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1. 发明授权

US06689884B1 Supramolecular pairing system, its preparation and use 有权
标题翻译：超分子配对体系，其制备和应用
公开(公告)号：US06689884B1
公开(公告)日：2004-02-10
申请号：US09509040
申请日：2000-08-03
申请人： Christian Miculka , Norbert Windhab , Albert Eschenmoser , Stefan Scherer , Gerhard Quinkert
发明人： Christian Miculka , Norbert Windhab , Albert Eschenmoser , Stefan Scherer , Gerhard Quinkert
IPC分类号： C07D23900
CPC分类号： C12Q1/68
摘要： The invention relates to a compound of formula (I), wherein R1 is NR3R4, OR3 or SR3 with R3 and R4 being H or CnH2n+1 independently of each other and being the same or different, n being a whole number from 1 to 12; R2 is equal to CmH2m—C(X)—Y with X being ═O, ═S or ═N, Y being equal to OR3, NR3R4 or SR3, R3 and R4 having the same meaning given above, and m being a whole number from 1 to 4; or R2 is equal to CmH2m—Z—Y′ with Z being a sulfonyl, phosphonyl, ether or amine group, Y′ being equal to H, CnH2n+1, OR3, NR3R4 or SR3 then Z is sulphonyl or phosphonyl group, n, R3 and R4 having the meaning given above, and Y′ being equal to CnH2n+1 when Z is an ether or an amine group; A, B, and D are the same or different and mean CR5R6, O, NR7 ou S independently of each other with R5, R6 and R7 being H or CnH2n+1, independently of each other, n having the meaning given above; and C is equal to CR8 or N with R8 having the meaning of R5 independently, A—B, B—C or C—D not being two identical heteroatoms; and nucleobase means thymine, uracile, adenine, cytosine, guanine, isocytosine, isoguanine, xanthine or hypoxanthine. The invention also relates to a method for producing these derivatives and to their use in pairing and/or testing systems.
摘要翻译：本发明涉及式（I）化合物，其中R 1为NR 3 R 4，OR 3或SR 3，R 3和R 4为H或C n H 2n +1彼此独立且相同或不同，n为1至12的整数; R 2等于CmH2m-C（X）-Y，其中X为= O，= S或= N，Y等于OR 3，NR 3 R 4或SR 3， R 3和R 4具有上述相同的含义，m为1至4的整数; 或R 2等于C m H 2 m-Z Y'，其中Z是磺酰基，膦酰基，醚或胺基，Y'等于H，C n H 2n + 1，OR 3，NR 3 R 4或当Z为醚或胺基时，Z为磺酰基或膦酰基，n，R 3和R 4具有上述含义，Y'等于C n H 2n + 1; A，B和D相同或不同，并且R 5，R 6和R 7独立地为CR 5，R 6和R 7独立地为CR 5 R 6，O，NR 7 H或C n H 2n + 1彼此独立地具有上述含义的n; 并且C等于CR 8或N，其中R 8独立地具有R 5的含义，A-B，B-C或C-D不是两个相同的杂原子; 核碱基是指胸腺嘧啶，尿嘧啶，腺嘌呤，胞嘧啶，鸟嘌呤，异胞嘧啶，异鸟嘌呤，黄嘌呤或次黄嘌呤。本发明还涉及一种制备这些衍生物的方法及其在配对和/或测试系统中的用途。

2. 发明授权

US07439345B2 Supramolecular pairing system, its preparation and use 失效
标题翻译：超分子配对体系，其制备和应用
公开(公告)号：US07439345B2
公开(公告)日：2008-10-21
申请号：US10746678
申请日：2003-12-23
申请人： Christian Miculka , Norbert Windhab , Albert Eschenmoser , Stefan Scherer , Gerhard Quinkert
发明人： Christian Miculka , Norbert Windhab , Albert Eschenmoser , Stefan Scherer , Gerhard Quinkert
IPC分类号： C07H21/00 , C07K5/00 , C07K7/00 , C07K15/00 , C07K17/00 , C07D487/00 , C07D230/00
CPC分类号： C12Q1/68
摘要： The invention relates to conjugates including at least one linker, a biomolecule coupled to the linker, and cyclohexane derivatives of the following formula: and oligomers thereof.
摘要翻译：本发明涉及包含至少一个接头，与接头连接的生物分子和下式的环己烷衍生物的缀合物：及其低聚物。

3. 发明授权

US3989739A Oxygenated decalin derivatives 失效
标题翻译：氧化十氢化萘衍生物
公开(公告)号：US3989739A
公开(公告)日：1976-11-02
申请号：US432643
申请日：1974-01-11
申请人： Paul A. Stadler , Albert Eschenmoser , Erling Sundt
发明人： Paul A. Stadler , Albert Eschenmoser , Erling Sundt
IPC分类号： C07C35/36 , C11B9/00 , C07C69/06 , C07C69/14 , C07C69/24 , C07C69/52 , C07C69/54
CPC分类号： C07C69/013 , C07C35/36 , C07C67/14 , C07C67/24 , C07C69/54 , C11B9/0053 , C07C2102/28
摘要： Oxygenated decalin derivatives, the use thereof as fragrances or odor-modifying agents, and methods for preparing the said derivatives.
摘要翻译：氧化十氢化萘衍生物，其作为香料或气味改性剂的用途，以及制备所述衍生物的方法。

4. 发明授权

US5461152A Carbocyclic nucleosides containing bicycle rings, oligonucleotides therefrom, process for their preparation, their use and intermediates 失效
标题翻译：含有自行车环的碳环核苷，其寡核苷酸，其制备方法，用途及中间体
公开(公告)号：US5461152A
公开(公告)日：1995-10-24
申请号：US83812
申请日：1993-06-28
申请人： Karl-Heinz Altmann , Rene Imwinkelried , Albert Eschenmoser
发明人： Karl-Heinz Altmann , Rene Imwinkelried , Albert Eschenmoser
IPC分类号： A61K31/435 , A61K31/505 , A61K31/52 , A61K31/522 , A61P31/12 , C07C215/44 , C07C275/50 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/54 , C07D471/04 , C07D473/00 , C07D473/02 , C07D473/16 , C07D473/18 , C07D473/26 , C07D487/04 , C07F7/18 , C07F9/6512 , C07F9/6561 , C07F9/02 , C07D239/02 , A61K31/695
CPC分类号： C07D239/47 , C07C215/44 , C07C275/50 , C07D239/48 , C07D239/50 , C07D239/54 , C07D473/00 , C07F7/1856 , C07F9/65121 , C07F9/65616 , Y02P20/55
摘要： Compounds of the formulae I and Ia and their racemates ##STR1## in which A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 --, R.sub.1 is hydrogen or a protective group, R.sub.2 is hydrogen or a protective group or a radical forming a phosphorus-containing nucleotide bridge group and B is a purine or pyrimidine radical or an analogue thereof, can be used as antiviral active ingredients or for the preparation of biologically active oligonucleotides.
摘要翻译：式I和Ia化合物及其外消旋物（Ⅰ）其中A为-CH2-或-CH2CH2-，R1为氢或保护基，R2为氢或保护基或形成含磷核苷酸桥基的基团，B是嘌呤或嘧啶基或其类似物，可以用作抗病毒活性成分或用于制备生物活性寡核苷酸。

5. 发明授权

US4014951A Process for the preparation of poly-unsaturated hydrocarbons 失效
标题翻译：多不饱和烃的制备方法
公开(公告)号：US4014951A
公开(公告)日：1977-03-29
申请号：US653245
申请日：1976-01-28
申请人： Ferdinand Naf , Gunther Ohloff , Albert Eschenmoser
发明人： Ferdinand Naf , Gunther Ohloff , Albert Eschenmoser
IPC分类号： A23L27/20 , C07C1/34 , C07C11/21 , C07F9/54
CPC分类号： C07F9/5428 , A23L27/202 , C07C1/34 , C07C11/21
摘要： Process for the preparation of poly-unsaturated hydrocarbons, in particular undeca-1,3,5-triene, which comprises reacting a quaternary phosphonium salt with hexanal.The product obtained in accordance with the process of the invention is a useful perfuming ingredient.
摘要翻译：制备多不饱和烃，特别是十一碳三烯-1,3,5-三烯的方法，其包括使季鏻盐与己醛反应。

6. 发明授权

US4328383A Process for preparing unsaturated bicyclic hydrocarbons 失效
标题翻译：制备不饱和双环烃的方法
公开(公告)号：US4328383A
公开(公告)日：1982-05-04
申请号：US224193
申请日：1981-01-12
申请人： Albert Eschenmoser , Dorothee Felix
发明人： Albert Eschenmoser , Dorothee Felix
IPC分类号： C07C1/247 , C07C1/00 , C07C1/20 , C07C13/32 , C07C13/47 , C07C13/72 , C07C67/00
CPC分类号： C07C13/32 , C07C1/20 , C07C2102/32 , C07C2527/08 , C07C2527/125 , C07C2527/138
摘要： New process for preparing unsaturated bicyclic hydrocarbons useful as intermediate compounds in the preparation of macrocyclic ketones.
摘要翻译：在制备大环酮中用作中间体化合物的不饱和二环烃的制备新方法。

7. 发明授权

US3939207A Method for preparing aldehydes 失效
标题翻译：醛的制备方法
公开(公告)号：US3939207A
公开(公告)日：1976-02-17
申请号：US341829
申请日：1973-03-16
申请人： Albert Eschenmoser
发明人： Albert Eschenmoser
IPC分类号： C07C45/56 , C07C45/58 , C07C47/20 , C07C47/21 , C07C47/222
CPC分类号： C07C47/222 , C07C45/562 , C07C45/58 , C07C47/20 , C07C47/21
摘要： A process for the manufacture of aldehydes of the general formula ##EQU1## in which the symbols R.sub.1, R.sub.2 and R.sub.3 stand for hydrogen or organic radicals and in which at least two of these radicals are linked together by fragmenting a corresponding aziridine compound of the general formula ##EQU2## in which R.sub.1, R.sub.2 and R.sub.3 are as above and R.sub.4 to R.sub.7 each represents hydrogen, an alkoxycarbonyl, cyano, nitro or sulphonyl group or an alkyl, alkenyl, cycloalkenyl or alkyl residue and two or more of these residues may be linked together with simultaneous evolution of nitrogen.
摘要翻译：制备通式为R2 ---- R1 |βγ| C 3BOND C CHO |αR3 ----的醛的方法，其中符号R1，R2和R3代表氢或有机基团，其中这些基团中的至少两个通过将相应的通式为R 2 - 的基团的氮丙啶化合物连接在一起，其中R 1，R 2，R 2，R 2，R 3，R 6，角R7-C-C-R4 || R6R5 R3 -----------其中R1，R2和R3如上，R4至R7各自表示氢，烷氧基羰基，氰基，硝基或磺酰基基团或烷基，烯基，环烯基或烷基残基，并且这些残基中的两个或多个可以与氮同时进入而连接在一起。

8. 发明授权

US06545134B1 Method for the production of pentopyranosyl nucleosides 失效
标题翻译：戊吡糖基核苷的生产方法
公开(公告)号：US06545134B1
公开(公告)日：2003-04-08
申请号：US09647829
申请日：2001-01-18
申请人： Albert Eschenmoser , Stefan Pitsch , Sebastian Wendeborn
发明人： Albert Eschenmoser , Stefan Pitsch , Sebastian Wendeborn
IPC分类号： C07H1500
CPC分类号： C07H19/04 , Y10S977/915
摘要： Processes for the preparation of 3′,4′-cyclic acetals of pentopyranosylnucleosides, in which the pentopyranosyl nucleoside is reacted with an aldehyde, ketone, acetal, or ketal under reduced pressure of less than about 500 mbar.
摘要翻译：制备五吡喃糖基核苷的3'，4'-环状缩醛的方法，其中在低于约500毫巴的减压下，戊吡喃糖基核苷与醛，酮，缩醛或缩酮反应。

9. 发明授权

US5700920A Carbocyclic nucleosides containing bicyclic rings, oligonucleotides therefrom, process for their preparation, their use and intermediates 失效
公开(公告)号：US5700920A
公开(公告)日：1997-12-23
申请号：US471212
申请日：1995-06-06
申请人： Karl-Heinz Altmann , Rene Imwinkelried , Albert Eschenmoser
发明人： Karl-Heinz Altmann , Rene Imwinkelried , Albert Eschenmoser
IPC分类号： A61K31/435 , A61K31/505 , A61K31/52 , A61K31/522 , A61P31/12 , C07C215/44 , C07C275/50 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/54 , C07D471/04 , C07D473/00 , C07D473/02 , C07D473/16 , C07D473/18 , C07D473/26 , C07D487/04 , C07F7/18 , C07F9/6512 , C07F9/6561 , C12Q1/68 , A01N43/04 , C07H21/02 , C07H19/00
CPC分类号： C07D239/47 , C07C215/44 , C07C275/50 , C07D239/48 , C07D239/50 , C07D239/54 , C07D473/00 , C07F7/1856 , C07F9/65121 , C07F9/65616 , Y02P20/55
摘要： Compounds of the formulae I and Ia and their racemates ##STR1## in which A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 --, R.sub.1 is hydrogen or a protective group, R.sub.2 is hydrogen or a protective group or a radical forming a phosphorus-containing nucleotide bridge group and B is a purine or pyrimidine radical or an analogue thereof, can be used as antiviral active ingredients or for the preparation of biologically active oligonucleotides.

10. 发明授权

US3950327A New nitrones, their manufacture and their use for the manufacture of N-substituted araliphatic aldehyde-nitrones 失效
标题翻译：新硝酸盐，他们的制造及其用于制备N-取代的阿拉伯糖 - 二氧化钛的方法
公开(公告)号：US3950327A
公开(公告)日：1976-04-13
申请号：US491197
申请日：1974-07-24
申请人： Albert Eschenmoser
发明人： Albert Eschenmoser
IPC分类号： C07C45/51 , C07C45/54 , C07C47/228 , C07C47/277 , C07C51/16 , C07C291/02 , C07D307/80 , C07C119/00
CPC分类号： C07D307/80 , C07C291/02 , C07C45/516 , C07C45/54 , C07C47/228 , C07C47/277 , C07C51/16
摘要： .alpha.-Halogen-nitrones of the formula ##EQU1## wherein Hal is a bromine or preferably a chlorine atom, R.sub.1 represents a cycloalkyl or an alkyl radical and R.sub.2 is hydrogen or an organic radical.Use as intermediates especially for the substitution of a hydrogen atom in aromatic compounds by the radical ##EQU2##

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