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1. 发明授权

US06514773B1 Method of detecting surface contamination by an analyte 失效
标题翻译：通过分析物检测表面污染的方法
公开(公告)号：US06514773B1
公开(公告)日：2003-02-04
申请号：US08506268
申请日：1995-07-24
申请人： Christian Klein , Hans-Peter Josel , Ada Goerlach-Graw , Reinhold Hilpert , Florian Binder , Josef Ritter , Rudolf Zimmermann
发明人： Christian Klein , Hans-Peter Josel , Ada Goerlach-Graw , Reinhold Hilpert , Florian Binder , Josef Ritter , Rudolf Zimmermann
IPC分类号： G01N33544
CPC分类号： C07D451/02 , C07D489/02 , G01N1/02 , G01N33/558 , G01N2001/007 , G01N2001/028 , Y10S436/809 , Y10S436/81
摘要： Subject matter of the invention is a method for detecting surface contamination by an analyte by wiping the analyte off the surface with the aid of a wiping surface, eluting the analyte from the wiping surface with an eluant, and detecting the analyte in the eluate in an immunological detection reaction, characterized in that: a) the surface to be tested for the analyte is wiped with a wiping surface, b) the wiping surface is brought into contact with the planar surface of a capillary active, chromatographic test strip which has an eluant application zone at its one end and a target zone at its other end whereby contact is made in an area between these two zones, c) eluting liquid is applied onto the zone provided for this purpose, said liquid moving toward the target zone passes the contact site with the wiping surface as a consequence of capillary forces, whereby analyte is taken up by the eluant, and d) in the target zone, the analyte is measured in an immunological binding reaction. The method is particularly suitable for the detection of drugs on surfaces.
摘要翻译：本发明的主题是通过擦拭表面擦拭分析物离开表面的方法，用分析物检测表面污染物的方法，用洗脱液从擦拭表面洗脱分析物，并用洗脱液检测洗脱液中的分析物免疫学检测反应，其特征在于：a）待分析物的表面用擦拭表面擦拭，b）擦拭表面与具有洗脱剂的毛细管活性色谱测试条的平面接触在其一端的应用区域和其另一端的目标区域，由此在这两个区域之间的区域中进行接触，c）将洗脱液施加到为此目的设置的区域上，朝向目标区域移动的所述液体通过接触作为毛细管力的结果，由于分析物被目标区域中的洗脱液和d）吸收，所以在免疫结合反应中测量分析物。方法特别适用于检测表面上的药物。

2. 发明授权

US06605444B1 Method and device for obtaining and detecting immunologically active substances from the gas phase 失效
标题翻译：从气相中获得和检测免疫活性物质的方法和装置
公开(公告)号：US06605444B1
公开(公告)日：2003-08-12
申请号：US08898085
申请日：1997-07-22
申请人： Christian Klein , Hans-Peter Josel , Rupert Herrmann , Josef Maier , Harald Ertl , Helmut Oberpriller , Reinhold Hilpert , Florian Binder , Josef Ritter
发明人： Christian Klein , Hans-Peter Josel , Rupert Herrmann , Josef Maier , Harald Ertl , Helmut Oberpriller , Reinhold Hilpert , Florian Binder , Josef Ritter
IPC分类号： G01N3353
CPC分类号： G01N33/54386 , G01N33/558 , Y10S435/97 , Y10S435/971 , Y10S436/807
摘要： A method is disclosed for obtaining and/or immunologically detecting an analyte contained in a gas phase by immunologically binding the analyte to a binding partner thereof contained in a gas- and liquid-permeable first carrier matrix. Said method is characterized in that a) the analyte-containing gas phase is brought into contact with the first carrier matrix (immune adsorber), b) the analyte is bound to the first binding partner which is contained in the first matrix and not bound to the matrix, and c) the complex of analyte and first binding partner and the free first binding partner are eluted from the first matrix, d) the eluted complex or the free first binding partner is determined as a measure for the amount of analyte present.
摘要翻译：公开了一种用于通过将分析物与包含在气体和液体可渗透的第一载体基质中的结合配偶体免疫结合来获得和/或免疫检测气相中包含的分析物的方法。所述方法的特征在于a）使含分析物的气相与第一载体基质（免疫吸附剂）接触，b）分析物与第一个结合配偶体结合，该第一个结合配偶体包含在第一个基质中，基质和c）分析物和第一结合配偶体和游离的第一结合配偶体的复合物从第一个基质中洗脱出来，d）洗脱的复合物或游离的第一结合配偶体被确定为测定存在的分析物的量。

3. 发明授权

US5690529A Adsorber material, apparatus and process for concentrating and recovering trace materials from the gaseous phase 失效
标题翻译：用于从气相中浓缩和回收痕量物质的吸附剂材料，设备和方法
公开(公告)号：US5690529A
公开(公告)日：1997-11-25
申请号：US748618
申请日：1996-11-13
申请人： Helmut Oberpriller , Reinhold Hilpert , Florian Binder , Josef Ritter , Harald Ertl , Rolf Lerch , Reiner Schlipfenbacher , Ludwig Angermaier , Christian Klein
发明人： Helmut Oberpriller , Reinhold Hilpert , Florian Binder , Josef Ritter , Harald Ertl , Rolf Lerch , Reiner Schlipfenbacher , Ludwig Angermaier , Christian Klein
IPC分类号： B01J20/24 , B01J20/26 , B01J20/28 , G01N1/22 , G01N1/34 , G01N13/00 , D04H3/00 , D04H3/12
CPC分类号： B01J20/28023 , B01J20/2803 , B01J20/28033 , G01N1/405 , G01N1/2214 , Y10T442/696 , Y10T442/697 , Y10T442/698
摘要： An adsorber material for collecting, concentrating and/or recovering gaseous and/or particle-shaped trace substances from an air or gas flow, in which the adsorber material is composed of fibrous elements made of natural and/or synthetic, organic, textile fibers which are worked into a nonwoven web having a planar geometry, the nonwoven web having a thickness of between 100 .mu.m and 2 mm and a weight per unit area of between 20 and 200 g/m.sup.2. Preferably the fibers have a fiber size between 1 and 10 dtex and are composed of cellulose and/or polyester, and if desired, the fibers may be provided with a binding agent and/or a moisture resistance agent. In preferred embodiments the nonwoven adsorber web is a fiber mixture of 80 parts polyester fibers, 20 parts viscose rayon staple fibers, and 20 parts polyvinyl alcohol fibers or a fiber mixture of 50 parts viscose rayon staple fibers and 50 parts linters, which are provided with an epichlorohydrin resin binder. The adsorber webs can be used to detect gaseous or particulate trace contaminants in air or another gas stream.
摘要翻译：用于从空气或气体流中收集，浓缩和/或回收气态和/或颗粒状痕量物质的吸附剂材料，其中吸附材料由天然和/或合成的有机纺织纤维制成的纤维元素组成，被加工成具有平面几何形状的非织造纤维网，非织造纤维网的厚度在100μm和2mm之间，每单位面积的重量在20和200g / m 2之间。优选地，纤维的纤维尺寸在1和10分特之间并且由纤维素和/或聚酯组成，如果需要，纤维可以具有粘合剂和/或防潮剂。在优选的实施方案中，非织造物吸附剂纤维网是80份聚酯纤维，20份粘胶人造丝短纤维和20份聚乙烯醇纤维或50份粘胶人造丝短纤维和50份绒毛的纤维混合物的纤维混合物，它们具有表氯醇树脂粘合剂。吸附器腹板可用于检测空气或其他气体流中的气态或微量痕量污染物。

4. 发明授权

US5712106A Process for the production of substituted thiazolin-dioxetan substrates and use thereof 失效
标题翻译：制备取代噻唑啉 - 二氧杂靛蓝基质的方法及其用途
公开(公告)号：US5712106A
公开(公告)日：1998-01-27
申请号：US450211
申请日：1995-05-25
申请人： Rupert Herrmann , Hans-Peter Josel , Christian Klein , Dieter Heindl
发明人： Rupert Herrmann , Hans-Peter Josel , Christian Klein , Dieter Heindl
IPC分类号： C07D513/10 , C07F9/6561 , C09K11/07 , C12Q1/34 , G01N33/535 , G01N33/58 , C12Q1/66
CPC分类号： C07D513/10 , C07F9/6561 , C09K11/07 , C12Q1/34 , G01N33/582
摘要： Compounds of the general formula III, ##STR1## in which R represents ##STR2## and in which R.sub.1 and R.sub.2 are the same or different and represent hydrogen or straight-chained or branched lower alkyl C.sub.1 -C.sub.6, and X represents a cleavable group, at least one of the groups R.sub.4 or R.sub.5 represents a group that stabilizes the dioxetan structure and at most one of the groups R.sub.4 or R.sub.5 represents hydrogen. These compounds can be used as substrates in immunological assays and in DNA diagnostics using activating agents for the formation of colour.
摘要翻译：通式III的化合物，其中R表示或，其中R1和R2相同或不同，表示氢或直链或支链的低级烷基C1-C6，X表示可切割基团，R4或R5中的至少一个表示稳定二氧杂环丁烷结构的基团，并且基团R4或R5中的至少一个表示氢。这些化合物可用作免疫学测定中的底物，以及使用活化剂形成颜色的DNA诊断。

5. 发明授权

US5662911A Benzodiazepine protein conjugates 失效
标题翻译：苯二氮卓蛋白偶联物
公开(公告)号：US5662911A
公开(公告)日：1997-09-02
申请号：US590830
申请日：1996-01-24
申请人： Erasmus Huber , Christian Klein , Hans-Peter Josel , Bruno Zink
发明人： Erasmus Huber , Christian Klein , Hans-Peter Josel , Bruno Zink
IPC分类号： G01N33/53 , A61K39/395 , C07D243/28 , C07D403/06 , C07D403/12 , C07K1/113 , C07K2/00 , C07K14/76 , C07K16/44 , G01N33/531 , A61K45/00
CPC分类号： C07D403/06 , C07D403/12 , C07K16/44
摘要： Benzodiazepine protein conjugates of the formula I ##STR1## wherein R1 is hydrogen, a methyl group or R, R2 is hydrogen, a hydroxyl or an OR group, with R1 or R2 containing an R group,R3 is a halogen, NO2 or NH2,X is hydrogen or a halogen,wherein R is a group of the formula II, wherein Z is a macromolecular immunogen reactive carrier substance and n is 2 or 3.The benzodiazepine protein conjugates are used as immunogens to obtain antibodies to benzodiazepines.The invention also relates to an immunoassay for the detection of benzodiazepines where the so generated antibodies are used.
摘要翻译：式I的苯并二氮杂类蛋白质缀合物其中R 1是氢，甲基或R 2，R 2是氢，羟基或OR基，其中R 1或R 2含有R基团，R 3是卤素，NO 2或NH 2，X是氢或卤素，其中R是式II的基团，其中Z是大分子免疫原反应性载体物质，n是2或3.苯并二氮杂蛋白质缀合物用作免疫原，苯并二氮杂。本发明还涉及用于检测如此产生的抗体的苯并二氮杂的免疫测定。

6. 发明授权

US5994552A Process for the production of substituted thiazoline-dioxetan substrates and use thereof 失效
标题翻译：制备取代噻唑啉 - 二氧杂靛蓝基质的方法及其用途
公开(公告)号：US5994552A
公开(公告)日：1999-11-30
申请号：US947065
申请日：1997-10-08
申请人： Rupert Herrmann , Hans-Peter Josel , Christian Klein , Dieter Heindl
发明人： Rupert Herrmann , Hans-Peter Josel , Christian Klein , Dieter Heindl
IPC分类号： C07D513/10 , C07F9/6561 , C09K11/07 , C12Q1/34 , G01N33/535 , G01N33/58
CPC分类号： C07D513/10 , C07F9/6561 , C09K11/07 , C12Q1/34 , G01N33/582
摘要： Compounds of the general formula III, ##STR1## in which R represents ##STR2## and in which R.sub.1 and R.sub.2 are the same or different and represent hydrogen or straight-chained or branched lower alkyl C.sub.1 - C.sub.6, and X represents a cleavable group, at least one of the groups R.sub.4 or R.sub.5 represents a group that stabilizes the dioxetan structure and at most one of the groups R.sub.4 or R.sub.5 represents hydrogen. These compounds can be used as substrates in immunological assays and in DNA diagnostics using activating agents for the formation of colour.
摘要翻译：通式III的化合物，其中R表示并且其中R 1和R 2相同或不同并且表示氢或直链或支链的低级烷基C 1 -C 6，X表示可切割基团，至少一个基团 R4或R5表示稳定二氧杂环丁烷结构的基团，R4或R5中至少一个表示氢。这些化合物可用作免疫学测定中的底物，以及使用活化剂形成颜色的DNA诊断。

7. 发明授权

US5455357A Substituted thiazoline-dioxetan substrates, process for the production and use 失效
标题翻译：取代的噻唑啉 - 二氧杂环丁烷底物，用于生产和使用的方法
公开(公告)号：US5455357A
公开(公告)日：1995-10-03
申请号：US150188
申请日：1993-11-30
申请人： Rupert Herrmann , Hans-Peter Josel , Christian Klein , Dieter Heindl
发明人： Rupert Herrmann , Hans-Peter Josel , Christian Klein , Dieter Heindl
IPC分类号： C07D513/10 , C07F9/6561 , C09K11/07 , C12Q1/34 , G01N33/535 , G01N33/58
CPC分类号： C07D513/10 , C07F9/6561 , C09K11/07 , C12Q1/34 , G01N33/582
摘要： Compounds of the general formula III, ##STR1## in which R represents ##STR2## and in which R.sub.1 and R.sub.2 are the same or different and represent hydrogen or straight-chained or branched lower alkyl C.sub.1 -C.sub.6, and X represents a cleavable group, at least one of the groups R.sub.4 or R.sub.5 represents a group that stabilizes the dioxetan structure and at most one of the groups R.sub.4 or R.sub.5 represents hydrogen. These compounds can be used as substrates in immunological assays and in DNA diagnostics using activating agents for the formation of colour.
摘要翻译： PCT No.PCT / EP93 / 00752 Sec。 371日期：1993年11月30日 102（e）日期1993年11月30日PCT 1993年3月29日PCT公布。 WO93 / 20083 PCT出版物日期：1993年10月14日。通式III，其中R表示或的通式III的化合物，其中R 1和R 2相同或不同，表示氢或直链或支链的低级烷基 C1-C6和X表示可切割基团，基团R4或R5中的至少一个表示稳定二氧杂环丁烷结构的基团，并且基团R4或R5中的至少一个表示氢。这些化合物可用作免疫学测定中的底物，以及使用活化剂形成颜色的DNA诊断。

8. 发明授权

US09890204B2 Trivalent, bispecific antibodies 有权
公开(公告)号：US09890204B2
公开(公告)日：2018-02-13
申请号：US13568224
申请日：2012-08-07
申请人： Ulrich Brinkmann , Rebecca Croasdale , Eike Hoffmann , Christian Klein , Ekkehard Moessner , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
发明人： Ulrich Brinkmann , Rebecca Croasdale , Eike Hoffmann , Christian Klein , Ekkehard Moessner , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
IPC分类号： C07K16/00 , C07K16/28 , C07K16/32
CPC分类号： C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.

9. 发明授权

US09156913B2 Anti-tenascin-C A2 antibodies and methods of use 有权
标题翻译：抗腱生蛋白-C A2抗体及其使用方法
公开(公告)号：US09156913B2
公开(公告)日：2015-10-13
申请号：US13207705
申请日：2011-08-11
申请人： Anne Freimoser-Grundschober , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umaña
发明人： Anne Freimoser-Grundschober , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umaña
IPC分类号： C07K16/30 , A61K47/48 , C07K16/00 , C12P21/08
CPC分类号： C07K16/18 , A61K47/6843 , A61K47/6851 , A61K49/0058 , A61K51/1018 , C07K16/30 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/92
摘要： The invention provides antibodies against the A2 domain of tenascin-C and methods of using the same.
摘要翻译：本发明提供针对腱生蛋白C的A2结构域的抗体及其使用方法。

10. 发明授权

US09080183B2 Promoter 有权
标题翻译：启动者
公开(公告)号：US09080183B2
公开(公告)日：2015-07-14
申请号：US12664399
申请日：2008-06-25
申请人： Christian Klein , Erhard Kopetzki
发明人： Christian Klein , Erhard Kopetzki
IPC分类号： C12N15/00 , C12N15/85 , C07K14/47
CPC分类号： C12N15/63 , C07K14/43595 , C07K14/4702 , C12N15/85
摘要： The current invention reports a promoter having the nucleic acid sequence of SEQ ID NO: 02, or SEQ ID NO: 03, or SEQ ID NO: 04, or SEQ ID NO: 06, which is a 5′ shortened SV40 promoter with reduced promoter strength especially useful for the limited expression of heterologous polypeptides or selectable markers.
摘要翻译：本发明报告了具有SEQ ID NO：02或SEQ ID NO：03或SEQ ID NO：04或SEQ ID NO：06的核酸序列的启动子，其是具有降低的启动子的5'缩短的SV40启动子对于异源多肽或选择性标记的有限表达特别有用的强度。

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