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1. 发明申请

US20080166768A1 Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptide and heterodimer thereof 有权
标题翻译：编码β样糖蛋白激素多肽的核酸分子及其异二聚体
公开(公告)号：US20080166768A1
公开(公告)日：2008-07-10
申请号：US12072822
申请日：2008-02-27
申请人： Chirstopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
发明人： Chirstopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
IPC分类号： C12P21/04 , C12N15/11 , C12N15/00 , C12N5/06 , C12N5/04 , C12N1/20
CPC分类号： G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
摘要： Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
摘要翻译：公开了新颖的β10多肽及其异源二聚体及其编码的核酸分子。本发明还提供载体，宿主细胞，选择性结合剂，以及用于产生β10多肽及其异二聚体形式，特别是α2/β10的方法。还提供了用于治疗，诊断，改善或预防具有β10多肽和α2/β10异源二聚体或其各自结合剂的疾病的方法。

2. 发明授权

US07514239B2 Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof 失效
标题翻译：编码β样糖蛋白激素多肽的核酸分子及其异源二聚体
公开(公告)号：US07514239B2
公开(公告)日：2009-04-07
申请号：US09818954
申请日：2001-03-27
申请人： Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
发明人： Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
IPC分类号： C07H21/04 , C07K14/59
CPC分类号： G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
摘要： Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
摘要翻译：公开了新颖的β10多肽及其异源二聚体及其编码的核酸分子。本发明还提供载体，宿主细胞，选择性结合剂，以及用于产生β10多肽及其异二聚体形式，特别是α2/β10的方法。还提供了用于治疗，诊断，改善或预防具有β10多肽和α2/β10异源二聚体或其各自结合剂的疾病的方法。

3. 发明申请

US20080057515A1 BETA-LIKE GLYCOPROTEIN HORMONE POLYPEPTIDE AND HETERODIMER 失效
标题翻译： BETA-like糖蛋白激素多肽和HETERBRER
公开(公告)号：US20080057515A1
公开(公告)日：2008-03-06
申请号：US10448771
申请日：2003-05-28
申请人： Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
发明人： Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
IPC分类号： G01N33/53 , C07H21/04 , C07K14/575
CPC分类号： G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
摘要： Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
摘要翻译：公开了新颖的β10多肽及其异源二聚体及其编码的核酸分子。本发明还提供载体，宿主细胞，选择性结合剂，以及用于产生β10多肽及其异二聚体形式，特别是α2/β10的方法。还提供了用于治疗，诊断，改善或预防具有β10多肽和α2/β10异源二聚体或其各自结合剂的疾病的方法。

4. 发明申请

US20100255537A1 NUCLEIC ACID MOLECULES ENCODING BETA-LIKE GLYCOPROTEIN HORMONE POLYPEPTIDE AND HETERODIMER THEREOF 失效
标题翻译：编码类似谷氨酸激素多聚核苷酸和其它杂环化合物的核酸分子
公开(公告)号：US20100255537A1
公开(公告)日：2010-10-07
申请号：US12816475
申请日：2010-06-16
申请人： Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
发明人： Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
IPC分类号： C12N15/16 , C12N15/63 , C12N1/21 , C12N1/19 , C12N5/10 , C12N15/09
CPC分类号： G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
摘要： Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
摘要翻译：公开了10种多肽及其异源二聚体及其编码的核酸分子。本发明还提供了载体，宿主细胞，选择性结合剂，以及用于产生10种多肽及其异二聚体形式的方法，特别是α2 / bgr。还提供了用于治疗，诊断，改善或预防具有10种多肽和α2/ bgr10异源二聚体或其各自结合剂的疾病的方法。

5. 发明申请

US20080188417A1 Beta-like glycoprotein hormone polypeptide and heterodimer 失效
公开(公告)号：US20080188417A1
公开(公告)日：2008-08-07
申请号：US12072855
申请日：2008-02-27
申请人： Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
发明人： Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
IPC分类号： A61K38/17 , C07K14/47 , C07K19/00
CPC分类号： G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
摘要： Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.

6. 发明授权

US07358341B2 Beta-like glycoprotein hormone polypeptide and heterodimer 失效
标题翻译： β样糖蛋白激素多肽和异二聚体
公开(公告)号：US07358341B2
公开(公告)日：2008-04-15
申请号：US10448771
申请日：2003-05-28
申请人： Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
发明人： Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
IPC分类号： C07K14/575 , C07K14/59
CPC分类号： G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
摘要： Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
摘要翻译：公开了新颖的β10多肽及其异源二聚体及其编码的核酸分子。本发明还提供载体，宿主细胞，选择性结合剂，以及用于产生β10多肽及其异二聚体形式，特别是α2/β10的方法。还提供了用于治疗，诊断，改善或预防具有β10多肽和α2/β10异源二聚体或其各自结合剂的疾病的方法。

7. 发明授权

US6016606A Navigation device having a viewer for superimposing bearing, GPS position and indexed map information 失效
标题翻译：具有用于重叠轴承的观察者，GPS位置和索引地图信息的导航装置
公开(公告)号：US6016606A
公开(公告)日：2000-01-25
申请号：US64606
申请日：1998-04-23
申请人： Michael F. Oliver , Richard A. MacDonald , David C. Hill
发明人： Michael F. Oliver , Richard A. MacDonald , David C. Hill
IPC分类号： G01C21/00 , G01C21/22 , G01C23/00
CPC分类号： G01C21/00
摘要： A hand-holdable viewer having a viewing end and a viewing axis, along the latter of which a transparent display is disposed. The viewer includes a Global Positioning System receiver (GPS) and a microprocessor connected to the GPS. The viewer is also provided with a slide holder for receiving a map slide having a map image and a EEPROM containing information about the geographical extent of the map image. When a map slide is inserted into the slide holder, it is aligned with the display, and so one is superimposed on the other, when viewed through the viewing end. The microprocessor reads the EEPROM and checks the GPS to determine whether the current position of the device is within the geographical extent of the map image. If this is so, the current position appears on the display. The EEPROM may also contain information about waypoints and routes which have previously been downloaded from a personal computer, or the like.
摘要翻译：具有观察端和观察轴的手持式观察器，沿着后视图，设置有透明显示器。观众包括全球定位系统接收器（GPS）和连接到GPS的微处理器。观察者还设置有用于接收具有地图图像的地图幻灯片和包含关于地图图像的地理范围的信息的EEPROM的幻灯片保持器。当地图幻灯片插入到幻灯片支架中时，它与显示器对齐，因此当通过观看端观看时，将其叠加在另一个上。微处理器读取EEPROM并检查GPS以确定设备的当前位置是否在地图图像的地理范围内。如果是这样，当前位置就会出现在显示屏上。 EEPROM还可以包含关于之前从个人计算机等下载的路线和路线的信息。

8. 外观设计

USD293468S I.V. infusion pump 失效
公开(公告)号：USD293468S
公开(公告)日：1987-12-29
申请号：US774623
申请日：1985-09-10
申请人： David C. Hill , Donald Stanley
设计人： David C. Hill , Donald Stanley

9. 发明授权

US4189509A Resistor device and method of making 失效
公开(公告)号：US4189509A
公开(公告)日：1980-02-19
申请号：US721729
申请日：1976-09-09
申请人： David C. Hill
发明人： David C. Hill
IPC分类号： F02M31/135 , H01C17/06 , H01C17/28
CPC分类号： F02M31/135 , Y02T10/126 , Y10T29/49082 , Y10T29/49101
摘要： An improved electrical resistor device is made by molding a body of ceramic material of positive temperature coefficient of resistivity so that a plurality of passages extend in a pattern in spaced side-by-side relation to each other between opposite ends of the body. In molding the body, lands or abutments of resistor material are formed around the ends of alternate body passages at one end of the body and similar lands or abutments are formed around the ends of the other passages at the opposite end of the body. A band of masking material is applied to the sides of the body extending around the body leaving the ends of the body, and bands of the body side surface adjacent each end of the body, free of masking material. The masked body is then immersed in a coating bath for simultaneously coating the inner walls of the body passages, the ends of the body, and the unmasked bands of the body side surface with an electrically conductive ohmic contact material. Preferably, the ohmic contact and masking materials are selected to be impervious to reducing atmospheres and the like for protecting masked and coated portions of the ceramic resistor material against degradation in such atmospheres. Preferably, the ends of the body are immersed in an additional coating bath or are otherwise treated for coating at least the unmasked bands of the body side surfaces with a material characterized by low electrical contact resistance. Thereafter, the outer ends of the abutments are abraded for removing coating materials from the ends of the abutments. In this way, ohmic contacts in alternate body passages are connected together at one end of the body to form a first device terminal having low contact resistance while ohmic contacts in the other body passages are connected together at the opposite end of the body to form a second device terminal. Alternatively, the ends of the body abutments are masked prior to immersion of the body in the contact coating baths for permitting omission of the noted abrading step.

10. 发明授权

US4189700A Resistor device 失效
标题翻译：电阻器件
公开(公告)号：US4189700A
公开(公告)日：1980-02-19
申请号：US904681
申请日：1978-05-10
申请人： David C. Hill
发明人： David C. Hill
IPC分类号： F02M31/135 , H01C1/14 , H01C7/02 , H01C7/00
CPC分类号： H01C1/1406 , F02M31/135 , H01C7/022 , Y02T10/126 , Y10T29/49085
摘要： A body of ceramic material of positive temperature coefficient of resistivity is molded so that a plurality of passages extend between opposite ends of the body. In molding the body, lands or abutments of resistor material are formed around the ends of alternate body passages at one end of the body and around the ends of the other passages at the opposite end of the body. A band of masking material is applied to the sides of the body and the body is then immersed in a coating bath for simultaneously coating the inner walls of the body passages, the ends of the body, and the unmasked bands of the body side surface with an electrically conductive ohmic contact material. Preferably, the ohmic contact and masking materials are selected to be impervious to reducing atmospheres and the ends of the body are treated for coating at least the unmasked bands of the body side surfaces with a material characterized by low electrical contact resistance. Thereafter, the outer ends of the abutments are abraded for removing coating materials from the ends of the abutments.
摘要翻译：模制电阻率正温度系数的陶瓷材料体，使得多个通道在主体的相对端之间延伸。在模制身体的过程中，电阻材料的平台或基台在身体一端的另一个通道的端部周围形成在身体相对端的其他通道的端部周围。将掩蔽材料带施加到身体的侧面，然后将身体浸入涂覆浴中，同时将身体通道，身体的端部和身体侧表面的未屏蔽带同时涂覆，导电欧姆接触材料。优选地，欧姆接触和掩蔽材料被选择为不可渗透减少的气氛，并且利用具有低电接触电阻的材料来处理体的端部至少涂覆身体侧表面的未掩蔽带。此后，对基台的外端进行研磨以从基台的端部除去涂层材料。

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