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1. 发明授权

US08727988B2 Tissue penetrating catheters having integral imaging transducers and their methods of use 有权
标题翻译：具有整体成像传感器的组织穿透导管及其使用方法
公开(公告)号：US08727988B2
公开(公告)日：2014-05-20
申请号：US13114987
申请日：2011-05-24
申请人： Christopher J. Flaherty , Jason B. Whitt , John Y. Chang , David R. Tholfsen , Philip C. Evard , Joshua Makower
发明人： Christopher J. Flaherty , Jason B. Whitt , John Y. Chang , David R. Tholfsen , Philip C. Evard , Joshua Makower
IPC分类号： A61B8/00 , A61B8/14 , A61M25/098
CPC分类号： A61B17/3403 , A61B1/3137 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B17/11 , A61B17/12109 , A61B17/12172 , A61B17/3207 , A61B17/320725 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/39 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/00455 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22038 , A61B2017/22069 , A61B2017/22072 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00869 , A61B2018/1425 , A61B2090/378 , A61B2090/3784 , A61B2090/3925 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61K31/195 , A61M25/0133 , A61M25/0152 , A61M29/00 , A61M29/02 , A61M2025/0076 , A61M2025/018 , A61M2025/1052
摘要： Devices and methods for penetrating from a vessel lumen in which a catheter device is positioned to a target location outside of that vessel lumen. A tissue penetrator advances from a catheter positioned within the vessel lumen to the target location when properly aimed. An imaging transducer fixedly mounted on or within the catheter body provides an imaging signal from which an image of the target location can be obtained. An imageable marker may be present on the catheter to form on the image obtainable from the imaging signal to predict the path that will be followed by the tissue penetrator when the tissue penetrator exits from the catheter. Alternatively, or addition thereto, the imaging transducer may comprise a plurality of imaging elements which are located so that the penetrator path indication can be obtained electronically without use of an imageable marker on the catheter.
摘要翻译：用于从其中导管装置定位到血管腔外的目标位置的血管腔穿透的装置和方法。当适当瞄准时，组织穿透器从位于血管腔内的导管前进到目标位置。固定地安装在导管主体上或内部的成像传感器提供成像信号，从该成像信号可以获得目标位置的图像。可以在导管上存在可成像的标记物以形成从成像信号获得的图像上，以便当组织穿透器从导管离开时预测组织穿透器将遵循的路径。或者，或者除此之外，成像换能器可以包括多个成像元件，其被定位成使得可以电子地获得穿透器路径指示，而不使用导管上的可成像标记。

2. 发明申请

US20110224596A1 Tissue Penetrating Catheters Having Integral Imaging Transducers and Their Methods of Use 有权
标题翻译：具有整体成像传感器的组织穿透导管及其使用方法
公开(公告)号：US20110224596A1
公开(公告)日：2011-09-15
申请号：US13114987
申请日：2011-05-24
申请人： J Christopher Flaherty , Jason B. Whitt , John Y. Chang , David R. Tholfsen , Philip C. Evard , Joshua Makower
发明人： J Christopher Flaherty , Jason B. Whitt , John Y. Chang , David R. Tholfsen , Philip C. Evard , Joshua Makower
IPC分类号： A61M1/00
CPC分类号： A61B17/3403 , A61B1/3137 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B17/11 , A61B17/12109 , A61B17/12172 , A61B17/3207 , A61B17/320725 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/39 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/00455 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22038 , A61B2017/22069 , A61B2017/22072 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00869 , A61B2018/1425 , A61B2090/378 , A61B2090/3784 , A61B2090/3925 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61K31/195 , A61M25/0133 , A61M25/0152 , A61M29/00 , A61M29/02 , A61M2025/0076 , A61M2025/018 , A61M2025/1052
摘要： A catheter device that is useable to penetrate from a blood vessel in which the catheter device is positioned to a target location comprises a flexible catheter advanceable into the first blood vessel, a tissue penetrator lumen adapted to receive an operative tissue penetrator which is usable to penetrate from the blood vessel to the target location when properly aimed. Further said catheter including an imaging transducer fixedly mounted on or within the catheter body to provide an imaging signal from which an image of the target location can be obtained. The catheter device may include an imageable marker on the catheter to form on the image obtainable from the imaging signal a penetrator path indication that indicates the path that will be followed by the tissue penetrator when the tissue penetrator exits from the catheter. Alternatively, or addition thereto, the imaging transducer may comprise a plurality of imaging elements which are located so that the penetrator path indication can be obtained. A method of utilizing such a catheter device to bypass an arterial obstruction is also disclosed.
摘要翻译：可用于从其中导管装置定位到目标位置的血管穿透的导管装置包括可推进到第一血管的柔性导管，适于接收可用于穿透的手术组织穿透器的组织穿透器腔从正确瞄准的血管到目标位置。另外所述导管包括固定地安装在导管主体上或导管本体内的成像传感器，以提供成像信号，从该成像信号可以获得目标位置的图像。导管装置可以包括导管上的可成像标记，以在成像信号上形成图像，该穿透器路径指示指示当组织穿透器从导管离开时将由组织穿透器跟随的路径。或者，或者除此之外，成像换能器可以包括多个成像元件，其被定位成可以获得穿透器路径指示。还公开了利用这种导管装置绕过动脉阻塞物的方法。

3. 发明授权

US06375615B1 Tissue penetrating catheters having integral imaging transducers and their methods of use 有权
标题翻译：具有整体成像传感器的组织穿透导管及其使用方法
公开(公告)号：US06375615B1
公开(公告)日：2002-04-23
申请号：US09282774
申请日：1999-03-31
申请人： J. Christopher Flaherty , Jason B. Whitt , John Y. Chang , David R. Tholfsen , Philip C. Evard , Joshua Makower
发明人： J. Christopher Flaherty , Jason B. Whitt , John Y. Chang , David R. Tholfsen , Philip C. Evard , Joshua Makower
IPC分类号： A61B812
CPC分类号： A61B17/3403 , A61B1/3137 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B17/11 , A61B17/12109 , A61B17/12172 , A61B17/3207 , A61B17/320725 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/39 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/00455 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22038 , A61B2017/22069 , A61B2017/22072 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00869 , A61B2018/1425 , A61B2090/378 , A61B2090/3784 , A61B2090/3925 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61K31/195 , A61M25/0133 , A61M25/0152 , A61M29/00 , A61M29/02 , A61M2025/0076 , A61M2025/018 , A61M2025/1052
摘要： A catheter device that is useable to penetrate from a blood vessel in which the catheter device is positioned to a target location comprises a flexible catheter advanceable into the first blood vessel, a tissue penetrator lumen adapted to receive an operative tissue penetrator which is usable to penetrate from the blood vessel to the target location when properly aimed. Further said catheter including an imaging transducer fixedly mounted on or within the catheter body to provide an imaging signal from which an image of the target location can be obtained. The catheter device may include an imageable marker on the catheter to form on the image obtainable from the imaging signal a penetrator path indication that indicates the path that will be followed by the tissue penetrator when the tissue penetrator exits from the catheter. Alternatively, or addition thereto, the imaging transducer may comprise a plurality of imaging elements which are located so that the penetrator path indication can be obtained. A method of utilizing such a catheter device to bypass an arterial obstruction is also disclosed.
摘要翻译：可用于从其中导管装置定位到目标位置的血管穿透的导管装置包括可推进到第一血管的柔性导管，适于接收可用于穿透的手术组织穿透器的组织穿透器腔从正确瞄准的血管到目标位置。另外所述导管包括固定地安装在导管主体上或导管本体内的成像传感器，以提供成像信号，从该成像信号可以获得目标位置的图像。导管装置可以包括导管上的可成像标记，以在成像信号上形成图像，该穿透器路径指示指示当组织穿透器从导管离开时将由组织穿透器跟随的路径。或者，或者除此之外，成像换能器可以包括多个成像元件，其被定位成可以获得穿透器路径指示。还公开了利用这种导管装置绕过动脉阻塞物的方法。

4. 发明申请

US20100121357A1 Tissue Penetrating Catheters having Integral Imaging Transducers and Their Methods of Use 审中-公开
标题翻译：具有整体成像传感器的组织穿透导管及其使用方法
公开(公告)号：US20100121357A1
公开(公告)日：2010-05-13
申请号：US12634916
申请日：2009-12-10
申请人： J. Christopher Flaherty , Jason B. Whitt , John Y. Chang , David R. Tholfsen , Philip C. Evard , Joshua Makower
发明人： J. Christopher Flaherty , Jason B. Whitt , John Y. Chang , David R. Tholfsen , Philip C. Evard , Joshua Makower
IPC分类号： A61B17/11 , A61B17/34
CPC分类号： A61B17/3403 , A61B1/3137 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B17/11 , A61B17/12109 , A61B17/12172 , A61B17/3207 , A61B17/320725 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/39 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/00455 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22038 , A61B2017/22069 , A61B2017/22072 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00869 , A61B2018/1425 , A61B2090/378 , A61B2090/3784 , A61B2090/3925 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61K31/195 , A61M25/0133 , A61M25/0152 , A61M29/00 , A61M29/02 , A61M2025/0076 , A61M2025/018 , A61M2025/1052
摘要： A catheter device that is useable to penetrate from a blood vessel in which the catheter device is positioned to a target location comprises a flexible catheter advanceable into the first blood vessel, a tissue penetrator lumen adapted to receive an operative tissue penetrator which is usable to penetrate from the blood vessel to the target location when properly aimed. Further said catheter including an imaging transducer fixedly mounted on or within the catheter body to provide an imaging signal from which an image of the target location can be obtained. The catheter device may include an imageable marker on the catheter to form on the image obtainable from the imaging signal a penetrator path indication that indicates the path that will be followed by the tissue penetrator when the tissue penetrator exits from the catheter. Alternatively, or addition thereto, the imaging transducer may comprise a plurality of imaging elements which are located so that the penetrator path indication can be obtained. A method of utilizing such a catheter device to bypass an arterial obstruction is also disclosed.
摘要翻译：可用于从其中导管装置定位到目标位置的血管穿透的导管装置包括可推进到第一血管的柔性导管，适于接收可用于穿透的手术组织穿透器的组织穿透器腔从正确瞄准的血管到目标位置。另外所述导管包括固定地安装在导管主体上或导管本体内的成像传感器，以提供成像信号，从该成像信号可以获得目标位置的图像。导管装置可以包括导管上的可成像标记，以在成像信号上形成图像，该穿透器路径指示指示当组织穿透器从导管离开时将由组织穿透器跟随的路径。或者，或者除此之外，成像换能器可以包括多个成像元件，其被定位成可以获得穿透器路径指示。还公开了利用这种导管装置绕过动脉阻塞物的方法。

5. 发明授权

US07637870B2 Tissue penetrating catheters having integral imaging transducers and their methods of use 有权
公开(公告)号：US07637870B2
公开(公告)日：2009-12-29
申请号：US10714155
申请日：2003-11-14
申请人： J. Christopher Flaherty , Jason B. Whitt , John Y. Chang , David R. Tholfsen , Philip C. Evard , Joshua Makower
发明人： J. Christopher Flaherty , Jason B. Whitt , John Y. Chang , David R. Tholfsen , Philip C. Evard , Joshua Makower
IPC分类号： A61B8/00 , A61B8/14 , A61M29/098
CPC分类号： A61B17/3403 , A61B1/3137 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B17/11 , A61B17/12109 , A61B17/12172 , A61B17/3207 , A61B17/320725 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/39 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/00455 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22038 , A61B2017/22069 , A61B2017/22072 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00869 , A61B2018/1425 , A61B2090/378 , A61B2090/3784 , A61B2090/3925 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61K31/195 , A61M25/0133 , A61M25/0152 , A61M29/00 , A61M29/02 , A61M2025/0076 , A61M2025/018 , A61M2025/1052
摘要： A catheter device that is useable to penetrate from a blood vessel in which the catheter device is positioned to a target location comprises a flexible catheter advanceable into the first blood vessel, a tissue penetrator lumen adapted to receive an operative tissue penetrator which is usable to penetrate from the blood vessel to the target location when properly aimed. Further said catheter including an imaging transducer fixedly mounted on or within the catheter body to provide an imaging signal from which an image of the target location can be obtained. The catheter device may include an imageable marker on the catheter to form on the image obtainable from the imaging signal a penetrator path indication that indicates the path that will be followed by the tissue penetrator when the tissue penetrator exits from the catheter. Alternatively, or addition thereto, the imaging transducer may comprise a plurality of imaging elements which are located so that the penetrator path indication can be obtained. A method of utilizing such a catheter device to bypass an arterial obstruction is also disclosed.

6. 发明授权

US06660024B1 Tissue penetrating catheters having integral imaging transducers and their methods of use 有权
公开(公告)号：US06660024B1
公开(公告)日：2003-12-09
申请号：US10033836
申请日：2001-12-26
申请人： J. Christopher Flaherty , Jason B. Whitt , John Y. Chang , David R. Tholfsen , Philip C. Evard , Joshua Makower
发明人： J. Christopher Flaherty , Jason B. Whitt , John Y. Chang , David R. Tholfsen , Philip C. Evard , Joshua Makower
IPC分类号： A61B812
CPC分类号： A61B17/3403 , A61B1/3137 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B17/11 , A61B17/12109 , A61B17/12172 , A61B17/3207 , A61B17/320725 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/39 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/00455 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22038 , A61B2017/22069 , A61B2017/22072 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00869 , A61B2018/1425 , A61B2090/378 , A61B2090/3784 , A61B2090/3925 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61K31/195 , A61M25/0133 , A61M25/0152 , A61M29/00 , A61M29/02 , A61M2025/0076 , A61M2025/018 , A61M2025/1052
摘要： A catheter device that is useable to penetrate from a blood vessel in which the catheter device is positioned to a target location comprises a flexible catheter advanceable into the first blood vessel, a tissue penetrator lumen adapted to receive an operative tissue penetrator which is usable to penetrate from the blood vessel to the target location when properly aimed. Further said catheter including an imaging transducer fixedly mounted on or within the catheter body to provide an imaging signal from which an image of the target location can be obtained. The catheter device may include an imageable marker on the catheter to form on the image obtainable from the imaging signal a penetrator path indication that indicates the path that will be followed by the tissue penetrator when the tissue penetrator exits from the catheter. Alternatively, or addition thereto, the imaging transducer may comprise a plurality of imaging elements which are located so that the penetrator path indication can be obtained. A method of utilizing such a catheter device to bypass an arterial obstruction is also disclosed.

7. 发明授权

US06602241B2 Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
公开(公告)号：US06602241B2
公开(公告)日：2003-08-05
申请号：US09766502
申请日：2001-01-17
申请人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John A. Reggie , John Y. Chang , Joseph Catanese, III , David R. Tholfsen
发明人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John A. Reggie , John Y. Chang , Joseph Catanese, III , David R. Tholfsen
IPC分类号： A61M3100
CPC分类号： A61M25/065 , A61B17/00491 , A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12122 , A61B17/12136 , A61B17/12186 , A61B18/24 , A61B2017/00243 , A61B2017/00247 , A61B2017/00575 , A61B2018/00392 , A61M25/0069 , A61M25/0084 , A61M25/0102 , A61M2025/018
摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).

8. 发明申请

US20100016836A1 Methods and Apparatus for Acute or Chronic Delivery or Substances or Apparatus to Extravascular Treatment Sites 有权
标题翻译：用于急性或慢性输送的方法和装置，或用于血管外治疗部位的物质或装置
公开(公告)号：US20100016836A1
公开(公告)日：2010-01-21
申请号：US12567915
申请日：2009-09-28
申请人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John A. Reggie , John Y. Chang , Joseph Catanese, III , David R. Tholfsen
发明人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John A. Reggie , John Y. Chang , Joseph Catanese, III , David R. Tholfsen
IPC分类号： A61M25/06 , A61K35/12
CPC分类号： A61M25/065 , A61B17/00491 , A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12122 , A61B17/12136 , A61B17/12186 , A61B18/24 , A61B2017/00243 , A61B2017/00247 , A61B2017/00575 , A61B2018/00392 , A61M25/0069 , A61M25/0084 , A61M25/0102 , A61M2025/018
摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).
摘要翻译：用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁。此后，输送导管穿过穿透器的内腔到目标部位。然后将所需的物质或装置输送到目标部位或从目标部位获得。在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品从目标网站。或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

9. 发明授权

US07606615B2 Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
标题翻译：将物质或器械急性或慢性传播至血管外治疗部位的方法和装置
公开(公告)号：US07606615B2
公开(公告)日：2009-10-20
申请号：US10458153
申请日：2003-06-10
申请人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John A. Reggie , John Y. Chang , Joseph Catanese, III , David R. Tholfsen
发明人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John A. Reggie , John Y. Chang , Joseph Catanese, III , David R. Tholfsen
IPC分类号： A61M25/00
CPC分类号： A61M25/065 , A61B17/00491 , A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12122 , A61B17/12136 , A61B17/12186 , A61B18/24 , A61B2017/00243 , A61B2017/00247 , A61B2017/00575 , A61B2018/00392 , A61M25/0069 , A61M25/0084 , A61M25/0102 , A61M2025/018
摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).
摘要翻译：用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁。此后，输送导管穿过穿透器的内腔到目标部位。然后将所需的物质或装置输送到目标部位或从目标部位获得。在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品从目标网站。或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

10. 发明授权

US07357794B2 Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
标题翻译：用于急性或慢性传播物质或器械至血管外治疗部位的装置，系统和方法
公开(公告)号：US07357794B2
公开(公告)日：2008-04-15
申请号：US10466622
申请日：2002-01-17
申请人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John A. Reggie , John Y. Chang , Joseph Catanese, III , David R. Tholfsen
发明人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John A. Reggie , John Y. Chang , Joseph Catanese, III , David R. Tholfsen
IPC分类号： A61M31/00
CPC分类号： A61M25/0108 , A61B6/12 , A61M5/007 , A61M25/0084 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2210/12
摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).
摘要翻译：用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁。此后，输送导管穿过穿透器的内腔到目标部位。然后将所需的物质或装置输送到目标部位或从目标部位获得。在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品从目标网站。或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

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