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1. 发明授权

US11911143B2 Devices, systems, and methods for improving the accuracy and utility of imaging for cardiovascular procedures 有权
公开(公告)号：US11911143B2
公开(公告)日：2024-02-27
申请号：US16435270
申请日：2019-06-07
申请人： Pierre Jais , Remi Dubois , Stephen A. Leeflang , Christian S. Eversull
发明人： Pierre Jais , Remi Dubois , Stephen A. Leeflang , Christian S. Eversull
IPC分类号： A61B5/06 , A61B5/00
CPC分类号： A61B5/066 , A61B5/0044 , A61B5/7425
摘要： Apparatus and methods are provided for using catheters to increase the accuracy of anatomical maps in the setting of patient movement.

2. 发明授权

US09849260B2 Adhesive devices and methods for improving breathing and/or sleep using such devices 有权
公开(公告)号：US09849260B2
公开(公告)日：2017-12-26
申请号：US14200010
申请日：2014-03-06
申请人： Jed Eric Black , Stephen A. Leeflang , Christian S. Eversull
发明人： Jed Eric Black , Stephen A. Leeflang , Christian S. Eversull
IPC分类号： A61B18/08 , A61M16/06 , A61M16/20 , A61F5/56
CPC分类号： A61M16/0616 , A61F5/56 , A61M16/0688 , A61M16/208
摘要： Devices and methods are provided for inhibiting mouth breathing and/or improving nasal breathing, e.g., for PAP users or users with other sleeping problems. In an exemplary embodiment, an adhesive device is provided that includes an elongate membrane comprising first and second ends and side edges extending between the first and second ends, a first surface comprising an adhesive layer. The adhesive layer may be a low tack adhesive that is adherent to skin, yet is also easily removable without leaving significant residue. Optionally, the device may include one or more valves to provide one-way flow across the membrane, one or more weakened regions in the membrane, and/or one or more tabs to facilitate removal of the membrane from over a user's mouth.

3. 发明授权

US09271631B2 Oral airway devices and methods for making and using them 有权
标题翻译：口服气道装置及其使用方法
公开(公告)号：US09271631B2
公开(公告)日：2016-03-01
申请号：US13419430
申请日：2012-03-13
申请人： Stephen A. Leeflang , Christian S. Eversull
发明人： Stephen A. Leeflang , Christian S. Eversull
IPC分类号： A61M16/00 , A61B1/00 , A61B1/015 , A61B1/24
CPC分类号： A61B1/00071 , A61B1/00154 , A61B1/015 , A61B1/24
摘要： Airway devices are provided for introducing an endoscope into a patient's gastrointestinal system that include a tubular proximal portion sized for placement in an oral cavity and including a passage for receiving an endoscope therethrough, and a curved distal portion. The distal portion may have a “C” shaped wall defining a channel extending from the passage to a distal tip of the distal portion. The proximal portion may include a flange for placement adjacent the patient's teeth when the airway device is inserted into the oral cavity, and the airway device may include sampling and fluid delivery lumens including ports on the face of the flange. The sampling lumen may include an inlet port within the passage, and the fluid delivery lumen may include an outlet port communicating with the channel such that the outlet port is offset distally relative to the inlet port.
摘要翻译：提供气道装置用于将内窥镜引入到患者的胃肠系统中，该系统包括尺寸适于放置在口腔中的管状近端部分，并且包括用于接收内窥镜的通道和弯曲远端部分。远侧部分可以具有限定从该通道延伸到远侧部分的远侧末端的通道的“C”形壁。当气道装置插入口腔时，近侧部分可包括用于放置在患者牙齿附近的凸缘，并且气道装置可包括取样和流体输送腔，其包括在凸缘表面上的端口。采样腔可以包括通道内的入口端口，并且流体输送腔可以包括与通道连通的出口端口，使得出口端口相对于入口端口向远侧偏移。

4. 发明申请

US20140364765A1 SYSTEMS AND METHODS FOR PERFORMING MEDICAL PROCEDURES INVOLVING ACCESSING THE LYMPHATIC SYSTEM 审中-公开
标题翻译：执行接触淋巴系统的医疗程序的系统和方法
公开(公告)号：US20140364765A1
公开(公告)日：2014-12-11
申请号：US14300179
申请日：2014-06-09
申请人： Matthew J. Callaghan , Christian S. Eversull , Stephen A. Leeflang
发明人： Matthew J. Callaghan , Christian S. Eversull , Stephen A. Leeflang
IPC分类号： A61M1/36 , A61B10/00
CPC分类号： A61M1/3653 , A61B10/0045 , A61M1/3496 , A61M1/3609 , A61M1/3659 , A61M1/367 , A61M2202/0405 , A61M2205/3306 , A61M2205/3317 , A61M2230/207 , A61M2230/208
摘要： System and methods are provided for treating a patient that include a delivery device sized for introduction into a target site within a patient's body, a source of one or more therapeutic and/or diagnostic agents coupled to the delivery device, and a tubular member sized for introduction into the patient's vasculature to isolate the thoracic duct. Once the thoracic duct is isolated, fluid may be removed from the thoracic duct, e.g., to prevent the agents that transit from the target site into the thoracic duct from entering the patient's vasculature, and/or to modulate flow through the thoracic duct to modulate concentration and/or resident time of the agents at the target site. The one or more agents may include particles sized for preferential transit into the lymphatic system.
摘要翻译：提供了用于治疗患者的系统和方法，所述患者包括大小适于引入到患者体内的靶位点的递送装置，与所述递送装置联接的一个或多个治疗和/或诊断剂的源，以及尺寸适于引入患者的脉管系统以分离胸导管。一旦分离出胸导管，可以从胸导管移除流体，例如，以防止从目标部位进入胸导管的药物进入患者的脉管系统，和/或调节通过胸导管的流动来调节在目标地点的药剂的浓度和/或驻留时间。所述一种或多种药剂可包括尺寸适于优先转运入淋巴系统的颗粒。

5. 发明申请

US20140303461A1 APPARATUS AND METHODS FOR ACCESSING THE LYMPHATIC SYSTEM 审中-公开
标题翻译：用于接受淋巴系统的装置和方法
公开(公告)号：US20140303461A1
公开(公告)日：2014-10-09
申请号：US14214882
申请日：2014-03-15
申请人： Matthew J. Callaghan , Stephen A. Leeflang , Christian S. Eversull
发明人： Matthew J. Callaghan , Stephen A. Leeflang , Christian S. Eversull
IPC分类号： A61M1/14 , A61M25/04 , A61B5/00 , A61M1/00
CPC分类号： A61B5/41 , A61M1/3496 , A61M1/3609 , A61M1/3653 , A61M1/3659 , A61M1/367 , A61M25/04 , A61M2202/0405
摘要： Systems and methods are provided for performing a medical procedure within a patient's body that involves a thoracic duct including an ostium communicating with the patient's venous system. A distal end of a catheter is introduced through the patient's venous system into a body lumen adjacent the ostium of the thoracic duct. An expandable member on the distal end of the tubular member may be expanded adjacent the ostium, e.g., within the body lumen or the thoracic duct itself, and used to isolate the thoracic duct from the body lumen, whereupon a medical procedure may be performed via the thoracic duct. For example, lymphatic fluid may be removed from the thoracic duct through a lumen of the tubular member and/or one or more agents may be introduced into the thoracic duct through the tubular member.
摘要翻译：提供了系统和方法，用于在患者体内进行涉及包括与患者静脉系统连通的口的胸导管的医疗程序。将导管的远端通过患者的静脉系统引入与胸导管的口相邻的体腔内。管状构件的远端上的可膨胀构件可以邻近口，例如在体腔或胸导管本身内扩张，并且用于将胸导管与体腔隔离，于是可以经由胸导管。例如，淋巴液可以通过管状构件的内腔从胸导管移除，和/或一个或多个试剂可以通过管状构件引入胸导管。

6. 发明申请

US20140251335A1 ADHESIVE DEVICES AND METHODS FOR IMPROVING BREATHING AND/OR SLEEP USING SUCH DEVICES 审中-公开
标题翻译：用于改善使用这种装置的呼吸和/或睡眠的粘合装置和方法
公开(公告)号：US20140251335A1
公开(公告)日：2014-09-11
申请号：US14200010
申请日：2014-03-06
申请人： Jed Eric Black , Stephen A. Leeflang , Christian S. Eversull
发明人： Jed Eric Black , Stephen A. Leeflang , Christian S. Eversull
IPC分类号： A61M16/06 , A61M16/00 , A61M16/20
CPC分类号： A61M16/0616 , A61F5/56 , A61M16/0688 , A61M16/208
摘要： Devices and methods are provided for inhibiting mouth breathing and/or improving nasal breathing, e.g., for PAP users or users with other sleeping problems. In an exemplary embodiment, an adhesive device is provided that includes an elongate membrane comprising first and second ends and side edges extending between the first and second ends, a first surface comprising an adhesive layer. The adhesive layer may be a low tack adhesive that is adherent to skin, yet is also easily removable without leaving significant residue. Optionally, the device may include one or more valves to provide one-way flow across the membrane, one or more weakened regions in the membrane, and/or one or more tabs to facilitate removal of the membrane from over a user's mouth.
摘要翻译：提供了用于抑制嘴呼吸和/或改善鼻呼吸的装置和方法，例如对于PAP用户或具有其他睡眠问题的用户。在一个示例性实施例中，提供一种粘合装置，其包括细长膜，该细长膜包括在第一和第二端之间延伸的第一和第二端和侧边缘，第一表面包括粘合剂层。粘合剂层可以是粘附于皮肤的低粘性粘合剂，但也容易除去而不留下显着的残留物。可选地，该装置可以包括一个或多个阀，以提供穿过膜的单向流动，膜中的一个或多个弱化区域，和/或一个或多个突片，以便于将膜从使用者的嘴部上方移除。

7. 发明授权

US08062258B2 Mechanical pump for removal of fragmented matter and methods of manufacture and use 有权
标题翻译：用于去除碎片物质的机械泵及其制造和使用方法
公开(公告)号：US08062258B2
公开(公告)日：2011-11-22
申请号：US12638149
申请日：2009-12-15
申请人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
发明人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
IPC分类号： A61M5/178
CPC分类号： A61M25/0023 , A61B17/320725 , A61B2017/00685 , A61B2017/320775 , A61M29/02
摘要： Material transport catheters and methods for their use rely on rotation of an impeller within a catheter body and a clearing element for preventing buildup of materials at the opening of the catheter body. The impeller preferably comprises an inner tube or shaft having a helical rotor formed over an outer surface thereof. The clearing element may comprise a free end of a structure near the distal end of the catheter body for disrupting clot, wherein the free end of the structure extends into the distal opening of the catheter body to break up materials as the impeller is rotated. Alternatively, the clearing element may comprise a cutting member disposed at the distal opening of the catheter body.
摘要翻译：材料输送导管及其使用方法依赖于导管主体内的叶轮的旋转和用于防止材料在导管体开口处积累的清除元件。叶轮优选地包括在其外表面上形成有螺旋转子的内管或轴。清除元件可以包括靠近导管主体的远端的结构的自由端，用于破坏凝块，其中结构的自由端延伸到导管主体的远端开口以在叶轮旋转时分解材料。或者，清除元件可以包括设置在导管主体的远端开口处的切割构件。

8. 发明申请

US20110264057A1 CATHETERS WITH LUBRICIOUS LININGS AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：带有润滑衬里的导管及其制造和使用它们的方法
公开(公告)号：US20110264057A1
公开(公告)日：2011-10-27
申请号：US13097051
申请日：2011-04-28
申请人： Christian S. Eversull , Stephen A. Leeflang
发明人： Christian S. Eversull , Stephen A. Leeflang
IPC分类号： A61L29/14 , B29C70/30
CPC分类号： A61L29/085 , A61L29/14 , A61L2400/10 , A61M25/0012 , A61M25/0045 , A61M25/005 , A61M2025/0046 , A61M2025/0047 , A61M2025/0048 , A61M2025/006 , A61N1/056 , B29C47/0021 , B29C47/0023 , B29C47/0026 , B29C47/0028 , B29C47/003 , B29C47/0038 , B29C47/0057 , B29C47/0064 , B29C47/0066 , B29C47/021 , B29C47/065 , B29C53/40 , B29C53/42 , B29C53/46 , B29C61/006 , B29C65/02 , B29C65/08 , B29C65/18 , B29C65/48 , B29C65/4835 , B29C65/4845 , B29C65/4895 , B29C65/68 , B29C65/7435 , B29C65/7439 , B29C66/112 , B29C66/1122 , B29C66/1142 , B29C66/135 , B29C66/344 , B29C66/432 , B29C66/4322 , B29C66/438 , B29C66/52272 , B29C66/63 , B29C66/81423 , B29C66/83413 , B29C66/84121 , B29C67/0018 , B29C69/001 , B29C2793/0081 , B29C2793/009 , B29D23/001 , B29L2031/602 , B29L2031/753 , B29L2031/7542 , B32B1/08 , B32B5/02 , B32B5/024 , B32B25/10 , B32B25/14 , B32B27/08 , B32B27/12 , B32B27/288 , B32B27/304 , B32B27/308 , B32B27/32 , B32B27/322 , B32B27/34 , B32B27/36 , B32B27/365 , B32B27/40 , B32B2255/10 , B32B2255/26 , B32B2262/0269 , B32B2262/101 , B32B2262/103 , B32B2262/14 , B32B2307/732 , B32B2535/00 , C08J7/047 , C08L77/00 , C08L75/04
摘要： Apparatus and methods are provided for creating tubular devices, e.g., as components for catheters, sheaths, and or other devices sized for introduction into a patient. In one embodiment, a method is provided for making a tubular device using a sheet of material including a coated first surface. The sheet is rolled around a mandrel until longitudinal edges of the sheet are disposed near or adjacent one another, e.g., without attaching the longitudinal edges together. A tubular braid is positioned over the sheet-wrapped mandrel, one or more tubular segments are positioned over the tubular braid, and heat shrink tubing is positioned over the tubular segments. The resulting assembly is heated to cause the tubular segments to at least partially reflow and/or otherwise laminate the tubular segments to the tubular braid and sheet. The heat shrink tubing and mandrel are then removed to create the tubular device.
摘要翻译：提供了用于创建管状装置的装置和方法，例如作为尺寸适于引入患者的导管，护套和其它装置的部件。在一个实施例中，提供了一种用于制造使用包括涂覆的第一表面的材料片的管状装置的方法。片材围绕心轴卷绕，直到片材的纵向边缘彼此靠近或相邻设置，例如不将纵向边缘连接在一起。管状编织物定位在片状卷绕的心轴上方，一个或多个管状部分定位在管状编织物上方，并且热收缩管定位在管状部分上方。所得组件被加热以使管状区段至少部分地回流和/或以其它方式将管状区段层压到管状编织物和片材上。然后去除热收缩管和心轴以产生管状装置。

9. 发明授权

US07837671B2 Slittable and peelable sheaths and methods for making and using them 有权
标题翻译：可剥离和可剥离的护套及其制造和使用方法
公开(公告)号：US07837671B2
公开(公告)日：2010-11-23
申请号：US12617163
申请日：2009-11-12
申请人： Christian S. Eversull , Stephen A. Leeflang , Nicholas J. Mourlas
发明人： Christian S. Eversull , Stephen A. Leeflang , Nicholas J. Mourlas
IPC分类号： A61M25/00
CPC分类号： A61M25/0668 , A61M25/0045 , A61M25/005
摘要： A sheath for delivering a lead or other device into a body lumen is adapted to be removed from around the delivered lead or device via a longitudinally extending feature. This feature of the sheath may be a ripcord, a seam or interlocking features the releasably engage one another.
摘要翻译：用于将引线或其他装置输送到体腔中的护套适于经由纵向延伸的特征从输送的引线或装置周围移除。护套的这个特征可以是撕开，接缝或互锁特征可释放地彼此接合。

10. 发明授权

US07575569B2 Apparatus and methods for delivering stem cells and other agents into cardiac tissue 有权
标题翻译：将干细胞和其他药物递送到心脏组织中的装置和方法
公开(公告)号：US07575569B2
公开(公告)日：2009-08-18
申请号：US11465109
申请日：2006-08-16
申请人： Christian S. Eversull , Stephen A. Leeflang , Christine P. Ventura , Nicholas J. Mourlas
发明人： Christian S. Eversull , Stephen A. Leeflang , Christine P. Ventura , Nicholas J. Mourlas
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61M2025/105 , A61M2025/1052
摘要： Apparatus, systems, and methods are provided for delivering stem cells or other agents to cardiac tissue surrounding a cardiac vessel or to tissue adjacent other body lumens. The apparatus includes an expandable member and a source of one or more agents communicating with a lumen extending between proximal and distal ends of the apparatus. The distal end of the apparatus is advanced through one or more body lumens until the distal end is disposed within or adjacent the target body lumen. The target body lumen is sealed, e.g., by expanding the expandable member, thereby isolating the target body lumen. One or more agents are delivered into the target body lumen with sufficient pressure to extravasate the one or more agents into tissue surrounding the target body lumen.
摘要翻译：提供了装置，系统和方法，用于将干细胞或其它药剂递送到围绕心脏血管的心脏组织或邻近其他体腔的组织。该装置包括可扩张构件和一个或多个试剂的源，其与在装置的近端和远端之间延伸的内腔连通。装置的远端通过一个或多个体腔前进直到远端设置在目标体腔内或邻近靶体腔。目标体腔被密封，例如通过膨胀可扩张构件，从而隔离目标体腔。一个或多个药剂以足够的压力被递送到目标体腔内，以将一种或多种药剂外渗到靶体周围的组织中。

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