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1. 发明申请

US20080300291A1 POTENT INDOLE-3-CARBINOL-DERIVED ANTITUMOR AGENTS 失效
标题翻译： POTENT INDOLE-3-CARBINOL衍生的抗菌剂
公开(公告)号：US20080300291A1
公开(公告)日：2008-12-04
申请号：US12118591
申请日：2008-05-09
申请人： Ching-Shih Chen , Dasheng Wang , Jing-Ru Weng
发明人： Ching-Shih Chen , Dasheng Wang , Jing-Ru Weng
IPC分类号： A61K31/404 , A61P35/00 , C07D209/14
CPC分类号： C07D209/12 , C07D209/14
摘要： Compounds and methods for treating cancer and inducing apoptosis in unwanted rapidly proliferating cells. The compounds are shown in formula I: wherein X is hydroxyl or amino; Y is carboxyl or sulfonyl; R1, R2, R3, and R4 can be the same or different and are selected from hydrogen, halogen, methoxy, trifluoromethyl, hydroxyl and combinations thereof, R5, R6, and R7 may be the same or different and are selected from hydrogen, chloro, bromo, nitro, phenyl, amino, methoxy, and combinations thereof, and derivatives or metabolites thereof.
摘要翻译：用于治疗癌症并诱导不需要的快速增殖细胞凋亡的化合物和方法。化合物示于式I中：其中X是羟基或氨基; Y是羧基或磺酰基; R 1，R 2，R 3和R 4可以相同或不同，并且选自氢，卤素，甲氧基，三氟甲基，羟基及其组合，R 5，R 6和R 7可以相同或不同，并且选自氢，氯，溴，硝基，苯基，氨基，甲氧基及其组合，及其衍生物或代谢物。

2. 发明授权

US07807705B2 Potent indole-3-carbinol-derived antitumor agents 失效
标题翻译：强力吲哚-3-甲醇衍生的抗肿瘤剂
公开(公告)号：US07807705B2
公开(公告)日：2010-10-05
申请号：US12118591
申请日：2008-05-09
申请人： Ching-Shih Chen , Dasheng Wang , Jing-Ru Weng
发明人： Ching-Shih Chen , Dasheng Wang , Jing-Ru Weng
IPC分类号： A61K31/404 , A61P35/00 , C07D209/14
CPC分类号： C07D209/12 , C07D209/14
摘要： Compounds and methods for treating cancer and inducing apoptosis in unwanted rapidly proliferating cells. The compounds are shown in formula I: wherein X is hydroxyl or amino; Y is carboxyl or sulfonyl; R1, R2, R3, and R4 can be the same or different and are selected from hydrogen, halogen, methoxy, trifluoromethyl, hydroxyl and combinations thereof, R5, R6, and R7 may be the same or different and are selected from hydrogen, chloro, bromo, nitro, phenyl, amino, methoxy, and combinations thereof, and derivatives or metabolites thereof.
摘要翻译：用于治疗癌症并诱导不需要的快速增殖细胞凋亡的化合物和方法。化合物示于式I中：其中X是羟基或氨基; Y是羧基或磺酰基; R 1，R 2，R 3和R 4可以相同或不同，并且选自氢，卤素，甲氧基，三氟甲基，羟基及其组合，R 5，R 6和R 7可以相同或不同，并且选自氢，氯，溴，硝基，苯基，氨基，甲氧基及其组合，及其衍生物或代谢物。

3. 发明授权

US08153680B2 Alkyl indole-3-carbinol-derived antitumor agents 有权
标题翻译：烷基吲哚-3-甲醇衍生的抗肿瘤剂
公开(公告)号：US08153680B2
公开(公告)日：2012-04-10
申请号：US12547036
申请日：2009-08-25
申请人： Ching-Shih Chen , Jing-Ru Weng
发明人： Ching-Shih Chen , Jing-Ru Weng
IPC分类号： A61K31/404 , C07D209/04
CPC分类号： A61K31/404 , C07D209/12
摘要： Compounds and methods for treating cancer or inducing apoptosis in proliferating cells. The compounds are shown in formula I: wherein X is selected from hydroxyl, thiol, and amino; Y is selected from carboxyl and sulfonyl; R1, R2, R3, and R4 are selected from hydrogen, lower alkyl, and combinations thereof; R5, R6, and R7 are selected from hydrogen, halo, nitro, amino, methoxy, and combinations thereof; and pharmaceutically acceptable salts thereof.
摘要翻译：用于在增殖细胞中治疗癌症或诱导细胞凋亡的化合物和方法。化合物示于式I中：其中X选自羟基，硫醇和氨基; Y选自羧基和磺酰基; R 1，R 2，R 3和R 4选自氢，低级烷基及其组合; R5，R6和R7选自氢，卤素，硝基，氨基，甲氧基及其组合; 及其药学上可接受的盐。

4. 发明申请

US20120184592A1 ALKYL INDOLE-3-CARBINOL-DERIVED ANTITUMOR AGENTS 有权
标题翻译：烷基吲哚-3-卡宾醇衍生的抗菌剂
公开(公告)号：US20120184592A1
公开(公告)日：2012-07-19
申请号：US13429779
申请日：2012-03-26
申请人： Ching-Shih Chen , Jing-Ru Weng
发明人： Ching-Shih Chen , Jing-Ru Weng
IPC分类号： A61K31/404 , A61P35/00 , C12N5/09 , C07D209/36
CPC分类号： A61K31/404 , C07D209/12
摘要： Compounds and methods for treating cancer or inducing apoptosis in proliferating cells. The compounds are shown in formula I: wherein X is selected from hydroxyl, thiol, and amino; Y is selected from carboxyl and sulfonyl; R1, R2, R3, and R4 are selected from hydrogen, lower alkyl, and combinations thereof; R5, R6, and R7 are selected from hydrogen, halo, nitro, amino, methoxy, and combinations thereof; and pharmaceutically acceptable salts thereof.
摘要翻译：用于在增殖细胞中治疗癌症或诱导细胞凋亡的化合物和方法。化合物示于式I中：其中X选自羟基，硫醇和氨基; Y选自羧基和磺酰基; R 1，R 2，R 3和R 4选自氢，低级烷基及其组合; R5，R6和R7选自氢，卤素，硝基，氨基，甲氧基及其组合; 及其药学上可接受的盐。

5. 发明授权

US08680133B2 Alkyl indole-3-carbinol-derived antitumor agents 有权
标题翻译：烷基吲哚-3-甲醇衍生的抗肿瘤剂
公开(公告)号：US08680133B2
公开(公告)日：2014-03-25
申请号：US13429779
申请日：2012-03-26
申请人： Ching-Shih Chen , Jing-Ru Weng
发明人： Ching-Shih Chen , Jing-Ru Weng
IPC分类号： A61K31/404 , C07D209/04
CPC分类号： A61K31/404 , C07D209/12
摘要： Compounds and methods for treating cancer or inducing apoptosis in proliferating cells. The compounds are shown in formula I: wherein X is selected from hydroxyl, thiol, and amino; Y is selected from carboxyl and sulfonyl; R1, R2, R3, and R4 are selected from hydrogen, lower alkyl, and combinations thereof; R5, R6, and R7 are selected from hydrogen, halo, ni tro, amino, methoxy, and combinations thereof; and pharmaceutically acceptable salts thereof.
摘要翻译：用于在增殖细胞中治疗癌症或诱导细胞凋亡的化合物和方法。化合物示于式I中：其中X选自羟基，硫醇和氨基; Y选自羧基和磺酰基; R 1，R 2，R 3和R 4选自氢，低级烷基及其组合; R5，R6和R7选自氢，卤素，氨基，甲氧基及其组合; 及其药学上可接受的盐。

6. 发明申请

US20110054002A1 ALKYL INDOLE-3-CARBINOL-DERIVED ANTITUMOR AGENTS 有权
标题翻译：烷基吲哚-3-卡宾醇衍生的抗菌剂
公开(公告)号：US20110054002A1
公开(公告)日：2011-03-03
申请号：US12547036
申请日：2009-08-25
申请人： Ching-Shih Chen , Jing-Ru Weng
发明人： Ching-Shih Chen , Jing-Ru Weng
IPC分类号： A61K31/404 , C07D209/12 , A61P35/00 , C12N5/00
CPC分类号： A61K31/404 , C07D209/12
摘要： Compounds and methods for treating cancer or inducing apoptosis in proliferating cells. The compounds are shown in formula I: wherein X is selected from hydroxyl, thiol, and amino; Y is selected from carboxyl and sulfonyl; R1, R2, R3, and R4 are selected from hydrogen, lower alkyl, and combinations thereof; R5, R6, and R7 are selected from hydrogen, halo, nitro, amino, methoxy, and combinations thereof; and pharmaceutically acceptable salts thereof.
摘要翻译：用于在增殖细胞中治疗癌症或诱导细胞凋亡的化合物和方法。化合物示于式I中：其中X选自羟基，硫醇和氨基; Y选自羧基和磺酰基; R 1，R 2，R 3和R 4选自氢，低级烷基及其组合; R5，R6和R7选自氢，卤素，硝基，氨基，甲氧基及其组合; 及其药学上可接受的盐。

7. 发明申请

US20070163292A1 Thin refrigeration air conditioner having a greater temperature difference 审中-公开
标题翻译：具有较大温度差的薄型制冷空调
公开(公告)号：US20070163292A1
公开(公告)日：2007-07-19
申请号：US11333407
申请日：2006-01-18
申请人： Kuo-Liang Weng , Jing-Ru Weng , Jing-Ying Tsai
发明人： Kuo-Liang Weng , Jing-Ru Weng , Jing-Ying Tsai
IPC分类号： F25D17/04 , F25D17/06
CPC分类号： F24F1/0007 , F24F1/0047 , F24F1/0059 , F24F13/30 , F25D17/045 , F25D17/067 , F25D21/14 , F25D2317/0665 , F25D2500/02
摘要： A thin refrigeration air conditioner has a casing which houses a thin heat exchanger, an air intake chamber, an air exit chamber, a side chamber and an air port baffle. The thin heat exchanger in cooperative with the air port baffle or a return air branch port can control airflow to maintain a high temperature difference and low flow rate operation while the air and refrigerant flow through the thin heat exchanger to perform heat exchange process. Return airflow and airflow delivery can be maintained in an optimal temperature difference condition according to energy requirement of the air conditioning zone. Thus it can provide a most comfortable condition and also save energy. It also takes less installation space and improves airflow distribution.
摘要翻译：薄型制冷空调器具有容纳薄型热交换器，进气室，出气室，侧室和空气口挡板的壳体。与空气端口挡板或回气分支口协作的薄型换热器可以控制气流，以保持高温差和低流量运行，同时空气和制冷剂流过薄热交换器进行热交换过程。根据空调区的能量需求，气流和气流的返回可以保持在最佳的温差状态。因此，它可以提供最舒适的条件并且还节省能量。它也减少了安装空间，改善了气流分布。

8. 发明申请

US20060179857A1 Method for automatically balancing air conditioning outdoor heat exchange 失效
标题翻译：自动平衡空调户外热交换的方法
公开(公告)号：US20060179857A1
公开(公告)日：2006-08-17
申请号：US11055681
申请日：2005-02-11
申请人： Kuo-Liang Weng , Jing-Ru Weng
发明人： Kuo-Liang Weng , Jing-Ru Weng
IPC分类号： F25B29/00 , F25D17/00 , F25D17/04
CPC分类号： F24F1/50 , F24F1/06 , F24F11/745 , F24F11/77
摘要： A method for automatically balancing air conditioning outdoor heat exchange detects a piping measured value of each piping equipment through a detection unit and compares the piping measured value with a set operation mode selected by users and a set value. Airflow amount of adjustable air vents is adjustable according to the comparing result. The method includes the steps of: (1) selecting an operation mode, (2) selecting an effective piping measured value which serves as the basis to operate an air fan device, and (3) based on the piping measured value corresponding to each exchange equipment to open the air vents at a desired degree. By means of the aforesaid method and system, the air conditioning outdoor heat exchange system can be balanced automatically.
摘要翻译：用于自动平衡空调室外热交换的方法通过检测单元检测每个管道设备的管道测量值，并将管道测量值与由用户选择的设定操作模式和设定值进行比较。根据比较结果，调节通风口的气流量可调。该方法包括以下步骤：（1）选择操作模式，（2）选择用作操作风扇装置的基础的有效管道测量值，以及（3）基于与每个交换对应的管道测量值设备以所需的程度打开通风口。通过上述方法和系统，空调室外热交换系统可以自动平衡。

9. 发明申请

US20060205808A1 Anti-inflammatory and cure for ageing, Alzheimer's disease on phloroglucinol derivatives 审中-公开
标题翻译：消炎和治愈老化，阿尔茨海默病对间苯三酚衍生物
公开(公告)号：US20060205808A1
公开(公告)日：2006-09-14
申请号：US11078194
申请日：2005-03-10
申请人： Chun-Nan Lin , Jih-Pyang Wang , Jing-Ru Weng
发明人： Chun-Nan Lin , Jih-Pyang Wang , Jing-Ru Weng
IPC分类号： A61K31/343 , C07C49/105 , C07D307/92 , A61K31/12
CPC分类号： C07D307/92 , C07C49/743 , C07D307/80
摘要： The fresh seeds obtained from the fresh fruits of Garcinia subelliptica, were extracted with chloroform at room temperature. The CHCl3 extract was concentrated under reduced pressure to afford a brown residue. This residue was subjected to column chromatography (silica gel) and eluted with appropriate solvent system to give two phloroglucinol derivatives (Compounds 1 and 4). Compound 1 exhibited potent inhibitory effects on the release of β-glucuronidase and lysozyme from rat neutrophils stimulated with formyl-Met-Leu-Phe(fMLP)/cyto-chalasin B (CB). Compound 1 also exhibited potent inhibitory effect on the superoxide anion generation in rat neutrophils stimulated with fMLP/CB. Compound 4 exhibited potent inhibitory effect on NO production in lipopolysaccharide (LPS)/interferon-γ (IFN-γ)-activation in N9 cells. These Compounds may be developed as anti-inflammatory, anti-cancer agent, cure for ageing, and Alzheimer's disease treatment drugs.
摘要翻译：从藤黄新鲜果实中获得的新鲜种子在室温下用氯仿萃取。将CHCl 3萃取物在减压下浓缩，得到棕色残余物。将该残余物进行柱色谱法（硅胶），并用合适的溶剂系统洗脱，得到两种间苯三酚衍生物（化合物1和4）。化合物1对用甲酰-Mly-Leu-Phe（fMLP）/细胞色素B（CB）刺激的大鼠嗜中性粒细胞释放β-葡糖苷酸酶和溶菌酶具有有效的抑制作用。化合物1还对用fMLP / CB刺激的大鼠嗜中性粒细胞中的超氧阴离子产生表现出有效的抑制作用。化合物4对N9细胞中脂多糖（LPS）/干扰素-γ（IFN-γ）活化的NO产生表现出有效的抑制作用。这些化合物可以被开发为抗炎，抗癌剂，治愈老化和阿尔茨海默病治疗药物。

10. 发明授权

US07367199B2 Method for automatically balancing air conditioning outdoor heat exchange 失效
标题翻译：自动平衡空调户外热交换的方法
公开(公告)号：US07367199B2
公开(公告)日：2008-05-06
申请号：US11055681
申请日：2005-02-11
申请人： Kuo-Liang Weng , Jing-Ru Weng
发明人： Kuo-Liang Weng , Jing-Ru Weng
IPC分类号： F25B29/00 , F25D17/00
CPC分类号： F24F1/50 , F24F1/06 , F24F11/745 , F24F11/77
摘要： A method for automatically balancing air conditioning outdoor heat exchange detects a piping measured value of each piping equipment through a detection unit and compares the piping measured value with a set operation mode selected by users and a set value. Airflow amount of adjustable air vents is adjustable according to the comparing result. The method includes the steps of: (1) selecting an operation mode, (2) selecting an effective piping measured value which serves as the basis to operate an air fan device, and (3) based on the piping measured value corresponding to each exchange equipment to open the air vents at a desired degree. By means of the aforesaid method and system, the air conditioning outdoor heat exchange system can be balanced automatically.
摘要翻译：用于自动平衡空调室外热交换的方法通过检测单元检测每个管道设备的管道测量值，并将管道测量值与由用户选择的设定操作模式和设定值进行比较。根据比较结果，调节通风口的气流量可调。该方法包括以下步骤：（1）选择操作模式，（2）选择用作操作风扇装置的基础的有效管道测量值，以及（3）基于与每个交换对应的管道测量值设备以所需的程度打开通风口。通过上述方法和系统，空调室外热交换系统可以自动平衡。

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