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1. 发明申请

US20100322859A1 ORAL DRUG COMPLIANCE MONITORING USING MAGNETIC-FIELD SENSORS 审中-公开
标题翻译：使用磁场传感器进行口服药物监测
公开(公告)号：US20100322859A1
公开(公告)日：2010-12-23
申请号：US12297321
申请日：2007-04-24
申请人： Christopher M. Jones , Maysam Ghovanloo , Douglas P. White , Peter K. Mercure , Malcolm W. Warren, II
发明人： Christopher M. Jones , Maysam Ghovanloo , Douglas P. White , Peter K. Mercure , Malcolm W. Warren, II
IPC分类号： A61K49/00 , G01R33/12 , G01N33/15
CPC分类号： A61B5/06 , A61B5/0002 , A61B5/4205 , A61B5/4833 , A61B5/4839 , A61B5/6822 , A61J3/007 , A61J2200/30
摘要： A method to measure compliance with a pharmaceutical regimen, by the steps of: (a) ingesting a dose of a medication (10) into the gastrointestinal tract of a person, the dose of medication (10) comprising a drug formulation (13) and a permanent magnet (14); (b) as a result of the ingestion of step (a), detecting passage of the permanent magnet (14) past at least two magnetic field sensors (20) positioned apart from each other and adjacent to the gastrointestinal tract; and (c) measuring compliance with the pharmaceutical regimen by way of the detection of step (b). And, apparatus useful to measure compliance with a pharmaceutical regimen by detecting ingestion of a dose of medication (10) comprising a drug formulation (13) and a permanent magnet (14), the apparatus including at least two magnetic field sensors (20) positioned apart from each other on a necklace (22), each magnetic field sensor (20) being in electronic communication with a microprocessor for receiving signals from the magnetic field sensors (20) to determine the passage of a permanent magnet (14) between the magnetic field sensors (20).
摘要翻译：一种通过以下步骤测量药物制剂的顺应性的方法：（a）将剂量的药物（10）摄入人的胃肠道，包含药物制剂（13）的药物剂量（10）和永久磁铁（14）; （b）作为步骤（a）摄取的结果，检测永磁体（14）经过位于彼此分开并邻近胃肠道的至少两个磁场传感器（20）的通道; 和（c）通过检测步骤（b）测量药物方案的顺应性。以及用于通过检测摄取包含药物制剂（13）和永磁体（14）的药物剂量（10）来测量药物方案的依从性的装置，所述装置包括至少两个磁场传感器（20），其定位在项链（22）上彼此分开，每个磁场传感器（20）与微处理器电子通信，用于接收来自磁场传感器（20）的信号，以确定永磁体（14）在磁性场传感器（20）。

2. 发明授权

US07382263B2 Oral drug compliance monitoring using radio frequency identification tags 有权
标题翻译：使用射频识别标签的口服药物依从性监测
公开(公告)号：US07382263B2
公开(公告)日：2008-06-03
申请号：US11436917
申请日：2006-05-18
申请人： Kristine L. Danowski , Larry S. Sun , Peter K. Mercure , Robert P. Haley , Douglas P. White , Michelle A. Pressler , Susan J. Babinec , Flor A. Castillo , Jahne Simon , Paul E. Cranley , Malcolm W. Warren, II , Diedre A. Strand , Bettina M. Rosner , Robert B. Fletcher , Christopher M. Jones , Thomas H. Kalantar , Mark T. Bernius , W. Chris McDougall , Mark S. B. Felix
发明人： Kristine L. Danowski , Larry S. Sun , Peter K. Mercure , Robert P. Haley , Douglas P. White , Michelle A. Pressler , Susan J. Babinec , Flor A. Castillo , Jahne Simon , Paul E. Cranley , Malcolm W. Warren, II , Diedre A. Strand , Bettina M. Rosner , Robert B. Fletcher , Christopher M. Jones , Thomas H. Kalantar , Mark T. Bernius , W. Chris McDougall , Mark S. B. Felix
IPC分类号： G08B13/14 , G08B23/00 , A61B19/00 , A61N5/00
CPC分类号： G06K19/04 , A01K11/007 , A61B5/4833 , A61J3/007 , A61J3/071 , A61J2200/30 , A61K9/0009 , A61K9/2072 , A61K9/4808 , G06K7/0008 , G06K7/10079 , G06K19/07327 , G06K19/07336 , G06K19/07345 , G06K19/07749 , H01Q1/2208 , H01Q1/273 , H01Q1/362 , H01Q7/00 , H01Q11/08
摘要： A device useful for oral drug delivery device consisting of: (a) a capsule, tablet or pill designed to disperse in the gastrointestinal system; (b) an RFID tag positioned in the capsule, tablet or pill, the RFID tag comprising an antenna; (c) an object selected from the group consisting of a magnet, a ferromagnetic object, a ferrite object and an electromagnetic shielding object positioned within, over or adjacent the antenna of the RFID tag to alter the antenna characteristics of the RFID tag so that if the RFID tag is interrogated before the capsule, tablet or pill disperses in the gastrointestinal system, the response of the RFID tag is sufficiently altered or attenuated to determine that the capsule, tablet or pill has not dispersed in the gastrointestinal system and so that if the RFID tag is interrogated after the capsule, tablet or pill has dispersed in the gastrointestinal system, the object separates from the RFID tag so that the response of the RFID tag is sufficiently detectable to determine that the capsule, tablet or pill has dispersed in the gastrointestinal system. Alternatively, a switch can be used to signal ingestion of the device, and change the response of the device.
摘要翻译：用于口服药物递送装置的装置包括：（a）设计成分散在胃肠系统中的胶囊，片剂或药丸; （b）定位在胶囊，药片或药丸中的RFID标签，RFID标签包括天线; （c）选自位于RFID标签的天线之内或之上的磁体，铁磁体，铁氧体物体和电磁屏蔽物体的物体，以改变RFID标签的天线特性，使得如果在胶囊，片剂或药丸分散在胃肠系统中之前询问RFID标签，RFID标签的反应被充分改变或减弱，以确定胶囊，片剂或药片未分散在胃肠系统中，并且如果在胶囊，片剂或药丸已经分散在胃肠系统中之后，RFID标签被询问，物体与RFID标签分离，使得RFID标签的反应充分可检测，以确定胶囊，片剂或药片已经分散在胃肠道系统。或者，可以使用开关来信号摄取设备，并且改变设备的响应。

3. 发明授权

US07145453B2 Harmonic wireless transponder sensor and method 有权
标题翻译：谐波无线应答器传感器和方法
公开(公告)号：US07145453B2
公开(公告)日：2006-12-05
申请号：US10932790
申请日：2004-09-02
申请人： Theodore E. Miller, Jr. , Eugene L. Liening , Malcolm W. Warren, II , Leo C. Kempel , Gregory L. Charvat
发明人： Theodore E. Miller, Jr. , Eugene L. Liening , Malcolm W. Warren, II , Leo C. Kempel , Gregory L. Charvat
IPC分类号： G08B1/08
CPC分类号： H04Q9/00 , G06K19/07749
摘要： A method for detecting a latent environmental effect (such as a corrosive environment under insulation) or a latent structural change (such as a crack in a concealed structural member) at a known remote concealed location. The method of the instant invention includes three steps. The first step is to use a harmonic electromagnetic transponder at the known remote concealed location of the latent environmental effect or the latent structural change, the harmonic electromagnetic transponder having a reactive portion which reacts to the latent environmental effect or latent structural change to modify the harmonic emission of the transponder. The second step is to remotely interrogate the transponder by directing electromagnetic radiation at the transponder. The third step is to use the harmonic emission of the transponder to remotely determine the latent environmental effect or the latent structural change.
摘要翻译：一种用于在已知的远程隐蔽位置检测潜在环境影响（例如绝缘下的腐蚀环境）或潜在结构变化（例如隐蔽结构构件中的裂纹）的方法。本发明的方法包括三个步骤。第一步是在已知的远程隐蔽位置使用谐波电磁应答器，潜在的环境效应或潜在的结构变化，谐波电磁应答器具有反应部分，与潜在的环境效应或潜在的结构变化相反，以改变谐波发射机的发射。第二步是通过在转发器上引导电磁辐射来远程询问应答器。第三步是使用应答器的谐波发射来远程确定潜在的环境影响或潜在的结构变化。

4. 发明授权

US6124027A Method for making porous zeolitic films 失效
标题翻译：多孔沸石薄膜的制备方法
公开(公告)号：US6124027A
公开(公告)日：2000-09-26
申请号：US237484
申请日：1994-05-03
申请人： Paul D. Ries , Michael M. Olken , Malcolm W. Warren, II , Robert C. Dye
发明人： Paul D. Ries , Michael M. Olken , Malcolm W. Warren, II , Robert C. Dye
IPC分类号： C23C14/06 , C23C14/28 , B05D3/06
CPC分类号： C23C14/06 , C23C14/28 , Y10T428/249953 , Y10T428/249987
摘要： A vapor deposition method for coating a substrate with a porous zeolitic film. The method includes two steps. The first step is to irradiate a zeolite with a pulsed laser beam to vaporize the zeolite in a plume adjacent to the zeolite. The second step is to intercept the plume on the substrate to form the porous zeolitic film. A piezoelectric substrate can be used to produce a chemical sensor.
摘要翻译：一种用多孔沸石膜涂覆基材的气相沉积方法。该方法包括两个步骤。第一步是用脉冲激光束照射沸石以使沸石在与沸石相邻的羽流中蒸发。第二步是拦截衬底上的羽流以形成多孔沸石膜。可以使用压电基板来生产化学传感器。

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