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1. 发明申请

US20160311779A1 2-BENZYL-BENZIMIDAZOLE COMPLEMENT FACTOR B INHIBITORS AND USES THEREOF 有权
标题翻译： 2-苄基 - 苯并咪唑补体因子B抑制剂及其用途
公开(公告)号：US20160311779A1
公开(公告)日：2016-10-27
申请号：US15032872
申请日：2014-10-29
申请人： Christopher ADAMS , Takeru EHARA , Keith JENDZA , Nan JI , Toshio KAWANAMI , Nello MAINOLFI , James J. POWERS , Michael SERRANO-WU , Chun ZHANG , Rajeshri Ganesh KARKI
发明人： Christopher ADAMS , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Nello MAINOLFI , James POWERS , Michael Serrano-WU , Chun ZHANG
IPC分类号： C07D235/12 , C07D235/14
CPC分类号： C07D235/12 , A61K31/4184 , A61K45/06 , C07D235/14 , A61K2300/00
摘要： The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式（I）化合物，其用于制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

2. 发明申请

US20160024079A1 Complement Factor B inhibitors and uses there of 有权
标题翻译：补体因子B抑制剂及其用途
公开(公告)号：US20160024079A1
公开(公告)日：2016-01-28
申请号：US14774430
申请日：2014-03-13
申请人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Liang XUE , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
发明人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Liang XUE , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.
摘要翻译：本发明提供了式（I）化合物：其中X为N或CH，Y为NH，O或S，制备这些化合物的方法及其作为因子B抑制剂用于治疗与补体相关的病症和疾病的用途替代途径激活如年龄相关性黄斑变性，糖尿病性视网膜病变和相关眼科疾病。本发明还提供药物组合物和药理活性剂的组合。

3. 发明申请

US20150250767A1 Complement pathway modulators and uses thereof 审中-公开
公开(公告)号：US20150250767A1
公开(公告)日：2015-09-10
申请号：US14715594
申请日：2015-05-19
申请人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Liang XUE , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
发明人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Liang XUE , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
IPC分类号： A61K31/4184 , A61K31/4439 , A61K31/4245
CPC分类号： A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/4439 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/14 , C07D413/06 , C07D413/14 , C07D487/04 , C07D491/048
摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

4. 发明申请

US20130296377A1 Complement pathway modulators and uses thereof 有权
公开(公告)号：US20130296377A1
公开(公告)日：2013-11-07
申请号：US13826725
申请日：2013-03-14
申请人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Xue LIANG , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
发明人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Xue LIANG , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
IPC分类号： C07D491/048 , A61K31/4184 , C07D413/06 , A61K45/06 , C07D403/14 , C07D401/14 , A61K31/4439 , C07D403/06 , A61K31/423
CPC分类号： A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/4439 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/14 , C07D413/06 , C07D413/14 , C07D487/04 , C07D491/048
摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

5. 发明申请

US20120316448A1 BLOOD PRESSURE MEASURING DEVICE AND METHOD OF CALIBRATING THEREOF 有权
标题翻译：血压测量装置及其校准方法
公开(公告)号：US20120316448A1
公开(公告)日：2012-12-13
申请号：US13364297
申请日：2012-02-01
申请人： Wenbo GU , Chun ZHANG , Tun LAM , Lap Wai Lydia LEUNG
发明人： Wenbo GU , Chun ZHANG , Tun LAM , Lap Wai Lydia LEUNG
IPC分类号： A61B5/022 , A61B5/021
CPC分类号： A61B5/02108 , A61B5/0082 , A61B5/0261 , A61B5/489 , A61B2560/0223 , A61B2562/046 , A61B2562/066
摘要： The present invention is a blood pressure measuring device comprising an optical sensing unit adapted for detecting optical pulses at a plurality of locations on an external surface of a user. The device also comprises a processing unit coupled to the optical sensing unit for determining an optimal location from the plurality of locations based on the detected optical pulses and a pressure sensing unit adapted for detecting a pressure pulse of the user at a location of measurement. The present invention also discloses a method of measuring a blood pressure of a user using a blood pressure measurement device. The advantage of the present invention is that by using an optical sensing unit to locate the artery of the user, or to compensate the misalignment from the artery, the blood pressure is more accurately determined. With the calibration method, the deficient cuff calibration can be waived in certain circumstances.
摘要翻译：本发明是一种血压测量装置，其包括适于检测用户外表面上的多个位置处的光脉冲的光学感测单元。该装置还包括耦合到光学感测单元的处理单元，用于基于检测到的光脉冲确定来自多个位置的最佳位置，以及适于在测量位置检测用户的压力脉冲的压力感测单元。本发明还公开了一种使用血压测量装置测量使用者的血压的方法。本发明的优点在于，通过使用光学感测单元来定位用户的动脉，或者补偿与动脉的不对准，可以更精确地确定血压。使用校准方法，可以在某些情况下放弃缺陷袖带校准。

6. 发明申请

US20130303921A1 System and Method for Measurement of Physiological Data with Light Modulation 审中-公开
标题翻译：光调制生理数据测量系统及方法
公开(公告)号：US20130303921A1
公开(公告)日：2013-11-14
申请号：US13469094
申请日：2012-05-11
申请人： Lut Hey CHU , Ka Cheung KWOK , Chun ZHANG
发明人： Lut Hey CHU , Ka Cheung KWOK , Chun ZHANG
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0075 , A61B5/0205 , A61B5/02416 , A61B5/029 , A61B5/113 , A61B5/1455
摘要： The present invention discloses a device for measuring physiological data of a subject. It comprises a light modulation unit, an optical detection unit and a signal processing unit. The present invention can operate in an active mode or a passive mode to measure a subject's heart rate, respiratory information, haemoglobin level, cardiac output or oxygen saturation of the blood, etc. Fourier Transform based lock-in technique is used to detect the physiological signals reliably even when the signal is weak. In addition, ambient light can be used as the light source to complete the measurement.
摘要翻译：本发明公开了一种用于测量对象的生理数据的装置。它包括光调制单元，光检测单元和信号处理单元。本发明可以以活动模式或被动模式操作以测量受试者的心率，呼吸信息，血红蛋白水平，心输出量或血液的氧饱和度等。基于傅里叶变换的锁定技术用于检测生理即使信号较弱，信号也可靠。此外，环境光可以用作光源来完成测量。

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