专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20140017665A1 ORGAN TRANSPORTER WITH OXYGEN GENERATION 审中-公开
标题翻译：具有氧气生成的有机运输机
公开(公告)号：US20140017665A1
公开(公告)日：2014-01-16
申请号：US13545514
申请日：2012-07-10
申请人： Christopher P. STEINMAN , David KRAVITZ , Aaron R. FERBER , Ross LOCKWOOD , Rodney H. MONSON , Evan D. SHAPIRO
发明人： Christopher P. STEINMAN , David KRAVITZ , Aaron R. FERBER , Ross LOCKWOOD , Rodney H. MONSON , Evan D. SHAPIRO
IPC分类号： A01N1/02
CPC分类号： A01N1/0247
摘要： An apparatus for perfusing an organ or tissue includes a perfusion circuit for perfusing the organ or tissue; an oxygenator for oxygenating perfusate that circulates through the perfusion circuit; and an oxygen supply device such as an oxygen concentrator or an oxygen generator configured to supply oxygen to the oxygenator. A method of perfusing an organ or tissue includes producing oxygen from a device such as an oxygen concentrator and an oxygen generator; supplying the produced oxygen, preferably as the oxygen is produced, to a perfusate to oxygenate the perfusate; and perfusing the organ or tissue with the oxygenated perfusate. The produced oxygen preferably has a concentration greater than the oxygen concentration in air.
摘要翻译：用于灌注器官或组织的装置包括用于灌注器官或组织的灌注回路; 用于氧化灌注液的氧合器，其通过灌注回路循环; 以及氧气供应装置，例如氧气浓缩器或氧气发生器，其被配置为向氧合器供应氧气。灌注器官或组织的方法包括从诸如氧气浓缩器和氧气发生器的装置产生氧气; 将产生的氧优选作为产生氧气供应给灌注液以使灌注液充氧; 并用含氧灌注液灌注器官或组织。所产生的氧优选具有大于空气中的氧浓度的浓度。

2. 发明申请

US20140017662A1 ORGAN PERFUSION APPARATUS WITH DOWNSTREAM FLOW CONTROL 审中-公开
标题翻译：具有下游流量控制的有机吸收装置
公开(公告)号：US20140017662A1
公开(公告)日：2014-01-16
申请号：US13545281
申请日：2012-07-10
申请人： David KRAVITZ , Christopher P. STEINMAN , Jeffrey S. LOUIS , Matthew COPITHORNE , Brian L. OTTS , Peter DEMUYLDER
发明人： David KRAVITZ , Christopher P. STEINMAN , Jeffrey S. LOUIS , Matthew COPITHORNE , Brian L. OTTS , Peter DEMUYLDER
IPC分类号： A01N1/02
CPC分类号： A01N1/0247
摘要： An organ perfusion apparatus may include at least two tubes connected to an organ or tissue. A method of perfusing an organ or tissue may include connecting a first end of each of the at least two tubes to an organ or tissue, applying a fluid motive force to a perfusion fluid in the two tubes to force the fluid through the two tubes into the organ or tissue, and perfusing the organ or tissue through the at least two tubes such that the fluid motive force, provided by, e.g., a pump, and backpressure generated by the organ or tissue, establishes a flow balance between the at least two tubes. The flow balance may be altered without altering the fluid motive force that is applied.
摘要翻译：器官灌注装置可以包括连接到器官或组织的至少两个管。灌注器官或组织的方法可以包括将至少两个管中的每一个的第一端连接到器官或组织，将流体动力施加到两个管中的灌注流体，以迫使流体通过两个管进入所述器官或组织，并且通过所述至少两个管灌注所述器官或组织，使得由例如泵提供的流体动力和由所述器官或组织产生的背压在所述至少两个管之间建立流动平衡管。可以改变流动平衡而不改变施加的流体动力。

3. 发明申请

US20140017657A1 ORGAN TRANSPORT APPARATUS WITH SAMPLE COMPARTMENTS 有权
标题翻译：机关运输装置
公开(公告)号：US20140017657A1
公开(公告)日：2014-01-16
申请号：US13545210
申请日：2012-07-10
申请人： David KRAVITZ , Christopher P. STEINMAN , David PETTINATO , Matthew COPITHORNE , Brian L. OTTS , Robert J. ALLEN , Frank P. NANNA , Peter DEMUYLDER
发明人： David KRAVITZ , Christopher P. STEINMAN , David PETTINATO , Matthew COPITHORNE , Brian L. OTTS , Robert J. ALLEN , Frank P. NANNA , Peter DEMUYLDER
IPC分类号： A01N1/02
CPC分类号： A01N1/0252 , A01N1/0247 , A01N1/0273
摘要： An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a coolant container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment.
摘要翻译：用于器官或组织的储存，处理，评估和运输中的至少一个的装置包括构造成冷却器官或组织的冷却剂容器，构造成灌注器官或组织的灌注回路，以及用于保持生物样品。优选的装置在装置的第一盖（盖）下方具有包括冷却剂容器和样品室的第一内部隔室。该装置可以包括设备的第二盖（盖）下的第二内部隔室，第二内部隔室包括至少部分灌注回路和样品室。

4. 发明申请

US20120015343A1 METHODS FOR INCREASING ISOLATION YIELDS OF CELLULAR PRODUCTS 有权
标题翻译：增加细胞分离产物的方法
公开(公告)号：US20120015343A1
公开(公告)日：2012-01-19
申请号：US13183961
申请日：2011-07-15
申请人： Michael J. TAYLOR , Simona C. BAICU , David KRAVITZ
发明人： Michael J. TAYLOR , Simona C. BAICU , David KRAVITZ
IPC分类号： C12N5/071
CPC分类号： C12N5/0676 , A01N1/0247
摘要： Methods of isolating cellular products, such as pancreatic islets, may be used in diabetes research and therapeutic transplantation. The methods may involve providing a donor tissue having desired cells and undesired cells, perfusing the donor tissue with a perfusion solution, developing edema during perfusion of the donor tissue to form a swelled tissue, and separating the desired cells from undesired cellular material to obtain a cellular product. The methods may also include disrupting the tissue, and separating the desired cells from undesired cellular material to obtain the cellular product. The methods may result in an increased yield of cellular product that retains sufficient functional integrity to be useful as a transplantation resource.
摘要翻译：分离细胞产物（如胰岛）的方法可用于糖尿病研究和治疗性移植。所述方法可以包括提供具有所需细胞和不想要的细胞的供体组织，用灌注溶液灌注供体组织，在供体组织灌注期间形成水肿以形成溶胀组织，以及将期望的细胞与不想要的细胞材料分离，以获得细胞产品。所述方法还可包括破坏组织，以及将期望的细胞与不期望的细胞材料分离以获得细胞产物。所述方法可导致增加的细胞产物的产量，其保留足够的功能完整性以用作移植资源。

5. 发明申请

US20120315618A1 ASSESSING, MAINTAINING AND/OR RESTORING VIABILITY OF ORGANS/TISSUES 审中-公开
标题翻译：评估，维护和/或恢复机关/组织的可行性
公开(公告)号：US20120315618A1
公开(公告)日：2012-12-13
申请号：US13490852
申请日：2012-06-07
申请人： David KRAVITZ , Kelvin G. M. BROCKBANK , Lia H. CAMPBELL
发明人： David KRAVITZ , Kelvin G. M. BROCKBANK , Lia H. CAMPBELL
IPC分类号： A01N1/02 , G06F17/30
CPC分类号： A01N1/0247
摘要： Methods for ex vivo perfusion of organs (and/or tissues) with a perfusate designed to condition the organ with the desired effect being that upon transplant, said organ, having been administered said perfusate, is less likely to experience delayed graft function, deleterious effects of ischemia/reperfusion injury, including inflammatory reactions, and/or other detrimental responses that can injure the organ or recipient including precipitating or enhancing an immunological reaction from the recipient with the potential of compromising the graft's and/or recipients short teen and/or long term health and proper functionality while monitoring, sustaining and/or restoring the viability of the organ and preserving the organ for storage and/or transport.
摘要翻译：使用设计用于调节器官的器官（和/或组织）的体外灌注具有所需效果的方法是在移植后，已经施用所述灌注液的所述器官不太可能经历延迟的移植功能，有害作用的缺血/再灌注损伤（包括炎症反应）和/或可能损伤器官或受体的其他有害反应，包括从接受者中沉淀或增强免疫反应，并且潜在地损害移植物和/或接收者短的青少年和/或长长期健康和适当的功能，同时监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。

6. 发明申请

US20120148542A1 MACHINE PERFUSION WITH COMPLEMENT INHIBITORS 审中-公开
标题翻译：机器灌注与补充抑制剂
公开(公告)号：US20120148542A1
公开(公告)日：2012-06-14
申请号：US13315556
申请日：2011-12-09
申请人： David KRAVITZ
发明人： David KRAVITZ
IPC分类号： A01N1/02 , A61K35/12
CPC分类号： A01N1/0226
摘要： Methods for perfusing one or more organs, tissues or the like (hereinafter “organs”) with a composition comprising at least one complement inhibitor to sustain, maintain or improve the viability of the organs before and/or during transplantation.
摘要翻译：用包含至少一种补体抑制剂的组合物灌注一种或多种器官，组织等（以下称为“器官”）的方法，以在移植之前和/或期间维持，维持或改善器官的活力。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式