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1. 发明申请

US20100203650A1 BIOMOLECULE BINDING LIGANDS 审中-公开
标题翻译：生物分子绑定配偶
公开(公告)号：US20100203650A1
公开(公告)日：2010-08-12
申请号：US12666322
申请日：2008-06-27
申请人： Christopher Robin Lowe , Abid Hussain , Michael Luis Mimmack , Jonathan Michael Haigh
发明人： Christopher Robin Lowe , Abid Hussain , Michael Luis Mimmack , Jonathan Michael Haigh
IPC分类号： G01N33/68 , C40B40/04 , C07C233/00 , C07C235/02 , C07D209/10 , C07D213/56 , C07D213/55 , C07D473/30 , C07C69/76 , C40B30/00 , G01N33/00 , G01N33/53 , C40B50/00
CPC分类号： C07C309/51 , B01D15/3804 , B01J20/286 , B01J20/289 , B01J20/3244 , B01J2220/54 , C07K1/22 , C40B30/04 , C40B40/04 , C40B50/14 , G01N33/531 , G01N33/532 , G01N33/54353 , Y10T436/143333 , Y10T436/145555 , Y10T436/147777 , Y10T436/17 , Y10T436/200833
摘要： The invention provides biomolecule binding ligands, collections of biomolecule binding ligands, and their use in the purification of biological mixtures and in the identification of ligands having an affinity for a substance. The ligand is a compound of formula (III) or a compound of formula (IV): wherein for compounds of formula (I) one of R1a, R1b, R2, R3 and R4 is a group comprising a linker attached to a support, and the others of R1a, R1b, R2, R3 and R4 are independently selected from optionally substituted C1-20 alkyl, optionally substituted C3-20 heterocyclyl or optionally substituted C5-20 aryl, and R1a, R1b and R2 are additionally selected from hydrogen, and R2 is additionally further selected from —S(═O)R5 and —C(═S)NR6R7, wherein R5, R6 and R7 are independently optionally substituted C1-20 alkyl, optionally substituted C3-20 heterocyclyl or optionally substituted C5-20 aryl, or, optionally, two or more of the others of R1a, R1b, R2, R3 and R4, together with the atoms to which they are bound, may form a ring; and for compounds of formula (II) one of R1a, R1b, R3 and R4 is a group comprising a linker attached to a support, and the others of R1a, R1b, R3 and R4 are independently selected optionally substituted C1-20 alkyl, optionally substituted C3-20 heterocyclyl or optionally substituted C5-20 aryl, and R1a, and R1b are additionally selected from hydrogen, or, optionally, two or more of the others of R1a, R1b, R3 and R4, together with the atoms to which they are bound, may form a ring.
摘要翻译：本发明提供生物分子结合配体，生物分子结合配体的集合，以及它们在生物混合物的纯化中的用途以及鉴定对物质具有亲和力的配体。配体是式（III）的化合物或式（IV）的化合物：其中对于式（I）的化合物，R 1a，R 1b，R 2，R 3和R 4中的一个是包含连接于载体的连接基团和其中R1a，R1b，R2，R3和R4独立地选自任选取代的C 1-20烷基，任选取代的C 3-20杂环基或任选取代的C 5-20芳基，并且R 1a，R 1b和R 2另外选自氢，和 R2还另外选自-S（= O）R 5和-C（= S）NR 6 R 7，其中R 5，R 6和R 7独立地是任选取代的C 1-20烷基，任选取代的C 3-20杂环基或任选取代的C 5-20芳基，或任选地，其中R1a，R1b，R2，R3和R4中的两个或更多个与它们所结合的原子一起形成环; 对于式（II）化合物，R 1a，R 1b，R 3和R 4中的一个是包含连接于载体的连接体的基团，R 1a，R 1b，R 3和R 4中的其它基团独立地选自任选取代的C 1-20烷基，取代的C 3-20杂环基或任选取代的C 5-20芳基，并且R 1a和R 1b另外选自氢，或任选地，R 1a，R 1b，R 3和R 4中的两个或多个，连同它们被绑定，可能形成一个戒指。

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