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1. 发明授权

US07316766B2 Electrochemical biosensor strip 有权
标题翻译：电化学生物传感器条
公开(公告)号：US07316766B2
公开(公告)日：2008-01-08
申请号：US11138403
申请日：2005-05-27
申请人： Chun-Tung Chen , Tsai-Yun Lee , Shu-Mei Wu , Chia-Chi Wu , Chun-Hui Pi , Chao-Wang Chen
发明人： Chun-Tung Chen , Tsai-Yun Lee , Shu-Mei Wu , Chia-Chi Wu , Chun-Hui Pi , Chao-Wang Chen
IPC分类号： G01N27/327
CPC分类号： G01N27/3272
摘要： An electrochemical biosensor strip has a base, an electrode system, an optional spacer and a cover. The electrode system is laid on the base. The spacer is laid on the electrode system and exposes a portion of the electrode system for electrical connection with a meter and a different portion of the electrode system for application of a test reagent. The cover is covered on the spacer to form a cavity. Between the test reagent and the base, a hydrophilic layer is laid between them for increasing the binding effect of the test reagent on the base. The hydrophilic layer is laid on the area excluding from the electrode system and laid on the electrode system about 50% to 0% of the electrode system corresponding to the test reagent. The hydrophilic layer will not interfere with signal transmission of the electrode system so the test is more accurate.
摘要翻译：电化学生物传感器条具有基底，电极系统，可选的间隔物和盖子。电极系统放在基座上。将间隔物放置在电极系统上并暴露电极系统的一部分，用于与仪表和用于施加测试试剂的电极系统的不同部分电连接。盖子覆盖在间隔件上以形成空腔。在测试试剂和碱之间，在它们之间铺设亲水层，以增加测试试剂在底物上的结合效果。将亲水层放置在除电极系统之外的区域上，并放置在与测试试剂相对应的电极系统的约50％至0％的电极系统上。亲水层不会干扰电极系统的信号传输，所以测试更准确。

2. 发明申请

US20060266645A1 Electrochemical biosensor strip 有权
标题翻译：电化学生物传感器条
公开(公告)号：US20060266645A1
公开(公告)日：2006-11-30
申请号：US11138403
申请日：2005-05-27
申请人： Chung-Tung Chen , Tsai-Yun Lee , Shu-Mei Wu , Chia-Chi Wu , Chun-Hui Pi , Chao-Wang Chen
发明人： Chung-Tung Chen , Tsai-Yun Lee , Shu-Mei Wu , Chia-Chi Wu , Chun-Hui Pi , Chao-Wang Chen
IPC分类号： G01N33/487
CPC分类号： G01N27/3272
摘要： An electrochemical biosensor strip has a base, an electrode system, an optional spacer and a cover. The electrode system is laid on the base. The spacer is laid on the electrode system and exposes a portion of the electrode system for electrical connection with a meter and a different portion of the electrode system for application of a test reagent. The cover is covered on the spacer to form a cavity. Between the test reagent and the base, a hydrophilic layer is laid between them for increasing the binding effect of the test reagent on the base. The hydrophilic layer is laid on the area excluding from the electrode system and laid on the electrode system about 50% to 0% of the electrode system corresponding to the test reagent. The hydrophilic layer will not interfere with signal transmission of the electrode system so the test is more accurate.
摘要翻译：电化学生物传感器条具有基底，电极系统，可选的间隔物和盖子。电极系统放在基座上。将间隔物放置在电极系统上并暴露电极系统的一部分，用于与仪表和用于施加测试试剂的电极系统的不同部分电连接。盖子覆盖在间隔件上以形成空腔。在测试试剂和碱之间，在它们之间铺设亲水层，以增加测试试剂在底物上的结合效果。将亲水层放置在除电极系统之外的区域上，并放置在与测试试剂相对应的电极系统的约50％至0％的电极系统上。亲水层不会干扰电极系统的信号传输，所以测试更准确。

3. 发明申请

US20060180467A1 Electrochemical biosensor strip 审中-公开
标题翻译：电化学生物传感器条
公开(公告)号：US20060180467A1
公开(公告)日：2006-08-17
申请号：US11056254
申请日：2005-02-14
申请人： Shu-Mei Wu , Chia-Chi Wu , Chun-Hui Pi , Chao-Wang Chen
发明人： Shu-Mei Wu , Chia-Chi Wu , Chun-Hui Pi , Chao-Wang Chen
IPC分类号： G01N33/487 , G01N27/30
CPC分类号： G01N27/3272
摘要： An electrochemical biosensor strip has a base, an electrode system, an optional spacer and a cover. The electrode system is laid on the base. The spacer is laid on the electrode system and exposes a portion of the electrode system for electrical connection with a meter and a different portion of the electrode system for application of a test reagent that is a reagent that is specific for the test to be performed by the strip. The cover is covered on the spacer to form a cavity. The spacer has an exhausting channel for exiting air such that receiving rate for drawing an analyte-containing fluid into the strip is increasing. Besides, the electrochemical biosensor strip may have a concave unit formed in the cover and corresponding to the test reagent for increasing receiving angles to draw an analyte-containing fluid into the strip such that the flow rate of the analyte-containing fluid is increasing so the test is more accurate.
摘要翻译：电化学生物传感器条具有基底，电极系统，可选的间隔物和盖子。电极系统放在基座上。将间隔物放置在电极系统上并暴露电极系统的一部分，用于与仪表和电极系统的不同部分电连接，以施加试验试剂，试剂特异于试验将由带子。盖子覆盖在间隔件上以形成空腔。间隔件具有用于排出空气的排气通道，使得将含分析物的流体拉入带中的接收速率增加。此外，电化学生物传感器条可以具有形成在盖中的凹形单元并且对应于测试试剂，用于增加接收角度以将含分析物的流体拉入带中，使得含分析物的流体的流速增加，测试更准确。

4. 发明申请

US20060182658A1 Intelligent biosensing meter 失效
公开(公告)号：US20060182658A1
公开(公告)日：2006-08-17
申请号：US11056089
申请日：2005-02-14
申请人： Shu-Mei Wu , Chia-Chi Wu , Chun-Hui Pi , Chao-Wang Chen
发明人： Shu-Mei Wu , Chia-Chi Wu , Chun-Hui Pi , Chao-Wang Chen
IPC分类号： G01N33/00
CPC分类号： G01N33/48771 , A61B2562/085 , G01N35/00732
摘要： An intelligent biosensing meter has a parameter storing unit stored a plurality of parameters that sample strips detection needed and at least one slot for receiving a sample strip or a code card. The code card can store a plurality of parameters therein that are not stored in the parameter storing unit. Therefore, the intelligent biosensing meter not only stores parameters therein but also receives the code card to store new parameter or download new parameter from an internet. Manufacturers can save budget for manufacturing code cards if parameters stored in the biosensing meter are suitable for testing a new batch of sample strip or download from the internet. Furthermore, the intelligent biosensing meter can insert different kind of cards or strips into one slot and recognize them by circuit design to control different functions. The biosensing meter of the present invention will decrease manufacturing cost and be operated easily.

5. 发明授权

US07514040B2 Intelligent biosensing meter 失效
标题翻译：智能生物传感仪
公开(公告)号：US07514040B2
公开(公告)日：2009-04-07
申请号：US11056089
申请日：2005-02-14
申请人： Shu-Mei Wu , Chia-Chi Wu , Chun-Hui Pi , Chao-Wang Chen
发明人： Shu-Mei Wu , Chia-Chi Wu , Chun-Hui Pi , Chao-Wang Chen
IPC分类号： G01N33/48 , G01N27/28 , G01N33/487
CPC分类号： G01N33/48771 , A61B2562/085 , G01N35/00732
摘要： An intelligent biosensing meter has a parameter storing unit stored a plurality of parameters that sample strips detection needed and at least one slot for receiving a sample strip or a code card. The code card can store a plurality of parameters therein that are not stored in the parameter storing unit. Therefore, the intelligent biosensing meter not only stores parameters therein but also receives the code card to store new parameter or download new parameter from an internet. Manufacturers can save budget for manufacturing code cards if parameters stored in the biosensing meter are suitable for testing a new batch of sample strip or download from the internet. Furthermore, the intelligent biosensing meter can insert different kind of cards or strips into one slot and recognize them by circuit design to control different functions. The biosensing meter of the present invention will decrease manufacturing cost and be operated easily.
摘要翻译：智能生物传感计具有一个参数存储单元，存储多个参数，这些参数需要样品条检测，至少一个槽用于接收样品条或代码卡。代码卡可以存储未存储在参数存储单元中的多个参数。因此，智能生物传感器不仅可以存储参数，还可以接收代码卡来存储新参数或从互联网下载新参数。制造商可以节省生产代码卡的预算，如果存储在生物传感计中的参数适用于测试新批次的样品条或从互联网下载。此外，智能生物传感仪可以将不同种类的卡片或条带插入到一个插槽中，并通过电路设计识别它们来控制不同的功能。本发明的生物传感计将降低制造成本并容易操作。

6. 发明申请

US20060070878A1 Electrochemical biosensor strip 审中-公开
标题翻译：电化学生物传感器条
公开(公告)号：US20060070878A1
公开(公告)日：2006-04-06
申请号：US10958291
申请日：2004-10-06
申请人： Shu-Mei Wu , Chia-Chi Wu , Yeong-Dar Chen , Chao-Wang Chen
发明人： Shu-Mei Wu , Chia-Chi Wu , Yeong-Dar Chen , Chao-Wang Chen
IPC分类号： G01N33/487 , G01N27/26
CPC分类号： G01N27/3272
摘要： An electrochemical biosensor strip has a base, an electrode system, a spacer and a cover. The electrode system is laid on the base and preferably comprises at least three electrodes. There is a short circuit formed between two selected electrodes of the at least three electrodes. The spacer is laid on the electrode system and exposes a portion of the electrode system for electrical connection with a meter and a different portion of the electrode system for application of a test reagent to those exposed surfaces of electrode system. The test reagent is a reagent that is specific for the test to be performed by the strip. The cover is covered on the spacer. The short circuit is used to switch on a meter for increasing the operative convenience and further used to recognize the suitable meter. The electrochemical biosensor strip may have a rough unit formed on the base for increasing the adhesion of the test reagent for the test to be performed by the strip.
摘要翻译：电化学生物传感器条具有基底，电极系统，间隔物和盖子。电极系统铺设在基底上，并且优选包括至少三个电极。在至少三个电极的两个所选择的电极之间形成短路。将间隔物放置在电极系统上并暴露电极系统的一部分，用于与仪表和电极系统的不同部分电连接，以将测试试剂施加到电极系统的暴露表面。测试试剂是一种试剂，该试剂特异性用于由条带进行的试验。盖子覆盖在垫片上。短路用于打开仪表，以增加操作方便性，并进一步用于识别合适的仪表。电化学生物传感器条可以具有形成在基底上的粗糙单元，以增加用于由条带执行的测试的测试试剂的粘附。

7. 发明申请

US20060074324A1 Biosensing meter plus blood pressure measuring apparatus 审中-公开
标题翻译：生物传感仪加血压测量仪
公开(公告)号：US20060074324A1
公开(公告)日：2006-04-06
申请号：US10958287
申请日：2004-10-06
申请人： Shu-Mei Wu , Chia-Chi Wu , Tung-Chuang Jan , Chao-Wang Chen
发明人： Shu-Mei Wu , Chia-Chi Wu , Tung-Chuang Jan , Chao-Wang Chen
IPC分类号： A61B5/02 , C12Q1/54 , A61B5/00
CPC分类号： A61B5/021 , A61B5/02225 , A61B5/14532 , A61B5/1495 , A61B2560/0223 , A61B2560/0252
摘要： A biosensing meter plus blood pressure measuring apparatus has a slot, an inflatable and deflatable cuff, a pressure sensor and a microprocessor. The slot is able to accept a code card with multiple parameters or a sample strip that comprises a reaction well and a plurality of electrodes thereon in contact with the reaction well. The pressure sensor is used for detecting arterial counterpressure pulses and oscillations at each of the cuff pressure deflating process. The microprocessor is used for controlling the cuff, converting counterpressure pulses and oscillations to voltage signals, processing the voltage signals into a sequence of peak amplitudes and determining a systolic pressure and a diastolic pressure. Furthermore, the microprocessor is used for reading multiple parameters in the code card to measure an analyte in an analyte-containing fluid and calculating a concentration of the analyte. When an analyte-containing fluid (normally blood) is received on the sample strip, the inspection result is obtained according to the operation procedure and parameters obtained previously by the code card. The present apparatus can monitor the blood glucose and blood pressure values at the same apparatus.
摘要翻译：生物传感仪加血压测量装置具有狭缝，充气和可放气的袖口，压力传感器和微处理器。插槽能够接受具有多个参数的代码卡或包含反应井和与反应井接触的多个电极的样品条。压力传感器用于在袖带压力放气过程中检测动脉反压脉冲和振荡。微处理器用于控制袖带，将反压脉冲和振荡转换为电压信号，将电压信号处理为峰值幅度序列，并确定收缩压和舒张压。此外，微处理器用于读取代码卡中的多个参数以测量含分析物的流体中的分析物并计算分析物的浓度。当在样品条上接收到含分析物的流体（通常为血液）时，根据操作程序和先前由代码卡获得的参数获得检查结果。本装置可以监视同一装置的血糖值和血压值。

8. 发明申请

US20110139634A1 SYSTEM AND METHOD FOR MEASURING ANALYTE CONCENTRATION WITH INTERFERANT CORRECTION 审中-公开
标题翻译：用于测量分析仪浓度与干扰物校正的系统和方法
公开(公告)号：US20110139634A1
公开(公告)日：2011-06-16
申请号：US12960777
申请日：2010-12-06
申请人： Tai-Cheng Chou , Chia-chi Wu , Tsai-Yun Lee , Chao-Wang Chen
发明人： Tai-Cheng Chou , Chia-chi Wu , Tsai-Yun Lee , Chao-Wang Chen
IPC分类号： G01F1/64 , G01N33/487
CPC分类号： G01N27/3274
摘要： The present invention is related to an electrochemical biosensing test strip, biosensing meter, system and method for analyte measurement incorporating a hematocrit correction. The biosensor strip comprises a first and a second electrode sets respectively for detecting analyte concentration and hematocrit level. The first and second electrode sets are respectively corresponding to different reaction zones and a reaction reagent is only formed on the first electrode set corresponding reaction zone. Applying a first signal comprising a DC component and a second signal comprising an AC component that has a constant frequency respectively to the first and second electrode sets can respectively detect an uncorrected analyte concentration and hematocrit level. Therefore, the corrected analyte concentration is more accurate by incorporating the hematocrit correction.
摘要翻译：本发明涉及一种电化学生物传感测试条，生物传感计，用于分析物测量的系统和方法，其包括血细胞比容校正。生物传感器条包括分别用于检测分析物浓度和血细胞比容水平的第一和第二电极组。第一和第二电极组分别对应于不同的反应区，反应试剂仅形成在第一电极组相应的反应区上。将包括DC分量的第一信号和包括具有恒定频率的AC分量的第二信号分别应用于第一和第二电极组可以分别检测未校正的分析物浓度和血细胞比容水平。因此，通过并入血细胞比容校正，校正的分析物浓度更准确。

9. 发明授权

US06475154B1 Method and apparatus for non-invasive blood-pressure measurement 失效
标题翻译：用于非侵入性血压测量的方法和装置
公开(公告)号：US06475154B1
公开(公告)日：2002-11-05
申请号：US09708465
申请日：2000-11-09
申请人： Shu-Mei Wu , Yao Ou-Yang , Ja-Shi Wu , Tung-Chuang Jan , Chao-Wang Chen
发明人： Shu-Mei Wu , Yao Ou-Yang , Ja-Shi Wu , Tung-Chuang Jan , Chao-Wang Chen
IPC分类号： A61B502
CPC分类号： A61B5/02225 , A61B5/0225
摘要： A method and an apparatus for non-invasive blood-pressure measurement performing step-by-step inflating and deflating of the cuff pressure are disclosed. The step-by-step inflation-and-deflation process of the invention can determine the highest inflating pressure and provide enough data to obtain a curve fitting envelope. Therefore, the inflation pressure of the cuff to be pumped much higher than the normal systolic pressure of the conventional method can be prevented. A comfortable systolic and diastolic pressure determination method applying fuzzy control is achieved.
摘要翻译：公开了一种用于非侵入式血压测量的方法和装置，其逐步地对袖带压力进行充气和放气。本发明的逐步通气和放气过程可以确定最高的充气压力并提供足够的数据以获得曲线拟合包络。因此，可以防止要泵送的袖带的充气压力远高于常规方法的正常收缩压。实现舒适的收缩压和舒张压测定方法应用模糊控制。

10. 发明授权

US06439768B1 Electronic thermometer and temperature prediction method therefor 失效
标题翻译：电子温度计及其温度预测方法
公开(公告)号：US06439768B1
公开(公告)日：2002-08-27
申请号：US09472746
申请日：1999-12-27
申请人： Shu-Mei Wu , Tung-Chuang Jan , Chao-Wang Chen
发明人： Shu-Mei Wu , Tung-Chuang Jan , Chao-Wang Chen
IPC分类号： G01K742
CPC分类号： G01K7/42
摘要： A thermometer having a symmetrical probe with a sensor for sensing temperatures and a processor, a method for calculating temperature of an object by a second-order differential equation comprises the steps of obtaining temperatures from object, performing a first temperature calculation to obtain an initial prediction of temperature of object, adding a compensation coefficient, generating a compensated temperature based on a combination of initial prediction of temperature of object and compensated coefficient, and calculating a stabilized prediction of temperature of object based on compensated temperature before sensor has reached temperature of object. This thermometer can effectively decreasing error during heat transfer process.
摘要翻译：具有用于感测温度的传感器的对称探头和处理器的温度计，通过二阶微分方程计算物体的温度的方法包括以下步骤：从物体获得温度，执行第一温度计算以获得初始预测的物体温度，加上补偿系数，根据物体的温度初始预测和补偿系数的组合产生补偿温度，并根据传感器达到物体温度之前的补偿温度计算物体温度的稳定预测。该温度计可以有效降低传热过程中的误差。

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