专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060099709A1 Targeted tumor therapy by use of recombinant adenovirus vectors that selectively replicate in hypoxic regions of tumors 审中-公开
标题翻译：通过使用在肿瘤缺氧区选择性复制的重组腺病毒载体进行靶向肿瘤治疗
公开(公告)号：US20060099709A1
公开(公告)日：2006-05-11
申请号：US10529071
申请日：2003-10-01
申请人： Chuan-Yuan Li , Qian Huang , Mark Dewhirst
发明人： Chuan-Yuan Li , Qian Huang , Mark Dewhirst
IPC分类号： C12N15/861 , A61K48/00
CPC分类号： C12N15/86 , A61K35/761 , A61K38/2013 , A61K38/208 , A61K48/00 , A61K48/0058 , C07K14/4702 , C07K14/52 , C07K14/525 , C12N15/85 , C12N2710/10332 , C12N2710/10343 , C12N2710/10345 , C12N2830/002 , C12N2830/008 , C12N2830/15 , C12N2830/60 , C12N2830/85 , C12N2840/20
摘要： The presently claimed subject matter provides conditionally replication competent adenoviral vectors that confer selective cytotoxicity on cells expressing HIF-1 by infecting cells that allow HIF-1 inducible promoters present within the vectors to function. Also provided are compositions and host cells based upon the vectors, as well as methods of propagating and using the vectors. The presently claimed subject matter further provides a method of inhibiting tumor growth by co-infecting cells in a tumor with a conditionally replication competent adenovirus vector in conjunction with a replication deficient adenovirus vector.
摘要翻译：目前要求保护的主题提供了条件复制的腺病毒载体，其通过感染允许存在于载体内的HIF-1诱导型启动子起作用的细胞赋予表达HIF-1的细胞的选择性细胞毒性。还提供了基于载体的组合物和宿主细胞，以及传播和使用载体的方法。目前要求保护的主题还提供了通过与复制缺陷型腺病毒载体结合的条件复制型腺病毒载体共同感染肿瘤中的细胞来抑制肿瘤生长的方法。

2. 发明申请

US20070135373A1 Method for selective expression of therapeutic genes by hyperthermia 审中-公开
标题翻译：通过热疗选择性表达治疗性基因的方法
公开(公告)号：US20070135373A1
公开(公告)日：2007-06-14
申请号：US11602476
申请日：2006-11-20
申请人： Chuan-Yuan Li , Qian Huang , Mark Dewhirst
发明人： Chuan-Yuan Li , Qian Huang , Mark Dewhirst
IPC分类号： A61K48/00 , A61N1/39
CPC分类号： A61K38/191 , A61K38/208 , A61K48/00 , A61K48/0058 , C12N15/86 , C12N2710/10343 , C12N2830/002 , C12N2830/85 , C12N2840/203
摘要： A method for controlling in vivo heat-inducible gene expression for provision of therapeutic polypeptide. The method includes the steps of: (a) providing a construct comprising a polynucleotide encoding a therapeutic polypeptide, wherein the polynucleotide is operatively linked to a heat-inducible promoter; (b) administering the construct to a warm-blooded vertebrate at a site at or near the tumor; and (c) applying heat to the site at or near the tumor to express the therapeutic polypeptide, whereby anti-tumor activity is observed.
摘要翻译：用于控制体内热诱导基因表达以提供治疗性多肽的方法。该方法包括以下步骤：（a）提供包含编码治疗性多肽的多核苷酸的构建体，其中所述多核苷酸可操作地连接于热诱导型启动子; （b）将该构建体施用于在肿瘤处或其附近的部位的温血脊椎动物; 和（c）向肿瘤处或附近的部位施加热量以表达治疗性多肽，由此观察到抗肿瘤活性。

3. 发明申请

US20100151576A1 TARGETED TUMOR THERAPY BY USE OF RECOMBINANT ADENOVIRUS VECTORS THAT SELECTIVELY REPLICATE IN HYPOXIC REGIONS OF TUMORS 审中-公开
标题翻译：通过使用重组腺病毒载体的靶向肿瘤治疗方法，其可选择性地替代肿瘤的高血压地区
公开(公告)号：US20100151576A1
公开(公告)日：2010-06-17
申请号：US12708866
申请日：2010-02-19
申请人： Chuan-Yuan Li , Qian Huang , Mark W. Dewhirst
发明人： Chuan-Yuan Li , Qian Huang , Mark W. Dewhirst
IPC分类号： C12N15/861
CPC分类号： C12N15/86 , A61K35/761 , A61K38/2013 , A61K38/208 , A61K48/00 , A61K48/0058 , C07K14/4702 , C07K14/52 , C07K14/525 , C12N15/85 , C12N2710/10332 , C12N2710/10343 , C12N2710/10345 , C12N2830/002 , C12N2830/008 , C12N2830/15 , C12N2830/60 , C12N2830/85 , C12N2840/20
摘要： The presently claimed subject matter provides conditionally replication competent adenoviral vectors that confer selective cytotoxicity on cells expressing HIF-1 by infecting cells that allow HIF-1 inducible promoters present within the vectors to function. Also provided are compositions and host cells based upon the vectors, as well as methods of propagating and using the vectors. The presently claimed subject matter further provides a method of inhibiting tumor growth by co-infecting cells in a tumor with a conditionally replication competent adenovirus vector in conjunction with a replication deficient adenovirus vector.
摘要翻译：目前要求保护的主题提供了条件复制的腺病毒载体，其通过感染允许存在于载体内的HIF-1诱导型启动子起作用的细胞赋予表达HIF-1的细胞的选择性细胞毒性。还提供了基于载体的组合物和宿主细胞，以及传播和使用载体的方法。目前要求保护的主题还提供了通过与复制缺陷型腺病毒载体结合的条件复制型腺病毒载体共同感染肿瘤中的细胞来抑制肿瘤生长的方法。

4. 发明申请

US20150190456A1 USE OF CASPASE 3 ACTIVITY AND ITS INHIBITORS 审中-公开
标题翻译：使用CASPASE 3活性及其抑制剂
公开(公告)号：US20150190456A1
公开(公告)日：2015-07-09
申请号：US14128228
申请日：2012-06-20
申请人： Chuan-Yuan Li , Qian Huang , Fang Li
发明人： Chuan-Yuan Li , Qian Huang , Fang Li
IPC分类号： A61K38/00 , G01N33/574 , A61K31/5377 , A61K31/27 , A61K45/06 , A61K31/404
CPC分类号： A61K38/005 , A61K31/10 , A61K31/27 , A61K31/404 , A61K31/5377 , A61K45/06 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/5743 , G01N2333/96466 , G01N2800/54
摘要： The present invention provides methods for using the level of caspase 3 activity for determining or prognosticating likelihood of cancer recurrence or relapse in a patient after the treatment for cancer. The present invention also provides methods for treating cancer in a patient using a caspase 3 inhibitor in conjunction with a conventional cancer treatment.
摘要翻译：本发明提供使用胱天蛋白酶3活性水平来确定或预测癌症治疗后患者癌症复发或复发的可能性的方法。本发明还提供了结合常规癌症治疗使用胱天蛋白酶3抑制剂治疗患者癌症的方法。

5. 发明授权

US07183262B2 Method for selective expression of therapeutic genes by hyperthermia 有权
公开(公告)号：US07183262B2
公开(公告)日：2007-02-27
申请号：US10172399
申请日：2002-06-14
申请人： Chuan-Yuan Li , Qian Huang , Mark W. Dewhirst
发明人： Chuan-Yuan Li , Qian Huang , Mark W. Dewhirst
IPC分类号： A01N43/04 , A01N63/00 , C12N15/00 , C12N15/63 , C07H21/04
CPC分类号： A61K38/191 , A61K38/208 , A61K48/00 , A61K48/0058 , C12N15/86 , C12N2710/10343 , C12N2830/002 , C12N2830/85 , C12N2840/203
摘要： A method for controlling in vivo heat-inducible gene expression for provision of therapeutic polypeptide. The method includes the steps of: (a) providing a construct comprising a polynucleotide encoding a therapeutic polypeptide, wherein the polynucleotide is operatively linked to a heat-inducible promoter; (b) administering the construct to a warm-blooded vertebrate at a site at or near the tumor; and (c) applying heat to the site at or near the tumor to express the therapeutic polypeptide, whereby anti-tumor activity is observed.

6. 发明授权

US09554128B2 Method and apparatus for reduction of deblocking filter 有权
标题翻译：去块滤波器的还原方法和装置
公开(公告)号：US09554128B2
公开(公告)日：2017-01-24
申请号：US14342334
申请日：2012-08-09
申请人： Chih-Wei Hsu , Qian Huang , Jicheng An , Xun Guo , Yu-Wen Huang , Shaw-Min Lei
发明人： Chih-Wei Hsu , Qian Huang , Jicheng An , Xun Guo , Yu-Wen Huang , Shaw-Min Lei
IPC分类号： H04N19/117 , H04N19/50 , H04N19/176 , H04N19/14 , H04N19/186 , H04N19/82 , H04N19/86
CPC分类号： H04N19/117 , H04N19/14 , H04N19/176 , H04N19/186 , H04N19/50 , H04N19/82 , H04N19/86
摘要： A method and apparatus for deblocking of reconstructed video are disclosed. In one embodiment, the method divides a block boundary into two sub-boundaries and separates lines or column across the sub-boundaries into two groups. The deblocking filter decision for each group is determined based on the lines or columns in the respective group. In another embodiment, the method divides block edges of blocks in the LCUs into two edge groups, where the first edge group corresponds to horizontal block edges between two LCUs and the second edge group corresponds to remaining block edges not included in the first edge group. The number of lines processed by a vertical filter in the first edge group is less than the number of lines processed by a vertical filter in the second edge group. Accordingly, a system embodying the present invention has reduced storage requirement.
摘要翻译：公开了一种重构视频解块的方法和装置。在一个实施例中，该方法将块边界划分为两个子边界，并将跨越子边界的线或列分成两组。基于相应组中的线或列确定每组的去块滤波器决定。在另一个实施例中，该方法将LCU中的块的块边缘划分为两个边缘组，其中第一边缘组对应于两个LCU之间的水平块边缘，并且第二边缘组对应于未包括在第一边缘组中的剩余块边缘。由第一边缘组中的垂直滤波器处理的线数小于由第二边缘组中的垂直滤波器处理的线数。因此，体现本发明的系统减少了存储要求。

7. 发明申请

US20130145243A1 TASK MANAGEMENT SYSTEM AND METHOD 审中-公开
标题翻译：任务管理系统与方法
公开(公告)号：US20130145243A1
公开(公告)日：2013-06-06
申请号：US13433740
申请日：2012-03-29
申请人： Qian Huang , Li-Juan Xu
发明人： Qian Huang , Li-Juan Xu
IPC分类号： G06F17/00
CPC分类号： G06Q10/109 , G06Q10/06311
摘要： A task management system including a monitor and a processing unit is provided. The monitor is for displaying a task schedule, which sequentially tabulates multiple time spots and multiple corresponding tasks. The processing unit is for operating an object at a to-be-executed time spot when the object is dragged to the to-be-executed time spot of the task schedule.
摘要翻译：提供了包括监视器和处理单元的任务管理系统。显示器用于显示任务计划，其顺序列出多个时间点和多个相应的任务。处理单元用于在将对象拖动到任务调度的待执行时间点时在待执行的时间点上操作对象。

8. 发明授权

US08370869B2 Video description system and method 失效
标题翻译：视频描述系统和方法
公开(公告)号：US08370869B2
公开(公告)日：2013-02-05
申请号：US11448114
申请日：2006-06-06
申请人： Seungyup Paek , Ana Benitez , Shih-Fu Chang , Atul Puri , Qian Huang , Chung-Sheng Li , John R. Smith , Lawrence Bergman
发明人： Seungyup Paek , Ana Benitez , Shih-Fu Chang , Atul Puri , Qian Huang , Chung-Sheng Li , John R. Smith , Lawrence Bergman
IPC分类号： H04H60/32 , G06K9/00
CPC分类号： G06K9/00711 , G06F17/30858 , G06K9/468
摘要： Systems and methods for describing video content establish video description records which include an object set (24), an object hierarchy (26) and entity relation graphs (28). Video objects can include global objects, segment objects and local objects. The video objects are further defined by a number of features organized in classes, which in turn are further defined by a number of feature descriptors (36, 38, and 40). The relationships (44) between and among the objects in the object set (24) are defined by the object hierarchy (26) and entity relation graphs (28). The video description records provide a standard vehicle for describing the content and context of video information for subsequent access and processing by computer applications such as search engines, filters and archive systems.
摘要翻译：用于描述视频内容的系统和方法建立包括对象集（24），对象层次（26）和实体关系图（28）的视频描述记录。视频对象可以包括全局对象，段对象和本地对象。视频对象由类别中组织的多个特征进一步限定，这些特征又由多个特征描述符（36,38和40）进一步限定。对象集合（24）中的对象之间和之间的关系（44）由对象层次结构（26）和实体关系图（28）定义。视频描述记录提供用于描述视频信息的内容和上下文的标准车辆，以便随后通过计算机应用（例如搜索引擎，过滤器和归档系统）进行访问和处理。

9. 发明授权

US07970822B2 Multimedia integration description scheme, method and system for MPEG-7 有权
标题翻译： MPEG-7多媒体集成描述方案，方法和系统
公开(公告)号：US07970822B2
公开(公告)日：2011-06-28
申请号：US12372052
申请日：2009-02-17
申请人： Ana Belen Benitez , Shih-Fu Chang , Qian Huang , Seungyup Paek , Atul Puri
发明人： Ana Belen Benitez , Shih-Fu Chang , Qian Huang , Seungyup Paek , Atul Puri
IPC分类号： G06F15/16 , G06F12/00
CPC分类号： G06F17/30044 , G06F17/3002 , G06F17/30038 , G06F17/30858 , G06F17/30914 , G06F17/30958 , Y10S707/99945 , Y10S707/99948
摘要： The invention provides a system and method for integrating multimedia descriptions in a way that allows humans, software components or devices to easily identify, represent, manage, retrieve, and categorize the multimedia content. In this manner, a user who may be interested in locating a specific piece of multimedia content from a database, Internet, or broadcast media, for example, may search for and find the multimedia content. In this regard, the invention provides a system and method that receives multimedia content and separates the multimedia content into separate components which are assigned to multimedia categories, such as image, video, audio, synthetic and text. Within each of the multimedia categories, the multimedia content is classified and descriptions of the multimedia content are generated. The descriptions are then formatted, integrated, using a multimedia integration description scheme, and the multimedia integration description is generated for the multimedia content. The multimedia description is then stored into a database. As a result, a user may query a search engine which then retrieves the multimedia content from the database whose integration description matches the query criteria specified by the user. The search engine can then provide the user a useful search result based on the multimedia integration description.
摘要翻译：本发明提供一种用于以允许人，软件组件或设备容易地识别，表示，管理，检索和分类多媒体内容的方式来集成多媒体描述的系统和方法。以这种方式，例如，可能有兴趣从数据库，因特网或广播媒体定位特定的多媒体内容的用户可以搜索和查找多媒体内容。在这方面，本发明提供了一种接收多媒体内容并将多媒体内容分离成分配给多媒体类别（诸如图像，视频，音频，合成和文本）的组件的系统和方法。在多媒体类别的每一个内，对多媒体内容进行分类，并且生成多媒体内容的描述。然后使用多媒体集成描述方案对所述描述进行格式化，集成化，并且为多媒体内容生成多媒体集成描述。然后将多媒体描述存储到数据库中。结果，用户可以查询搜索引擎，该搜索引擎然后从整合描述与用户指定的查询标准匹配的数据库中检索多媒体内容。然后，搜索引擎可以基于多媒体整合描述向用户提供有用的搜索结果。

10. 发明授权

US07843193B2 System for testing magnetic sensitivity of Hall-effect switch 有权
标题翻译：霍尔效应开关的磁敏度测试系统
公开(公告)号：US07843193B2
公开(公告)日：2010-11-30
申请号：US11859020
申请日：2007-09-21
申请人： Qian Huang
发明人： Qian Huang
IPC分类号： G01R33/06
CPC分类号： G01R33/07
摘要： A system and method for determining the magnetic sensitivity of a Hall-effect switch through the use of a variable powered DC electromagnet having a permanent magnet attached to it. In use the electromagnet is placed in contact with a Hall-effect switch component and the DC voltage varied until a detector determines the Hall-effect switch has been triggered. The electromagnet is then moved to be in contact with a probe connected to a Gauss meter to determine the magnetic sensitivity of the Hall-effect switch.
摘要翻译：一种用于通过使用具有附接到其上的永磁体的可变动力DC电磁铁来确定霍尔效应开关的磁敏感度的系统和方法。在使用中，电磁体与霍尔效应开关组件接触，直流电压变化，直到检测器确定霍尔效应开关已被触发。然后将电磁铁移动与与高斯计连接的探头接触，以确定霍尔效应开关的磁敏感度。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式