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    • 2. 发明授权
    • Methods and devices for intragastric support of functional or prosthetic gastrointestinal devices
    • 用于功能性或假性胃肠器官胃内支持的方法和装置
    • US08182441B2
    • 2012-05-22
    • US12136003
    • 2008-06-09
    • Christopher Paul SwainCole ChenMitchell DannGreg FluetJohn HancockJosiah VerkaikGerard von HoffmannJames Wright
    • Christopher Paul SwainCole ChenMitchell DannGreg FluetJohn HancockJosiah VerkaikGerard von HoffmannJames Wright
    • A61M1/36
    • A61F5/0076A61J15/0003A61J15/003A61J15/0049A61J15/0069A61J15/0084A61M31/00
    • Disclosed herein are systems and methods for attaching or maintaining the position of a therapeutic or diagnostic device in a body lumen, such as the GI tract without necessarily requiring any penetrating attachments through any body walls. The system can include at least two elements: a proximal orientation element and a distal support element. The proximal orientation element can be configured to reside at least partially within the esophageal lumen and the distal support element can be configured to reside in the stomach, such as along the greater curve of the stomach. An intragastric support system can have a first configuration in which the long axis of the proximal orientation element is substantially parallel and/or substantially coaxial with the long axis of the distal support element, and a second configuration in which the long axis of the proximal orientation element is not substantially coaxial with the long axis of the distal support element. The second configuration can thus advantageously retain the intragastric support system in place and prevent unwanted proximal migration of the distal support element into the esophagus or distal migration into the intestine.
    • 本文公开了用于将治疗或诊断装置的位置附接或维持在诸如GI道的体腔中的系统和方法,而不需要通过任何身体壁的任何穿透附着物。 该系统可以包括至少两个元件:近端定向元件和远侧支撑元件。 近端定向元件可被配置为至少部分地位于食管腔内,并且远端支撑元件可被配置为驻留在胃中,例如沿着胃的较大曲线。 胃内支持系统可以具有第一构造,其中近侧定向元件的长轴基本上与远侧支撑元件的长轴平行和/或基本上同轴,并且第二构造,其中近端定向的长轴 元件基本上与远侧支撑元件的长轴同轴。 因此,第二配置可以有利地将胃内支持系统保持在适当位置,并且防止远端支撑元件进入食道的不必要的近端迁移或远端移入肠内。
    • 3. 发明申请
    • METHODS AND DEVICES FOR INTRAGASTRIC SUPPORT OF FUNCTIONAL OR PROSTHETIC GASTROINTESTINAL DEVICES
    • 用于功能性或前置性胃肠道装置的肠内支持的方法和装置
    • US20090012553A1
    • 2009-01-08
    • US12136003
    • 2008-06-09
    • Christopher Paul SwainMitchell DannGreg FluetJohn HancockGerard von HoffmannJames Wright
    • Christopher Paul SwainMitchell DannGreg FluetJohn HancockGerard von HoffmannJames Wright
    • A61M29/00
    • A61F5/0076A61J15/0003A61J15/003A61J15/0049A61J15/0069A61J15/0084A61M31/00
    • Disclosed herein are systems and methods for attaching or maintaining the position of a therapeutic or diagnostic device in a body lumen, such as the GI tract without necessarily requiring any penetrating attachments through any body walls. The system can include at least two elements: a proximal orientation element and a distal support element. The proximal orientation element can be configured to reside at least partially within the esophageal lumen and the distal support element can be configured to reside in the stomach, such as along the greater curve of the stomach. An intragastric support system can have a first configuration in which the long axis of the proximal orientation element is substantially parallel and/or substantially coaxial with the long axis of the distal support element, and a second configuration in which the long axis of the proximal orientation element is not substantially coaxial with the long axis of the distal support element. The second configuration can thus advantageously retain the intragastric support system in place and prevent unwanted proximal migration of the distal support element into the esophagus or distal migration into the intestine.
    • 本文公开了用于将治疗或诊断装置的位置附接或维持在诸如GI道的体腔中的系统和方法,而不需要通过任何身体壁的任何穿透附着物。 该系统可以包括至少两个元件:近端定向元件和远侧支撑元件。 近端定向元件可被配置为至少部分地位于食管腔内,并且远端支撑元件可被配置为驻留在胃中,例如沿着胃的较大曲线。 胃内支持系统可以具有第一构造,其中近侧定向元件的长轴基本上与远侧支撑元件的长轴平行和/或基本上同轴,并且第二构造,其中近端定向的长轴 元件基本上与远侧支撑元件的长轴同轴。 因此,第二配置可以有利地将胃内支持系统保持在适当位置,并且防止远端支撑元件进入食道的不必要的近端迁移或远端移入肠内。
    • 9. 发明授权
    • High specific gravity intragastric device
    • 高比重胃内装置
    • US08758385B2
    • 2014-06-24
    • US12645466
    • 2009-12-22
    • John Hancock
    • John Hancock
    • A61M29/00
    • A61F5/0036A61F5/003
    • The teachings are directed to an intragastric device comprising a flexible and expandable bladder having a predetermined shape upon expansion for contacting the antrum of the stomach of a subject. The device is designed to avoid passage of any part of the device beyond the pylorus and lower esophageal sphincter while the bladder is expanded during use. In these embodiments, the bladder can contain a high specific gravity material when expanded; wherein, the high specific gravity material contributes to an in vivo specific gravity of the device that ranges from about 1.2 g/ml to about 2.1 g/ml and functions to direct the device to the pyloric antrum of the subject during use of the device. Moreover, these embodiments can include a filling material comprising a biocompatible fluid component and a hydrogel component to make the device substantially leakproof and contribute to the in vivo specific gravity of the device.
    • 该教导涉及一种胃内装置,其包括在膨胀时具有预定形状的柔性和可膨胀囊,用于接触受试者胃的胃窦。 该装置被设计成在使用过程中膀胱膨胀时避免设备的任何部分超过幽门和食管下括约肌。 在这些实施例中,当膨胀时,气囊可以包含高比重材料; 其中,所述高比重物质有助于所述装置的体内比重为约1.2g / ml至约2.1g / ml,并且用于在使用所述装置期间将所述装置引导至所述受试者的幽门窦。 此外,这些实施方案可以包括包含生物相容性流体组分和水凝胶组分的填充材料,以使得该装置基本上防漏并有助于该装置的体内比重。