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1. 发明申请

US20080004429A1 Insulinotropic peptide synthesis using solid and solution phase combination techniques 审中-公开
标题翻译：使用固相和溶液相组合技术的胰岛素肽合成
公开(公告)号：US20080004429A1
公开(公告)日：2008-01-03
申请号：US11821017
申请日：2007-06-21
申请人： Christopher Roberts , Lin Chen , Yeun-Kwei Han
发明人： Christopher Roberts , Lin Chen , Yeun-Kwei Han
IPC分类号： C07K1/10 , C07K1/00 , C07K5/00
CPC分类号： C07K14/605 , A61K38/00
摘要： The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybrid”) approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to add additional amino acid material to one of the fragments. The fragments are then coupled together in the solid solution phase. The use of a pseudoproline in one of the fragments eases solid phase synthesis of that fragment and also eases subsequent solution phase coupling of this fragment to other fragments. The present invention is very useful for forming insulinotropic peptides such as GLP-1(7-36) and its natural and non-natural counterparts.
摘要翻译：本发明涉及使用固相和溶液相（“混合”）方法合成的促胰岛素肽的制备。通常，该方法包括使用固相化学合成三种不同的肽中间体片段。然后使用溶液相化学为其中一个片段添加另外的氨基酸材料。然后将片段在固溶相中偶联在一起。在其中一个片段中使用假脯氨酸使得该片段的固相合成减轻了该片段随后与其它片段的溶液相偶联。本发明对于形成促胰岛素肽如GLP-1（7-36）及其天然和非天然对应物非常有用。

2. 发明申请

US20070179279A1 Methods for the synthesis of arginine-containing peptides 审中-公开
标题翻译：合成含精氨酸肽的方法
公开(公告)号：US20070179279A1
公开(公告)日：2007-08-02
申请号：US11646779
申请日：2006-12-28
申请人： Lin Chen , Christopher Roberts
发明人： Lin Chen , Christopher Roberts
IPC分类号： C07K1/02
CPC分类号： C07K14/665 , C07K1/02 , C07K1/026 , C07K1/04 , C07K1/1075 , C07K5/06139 , C07K5/0817
摘要： Methods for the synthesis of arginine-containing peptides are provided. The methods include a step that minimizes contact of side chain protected arginine with base prior to the coupling step.
摘要翻译：提供了含有精氨酸的肽的合成方法。所述方法包括在偶联步骤之前使侧链保护的精氨酸与碱的接触最小化的步骤。

3. 发明申请

US20180162851A1 COMPOUNDS FOR THE MODULATION OF MYC ACTIVITY 审中-公开
公开(公告)号：US20180162851A1
公开(公告)日：2018-06-14
申请号：US15579833
申请日：2016-06-05
申请人： Christopher Roberts , Yi Zhang , Francis Beaumier , Luce Lépissier , Syros Pharmaceuticals, Inc.
发明人： Jason J. Marineau , Peter B. Rahl , Kevin Sprott , Stephane Ciblat , Boubacar Sow , Robin Larouche-Gauthier , Lauren Berstler , Christopher Roberts , Yi Zhang , Francis Beaumier , Luce Lépissier
IPC分类号： C07D417/04 , C07D417/14 , C07D495/04 , C07D513/02 , A61P35/00
CPC分类号： C07D417/04 , A61P35/00 , C07D417/14 , C07D495/04 , C07D513/02
摘要： The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angio genesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.

4. 发明申请

US20100272680A1 Piperidinyl Cyclic Amido Antiviral Agents 审中-公开
标题翻译：哌啶基环状酰氨基抗病毒剂
公开(公告)号：US20100272680A1
公开(公告)日：2010-10-28
申请号：US12702702
申请日：2010-02-09
申请人： Subramanian Baskaran , Jack Maung , Martin Neitzel , Rai Roopa , Christopher Roberts , Vincent Tai
发明人： Subramanian Baskaran , Jack Maung , Martin Neitzel , Rai Roopa , Christopher Roberts , Vincent Tai
IPC分类号： A61K38/21 , C07D471/04 , A61K31/437 , A61P31/12 , A61P31/14
CPC分类号： C07D471/04
摘要： Provided are compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).
摘要翻译：提供式（I）的化合物及其药学上可接受的盐，其药物组合物，其制备方法及其用于治疗由病毒如丙型肝炎病毒（HCV）的黄病毒科家族介导的病毒感染的用途。

5. 发明申请

US20070265262A1 N-(6-MEMBERED AROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS 失效
标题翻译： N-（6-MEMBERED AROMATIC RING）-AMIDO抗病毒化合物
公开(公告)号：US20070265262A1
公开(公告)日：2007-11-15
申请号：US11609854
申请日：2006-12-12
申请人： Franz SCHMITZ , Christopher Roberts , Ali Dehghani Abadi , Ronald Griffith , Martin Leivers
发明人： Franz SCHMITZ , Christopher Roberts , Ali Dehghani Abadi , Ronald Griffith , Martin Leivers
IPC分类号： A61K31/40 , A61K31/4164 , A61K31/426 , A61K31/445 , A61K31/47 , A61K31/497 , A61K31/517 , A61K31/535 , A61P31/12 , C07D207/02 , C07D277/62 , C07D401/12 , C07D403/12
CPC分类号： C07D207/16 , C07D209/18 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Disclosed are compounds having Formula (I) and the compositions and methods relating to these compounds, for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T, Z, R1, Y, and p are disclosed herein.
摘要翻译：公开了具有式（I）的化合物以及与这些化合物有关的组合物和方法，用于治疗或预防病毒感染至少部分地由病毒在黄病毒科中的病毒介导，其中A，R 2，本文公开了SUP，m，R，V，W，T，Z，R 1，Y和p。

6. 发明申请

US20070264283A1 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：US20070264283A1
公开(公告)日：2007-11-15
申请号：US11760127
申请日：2007-06-08
申请人： Gerald Gough , Christopher Roberts
发明人： Gerald Gough , Christopher Roberts
IPC分类号： A61K39/12 , A61K31/7088 , A61P15/00 , A61P31/22 , A61P35/00 , C07H21/04 , C12N15/63
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C12N2710/20022
摘要： The present invention relates to methods and compositions useful in the treatment and prevention of human papilloma virus infections. In particular the invention relates to nucleic acid molecules encoding E1 and/or E2 and vectors suitable for DNA vaccine delivery, and pharmaceutical compositions containing them. Methods for manufacturing said molecules, vectors and composition are also contemplated.
摘要翻译：本发明涉及可用于治疗和预防人乳头状瘤病毒感染的方法和组合物。特别地，本发明涉及编码E1和/或E2的核酸分子和适合于DNA疫苗递送的载体，以及含有它们的药物组合物。也可以考虑制造所述分子，载体和组合物的方法。

7. 发明申请

US20050137392A1 Process for producing N4-Acyl-5'-deoxy-5-fluorocytidine 有权
标题翻译：制备N4-酰基-5'-脱氧-5-氟胞苷的方法
公开(公告)号：US20050137392A1
公开(公告)日：2005-06-23
申请号：US11021703
申请日：2004-12-22
申请人： Christopher Roberts , Jim-wah Wong
发明人： Christopher Roberts , Jim-wah Wong
IPC分类号： C07H19/067
CPC分类号： C07H19/067
摘要： The present invention provides a process for producing a N4-acyl-5′-deoxy-5-fluorocytidine compound of the formula: where R2 is alkyl, cycloalkyl, aralkyl, aryl, or alkoxy.
摘要翻译：本发明提供下式的N 4 - 酰基-5'-脱氧-5-氟胞苷化合物的制备方法：其中R 2是烷基，环烷基，芳烷基，芳基或烷氧基。

8. 发明申请

US20080045498A1 POLYCYCLIC VIRAL INHIBITORS 审中-公开
标题翻译：多环病毒抑制剂
公开(公告)号：US20080045498A1
公开(公告)日：2008-02-21
申请号：US11780378
申请日：2007-07-19
申请人： Ronald Griffith , Christopher Roberts , Franz Schmitz , Janos Botyanszki , Rachel Marek , Dong-Fang Shi , Son Pham
发明人： Ronald Griffith , Christopher Roberts , Franz Schmitz , Janos Botyanszki , Rachel Marek , Dong-Fang Shi , Son Pham
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/5513 , A61K31/553 , A61P31/12 , C07D471/04 , C07D471/22 , C07D487/04 , C07D495/22 , C07D498/04
CPC分类号： C07D495/04 , C07D471/04
摘要： Disclosed are compounds and compositions of Formula (A) and their uses for treating Flaviviridae family virus infections.
摘要翻译：公开了式（A）的化合物和组合物及其用于治疗黄病毒科家族病毒感染的用途。

9. 发明授权

US07334041B2 Vehicle communications interface 有权
标题翻译：车辆通讯接口
公开(公告)号：US07334041B2
公开(公告)日：2008-02-19
申请号：US10787687
申请日：2004-02-26
申请人： Robert J. Swindells , Christopher Roberts
发明人： Robert J. Swindells , Christopher Roberts
IPC分类号： G06F15/173
CPC分类号： H04L29/06 , H04L41/06 , H04L67/12 , H04L69/329
摘要： An improved vehicle communications interface (VCI) is both economical and readily adaptable for running new software. The improved VCI includes a server coupled to a bank of processors. The server can communicate with a host, and the processors can communicate with different vehicle networks. Each processor includes a state machine and a media access controller for a particular vehicle network. The state machine identifies incoming messages that require real time responses and provides the requisite responses directly back to the network, without involvement of the server. Real time requirements of the server are thus relieved, allowing the server to run a non-real time, mainstream operating system for which new product software is readily available.
摘要翻译：改进的车辆通信接口（VCI）既经济又易于适应于运行新的软件。改进的VCI包括耦合到一组处理器的服务器。服务器可以与主机通信，并且处理器可以与不同的车辆网络进行通信。每个处理器包括用于特定车辆网络的状态机和媒体访问控制器。状态机识别需要实时响应的传入消息，并将必要的响应直接提供给网络，而不需要服务器的参与。因此，服务器的实时要求得到了缓解，使服务器能够运行一个非实时的主流操作系统，为新产品软件提供便利。

10. 发明申请

US20070265265A1 N-(5-MEMBERED AROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS 失效
标题翻译： N-（5-MEMBERED AROMATIC RING）-AMIDO抗病毒化合物
公开(公告)号：US20070265265A1
公开(公告)日：2007-11-15
申请号：US11609858
申请日：2006-12-12
申请人： Franz Schmitz , Christopher Roberts , Ali Dehghani Abadi , Ronald Griffith , Martin Leivers , Irina Slobodov , Roopa Rai
发明人： Franz Schmitz , Christopher Roberts , Ali Dehghani Abadi , Ronald Griffith , Martin Leivers , Irina Slobodov , Roopa Rai
IPC分类号： A61K31/426 , A61K31/5377 , A61P31/12 , A61P31/14 , C07D277/04 , C07D417/00
CPC分类号： C07D417/12 , C07D403/12 , C07D413/12 , C07D417/14 , C07D495/04 , C07D513/04
摘要： Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T, Z, R1, Y, and p are disclosed herein.
摘要翻译：公开了具有式（I）的化合物及其用于治疗或预防病毒感染的组合物和方法，所述病毒感染至少部分地由病毒的黄病毒科病毒介导，其中A，R 2，m 本文公开了R，V，W，T，Z，R 1，Y和p。

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