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1. 发明申请

US20060073529A1 Luciferyl peptide substrate 审中-公开
标题翻译：萤光素肽底物
公开(公告)号：US20060073529A1
公开(公告)日：2006-04-06
申请号：US11204480
申请日：2005-08-15
申请人： Christopher Contag , Rajesh Shinde , Mark Bednarski , Samira Guccione
发明人： Christopher Contag , Rajesh Shinde , Mark Bednarski , Samira Guccione
IPC分类号： G01N33/574 , C12Q1/66 , C07K7/06
CPC分类号： C07K5/1013 , C12Q1/37 , C12Q1/66
摘要： Provided are luciferyl peptide substrates that are produced by attaching specifically prepared peptide conjugates to luciferin, and/or its analogs and derivatives. The luciferyl peptide substrates are incapable of penetrating cell membranes and tissue barriers. Cleavage of the peptide conjugates from the luciferyl peptide substrates releases the luciferin, which upon contact with luciferase emits photons for easy detection. The luciferyl peptide substrates may be used in assays to detect pathogens, test protease inhibitors, probe cell physiology, assess protease activity in oncogenesis, and improve specific and regulated drug delivery.
摘要翻译：提供的是荧光素肽底物，其通过将特异性制备的肽缀合物连接到荧光素和/或其类似物和衍生物而产生。萤光素肽基质不能穿透细胞膜和组织屏障。从荧光素肽底物切割肽缀合物释放荧光素，荧光素与萤光素酶接触时发射光子以便于检测。荧光素肽底物可用于检测病原体，测试蛋白酶抑制剂，探针细胞生理学，评估肿瘤发生中的蛋白酶活性，并改善特异性和调节药物递送的测定。

2. 发明申请

US20080095856A1 Encapsulated Nanoparticles for Drug Delivery 审中-公开
标题翻译：用于药物递送的封装纳米颗粒
公开(公告)号：US20080095856A1
公开(公告)日：2008-04-24
申请号：US11748408
申请日：2007-05-14
申请人： Gunilla Jacobson , Richard Zare , Karin Markides , Rajesh Shinde , Christopher Contag
发明人： Gunilla Jacobson , Richard Zare , Karin Markides , Rajesh Shinde , Christopher Contag
IPC分类号： A61K9/14 , A61K31/70 , A61K38/02
CPC分类号： A61K9/5153 , A61K9/5031 , A61K9/5036 , A61K9/5042 , A61K9/5192 , A61K47/6935 , A61K47/6937 , A61K49/0093 , B82Y5/00
摘要： Compositions and methods are provided for preparing nanosized biologically active agents, including agents formulated for target specific drug delivery. The nanosized agents are prepared with supercritical carbon dioxide as an antisolvent, providing nanoparticles whose size, shape, and surroundings are well-controlled. The nanoparticles are made of small molecules, e.g. drugs, anti-oxidants, luciferin, polypeptides, e.g. oligopeptides; polynucleotides, e.g. siRNA, antisense oligonucleotides, etc. In some embodiments, the nanoparticles comprise a polymer coating, which can provide for controlled delivery, targeting, controlled release, and the like. In other embodiments, the nanoparticles comprise a target specific tag for targeting the nanoparticles to a site of interest, e.g. tissue, cell, etc.
摘要翻译：提供组合物和方法用于制备纳米尺寸生物活性剂，包括配制用于靶特异性药物递送的试剂。用超临界二氧化碳作为反溶剂制备纳米尺寸剂，提供其尺寸，形状和环境受到良好控制的纳米颗粒。纳米颗粒由小分子制成。药物，抗氧化剂，荧光素，多肽等。寡肽; 多核苷酸，例如 siRNA，反义寡核苷酸等。在一些实施方案中，纳米颗粒包含可提供受控递送，靶向，控制释放等的聚合物涂层。在其它实施方案中，纳米颗粒包含靶标特异性标签，用于将纳米颗粒靶向感兴趣的位点。组织，细胞等

3. 发明申请

US20070254852A1 IMPROVED NITROREDUCTASE ENZYMES 失效
标题翻译：改进的硝酸酯酶
公开(公告)号：US20070254852A1
公开(公告)日：2007-11-01
申请号：US11643628
申请日：2006-12-20
申请人： A.C. Matin , Yoram Barak , Susan Lynch , David Ackerly , Stephen Thorne , Christopher Contag , Jianghong Rao
发明人： A.C. Matin , Yoram Barak , Susan Lynch , David Ackerly , Stephen Thorne , Christopher Contag , Jianghong Rao
IPC分类号： A61K31/7052 , C07H21/04 , C12N9/06 , C12Q1/26
CPC分类号： C12N9/0036 , G01N2333/90209
摘要： Compositions and methods are provided for the treatment of cancer.
摘要翻译：提供用于治疗癌症的组合物和方法。

4. 发明申请

US20050287072A1 Non-invasive localization of a light-emitting conjugate in a mammal 失效
公开(公告)号：US20050287072A1
公开(公告)日：2005-12-29
申请号：US11143422
申请日：2005-06-02
申请人： Pamela Contag , Christopher Contag , David Benaron
发明人： Pamela Contag , Christopher Contag , David Benaron
IPC分类号： A01K67/027 , A61K39/112 , A61K49/00 , C07K14/195 , C12N1/21 , C12Q1/02 , C12Q1/66 , G01N33/58
CPC分类号： A61K49/0008 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0337 , A01K2267/0393 , A61K49/0045 , A61K49/0097 , C07K14/195 , C12N2830/60 , C12Q1/02 , C12Q1/66 , G01N33/582 , Y10S436/80
摘要： Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.

5. 发明申请

US20070077231A1 Immune effector cells pre-infected with oncolytic virus 审中-公开
标题翻译：用溶瘤病毒预感染的免疫效应细胞
公开(公告)号：US20070077231A1
公开(公告)日：2007-04-05
申请号：US11529807
申请日：2006-09-29
申请人： Christopher Contag , Stephen Thorne
发明人： Christopher Contag , Stephen Thorne
IPC分类号： A61K48/00 , C12N5/08 , C12N15/86
CPC分类号： A61K35/17 , A61K35/13 , A61K39/0011 , A61K48/00 , A61K2035/124 , A61K2039/5156 , A61K2039/5158 , C12N5/0636 , C12N5/0638 , C12N5/0646 , C12N2710/24132
摘要： Compositions and methods are provided for the treatment of cancer. An immune effector cell population is pre-infected with an oncolytic virus. The combined therapeutic is safe and highly effective, producing an enhanced anti-tumor effect compared to either therapy alone. The methods of the invention thus provide for a synergistic effect based on the combined biotherapeutics.
摘要翻译：提供用于治疗癌症的组合物和方法。免疫效应细胞群体用溶瘤病毒预感染。联合治疗是安全和高效的，与单独的治疗相比，产生增强的抗肿瘤效果。因此，本发明的方法提供了基于组合的生物治疗剂的协同效应。

6. 发明申请

US20050238582A1 Non-invasive localization of a light-emitting conjugate in a mammal 失效
公开(公告)号：US20050238582A1
公开(公告)日：2005-10-27
申请号：US11147978
申请日：2005-06-08
申请人： Pamela Contag , Christopher Contag , David Benaron
发明人： Pamela Contag , Christopher Contag , David Benaron
IPC分类号： A01K67/027 , A61K39/112 , A61K49/00 , C07K14/195 , C12N1/21 , C12Q1/02 , C12Q1/66 , G01N33/58
CPC分类号： A61K49/0008 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0337 , A01K2267/0393 , A61K49/0045 , A61K49/0097 , C07K14/195 , C12N2830/60 , C12Q1/02 , C12Q1/66 , G01N33/582 , Y10S436/80
摘要： Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.

7. 发明授权

US06495355B1 Red-shifted luciferase 失效
标题翻译：红移荧光素酶
公开(公告)号：US06495355B1
公开(公告)日：2002-12-17
申请号：US09602628
申请日：2000-06-21
申请人： Christopher Contag , Brian Eames
发明人： Christopher Contag , Brian Eames
IPC分类号： C12N1553
CPC分类号： C12N9/0069
摘要： Nucleic acid compositions and polypeptides encoding a red-shifted form of firefly luciferase are provided. These red-shifted luciferases are characterized by spectrum of light emission having detectable emissions at 610 nm (luc610), preferably a primary peak at 610 nm. The nucleic acid compositions find use in various systems as a reporter gene, and are of particular interest for use as a reporter with in vivo systems, because of the efficient transfer of red light through tissues. The red-shifted luciferase may be combined in such assays with luciferases emitting at other spectra, in order to monitor multiple processes simultaneously.
摘要翻译：提供编码萤火虫荧光素酶的红移形式的核酸组合物和多肽。这些红移萤光素酶的特征在于在610nm具有可检测的发射光（luc610）的发光光谱，优选在610nm的主峰。核酸组合物在各种系统中用作报告基因，并且由于红光有效转移通过组织，因此特别关注用作体内系统的报告物。红移荧光素酶可以在这种测定中与在其它光谱发射的荧光素酶组合，以便同时监测多个过程。

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