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1. 发明申请

US20090082623A1 Visualization and treatment via percutaneous methods and devices 有权
标题翻译：通过经皮方法和装置进行可视化和治疗
公开(公告)号：US20090082623A1
公开(公告)日：2009-03-26
申请号：US11810850
申请日：2007-06-07
申请人： Chris A. Rothe , Vahid Saadat , Kevin H. Van Bladel
发明人： Chris A. Rothe , Vahid Saadat , Kevin H. Van Bladel
IPC分类号： A61B1/04
CPC分类号： A61B1/3137 , A61B1/00082 , A61B1/00089 , A61B1/00147 , A61B17/0057 , A61B17/064 , A61B2017/00243 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/0061 , A61B2017/00615 , A61B2017/00623 , A61B2017/0641
摘要： Visualization and treatment of tissue regions via percutaneous access methods and devices are described herein. The system may include a deployment catheter and an expandable imaging hood. In use, the hood may be introduced from outside the patient body through a percutaneous incision and advanced through a subxiphoid pathway, for example, to the heart where entry may be accomplished via an incision through the left atrial appendage. Once within the heart, the hood can be advanced to any chamber to visualize and/or treat tissue by placing the hood against the tissue to be imaged and pumping translucent fluids into the hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. Additionally, any number of therapeutic tools can also be passed through the deployment catheter and into the imaging hood for treating the tissue of interest.
摘要翻译：本文描述了通过经皮访问方法和装置对组织区域的可视化和治疗。该系统可以包括展开导管和可扩展成像罩。在使用中，引擎盖可以通过经皮切口从患者身体的外部引入，并穿过亚剑突途径，例如穿过左心耳通过切口进入心脏。一旦在心脏内，通过将罩放置在待成像的组织上并将半透明流体泵入罩中直到流体移动任何血液，从而留下清晰的区域要通过部署导管中的成像元件成像的组织。此外，任何数量的治疗工具也可以通过展开导管并进入成像罩以用于感兴趣的组织。

2. 发明授权

US10064540B2 Visualization apparatus for transseptal access 有权
公开(公告)号：US10064540B2
公开(公告)日：2018-09-04
申请号：US11763399
申请日：2007-06-14
申请人： Vahid Saadat , Amir Abolfathi , Chris A. Rothe , Kevin H. Van Bladel
发明人： Vahid Saadat , Amir Abolfathi , Chris A. Rothe , Kevin H. Van Bladel
IPC分类号： A61B1/00 , A61B1/005 , A61B1/313 , A61B8/12 , A61B1/015 , A61B1/018 , A61B1/04 , A61B5/02 , A61B8/00
CPC分类号： A61B1/00089 , A61B1/0008 , A61B1/00082 , A61B1/00085 , A61B1/005 , A61B1/015 , A61B1/018 , A61B1/04 , A61B1/3137 , A61B5/02007 , A61B8/12 , A61B8/4472
摘要： Visualization apparatus and methods for transseptal access are described herein where intravascular access across a septal wall is facilitated via devices which provide for direct visual viewing of tissue area. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to the tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid can be pumped into the imaging hood until the fluid displaces any blood leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. Any number of therapeutic tools or a guidewire can be passed through the catheter and into the imaging hood for crossing the septal wall and passing the guidewire or instruments therethrough.

3. 发明授权

US09220402B2 Visualization and treatment via percutaneous methods and devices 有权
公开(公告)号：US09220402B2
公开(公告)日：2015-12-29
申请号：US11810850
申请日：2007-06-07
申请人： Chris A. Rothe , Vahid Saadat , Kevin H. Van Bladel
发明人： Chris A. Rothe , Vahid Saadat , Kevin H. Van Bladel
IPC分类号： A61B1/00 , A61B1/04 , A61B1/06 , A61B6/00 , A61B18/18 , A61B1/313 , A61B17/00 , A61B17/064
CPC分类号： A61B1/3137 , A61B1/00082 , A61B1/00089 , A61B1/00147 , A61B17/0057 , A61B17/064 , A61B2017/00243 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/0061 , A61B2017/00615 , A61B2017/00623 , A61B2017/0641
摘要： Visualization and treatment of tissue regions via percutaneous access methods and devices are described herein. The system may include a deployment catheter and an expandable imaging hood. In use, the hood may be introduced from outside the patient body through a percutaneous incision and advanced through a subxiphoid pathway, for example, to the heart where entry may be accomplished via an incision through the left atrial appendage. Once within the heart, the hood can be advanced to any chamber to visualize and/or treat tissue by placing the hood against the tissue to be imaged and pumping translucent fluids into the hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. Additionally, any number of therapeutic tools can also be passed through the deployment catheter and into the imaging hood for treating the tissue of interest.

4. 发明授权

US07311672B2 Device for biopsy of tumors 有权
标题翻译：肿瘤活检装置
公开(公告)号：US07311672B2
公开(公告)日：2007-12-25
申请号：US10421598
申请日：2003-04-22
申请人： Kevin H. Van Bladel , Shigeru Tanaka , Daren L. Stewart
发明人： Kevin H. Van Bladel , Shigeru Tanaka , Daren L. Stewart
IPC分类号： A61B10/00
CPC分类号： A61B10/0266 , A61B18/02 , A61B2010/0208 , A61B2018/0262 , A61B2018/0293 , H04L41/147 , H04L47/11 , H04L47/14
摘要： A device and method of use for securing and coring of tumors within the body during a biopsy of the tumor, specifically breast tumors. An adhesion probe for securing the tumor is described. The probe secures the tumor by piercing the tumor and providing a coolant to the distal tip to cool the tip. The cooled tip adheres to the tumor. A coring instrument adapted for cutting a core sample of the tumor is described. The instrument is provided with a cannula that can cut a core sample of the tumor. The instrument is adapted for use with the probe with the probe fitting within the cannula. The instrument can be used in conjunction with the probe to secure and core a sample of the tumor for biopsy.
摘要翻译：用于在肿瘤活检期间，特别是乳腺肿瘤中用于确保和取出体内肿瘤的装置和方法。描述了用于固定肿瘤的粘附探针。探针通过刺穿肿瘤固定肿瘤，并向远端提供冷却剂以冷却末端。冷却的尖端附着于肿瘤。描述适于切割肿瘤的核心样本的取芯器械。该仪器设置有可以切割肿瘤的核心样本的套管。该仪器适用于带探头接头的探头与套管内的接头。该仪器可以与探头一起使用，以固定和核心肿瘤样本进行活检。

5. 发明授权

US07049346B1 Swollen hydrogel for sphincter augmentation 失效
标题翻译：肿胀水凝胶用于括约肌增生
公开(公告)号：US07049346B1
公开(公告)日：2006-05-23
申请号：US08700168
申请日：1996-08-20
申请人： Kevin H. Van Bladel , Robert S. Bley , John D. Wallace
发明人： Kevin H. Van Bladel , Robert S. Bley , John D. Wallace
IPC分类号： A61F13/00
CPC分类号： A61L27/52 , A61L27/26 , Y10S514/944
摘要： A physiologically acceptable composition comprises a plurality of physiologically acceptable hydrogel particles which have been swollen in a water solution containing a low molecular weight water soluble organic compound, the solution having the ability to swell the particles. The concentration of the organic compound is such that the resulting particles can be inserted, without use of a carrier liquid utilizing a hand driven hypodermic syringe. The swollen hydrogel particles are substantially insoluble in body fluids. The composition is useful for treating urinary tract disorders.
摘要翻译：生理上可接受的组合物包含在含有低分子量水溶性有机化合物的水溶液中溶胀的多个生理上可接受的水凝胶颗粒，该溶液具有使颗粒溶胀的能力。有机化合物的浓度使得所得颗粒可以插入，而不使用手动皮下注射器的载体液体。溶胀的水凝胶颗粒基本上不溶于体液。该组合物可用于治疗尿路疾病。

6. 发明授权

US06540694B1 Device for biopsy tumors 有权
标题翻译：活检肿瘤装置
公开(公告)号：US06540694B1
公开(公告)日：2003-04-01
申请号：US09690321
申请日：2000-10-16
申请人： Kevin H. Van Bladel , Shigeru Tanaka , Daren L. Stewart
发明人： Kevin H. Van Bladel , Shigeru Tanaka , Daren L. Stewart
IPC分类号： A61B1000
CPC分类号： A61B10/0266 , A61B18/02 , A61B2010/0208 , A61B2018/0262
摘要： A device and method of use for securing and coring of tumors within the body during a biopsy of the tumor, specifically breast tumors. An adhesion probe for securing the tumor is described. The probe secures the tumor by piercing the tumor and providing a coolant to the distal tip to cool the tip. The cooled tip adheres to the tumor. A coring instrument adapted for cutting a core sample of the tumor is described. The instrument is provided with a cannula that can cut a core sample of the tumor. The instrument is adapted for use with the probe with the probe fitting within the cannula. The instrument can be used in conjunction with the probe to secure and core a sample of the tumor for biopsy.
摘要翻译：用于在肿瘤活检期间，特别是乳腺肿瘤中用于确保和取出体内肿瘤的装置和方法。描述了用于固定肿瘤的粘附探针。探针通过刺穿肿瘤固定肿瘤，并向远端提供冷却剂以冷却末端。冷却的尖端附着于肿瘤。描述适于切割肿瘤的核心样本的取芯器械。该仪器设置有可以切割肿瘤的核心样本的套管。该仪器适用于带探头接头的探头与套管内的接头。该仪器可以与探头一起使用，以固定和核心肿瘤样本进行活检。

7. 发明授权

US06228024B1 Vascular retractor 有权
标题翻译：血管牵开器
公开(公告)号：US06228024B1
公开(公告)日：2001-05-08
申请号：US09299693
申请日：1999-04-26
申请人： Fred H. Co , Kevin H. Van Bladel
发明人： Fred H. Co , Kevin H. Van Bladel
IPC分类号： A61B132
CPC分类号： A61B17/02 , A61B17/00008 , A61B17/0218 , A61B90/30 , A61B90/50 , A61B2017/00778 , A61B2017/320044
摘要： A self-supporting retractor for holding open an anatomic space for performing endoscopic surgical procedures. The retractor includes a substantially rigid elongate member, having proximal and distal ends, and having an arch shape or “C” cross-section, defining a passage and longitudinal working window along the retractor. The distal end is preferably rounded or streamlined to facilitate insertion along a dissected space with minimized tissue trauma, and may include a hooded portion enclosing the passage at the distal end. The elongate member may include radially cooperating segments or self-retaining edges to maximize the area of the space held open by the retractor. The retractor may include a handle or a pivotable finger grip on the proximal end to manipulate the retractor during use, and/or a curved handle to tent the incision providing access to the dissected space. The retractor may also include a channel member for an endoscope, integrally formed or pivotally attached to the retractor.
摘要翻译：一种自支撑牵开器，用于支撑用于进行内窥镜手术的解剖空间。牵开器包括基本上刚性的细长构件，其具有近端和远端，并且具有拱形或“C”横截面，沿着牵开器限定通道和纵向工作窗口。远端优选是圆形或流线型的，以便于沿着解剖空间以最小的组织创伤插入，并且可以包括在远端封闭通道的连接部分。细长构件可以包括径向配合的区段或自固位边缘，以使由牵开器保持打开的空间的面积最大化。牵开器可以包括手柄或近端的可枢转手指手柄，以在使用过程中操纵牵开器，和/或弯曲的手柄以对切口提供进入到解剖空间的帐篷。牵开器还可以包括用于内窥镜的通道构件，整体形成或枢转地附接到牵开器。

8. 发明授权

US5855615A Controller expansion sphincter augmentation media 失效
标题翻译：控制器扩张括约肌增强介质
公开(公告)号：US5855615A
公开(公告)日：1999-01-05
申请号：US660127
申请日：1996-06-07
申请人： Robert Steven Bley , Kevin H. Van Bladel
发明人： Robert Steven Bley , Kevin H. Van Bladel
IPC分类号： A61L27/00 , A61F2/08 , A61L27/16 , A61L27/18 , A61F2/02
CPC分类号： A61L27/16 , A61L27/18
摘要： A composition for injecting into tissues surrounding the urethra or ureter. It comprises a plurality of physiologically acceptable solid polymer particles dispersed in a physiologically acceptable biodissipatable liquid carrier. The polymer comprises a hydrophilic component. The solid polymer particles are a glycerine insoluble poly(ethylene oxide) (PEO) polymer or copolymer or a mineral oil insoluble polyvinylpyrrolidone polymer or copolymer. The plurality of solid polymer particles are capable of hydrating and upon hydration of absorbing at least about 30% water and of swelling to a predetermined volume. The solid particles are substantially insoluble in body fluids and substantially insoluble in and non-swellable by the liquid carrier. The composition is especially suitable in treating patients with urinary incontinence and patients with vesicoureteral reflux via injection into the tissues around the urethra or ureter.
摘要翻译：用于注射到尿道或输尿管周围组织的组合物。它包含分散在生理上可接受的生物可分解液体载体中的多个生理可接受的固体聚合物颗粒。聚合物包含亲水组分。固体聚合物颗粒是甘油不溶性聚（环氧乙烷）（PEO）聚合物或共聚物或矿物油不溶性聚乙烯吡咯烷酮聚合物或共聚物。多个固体聚合物颗粒能够水合并在水合时吸收至少约30％的水并膨胀至预定体积。固体颗粒基本上不溶于体液，并且基本上不溶于液体载体并且不溶于液体载体。该组合物特别适用于通过注射到尿道或输尿管周围的组织中治疗尿失禁患者和膀胱输尿管反流患者。

9. 发明授权

US5813411A Method of deforming tissue with a swollen hydrogel 失效
标题翻译：使肿胀水凝胶变形组织的方法
公开(公告)号：US5813411A
公开(公告)日：1998-09-29
申请号：US700004
申请日：1996-08-20
申请人： Kevin H. Van Bladel , Robert S. Bley , John D. Wallace
发明人： Kevin H. Van Bladel , Robert S. Bley , John D. Wallace
IPC分类号： A61L27/26 , A61L27/52 , A61B19/00
CPC分类号： A61L27/52 , A61L27/26 , Y10S623/915
摘要： A method of treating urinary disorders utilizing a physiologically acceptable composition including a plurality of physiologically acceptable hydrogel particles which have been swollen in a water solution containing a low molecular weight water soluble organic compound, the solution having the ability to swell the particles. The concentration of the organic compound is such that the resulting particles can be inserted, without use of a carrier liquid utilizing a hand driven hypodermic syringe. The swollen hydrogel particles are substantially insoluble in body fluids.
摘要翻译：一种使用生理上可接受的组合物治疗尿失调的方法，所述组合物包括在含有低分子量水溶性有机化合物的水溶液中溶胀的多个生理上可接受的水凝胶颗粒，所述溶液具有使颗粒膨胀的能力。有机化合物的浓度使得所得颗粒可以插入，而不使用手动皮下注射器的载体液体。溶胀的水凝胶颗粒基本上不溶于体液。

10. 发明授权

US06945942B2 Device for biopsy and treatment of breast tumors 失效
标题翻译：用于乳腺肿瘤活检和治疗的装置
公开(公告)号：US06945942B2
公开(公告)日：2005-09-20
申请号：US10321136
申请日：2002-12-16
申请人： Kevin H. Van Bladel , Seth Stabinsky , Lisa Zindel , Glenn Foy , Paul Mikus
发明人： Kevin H. Van Bladel , Seth Stabinsky , Lisa Zindel , Glenn Foy , Paul Mikus
IPC分类号： A61B17/22 , A61B10/00 , A61B10/02 , A61B17/34 , A61B18/02
CPC分类号： A61B18/02 , A61B10/0041 , A61B10/0283 , A61B2018/00291
摘要： A device for diagnosis and treatment of tumors and lesions within the body. A cannula adapted to apply suction through the lumen of the catheter to the tumor or lesion is described. The lumen has a self sealing valve through which a cryoprobe is inserted while the suction is being applied. The cryoprobe is then inserted into the lesion, and operated to ablate the lesion.
摘要翻译：用于诊断和治疗体内肿瘤和病变的装置。描述了适于将吸引通过导管的内腔的套管到肿瘤或病变。管腔具有自密封阀，当施加抽吸时通过该自封闭阀插入冷冻探针。然后将冷冻探针插入病变，并操作以烧蚀病变。

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