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1. 发明授权

US06998140B2 Dispersion comprising a non-ionic emulsifier 有权
标题翻译：包含非离子乳化剂的分散体
公开(公告)号：US06998140B2
公开(公告)日：2006-02-14
申请号：US09926484
申请日：2001-02-02
申请人： Christian Meier , Johanna Eisele , Michael Schnabel , Klaus Schultes , Stefan Grimm , Hans-Ulrich Petereit , Thomas Suefke
发明人： Christian Meier , Johanna Eisele , Michael Schnabel , Klaus Schultes , Stefan Grimm , Hans-Ulrich Petereit , Thomas Suefke
IPC分类号： A61K9/16 , A61K9/14
CPC分类号： A61K9/2027 , A61K9/5026 , C08F2/30 , C08F220/18 , C08F2220/1816 , C08F220/14 , C08F220/06
摘要： The invention relates to a dispersion suitable for use as coating agent and binder for pharmaceutical forms, having a solids content of 10–70% by weight consisting of a) from 90 to 99% by weight of a methacrylate copolymer consisting of at least 90% by weight of (meth)acrylate monomers containing neutral radicals and having a glass transition temperature Tg of from −20° C. to +20° C. as determined by the DSC method, and b) 1–10% by weight of a nonionic emulsifier having an HLB of from 15.2 to 17.3.
摘要翻译：本发明涉及适合用作药物形式的包衣剂和粘合剂的分散体，其固含量为10-70重量％

2. 发明授权

US07833546B2 Pharmaceutical dosage form and method for the production thereof 有权
标题翻译：药物剂型及其制备方法
公开(公告)号：US07833546B2
公开(公告)日：2010-11-16
申请号：US10502648
申请日：2003-01-30
申请人： Hans-Ulrich Petereit , Thomas Suefke , Christian Meier , Michael Schnabel , Ingrid Blesing , Stefan Grimm
发明人： Hans-Ulrich Petereit , Thomas Suefke , Christian Meier , Michael Schnabel , Ingrid Blesing , Stefan Grimm
IPC分类号： A61K9/20 , A61K9/22 , A61K9/48 , A61K9/14 , A61F13/00
CPC分类号： A61K9/5026 , A61K9/2846 , Y02A50/473
摘要： The invention relates to a method for producing a pharmaceutical dosage form as tablets, pellets and/or in the form of an active ingredient-containing matrix, whereby the tablets, pellets and/or active ingredient-containing matrix contain a pharmaceutical active ingredient and a copolymer serving as a coating agent and/or binding agent, and optionally contain a core and pharmaceutically common additives. According to the invention, the copolymer, the pharmaceutical active ingredient, the optionally present core and/or the pharmaceutically common additives are processed using known techniques by melting, injection molding, extrusion, wet granulation, casting, dipping, spreading out, spraying on, or pressing to form tablets, pellets and/or an active ingredient-containing matrix. The inventive method is characterized in that a copolymer is used that consists of 20 to 34 wt. % methacrylic acid, 20 to 69 wt. % methylacrylate and 0 to 40 wt. % ethylacrylate and, optionally, of 0 to 10 wt. % of additional vinylically copolymerizable monomers with the provision that the glass transition temperature of the copolymer is no higher than 60° C. according to ISO 11357-2, Item 3.3.3. The invention also relates to the pharmaceutical dosage form produced according to this method, said copolymer and the use thereof.
摘要翻译：本发明涉及用于制备药物剂型作为片剂，丸粒和/或含有活性成分的基质形式的方法，由此所述片剂，丸剂和/或含活性成分的基质含有药物活性成分和共聚物作为包衣剂和/或粘合剂，并且任选地含有核心和药学上常用的添加剂。根据本发明，共聚物，药物活性成分，任选存在的核心和/或药学上常用的添加剂使用已知技术通过熔融，注射成型，挤出，湿法制粒，浇铸，浸渍，扩散，喷涂，或压制以形成片剂，丸剂和/或含活性成分的基质。本发明的方法的特征在于使用由20〜34重量％％甲基丙烯酸，20〜69重量％％甲基丙烯酸酯和0至40wt。％丙烯酸乙酯和任选地0至10wt。％的额外的乙烯基共聚单体，其规定，根据ISO 11357-2，项目3.3.3，共聚物的玻璃化转变温度不高于60℃。本发明还涉及根据该方法生产的药物剂型，所述共聚物及其用途。

3. 发明申请

US20050079216A1 Pharmaceutical dosage form and method for the production thereof 有权
标题翻译：药物剂型及其制备方法
公开(公告)号：US20050079216A1
公开(公告)日：2005-04-14
申请号：US10502648
申请日：2003-01-30
申请人： Hans-Ulrich Petereit , Thomas Suefke , Christian Meier , Michael Schnabel , Ingrid Blesing , Stefan Grimm
发明人： Hans-Ulrich Petereit , Thomas Suefke , Christian Meier , Michael Schnabel , Ingrid Blesing , Stefan Grimm
IPC分类号： A61J3/06 , A61K9/02 , A61K9/08 , A61K9/20 , A61K9/28 , A61K9/32 , A61K9/48 , A61K9/50 , A61K9/52 , A61K31/49 , A61K47/20 , A61K47/32 , A61P9/06 , A61K9/14
CPC分类号： A61K9/5026 , A61K9/2846 , Y02A50/473
摘要： The invention relates to a method for producing a pharmaceutical dosage form as tablets, pellets and/or in the form of an active ingredient-containing matrix, whereby the tablets, pellets and/or active ingredient-containing matrix contain a pharmaceutical active ingredient and a copolymer serving as a coating agent and/or binding agent, and optionally contain a core and pharmaceutically common additives. According to the invention, the copolymer, the pharmaceutical active ingredient, the optionally present core and/or the pharmaceutically common additives are processed using known techniques by melting, injection molding, extrusion, wet granulation, casting, dipping, spreading out, spraying on, or pressing to form tablets, pellets and/or an active ingredient-containing matrix. The inventive method is characterized in that a copolymer is used that consists of 20 to 34 wt. % methacrylic acid, 20 to 69 wt. % methylacrylate and 0 to 40 wt. % ethylacrylate and, optionally, of 0 to 10 wt. % of additional vinylically copolymerizable monomers with the provision that the glass transition temperature of the copolymer is no higher than 60° C. according to ISO 11357-2, Item 3.3.3. The invention also relates to the pharmaceutical dosage form produced according to this method, said copolymer and the use thereof.
摘要翻译：本发明涉及用于制备药物剂型作为片剂，丸粒和/或含有活性成分的基质形式的方法，由此所述片剂，丸剂和/或含活性成分的基质含有药物活性成分和共聚物作为包衣剂和/或粘合剂，并且任选地含有核心和药学上常用的添加剂。根据本发明，共聚物，药物活性成分，任选存在的核心和/或药学上常用的添加剂使用已知技术通过熔融，注射成型，挤出，湿法制粒，浇铸，浸渍，扩散，喷涂，或压制以形成片剂，丸剂和/或含活性成分的基质。本发明的方法的特征在于使用由20〜34重量％％甲基丙烯酸，20〜69重量％％甲基丙烯酸酯和0至40wt。％丙烯酸乙酯和任选地0至10wt。％的额外的乙烯基共聚单体，其规定，根据ISO 11357-2，项目3.3.3，共聚物的玻璃化转变温度不高于60℃。本发明还涉及根据该方法生产的药物剂型，所述共聚物及其用途。

4. 发明申请

US20100272960A1 MOLDED BODY HAVING MATT AND STRUCTURED SURFACE PROPERTIES 审中-公开
标题翻译：具有匹配和结构表面性能的模制体
公开(公告)号：US20100272960A1
公开(公告)日：2010-10-28
申请号：US12738033
申请日：2008-08-29
申请人： Klaus Schultes , Sabine Schwarz-Barac , Klaus Albrecht , Ursula Golchert , Stefan Nau , Sabrina Thomas , Michael Schnabel
发明人： Klaus Schultes , Sabine Schwarz-Barac , Klaus Albrecht , Ursula Golchert , Stefan Nau , Sabrina Thomas , Michael Schnabel
IPC分类号： B32B3/30 , C08L33/12
CPC分类号： C08L33/08 , C08L33/10 , C08L2205/02 , C08L2555/40 , Y10T428/24479 , C08L2666/04
摘要： Composition for the production of mouldings having a matt and structured surface character, comprising a polymer matrix and crosslinked polymer particles, the polymer matrix comprising at least one acrylic polymer and the composition containing (i) first crosslinked polymer particles having a volume average of the particle size in the range from 30 μm to 1500 μm and (ii) second crosslinked polymer particles having a volume average of the particle size of less than 30 μm, the difference between the refractive index of the first polymer particles and the refractive index of the polymer matrix, measured in each case at 25° C., being less than 0.015 as an absolute value and the difference between the refractive index of the second polymer particles and the refractive index of the polymer matrix, measured at 25° C., being greater than or equal to 0.015 as an absolute value. The mouldings of the invention are suitable in particular for use as components for lighting, signs and symbols, points-of-sale, cosmetics display stands, containers, home and office decoration, furniture applications, shower cabinet doors and office doors.
摘要翻译：用于生产具有无光泽和结构化表面特征的模制品的组合物，其包含聚合物基质和交联的聚合物颗粒，所述聚合物基质包含至少一种丙烯酸类聚合物，所述组合物包含（i）具有所述颗粒的体积平均值的第一交联聚合物颗粒尺寸在30μm至1500μm的范围内，和（ii）具有小于30μm的体积平均粒径的第二交联聚合物颗粒，第一聚合物颗粒的折射率与聚合物的折射率之间的差异在25℃下每种情况下测定的基体作为绝对值小于0.015，并且在25℃下测量的第二聚合物颗粒的折射率与聚合物基质的折射率之间的差异更大不大于或等于0.015作为绝对值。本发明的模制品特别适用于照明，标志和符号，销售点，化妆品展示架，集装箱，家庭和办公室装饰，家具应用，淋浴柜门和办公室门的部件。

5. 发明申请

US20080188616A1 Method For Production of Bead Polymers With an Average Particle Size in the Range of 1 Micrometer to 40 Micrometers and Moulded Masses and Moulded Bodies Comprising Bead Polymers 审中-公开
标题翻译：平均粒度在1微米至40微米范围内的珠粒聚合物的生产方法和包含珠聚合物的成型体和成型体
公开(公告)号：US20080188616A1
公开(公告)日：2008-08-07
申请号：US11913325
申请日：2006-03-16
申请人： Sabine Scharz-Barac , Klaus Schultes , Michael Schnabel , Stefan Nau , Ursula Golchert
发明人： Sabine Scharz-Barac , Klaus Schultes , Michael Schnabel , Stefan Nau , Ursula Golchert
IPC分类号： C08K3/10
CPC分类号： C08F2/18 , C08F2/44 , C08F212/08 , C08F220/14 , C08F222/1006
摘要： Process for preparation of bead polymers whose average particle size is in the range from 1 μm to 40 μm, by dispersing and polymerizing a polymerizable composition in an aqueous phase, where the dispersion stabilized by an aluminium compound is prepared at a shear rate ≧103 s−1. A polymerizable composition is used here which, in each case based on its total weight, comprises a) more than 50.0% by weight of at least one compound of the formula (I), where the radicals 1R to 6R have definitions according to the Description, b) from 0.1% by weight to 10.0% by weight of at least one crosslinking agent and c) less than 49.9% by weight of at least one compound of the formula (II) where the radicals R and 7R to 9R have definitions according to the Description The bead polymers prepared according to the inventive process are particularly suitable for production of mouldings with light-scattering properties.
摘要翻译：通过在水相中分散和聚合可聚合组合物制备其平均粒度在1〜40μm范围内的珠粒聚合物的方法，其中通过铝化合物稳定的分散体以剪切速率> 10 ^{3 -1 。在这里使用可聚合组合物，其在每种情况下基于其总重量包含a）超过50.0重量％的至少一种式（I）化合物，其中基团R 1 至<6> R具有根据描述的定义，b）0.1重量％至10.0重量％的至少一种交联剂和c）小于49.9重量％的至少一种其中基团R和R 7至R 9 R的式（II）具有根据说明书的定义根据本发明方法制备的珠粒聚合物特别适用于生产具有光散射特性的模制品。}

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