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1. 发明申请

US20090124785A1 Process for production of isocyanate, isocyanate produced by the process, and use of the isocyanate 有权
标题翻译：通过该方法生产异氰酸酯，异氰酸酯和使用异氰酸酯的方法
公开(公告)号：US20090124785A1
公开(公告)日：2009-05-14
申请号：US11988490
申请日：2006-07-20
申请人： Chitoshi Shimakawa , Hiroyuki Morijiri , Hidetoshi Hayashi , Norihiko Fukatsu , Seiichi Kobayashi , Homare Yumoto , Junichi Ishiyama , Shinya Tsuchiyama
发明人： Chitoshi Shimakawa , Hiroyuki Morijiri , Hidetoshi Hayashi , Norihiko Fukatsu , Seiichi Kobayashi , Homare Yumoto , Junichi Ishiyama , Shinya Tsuchiyama
IPC分类号： C08G18/32 , C07C263/00 , C07C209/74
CPC分类号： C08G18/72 , C07C263/10 , C08G18/757 , C08G18/7642 , C07C265/14
摘要： An isocyanate has been widely used as a starting material for the production of a polyurethane material, a polyisocyanurate material or the like which is suitably applicable to the field of optical materials. Disclosed is a process for producing an isocyanate which includes a step for producing the isocyanate in the form of a hydrochloride with improved productivity. A process for producing a linear or cyclic aliphatic isocyanate comprising the step of reacting a linear or cyclic aliphatic amine with hydrogen chloride to yield a hydrochloride of the linear or cyclic aliphatic amine, the step being performed under a pressure higher by 0.01 MPa or more than the atmospheric pressure.
摘要翻译：异氰酸酯已经广泛用作生产适用于光学材料领域的聚氨酯材料，聚异氰脲酸酯材料等的起始材料。公开了一种异氰酸酯的制造方法，其包括以生产率提高的盐酸盐形式的异氰酸酯的制造工序。一种直链或环状脂肪族异氰酸酯的制造方法，其特征在于，使直链状或环状的脂肪族胺与氯化氢反应，生成线性或环状脂族胺的盐酸盐，该步骤是在高于0.01MPa以上的压力下进行的大气压力。

2. 发明授权

US08183407B2 Process for production of isocyanate, isocyanate produced by the process, and use of the isocyanate 有权
标题翻译：通过该方法生产异氰酸酯，异氰酸酯和使用异氰酸酯的方法
公开(公告)号：US08183407B2
公开(公告)日：2012-05-22
申请号：US11988490
申请日：2006-07-20
申请人： Chitoshi Shimakawa , Hiroyuki Morijiri , Hidetoshi Hayashi , Norihiko Fukatsu , Seiichi Kobayashi , Homare Yumoto , Junichi Ishiyama , Shinya Tsuchiyama
发明人： Chitoshi Shimakawa , Hiroyuki Morijiri , Hidetoshi Hayashi , Norihiko Fukatsu , Seiichi Kobayashi , Homare Yumoto , Junichi Ishiyama , Shinya Tsuchiyama
IPC分类号： C07C291/00
CPC分类号： C08G18/72 , C07C263/10 , C08G18/757 , C08G18/7642 , C07C265/14
摘要： An isocyanate has been widely used as a starting material for the production of a polyurethane material, a polyisocyanurate material or the like which is suitably applicable to the field of optical materials. Disclosed is a process for producing an isocyanate which includes a step for producing the isocyanate in the form of a hydrochloride with improved productivity. A process for producing a linear or cyclic aliphatic isocyanate comprising the step of reacting a linear or cyclic aliphatic amine with hydrogen chloride to yield a hydrochloride of the linear or cyclic aliphatic amine, the step being performed under a pressure higher by 0.01 MPa or more than the atmospheric pressure.
摘要翻译：异氰酸酯已经广泛用作生产适用于光学材料领域的聚氨酯材料，聚异氰脲酸酯材料等的起始材料。公开了一种异氰酸酯的制造方法，其包括以生产率提高的盐酸盐形式的异氰酸酯的制造工序。一种直链或环状脂肪族异氰酸酯的制造方法，其特征在于，使直链状或环状的脂肪族胺与氯化氢反应，生成线性或环状脂族胺的盐酸盐，该步骤是在高于0.01MPa以上的压力下进行的大气压力。

3. 发明授权

US07879846B2 Serine hydrolase inhibitors 有权
标题翻译：丝氨酸水解酶抑制剂
公开(公告)号：US07879846B2
公开(公告)日：2011-02-01
申请号：US11903483
申请日：2007-09-20
申请人： Kevin Shreder , Yi Hu , Allister Fraser , Yasushi Kohno , Akihiko Kojima , Junichi Ishiyama
发明人： Kevin Shreder , Yi Hu , Allister Fraser , Yasushi Kohno , Akihiko Kojima , Junichi Ishiyama
IPC分类号： C07D413/04 , A61K31/536
CPC分类号： C07D413/04 , C07D413/14
摘要： Provided herein are benzoxazinone compounds of formula I and compositions containing the compounds. The compounds and compositions are useful in the methods of inhibiting the action of serine hydrolase, including neutrophil elastase. In certain embodiments, the compounds and compositions are useful in the prevention, amelioration or treatment of serine hydrolase-mediated diseases.
摘要翻译：本文提供了式I的苯并嗪酮化合物和含有该化合物的组合物。化合物和组合物可用于抑制丝氨酸水解酶（包括嗜中性粒细胞弹性蛋白酶）的作用的方法。在某些实施方案中，化合物和组合物可用于预防，改善或治疗丝氨酸水解酶介导的疾病。

4. 发明申请

US20120318164A1 BOGIE FRAME FOR RAILROAD VEHICLE 有权
标题翻译： BOGIE框架的铁路车辆
公开(公告)号：US20120318164A1
公开(公告)日：2012-12-20
申请号：US13578495
申请日：2010-07-08
申请人： Hiroshi Shinmura , Daizo Kanaya , Yasuyuki Fukui , Yuki Kunimatsu , Shotaro Ozu , Yoshitomo Watanabe , Takehiro Tozawa , Koichi Yamada , Junichi Ishiyama
发明人： Hiroshi Shinmura , Daizo Kanaya , Yasuyuki Fukui , Yuki Kunimatsu , Shotaro Ozu , Yoshitomo Watanabe , Takehiro Tozawa , Koichi Yamada , Junichi Ishiyama
IPC分类号： B61F5/52 , B61C17/00
CPC分类号： B61F5/52 , B61C17/00
摘要： In a bogie frame, a lateral beam disposed in the left-right direction which is the direction in which the rail ties extend is joined to left and right side beams arranged so as to extend in the front-rear direction which is the direction in which the rails extend. The lateral beam has a flat shape having a width in the front-rear direction greater than the thickness thereof in the top-bottom direction, and the lateral beam is provided with left and right joining sections joined to the side beams, and also with an intermediate section sandwiched between the left and right joining sections. The width of the intermediate section in the front-rear direction is greater than the width of the joining sections in the front-rear direction. A through-hole is formed in the intermediate section.
摘要翻译：在转向架框架中，沿着导轨延伸的方向在左右方向上设置的横向梁被连接到左侧梁和右侧梁，该左侧梁和右侧梁以沿其前后方向延伸的方向轨道延伸。横梁具有在前后方向上的宽度大于其在上下方向上的厚度的平坦形状，并且横梁设置有连接到侧梁的左和右连接部分，并且还具有中间部分夹在左和右连接部分之间。中间部分在前后方向上的宽度大于接合部分在前后方向上的宽度。在中间部分形成通孔。

5. 发明授权

US08720346B2 Bogie frame for railroad vehicle 有权
标题翻译：铁路车辆转向架
公开(公告)号：US08720346B2
公开(公告)日：2014-05-13
申请号：US13578495
申请日：2010-07-08
申请人： Hiroshi Shinmura , Daizo Kanaya , Yasuyuki Fukui , Yuki Kunimatsu , Shotaro Ozu , Yoshitomo Watanabe , Takehiro Tozawa , Koichi Yamada , Junichi Ishiyama
发明人： Hiroshi Shinmura , Daizo Kanaya , Yasuyuki Fukui , Yuki Kunimatsu , Shotaro Ozu , Yoshitomo Watanabe , Takehiro Tozawa , Koichi Yamada , Junichi Ishiyama
IPC分类号： B61F5/52 , B61C17/00
CPC分类号： B61F5/52 , B61C17/00
摘要： In a bogie frame, a lateral beam disposed in the left-right direction which is the direction in which the rail ties extend is joined to left and right side beams arranged so as to extend in the front-rear direction which is the direction in which the rails extend. The lateral beam has a flat shape having a width in the front-rear direction greater than the thickness thereof in the top-bottom direction, and the lateral beam is provided with left and right joining sections joined to the side beams, and also with an intermediate section sandwiched between the left and right joining sections. The width of the intermediate section in the front-rear direction is greater than the width of the joining sections in the front-rear direction. A through-hole is formed in the intermediate section.
摘要翻译：在转向架框架中，沿着导轨延伸的方向在左右方向上设置的横向梁被连接到左侧梁和右侧梁，该左侧梁和右侧梁以沿其前后方向延伸的方向轨道延伸。横梁具有在前后方向上的宽度大于其在上下方向上的厚度的平坦形状，并且横梁设置有连接到侧梁的左和右连接部分，并且还具有中间部分夹在左和右连接部分之间。中间部分在前后方向上的宽度大于接合部分在前后方向上的宽度。在中间部分形成通孔。

6. 发明申请

US20090235815A1 PISTON WITH BUILT-IN SEAL 审中-公开
标题翻译：活塞密封
公开(公告)号：US20090235815A1
公开(公告)日：2009-09-24
申请号：US12440536
申请日：2007-08-23
申请人： Tomoaki Nishimura , Junichi Ishiyama
发明人： Tomoaki Nishimura , Junichi Ishiyama
IPC分类号： F16J1/00
CPC分类号： F16D25/12 , F16D25/0638 , F16D2048/0212 , F16J15/3236 , F16J15/56
摘要： A piston with a built-in seal comprises a piston body (121) formed of a metal press-formed part and axially movably disposed in a clutch cylinder (110) and seal lips (122, 123) formed integrally with the piston body (121). A through tubular guide projection (124) is formed on the piston body (121). A return spring (150) for biasing the piston body (121) toward the pressurizing chamber (A) side is held on the guide projection (124). Since the press-formed through tubular guide projection (124) is higher in projecting height than the bottomed tubular one, the length over which the return spring (150) is held is longer. A pressurizing chamber (A) is prevented from being opened by the guide projection (124).
摘要翻译：具有内置密封件的活塞包括由金属压制成形部分形成的轴向移动地设置在离合器缸（110）中的活塞体（121）和与活塞体（121）一体形成的密封唇（122,123））。在活塞主体（121）上形成贯通的管状引导突起（124）。用于将活塞体（121）朝向加压室（A）侧偏置的复位弹簧（150）保持在引导突起（124）上。由于压制成型的通过管状引导突起（124）的突出高度高于有底的管状突出部，所以复位弹簧（150）保持的长度较长。防止加压室（A）被引导突起（124）打开。

7. 发明申请

US20080161290A1 Serine hydrolase inhibitors 有权
标题翻译：丝氨酸水解酶抑制剂
公开(公告)号：US20080161290A1
公开(公告)日：2008-07-03
申请号：US11903483
申请日：2007-09-20
申请人： Kevin Shreder , Yi Hu , Allister Fraser , Yasushi Kohno , Akihiko Kojima , Junichi Ishiyama
发明人： Kevin Shreder , Yi Hu , Allister Fraser , Yasushi Kohno , Akihiko Kojima , Junichi Ishiyama
IPC分类号： A61K31/551 , C07D265/12 , A61K31/536 , C07D295/00 , A61P19/02 , A61P11/00 , A61K31/541 , C07D243/08
CPC分类号： C07D413/04 , C07D413/14
摘要： Provided herein are benzoxazinone compounds of formula I and compositions containing the compounds. The compounds and compositions are useful in the methods of inhibiting the action of serine hydrolase, including neutrophil elastase. In certain embodiments, the compounds and compositions are useful in the prevention, amelioration or treatment of serine hydrolase-mediated diseases.
摘要翻译：本文提供了式I的苯并嗪酮化合物和含有该化合物的组合物。化合物和组合物可用于抑制丝氨酸水解酶（包括嗜中性粒细胞弹性蛋白酶）的作用的方法。在某些实施方案中，化合物和组合物可用于预防，改善或治疗丝氨酸水解酶介导的疾病。

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