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1. 发明申请

US20070161711A1 Process for producing pellets for pharmaceutical compositions 审中-公开
标题翻译：制备药物组合物丸剂的方法
公开(公告)号：US20070161711A1
公开(公告)日：2007-07-12
申请号：US10581595
申请日：2004-12-15
申请人： Christopher Speirs , Peter Moir , Richard Williams , Michael Clark
发明人： Christopher Speirs , Peter Moir , Richard Williams , Michael Clark
IPC分类号： A61K31/12
CPC分类号： A61K9/1682 , A61J3/00 , A61K9/1694 , A61K31/00 , A61K31/165 , A61K31/4164 , A61K31/573
摘要： Water is used to control particle size in a process comprising mixing water with a composition comprising a rheology modifying agent and possibly sugar and cellulose to produce a paste. The paste is extruded to form particles which are then spheronised and dried. One advantage of using water to control particle size is that the number of particles having a diameter within required range, e.g. between from about 800 to about 1500 μm, may be increased.
摘要翻译：水用于在包括将水与包含流变改性剂和可能的糖和纤维素的组合物混合以产生糊料的方法中控制粒度。将糊料挤出以形成颗粒，然后将其球化并干燥。使用水来控制粒度的一个优点是具有所需范围内的直径的颗粒的数量，例如。介于约800至约1500μm之间，可以增加。

2. 发明申请

US20060127484A1 Controlled release composition 审中-公开
标题翻译：控制释放组成
公开(公告)号：US20060127484A1
公开(公告)日：2006-06-15
申请号：US10516950
申请日：2003-07-04
申请人： Christopher Speirs , Peter Moir , Richard Williams , Michael Clark
发明人： Christopher Speirs , Peter Moir , Richard Williams , Michael Clark
IPC分类号： A61K31/573 , A61K31/4164 , A61K9/14
CPC分类号： A61K9/1635 , A61K9/5084 , A61K31/167 , A61K31/4164 , A61K31/573 , A61K38/47
摘要： An improved composition for controlling the release profile of an active compound through the intestinal tract comprises particles, especially pellets, containing the active compound, which are coated with a pH dissolution dependent coating material or a polymethacrylate material, which is preferably pH dissolution dependent, to a certain thickness depending upon the location and rate of release of the active compound that is desired. In preferred compositions, two or more pluralities of particles, in which particles of each plurality are coated with pH dissolution dependent coating material or polymethacrylate material to a different thickness to those of each other plurality, are contained within an enterically coated capsule and provide release of the active compound at various desired locations in the intestinal tract.
摘要翻译：用于控制通过肠道的活性化合物的释放曲线的改进的组合物包含含有活性化合物的颗粒，特别是颗粒，其涂覆有pH溶解依赖性涂层材料或聚甲基丙烯酸甲酯材料，其优选pH溶解依赖性，一定的厚度取决于所需活性化合物的释放位置和速率。在优选的组合物中，两个或更多个颗粒，其中每个颗粒中的多个颗粒被pH溶解依赖性涂层材料或聚甲基丙烯酸甲酯材料涂覆至彼此不同厚度的颗粒，包含在肠溶包衣胶囊内，并提供活性化合物在肠道中的各种所需位置。

3. 发明申请

US20110210460A1 PROCESS FOR PRODUCING PELLETS FOR PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：生产药物组合物的细胞的方法
公开(公告)号：US20110210460A1
公开(公告)日：2011-09-01
申请号：US13103580
申请日：2011-05-09
申请人： Christopher SPEIRS , Peter Moir , Richard Williams , Michael Clark
发明人： Christopher SPEIRS , Peter Moir , Richard Williams , Michael Clark
IPC分类号： B29B9/16
CPC分类号： A61K9/1682 , A61J3/00 , A61K9/1694 , A61K31/00 , A61K31/165 , A61K31/4164 , A61K31/573
摘要： Water is used to control particle size in a process comprising mixing water with a composition comprising a rheology modifying agent and possibly sugar and cellulose to produce a paste. The paste is extruded to form particles which are then spheronised and dried. One advantage of using water to control particle size is that the number of particles having a diameter within a required range, e.g. between from about 800 to about 1500 μm, may be increased.
摘要翻译：水用于在包括将水与包含流变改性剂和可能的糖和纤维素的组合物混合以产生糊料的方法中控制粒度。将糊料挤出以形成颗粒，然后将其球化并干燥。使用水来控制颗粒尺寸的一个优点是具有所需范围内的直径的颗粒的数量，例如，介于约800至约1500μm之间。

4. 发明申请

US20110182986A1 CONTROLLED RELEASE COMPOSITION 审中-公开
标题翻译：控制释放组成
公开(公告)号：US20110182986A1
公开(公告)日：2011-07-28
申请号：US13079956
申请日：2011-04-05
申请人： Christopher J. Speirs , Peter Moir , Richard H. C. Williams , Michael S. Clark
发明人： Christopher J. Speirs , Peter Moir , Richard H. C. Williams , Michael S. Clark
IPC分类号： A61K9/14 , A61K9/48 , A61K31/573 , A61K38/47 , A61K31/4164 , A61K31/167 , A61P29/00 , A61P1/00
CPC分类号： A61K9/1635 , A61K9/5084 , A61K31/167 , A61K31/4164 , A61K31/573 , A61K38/47
摘要： An improved composition for controlling the release profile of an active compound through the intestinal tract comprises particles, especially pellets, containing the active compound, which are coated with a pH dissolution dependent coating material or a polymethacrylate material, which is preferably pH dissolution dependent, to a certain thickness depending upon the location and rate of release of the active compound that is desired. In preferred compositions, two or more pluralities of particles, in which particles of each plurality are coated with pH dissolution dependent coating material or polymethacrylate material to a different thickness to those of each other plurality, are contained within an enterically coated capsule and provide release of the active compound at various desired locations in the intestinal tract.
摘要翻译：用于控制通过肠道的活性化合物的释放曲线的改进的组合物包含含有活性化合物的颗粒，特别是颗粒，其涂覆有pH溶解依赖性涂层材料或聚甲基丙烯酸甲酯材料，其优选pH溶解依赖性，一定的厚度取决于所需活性化合物的释放位置和速率。在优选的组合物中，两个或更多个颗粒，其中每个颗粒中的多个颗粒被pH溶解依赖性涂层材料或聚甲基丙烯酸甲酯材料涂覆至彼此不同厚度的颗粒，包含在肠溶包衣胶囊内，并提供活性化合物在肠道中的各种所需位置。

5. 发明申请

US20050145048A1 Material stability test system 失效
标题翻译：材料稳定性试验系统
公开(公告)号：US20050145048A1
公开(公告)日：2005-07-07
申请号：US10964734
申请日：2004-10-15
申请人： Peter Moir , Nigel McSweeney
发明人： Peter Moir , Nigel McSweeney
IPC分类号： B01L3/14 , G01N17/00
CPC分类号： B01L3/50825 , B01L2200/147 , B01L2300/024 , B01L2300/046 , B01L2300/0663 , B01L2300/10 , B01L2300/12 , G01N17/002
摘要： A material stability test system has a plurality of sealed test containers mounted in an environmental chamber. Each container has means for generating a desired humidity within the container. The environmental chamber is operable to provide a desired temperature within the environmental chamber. A test sample is mounted in each container. A sensor unit on each container senses the temperature and humidity within the container. An associated datalogger unit on each container connected to the sensor unit collects and transmits sensed temperature and humidity data at timed intervals via radio link to a remote monitoring station including a PC for recordal and/or display.
摘要翻译：材料稳定性测试系统具有安装在环境室中的多个密封测试容器。每个容器具有用于在容器内产生所需湿度的装置。环境室可操作以在环境室内提供期望的温度。测试样品安装在每个容器中。每个容器上的传感器单元感测容器内的温度和湿度。连接到传感器单元的每个容器上的相关联的数据记录器单元经由无线电链路以定时的间隔将检测到的温度和湿度数据传送到包括用于记录和/或显示的PC的远程监控站。

6. 发明授权

US06177421B1 Amoxicillin and clavulanate composition 失效
标题翻译：阿莫西林和克拉维酸组成
公开(公告)号：US06177421B1
公开(公告)日：2001-01-23
申请号：US09304786
申请日：1999-05-04
申请人： Peter Moir , Siobhan Greene
发明人： Peter Moir , Siobhan Greene
IPC分类号： A61K3143
CPC分类号： A61K9/2027 , A61K9/2054
摘要： A storage-stable combination of at least one &bgr;-lactam antibiotic and at least one &bgr;-lactam inhibitor compressed into tablet form having a hardness of greater than 30 KP is disclosed.
摘要翻译：公开了至少一种β-内酰胺抗生素和至少一种压制成片剂形式的至少一种β-内酰胺抑制剂的储存稳定组合，其硬度大于30KP。

7. 发明申请

US20060013728A1 Material stability test kit 审中-公开
标题翻译：物质稳定性试剂盒
公开(公告)号：US20060013728A1
公开(公告)日：2006-01-19
申请号：US11228387
申请日：2005-09-19
申请人： Peter Moir
发明人： Peter Moir
IPC分类号： B01L3/00
CPC分类号： G01N17/002 , G01N2035/00455
摘要： A material stability test kit (50) has a container (51) which can be closed and sealed by a screw-on cover (52) after insertion of a test sample (26) together with a chemical humidifier (53) for generating a desired humidity within the container (51). The container (51) is of two part construction comprising an outer container (54) within which is nested a smaller inner container (55) supporting the test sample (26). The containers (54, 55) are of transparent material to allow viewing and inspection of the test sample (26) without removing the test sample from the container (51) which would disturb the desired climate condition generated within the container (51) by the humidifier (53). The humidifier (53) comprises a perforated receptacle (80) containing a saturated or non-saturated salt solution.
摘要翻译：材料稳定性测试试剂盒（50）具有容器（51），其可以在将测试样品（26）与化学加湿器（53）一起插入之后通过螺旋盖（52）封闭并密封，用于产生期望的容器（51）内的湿度。容器（51）是两部分构造，其包括外部容器（54），其中嵌套有支撑测试样品（26）的较小内部容器（55）。容器（54,55）是透明材料，以允许观察和检查测试样品（26），而不从容器（51）中移除测试样品，所述测试样品将通过所述容器（51）干扰所述容器（51）内产生的期望的气候条件加湿器（53）。加湿器（53）包括含有饱和或不饱和盐溶液的穿孔容器（80）。

8. 发明授权

US6066629A Storage stable amoxycillin and clavulanate suspension composition 失效
标题翻译：储存稳定的阿莫西林和克拉维酸悬浮液组成
公开(公告)号：US6066629A
公开(公告)日：2000-05-23
申请号：US304785
申请日：1999-05-04
申请人： Peter Moir , Siobhan Greene
发明人： Peter Moir , Siobhan Greene
IPC分类号： A61K9/00 , A61K31/43
CPC分类号： A61K9/0095 , A61K31/43
摘要： A dry powder formulation of antibiotic and .beta.-lactam inhibitor is provided which is suitable for use in a liquid suspension.
摘要翻译：提供抗生素和β-内酰胺抑制剂的干粉制剂，其适用于液体悬浮液。

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