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1. 发明申请

US20050009117A1 Diagnostic kit and method using phycoerythrin to label tumor tissues and cells 审中-公开
标题翻译：诊断试剂盒和使用藻红蛋白标记肿瘤组织和细胞的方法
公开(公告)号：US20050009117A1
公开(公告)日：2005-01-13
申请号：US10682192
申请日：2003-10-10
申请人： Chuang-Chun Chiueh , Err-Cheng Chan , Chia-Rui Shen
发明人： Chuang-Chun Chiueh , Err-Cheng Chan , Chia-Rui Shen
IPC分类号： A61K49/00 , G01N1/30 , C12Q1/68 , G01N33/48 , G01N33/574
CPC分类号： A61K49/0045 , G01N1/30
摘要： This invention provides a method and a diagnostic kit that utilizes phycoerythrin to label tumor cells, wherein the high specificity and high affinity of phycoerythrin is to be used to label and enter tumor cells. With effective amount of phycoerythrin and suitable wavelength of light, the stimulated fluorescence from phycoerythrin can be used for tumor diagnosis.
摘要翻译：本发明提供了利用藻红蛋白标记肿瘤细胞的方法和诊断试剂盒，其中藻红蛋白的高特异性和高亲和力用于标记和进入肿瘤细胞。有效量的藻红蛋白和合适的波长的光，来自藻红蛋白的刺激荧光可用于肿瘤诊断。

2. 发明申请

US20050272104A1 Method for detection of Mycobacterium tuberculosis antigens in biological fluids 审中-公开
标题翻译：检测生物体液中结核分枝杆菌抗原的方法
公开(公告)号：US20050272104A1
公开(公告)日：2005-12-08
申请号：US10862748
申请日：2004-06-07
申请人： Err-Cheng Chan , Ming-Ying Yang
发明人： Err-Cheng Chan , Ming-Ying Yang
IPC分类号： G01N33/53 , G01N33/554 , G01N33/569
CPC分类号： G01N33/5695 , G01N33/554
摘要： A method for detection of mycobacterium tuberculosis antigens in biological fluids provides immunoassay methods, diagnostic kits, and an immunochromatoraphic assay device for detection of Mycobacterium tuberculosis antigens in biological specimens, preferably body fluids and tissues. The preferred body fluids are blood, serum, plasma, urine, pulmonary fluid, sputum, cerebrospinal fluid, and the preferred tissue is the lung biopsy specimen. The immunoassays require two primary antibodies against RD1, RD2, or RD3 of Mycobacterium tuberculosis. At least one of the primary antibodies is attached to a solid carrier. Optional, a second antibody against an animal species producing one of the primary antibodies can be added. Either the other primary antibody or the secondary antibody is labeled with a detection agent, which can be an enzymatic marker, a fluorescent or luminescent agent, a radio active label or a color particle. The biological specimens may be used directly, concentrated or diluted for the immunoassays.
摘要翻译：用于在生物流体中检测结核分枝杆菌抗原的方法提供免疫测定方法，诊断试剂盒和用于在生物样品中优选体液和组织中检测结核分枝杆菌抗原的免疫色谱测定装置。优选的体液是血液，血清，血浆，尿液，肺液，痰液，脑脊液，优选的组织是肺活检标本。免疫测定需要针对结核分枝杆菌的RD1，RD2或RD3的两种一抗。至少一种第一抗体连接到固体载体上。可以加入针对产生其中一种抗体的动物物种的第二抗体。另一个一抗或二次抗体用检测剂标记，其可以是酶标记物，荧光或发光剂，无线电活性标记物或着色颗粒。生物标本可直接使用，浓缩或稀释用于免疫测定。

3. 发明授权

US08691229B2 Method of PLSCR inhibition for cancer therapy 有权
标题翻译：癌症治疗PLSCR抑制方法
公开(公告)号：US08691229B2
公开(公告)日：2014-04-08
申请号：US13452515
申请日：2012-04-20
申请人： Err-Cheng Chan , Hong-Arh Fan , Kuei-Tien Chen , Yung-Bin Kuo , Jinn-Shiun Chen , Chung-Wei Fan
发明人： Err-Cheng Chan , Hong-Arh Fan , Kuei-Tien Chen , Yung-Bin Kuo , Jinn-Shiun Chen , Chung-Wei Fan
IPC分类号： A61K38/00
CPC分类号： A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/30 , C07K16/40 , C07K2317/34 , C07K2317/73 , C07K2317/734 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to a method of using inhibitors of phospholipid scramblases (PLSCRs) for the prophylactic or therapeutic treatment of cancers. The PLSCR-inhibitors of the invention comprise compounds PLSCR-specific monoclonal antibodies, antagonists or nucleic acids, which have ability to decrease the level and/or biological activity of PLSCRs in cancer cells.
摘要翻译：本发明涉及使用磷脂酶抑制剂（PLSCR）用于预防或治疗癌症的方法。本发明的PLSCR抑制剂包含具有降低癌细胞中PLSCR的水平和/或生物活性的能力的化合物PLSCR特异性单克隆抗体，拮抗剂或核酸。

4. 发明申请

US20130084582A1 SEROLOGICAL MARKERS FOR DETECTING COLORECTAL CANCER AND THEIR APPLICATION FOR INHIBITING COLORECTAL CANCER CELLS 审中-公开
标题翻译：用于检测彩色癌的血清学标记及其抑制色素细胞的应用
公开(公告)号：US20130084582A1
公开(公告)日：2013-04-04
申请号：US13252976
申请日：2011-10-04
申请人： Err-Cheng Chan , Kuei-Tien Chen , Jau-Song Yu , Yu-Sun Chang , Jinn-Shiun Chen
发明人： Err-Cheng Chan , Kuei-Tien Chen , Jau-Song Yu , Yu-Sun Chang , Jinn-Shiun Chen
IPC分类号： G01N33/574 , C12N5/09 , G01N21/76 , C12N9/14 , C07K14/47
CPC分类号： G01N33/92 , C07K14/47 , C12N9/14 , G01N33/57419
摘要： Embodiments relate to serological markers for detecting the colorectal cancer and applications of the serological markers. A phospholipid scramblase1 (PLSCR1), a stomatin-like protein 2 (STOML2) or a transport protein Sec61β (SEC61β) increases expression in the blood at the earlier stage of the colorectal cancer. Detecting the expression of the PLSCR1, STOML2 or SEC61β protein or an induced autoantibody of each protein in a blood sample is used to diagnose the colorectal cancer. Moreover, the serological marker improves the detection efficiency and the sensitivity in detecting the colorectal cancer and is used to predict the prognosis. The serological markers are applied in preparing a detection device or inhibiting the growth of the colorectal cancer cells.
摘要翻译：实施方案涉及用于检测结肠直肠癌的血清学标志物和血清学标记物的应用。磷脂蛋白酶1（PLSCR1），类胡萝卜素蛋白2（STOML2）或运输蛋白Sec61＆bgr; （SEC61＆bgr）在结肠直肠癌早期增加血液中的表达。检测PLSCR1，STOML2或SEC61＆bgr的表达; 蛋白质或血液样品中每种蛋白质的诱导自身抗体用于诊断结肠直肠癌。此外，血清学标记提高了检测结直肠癌的检测效率和灵敏度，并用于预测预后。血清学标记物用于制备检测装置或抑制结肠直肠癌细胞的生长。

5. 发明申请

US20080164156A1 Enzymatic method for detecting a sulfur containing amino acid using an electrochemical sensor 审中-公开
标题翻译：使用电化学传感器检测含硫氨基酸的酶法
公开(公告)号：US20080164156A1
公开(公告)日：2008-07-10
申请号：US12006380
申请日：2008-01-02
申请人： Xueji Zhang , Dong Zhao , Err-Cheng Chan , Tsan-Zon Liu
发明人： Xueji Zhang , Dong Zhao , Err-Cheng Chan , Tsan-Zon Liu
IPC分类号： G01N27/26
CPC分类号： C12Q1/001 , G01N33/6815
摘要： A method of detecting and measuring levels of a sulfur-containing amino acid in a sample is provided. The method includes combining an enzyme with an aqueous solution possibly comprising a sulfur-containing amino acid. When a sulfur-containing amino acid is present in the solution, it reacts with the enzyme and produces hydrogen sulfide or ammonia. An electrochemical sensor is employed to detect the presence of hydrogen sulfide or ammonia in the solution, and thereby detect the presence of sulfur-containing amino acid. The concentration of sulfur-containing amino acid present in the sample can be quantitatively measured or calculated using this method.
摘要翻译：提供了检测和测量样品中含硫氨基酸水平的方法。该方法包括将酶与可能包含含硫氨基酸的水溶液组合。当溶液中存在含硫氨基酸时，它与酶反应并产生硫化氢或氨。使用电化学传感器来检测溶液中硫化氢或氨的存在，从而检测含硫氨基酸的存在。存在于样品中的含硫氨基酸的浓度可以使用该方法定量测量或计算。

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