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    • 4. 发明申请
      US20110008446A1 Method of Drug Delivery 审中-公开
    • Method of Drug Delivery
    • 药物递送方法
    • US20110008446A1
    • 2011-01-13
    • US12498698
    • 2009-07-07
    • Chris C. Yu , He Yu
    • Chris C. Yu , He Yu
    • A61K9/14 , A61P43/00
    • A61K9/0097
    • A drug delivery method for effective drug application is disclosed in this invention. In this method, a micro-carrier delivers an encapsulated, desired drug directly to targeted sites without significant interactions with other components in the biological system in the pathway. In one embodiment, a micro-carrier containing encapsulated drug is first delivered to the general area for treatment. It then scans the area and selectively attaches itself the cell site or organ location to be treated. Finally, the desired drug contained in the micro-carrier is released to the attached cell or organ. In another embodiment, a micro-device is first used to process the general area to be treated to enhance differentiation in properties (such as surface charge) between healthy cells and unhealthy cells (such as cancer cells). Drug encapsulated in the micro-carrier is next applied to preferentially attach onto the targeted sites (such as cancer cell sites) to be treated. Finally, drug is released from the micro-carrier onto the sites to be treated. Such micro-carrier preferably contains multiple functions comprised of at least two functions from the group of sensing, analyzing, logic processing, surface treatment, position detection, motion, injecting, delivering, cutting functions, removing functions, biodegradation and disintegration.
    • 在本发明中公开了用于有效药物应用的药物递送方法。 在该方法中，微载体将封装的期望药物直接递送到靶位点，而与途径中的生物系统中的其它组分没有明显的相互作用。 在一个实施方案中，首先将含有包封药物的微载体递送至一般区域进行处理。 然后扫描该区域并选择性地将其固定在待处理的细胞部位或器官位置。 最后，将包含在微载体中的所需药物释放到附着的细胞或器官中。 在另一个实施方案中，微装置首先用于处理待处理的一般区域以增强健康细胞与不健康细胞（例如癌细胞）之间的性质（例如表面电荷）的分化。 封装在微载体中的药物接下来应用于优先附着到待治疗的靶位点（如癌细胞部位）上。 最后，将药物从微载体释放到待治疗的部位上。 这种微载体优选包含多个功能，其包括来自感测，分析，逻辑处理，表面处理，位置检测，运动，注射，递送，切割功能，去除功能，生物降解和分解的组中的至少两个功能。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 6. 发明申请
      US20100256518A1 Micro-Devices for Biomedical Applications and Method of Use of Same 审中-公开
    • Micro-Devices for Biomedical Applications and Method of Use of Same
    • US20100256518A1
    • 2010-10-07
    • US12416280
    • 2009-04-01
    • Chris C. Yu , He Yu
    • Chris C. Yu , He Yu
    • A61B10/04 , A61B5/00 , A61B17/22 , A61M37/00
    • A61B5/0215 , A61B5/00 , A61B5/07 , A61B5/417 , A61M37/0015 , A61M2037/0023
    • Micro-devices for biological applications are disclosed herein. The types of micro-devices include, but are not limited to, micro-mechanical, micro-chemical, micro-chemical-mechanical, micro-electro-mechanical, micro-electro-chemical-mechanical, micro-bio-electro-chemical-mechanical, micro-optical, micro-acoustical, micro-biological, micro-electromechanical, micro-electromagnetic mechanical, micro-acoustic-mechanical and micro-superconducting mechanical devices and various combinations thereof. Such devices can range from a single material with desired properties to a complex unit with multiple materials and sub-unit or units integrated onto it capable of carrying out multiple functions. Such devices are designed to carry out a range of functions in biological applications including but not limited to scanning and testing for diseased cells and organs, treating diseases, and preventing diseases in live biological systems. One of such applications using the said micro-device is to carry out cleaning functions for medical purposes, in which micro-devices are employed to “clean” various organs in the human body, including arteries and veins, to remove unwanted deposits to prevent strokes and heart attacks. Another application is to perform micro-surgical functions in a non-invasive manner with a high degree of precision and a minimum degree of damage to healthy cells and organs. Another application using the said micro-device is to selectively remove or destroy cancer cells through novel approaches including targeted attachment of desired micro-shields to healthy cells, or targeted attachment of micro-injectors to unhealthy or cancer cells. Yet another application employing the said micro-device includes one or a combination of performing drug delivery, cutting, removing, polishing, transporting, jointing, diagnosing, sensing, and measuring functions at the cellular structure level or organ level for medical purposes.
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 7. 发明授权
      US10105317B2 Method of drug delivery 有权
    • Method of drug delivery
    • US10105317B2
    • 2018-10-23
    • US12498698
    • 2009-07-07
    • Chris C. Yu , He Yu
    • Chris C. Yu , He Yu
    • A61K9/00
    • A drug delivery method for effective drug application is disclosed in this invention. In this method, a micro-carrier delivers an encapsulated, desired drug directly to targeted sites without significant interactions with other components in the biological system in the pathway. In one embodiment, a micro-carrier containing encapsulated drug is first delivered to the general area for treatment. It then scans the area and selectively attaches itself the cell site or organ location to be treated. Finally, the desired drug contained in the micro-carrier is released to the attached cell or organ. In another embodiment, a micro-device is first used to process the general area to be treated to enhance differentiation in properties (such as surface charge) between healthy cells and unhealthy cells (such as cancer cells). Drug encapsulated in the micro-carrier is next applied to preferentially attach onto the targeted sites (such as cancer cell sites) to be treated. Finally, drug is released from the micro-carrier onto the sites to be treated. Such micro-carrier preferably contains multiple functions comprised of at least two functions from the group of sensing, analyzing, logic processing, surface treatment, position detection, motion, injecting, delivering, cutting functions, removing functions, biodegradation and disintegration.
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
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