（32）。在一个实施例中，提供具有圆形形状的磁环（30）和比色杯环（32）。温度控制的壳体（28）围绕比色皿和磁体环设置，以提供旋转孵育和颗粒分离室（12）。试管环（32）容纳多个比色皿，每个比色杯可以在其中设置不同的测定。比色皿环（32）将孵育室周围的比色杯推进。多个用于抽吸和分配液体样品，试剂和洗涤液的离散处理中心设置在围绕孵育室（12）的预定位置处。试管环（32）围绕孵育室（12）沿顺时针和逆时针方向移动试管，以将特定的比色杯定位在多个离散加工中心中的特定的比色皿上，从而适应每个测定的不同方案。通过控制比色皿环（32）在孵育室（12）内移动的方式，可以在分析仪器中同时处理多个不同的方案测定，每种方法都需要不同的孵育时间。

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