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1. 发明申请

US20080176853A1 TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS 有权
标题翻译： TRIAZINE衍生物及其治疗应用
公开(公告)号：US20080176853A1
公开(公告)日：2008-07-24
申请号：US11956883
申请日：2007-12-14
申请人： Chunlin Tao , Qinwei Wang , Neil P. Desai , Patrick Soon-Shiong
发明人： Chunlin Tao , Qinwei Wang , Neil P. Desai , Patrick Soon-Shiong
IPC分类号： A61K31/53 , C07D403/12 , C07D403/14 , C07D413/14
CPC分类号： C07D417/12 , C07D251/16 , C07D401/12 , C07D417/14
摘要： The invention provides for Triazine derivatives and their use to modulate protein kinase activity in a variety of conditions and diseases.
摘要翻译：本发明提供三嗪衍生物及其在多种病症和疾病中调节蛋白激酶活性的用途。

2. 发明授权

US08580786B2 Triazine derivatives and their therapeutical applications 有权
标题翻译：三嗪衍生物及其治疗应用
公开(公告)号：US08580786B2
公开(公告)日：2013-11-12
申请号：US12971786
申请日：2010-12-17
申请人： Neil P. Desai , Patrick Soon-Shiong , Chunlin Tao , Qinwei Wang
发明人： Neil P. Desai , Patrick Soon-Shiong , Chunlin Tao , Qinwei Wang
IPC分类号： A61K31/53 , A61K31/496 , A61K31/5377 , A61P19/02 , C07D401/14 , C07D403/14 , C07D413/14
CPC分类号： C07D417/12 , C07D251/16 , C07D401/12 , C07D417/14
摘要： The invention provides for Triazine derivatives and their use to modulate protein kinase activity in a variety of conditions and diseases.
摘要翻译：本发明提供三嗪衍生物及其在多种病症和疾病中调节蛋白激酶活性的用途。

3. 发明授权

US07858782B2 Triazine derivatives and their therapeutical applications 有权
标题翻译：三嗪衍生物及其治疗应用
公开(公告)号：US07858782B2
公开(公告)日：2010-12-28
申请号：US11956883
申请日：2007-12-14
申请人： Chunlin Tao , Qinwei Wang , Neil P. Desai , Patrick Soon-Shiong
发明人： Chunlin Tao , Qinwei Wang , Neil P. Desai , Patrick Soon-Shiong
IPC分类号： C07D401/14 , C07D403/14 , C07D413/14 , A61K31/53 , A61K31/496 , A61K31/5377 , A61P35/00
CPC分类号： C07D417/12 , C07D251/16 , C07D401/12 , C07D417/14
摘要： The invention provides for Triazine derivatives and their use to modulate protein kinase activity in a variety of conditions and diseases.
摘要翻译：本发明提供三嗪衍生物及其在多种病症和疾病中调节蛋白激酶活性的用途。

4. 发明申请

US20090130163A1 Drugs With Improved Hydrophobicity For Incorporation in Medical Devices 审中-公开
标题翻译：具有改善疏水性的药物用于医疗器械中的并入
公开(公告)号：US20090130163A1
公开(公告)日：2009-05-21
申请号：US11816307
申请日：2006-02-21
申请人： Neil P. Desai , Chunlin Tao , Cheng Zhi Yu , Qinwei Wang , Patrick Soon-Shiong
发明人： Neil P. Desai , Chunlin Tao , Cheng Zhi Yu , Qinwei Wang , Patrick Soon-Shiong
IPC分类号： A61F2/04 , A61K31/337 , A61K31/4375 , A61K31/395 , A61K31/09 , C07D305/08 , A61K31/44 , A61K31/436 , A61K9/00
CPC分类号： A61L31/16 , A61K31/145 , A61K31/337 , A61K31/395 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/148 , A61L2300/204 , A61L2300/416 , A61L2300/426 , A61L2420/06
摘要： The invention provides a medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The invention also provides a method of treating a narrowing in a body passageway comprising placing an implantable medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The medicaments can be incorporated within or coated on the device. The invention further provides hydrophobic analogs of medicaments known to inhibit cell proliferation and migration.
摘要翻译：本发明提供包含已知抑制细胞增殖和迁移的药物的疏水类似物的医疗装置。本发明还提供了一种治疗身体通道变窄的方法，包括放置包含已知抑制细胞增殖和迁移的药物的疏水类似物的可植入医疗装置。药物可以结合在装置中或涂覆在装置上。本发明还提供已知抑制细胞增殖和迁移的药物的疏水类似物。

5. 发明申请

US20110150763A1 TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS 有权
标题翻译： TRIAZINE衍生物及其治疗应用
公开(公告)号：US20110150763A1
公开(公告)日：2011-06-23
申请号：US12971786
申请日：2010-12-17
申请人： Chunlin Tao , Qinwei Wang , Neil P. Desai , Patrick Soon-Shiong
发明人： Chunlin Tao , Qinwei Wang , Neil P. Desai , Patrick Soon-Shiong
IPC分类号： A61K51/00 , A61K31/53 , A61K31/5377 , A61K38/21 , A61K33/24 , A61K38/20 , A61P35/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P19/02 , A61P29/00 , A61P7/10 , A61P27/02 , A61P11/00
CPC分类号： C07D417/12 , C07D251/16 , C07D401/12 , C07D417/14
摘要： The invention provides for Triazine derivatives and their use to modulate protein kinase activity in a variety of conditions and diseases.
摘要翻译：本发明提供三嗪衍生物及其在多种病症和疾病中调节蛋白激酶活性的用途。

6. 发明申请

US20130045240A1 COMBINATION THERAPY WITH NANOPARTICLE COMPOSITIONS OF TAXANE AND HEDGEHOG INHIBITORS 审中-公开
标题翻译：与TAXANE和HEDGEHOG抑制剂纳米复合物的组合治疗
公开(公告)号：US20130045240A1
公开(公告)日：2013-02-21
申请号：US13392501
申请日：2010-08-25
申请人： Chunlin Tao , Neil P. Desai , Patrick Soon-Shiong
发明人： Chunlin Tao , Neil P. Desai , Patrick Soon-Shiong
IPC分类号： A61K9/14 , A61P35/02 , A61K38/38 , A61P35/00 , B82Y5/00
CPC分类号： A61K47/42 , A61K9/5169 , A61K31/337 , A61K31/4355 , A61K31/7056
摘要： The present invention provides combination therapy methods of treating a proliferative disease (such as cancer) comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a hedgehog inhibitor that inhibits a hedgehog signaling pathway.
摘要翻译：本发明提供了治疗增殖性疾病（例如癌症）的组合治疗方法，其包括向个体施用有效量的纳米颗粒组合物中的紫杉烷，以及抑制刺猬蛋白信号传导途径的刺猬蛋白抑制剂。

7. 发明授权

US08026275B2 Compositions, methods of use and preparation of 2,6-diisopropyl phenol and analogs for ischemic injury 有权
标题翻译：组合物，使用方法和制备2,6-二异丙基苯酚和类似物用于缺血性损伤
公开(公告)号：US08026275B2
公开(公告)日：2011-09-27
申请号：US11816311
申请日：2006-02-17
申请人： Neil P. Desai , Chunlin Tao , Cheng Zhi Yu , Vuong Trieu , Patrick Soon-Shiong
发明人： Neil P. Desai , Chunlin Tao , Cheng Zhi Yu , Vuong Trieu , Patrick Soon-Shiong
IPC分类号： A01N43/06 , A01N36/00 , A61K31/12 , A61K31/38
CPC分类号： A61K31/05 , A61K31/12
摘要： The present invention provides novel 2,6-diisopropyl phenol2,6-diisopropyl phenol analogs and sterile, stable pharmaceutical compositions of 2,6-diisopropyl phenol 2,6-diisopropyl phenol and analogs thereof useful as an antioxidant in the treatment of ischemic injury including stroke and other cerebral injury. 2,6-diisopropyl phenol or its analogs are administered in a dosage effective to produce blood levels and brain levels of the drug that can prevent free radical damage associated with ischemic injury.
摘要翻译：本发明提供新颖的2,6-二异丙基苯酚2,6,6-二异丙基苯酚类似物和2,6-二异丙基苯酚2,6-二异丙基苯酚的无菌稳定药物组合物及其类似物，用作治疗缺血性损伤的抗氧化剂，包括中风等脑损伤。 2,6-二异丙基苯酚或其类似物以有效产生能够防止与缺血性损伤相关的自由基损伤的药物的血液水平和脑水平的剂量施用。

8. 发明授权

US5780653A Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers 失效
标题翻译：硝基苯基，10-脱乙酰基取代紫杉醇衍生物作为双功能细胞毒/放射增敏剂
公开(公告)号：US5780653A
公开(公告)日：1998-07-14
申请号：US485496
申请日：1995-06-07
申请人： Chunlin Tao , Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford
发明人： Chunlin Tao , Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford
IPC分类号： A61K41/00 , C07D233/91 , C07D305/14 , C07D305/00 , A61K51/04 , C07D233/02 , C07D413/00
CPC分类号： C07D305/14 , A61K41/0038
摘要： In accordance with the present invention, there are provided derivatives of chemotherapeutic agents (e.g., paclitaxel), which serve as bifunctional agents. Invention derivatives retain the antitumor activity of the parent compound, and, coupled with the electron affinic substituents thereon, produce compounds which show a strong capability for radiosensitizing tumor cells growing in vitro. It is expected that a single drug which combines the properties of a radiosensitizer with chemotherapeutic activity will offer significant advantages not only to patients, but also to radiotherapists seeking improved modes of treatment. The combination of antitumor properties with electron-affinic function produces novel radiosensitizers, a second generation of drugs which are more powerful to fight cancers. Bifunctional agents with the dual properties of tubulin assembly and electron affinity will make the compounds useful not only as radiosensitizers, but also as cytotoxins.
摘要翻译：根据本发明，提供了用作双功能试剂的化学治疗剂（例如紫杉醇）的衍生物。本发明衍生物保留了母体化合物的抗肿瘤活性，并且与其上的电子亲和取代基一起产生显示出对体外生长的肿瘤细胞放射增敏的强大能力的化合物。预期将放射增敏剂的性质与化疗活性相结合的单一药物将不仅对患者具有显着的优点，而且还将提供寻求改善治疗方式的放射治疗师的显着优点。抗肿瘤性质与电子亲和功能的组合产生新型放射增敏剂，第二代更强大的抗癌药物。具有微管蛋白装配和电子亲和力的双重特性的双功能试剂将使得该化合物不仅用作放射增敏剂，而且用作细胞毒素。

9. 发明授权

US07700612B2 Di-ester prodrugs of camptothecin, process for their preparation and their therapeutical applications 失效
标题翻译：喜树碱的二酯前药，其制备方法及其治疗应用
公开(公告)号：US07700612B2
公开(公告)日：2010-04-20
申请号：US10583803
申请日：2004-12-23
申请人： Patrick Soon-Shiong , Neil P. Desai , Chunlin Tao , Cheng Zhi Yu
发明人： Patrick Soon-Shiong , Neil P. Desai , Chunlin Tao , Cheng Zhi Yu
IPC分类号： A61K31/4745 , C07D491/22
CPC分类号： C07D491/22 , C07D498/14
摘要： The present invention is related to 10,20-di-O ester derivatives of camptothecin and pharmaceutical formulations thereof. The compounds and pharmaceutical formulations of the present invention possess increased biological life span and bioavailability and reduced toxicity, while maintaining anti-cancer activity.
摘要翻译：本发明涉及喜树碱的10,20-二-O-酯衍生物及其药物制剂。本发明的化合物和药物制剂在保持抗癌活性的同时具有增加的生物寿命和生物利用度和降低的毒性。

10. 发明申请

US20080171687A1 Compositions And Methods For The Preparation And Administration Of Poorly Water Soluble Drugs 审中-公开
标题翻译：用于制备和施用不良水溶性药物的组合物和方法
公开(公告)号：US20080171687A1
公开(公告)日：2008-07-17
申请号：US11575031
申请日：2005-09-16
申请人： Neil P. Desai , Chunlin Tao , Andrew Yang , Bridget Beal-Grim , Tapas De , Patrick Soon-Shiong
发明人： Neil P. Desai , Chunlin Tao , Andrew Yang , Bridget Beal-Grim , Tapas De , Patrick Soon-Shiong
IPC分类号： A61K38/02 , A61K31/351 , A61K31/222 , A61K31/427
CPC分类号： A61K9/0019 , A61K31/00 , A61K47/26
摘要： Sterile, stable pharmaceutical formulations of poorly water-soluble drugs dissolved in dimethyl isosorbide, a water-miscible solvent, as well as methods for their preparation and administration.
摘要翻译：溶于二甲基异山梨醇，水溶性溶剂的水溶性差的药物的无菌，稳定的药物制剂，以及其制备和给药方法。

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