专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08377897B2 Compositions and methods for non-parenteral delivery of oligonucleotides 有权
公开(公告)号：US08377897B2
公开(公告)日：2013-02-19
申请号：US11237063
申请日：2005-09-28
申请人： Ching-Leou Teng , Phillip Dan Cook , Lloyd Tillman , Gregory E. Hardee , David J. Ecker , Muthiah Manoharan
发明人： Ching-Leou Teng , Phillip Dan Cook , Lloyd Tillman , Gregory E. Hardee , David J. Ecker , Muthiah Manoharan
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04
CPC分类号： A61K48/0008 , A61K9/0014 , A61K9/0031 , A61K9/107 , A61K9/1075 , A61K38/00 , A61K47/12 , A61K47/28 , A61K48/00 , A61K48/0025 , A61K48/0041 , C12N15/113 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3527 , C12N2310/3525
摘要： The present invention relates to compositions and methods which enhance the local and systemic uptake and delivery of oligonucleotides and nucleic acids via non-parenteral routes of administration. Pharmaceutical compositions comprising oligonucleotides disclosed herein include, for systemic delivery, emulsion and microemulsion formulations for a variety of applications and oral dosage formulations. It has also surprisingly been discovered that oligonucleotides may be locally delivered to colonic sites by rectal enemas and suppositories in simple solutions, e.g., neat or in saline. Such pharmaceutical compositions of oligonucleotides may further include one or more penetration enhancers for the transport of oligonucleotides and other nucleic acids across mucosal membranes. The compositions and methods of the invention are utilized to effect the oral, buccal, rectal or vaginal administration of an antisense oligonucleotide to an animal in order to modulate the expression of a gene in the animal for investigative, therapeutic, palliative or prophylactic purposes.

2. 发明授权

US06747014B2 Compositions and methods for non-parenteral delivery of oligonucleotides 失效
标题翻译：用于非肠胃外递送寡核苷酸的组合物和方法
公开(公告)号：US06747014B2
公开(公告)日：2004-06-08
申请号：US10029598
申请日：2001-12-21
申请人： Ching-Leou Teng , Phillip Dan Cook , Lloyd Tillman , Gregory E. Hardee , David J. Ecker , Muthiah Manoharan
发明人： Ching-Leou Teng , Phillip Dan Cook , Lloyd Tillman , Gregory E. Hardee , David J. Ecker , Muthiah Manoharan
IPC分类号： A61K3170
CPC分类号： A61K48/0075 , A61K9/0014 , A61K9/0019 , A61K47/12 , A61K47/28 , A61K48/00 , C07H21/00 , Y10S514/946
摘要： The present invention relates to compositions and methods which enhance the local and systemic uptake and delivery of oligonucleotides and nucleic acids via non-parenteral routes of administration. Pharmaceutical compositions comprising oligonucleotides disclosed herein include, for systemic delivery, emulsion and microemulsion formulations for a variety of applications and oral dosage formulations. It has also surprisingly been discovered that oligonucleotides may be locally delivered to colonic sites by rectal enemas and suppositories in simple solutions, e.g., neat or in saline. Such pharmaceutical compositions of oligonucleotides may further include one or more penetration enhancers for the transport of oligonucleotides and other nucleic acids across mucosal membranes. The compositions and methods of the invention are utilized to effect the oral, buccal, rectal or vaginal administration of an antisense oligonucleotide to an animal in order to modulate the expression of a gene in the animal for investigative, therapeutic, palliative or prophylactic purposes.
摘要翻译：本发明涉及通过非肠胃外给药途径增强寡核苷酸和核酸的局部和全身摄取和递送的组合物和方法。包含本文公开的寡核苷酸的药物组合物包括用于全身递送的乳液和微乳液制剂用于各种应用和口服剂型。还令人惊讶地发现，可以用简单的溶液，例如纯的或盐水，通过直肠灌肠剂和栓剂将寡核苷酸局部递送至结肠部位。寡核苷酸的这种药物组合物可以进一步包括一种或多种用于将寡核苷酸和其它核酸转移穿过粘膜的渗透增强剂。本发明的组合物和方法用于对动物进行口服，口腔，直肠或阴道施用反义寡核苷酸，以调节动物中基因在调查，治疗，姑息或预防目的中的表达。

3. 发明申请

US20090326045A1 COMPOSITIONS AND METHODS FOR TOPICAL DELIVERY OF OLIGONUCLEOTIDES 失效
标题翻译：用于局部输送寡核苷酸的组合物和方法
公开(公告)号：US20090326045A1
公开(公告)日：2009-12-31
申请号：US12545778
申请日：2009-08-21
申请人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
发明人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
IPC分类号： A61K31/7088 , A61P35/00
CPC分类号： A61K48/0008 , A61K48/0025 , A61K48/0041 , A61K48/0075
摘要： The present invention relates to compositions and methods which enhance the delivery of oligonucleotides and other nucleosidic moieties via topical routes of administration. Preferred compositions include liposomes or penetration enhancers for the delivery of such moieties to dermal and/or epidermal tissue in an animal for investigative, therapeutic or prophylactic purposes.
摘要翻译：本发明涉及通过局部施用途径增强寡核苷酸和其它核苷部分的递送的组合物和方法。优选的组合物包括用于将这些部分递送到动物中用于调查，治疗或预防目的的皮肤和/或表皮组织的脂质体或渗透增强剂。

4. 发明申请

US20110213014A1 COMPOSITIONS AND METHODS FOR TOPICAL DELIVERY OF OLIGONUCLEOTIDES 审中-公开
标题翻译：用于局部输送寡核苷酸的组合物和方法
公开(公告)号：US20110213014A1
公开(公告)日：2011-09-01
申请号：US13107131
申请日：2011-05-13
申请人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
发明人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
IPC分类号： A61K31/7088 , A61P31/00 , A61P35/00 , A61P37/00
CPC分类号： A61K48/0008 , A61K48/0025 , A61K48/0041 , A61K48/0075
摘要： The present invention relates to compositions and methods which enhance the delivery of oligonucleotides and other nucleosidic moieties via topical routes of administration. Preferred compositions include liposomes or penetration enhancers for the delivery of such moieties to dermal and/or epidermal tissue in an animal for investigative, therapeutic or prophylactic purposes.
摘要翻译：本发明涉及通过局部施用途径增强寡核苷酸和其它核苷部分的递送的组合物和方法。优选的组合物包括用于将这些部分递送到动物中用于调查，治疗或预防目的的皮肤和/或表皮组织的脂质体或渗透增强剂。

5. 发明授权

US07964579B2 Compositions and methods for topical delivery of oligonucleotides 失效
标题翻译：用于局部递送寡核苷酸的组合物和方法
公开(公告)号：US07964579B2
公开(公告)日：2011-06-21
申请号：US12545778
申请日：2009-08-21
申请人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
发明人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
IPC分类号： C07H21/02 , C07H21/04 , A61K31/70 , C12Q1/68
CPC分类号： A61K48/0008 , A61K48/0025 , A61K48/0041 , A61K48/0075
摘要： The present invention relates to compositions and methods which enhance the delivery of oligonucleotides and other nucleosidic moieties via topical routes of administration. Preferred compositions include liposomes or penetration enhancers for the delivery of such moieties to dermal and/or epidermal tissue in an animal for investigative, therapeutic or prophylactic purposes.
摘要翻译：本发明涉及通过局部施用途径增强寡核苷酸和其它核苷部分的递送的组合物和方法。优选的组合物包括用于将这些部分递送到动物中用于调查，治疗或预防目的的皮肤和/或表皮组织的脂质体或渗透增强剂。

6. 发明授权

US06841539B1 Compositions and methods for topical delivery of oligonucleotides 失效
标题翻译：用于局部递送寡核苷酸的组合物和方法
公开(公告)号：US06841539B1
公开(公告)日：2005-01-11
申请号：US09315294
申请日：1999-05-20
申请人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
发明人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
IPC分类号： C12N15/09 , A61K9/107 , A61K31/7088 , A61K31/7125 , A61K47/12 , A61K47/24 , A61K47/38 , A61K48/00 , C07H21/04 , C12Q1/68
CPC分类号： A61K48/0008 , A61K48/0025 , A61K48/0041 , A61K48/0075
摘要： The present invention relates to compositions and methods which enhance the delivery of oligonucleotides and other nucleosidic moieties via topical routes of administration. Preferred compositions include liposomes or penetration enhancers for the delivery of such moieties to dermal and/or epidermal tissue in an animal for investigative, therapeutic or prophylactic purposes.
摘要翻译：本发明涉及通过局部施用途径增强寡核苷酸和其它核苷部分的递送的组合物和方法。优选的组合物包括用于将这些部分递送到动物中用于调查，治疗或预防目的的皮肤和/或表皮组织的脂质体或渗透增强剂。

7. 发明授权

US06262241B1 Compound for detecting and modulating RNA activity and gene expression 失效
标题翻译：用于检测和调节RNA活性和基因表达的化合物
公开(公告)号：US06262241B1
公开(公告)日：2001-07-17
申请号：US08383666
申请日：1995-02-03
申请人： Phillip Dan Cook , David J. Ecker , Charles John Guinosso , Oscar Leobardo Acevedo , Andrew Kawasaki , Kandasamy Ramasamy
发明人： Phillip Dan Cook , David J. Ecker , Charles John Guinosso , Oscar Leobardo Acevedo , Andrew Kawasaki , Kandasamy Ramasamy
IPC分类号： C12Q168
CPC分类号： C12N15/113 , A61K38/00 , A61K47/51 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C12N9/0069 , C12N15/1131 , C12N15/1132 , C12N15/1133 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N2310/3125 , C12N2310/315 , C12N2310/318 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12Q1/68 , C12Y113/11012
摘要： Compositions and methods for modulating the activity of RNA and DNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. Reactive portions which act, alternatively, through phosphorodiester bond cleavage, through backbone sugar bond cleavage or through base modification are preferrably employed. Groups which improve the pharmacodynamic and pharmacokinetic properties of the oligonucleotides are also useful in accordance with certain embodiments of this invention. Delivery of the reactive or non-reactive functionalities into the minor groove formed by the hybridization of the composition with the target RNA is also preferrably accomplished. Therapeutics, diagnostics and research methods and also disclosed. Synthetic nucleosides and nucleoside fragments are also provided useful for elaboration of oligonucleotides and oligonucleotide analogs for such purposes.
摘要翻译：公开了调节RNA和DNA活性的组合物和方法。根据优选实施方案，制备包含靶向和反应部分的反义组合物。优选使用通过骨架糖键切割或通过碱改性而作用或通过磷酸酯键断裂的反应性部分。根据本发明的某些实施方案，提高寡核苷酸的药效学和药代动力学性质的组也是有用的。通过组合物与靶RNA的杂交形成的反应性或非反应性官能团的递送也是优选的。治疗，诊断和研究方法也被披露。合成核苷和核苷片段也可用于制备用于这些目的的寡核苷酸和寡核苷酸类似物。

8. 发明授权

US5965722A Antisense inhibition of ras gene with chimeric and alternating oligonucleotides 失效
公开(公告)号：US5965722A
公开(公告)日：1999-10-12
申请号：US848840
申请日：1997-04-30
申请人： David J. Ecker , Phillip Dan Cook , Brett P. Monia , Susan M. Freier , Yogesh S. Sanghvi
发明人： David J. Ecker , Phillip Dan Cook , Brett P. Monia , Susan M. Freier , Yogesh S. Sanghvi
IPC分类号： C12N15/09 , A61K31/7125 , A61K48/00 , A61P35/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1135 , C07H21/00 , C12Q1/6876 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Q2600/158
摘要： Compositions and methods are provided for the modulation of expression of the human ras gene in both the normal and activated forms. Oligonucleotides are provided that have methylene(methylimino) linkages alternating with phosphorothioate or phosphodiester linkages. Further oligonucleotides are provide that have a first region having a methylene(methylimino) linkage alternating with a phosphorothioate or phosphodiester linkage and a second region having phosphorothioate linkages. Such oligonucleotides can be used for diagnostics as well as for research purposes including methods for diagnosis, detection and treatment of conditions arising from the activation of the H-ras gene.

9. 发明授权

US06359124B1 Antisense inhibition of ras gene with chimeric and alternating oligonucleotides 有权
标题翻译：用嵌合和交替寡核苷酸反义ras基因的抑制
公开(公告)号：US06359124B1
公开(公告)日：2002-03-19
申请号：US09248386
申请日：1999-02-12
申请人： David J. Ecker , Phillip Dan Cook , Brett P. Monia , Susan M. Freier , Yogesh S. Sanghvi
发明人： David J. Ecker , Phillip Dan Cook , Brett P. Monia , Susan M. Freier , Yogesh S. Sanghvi
IPC分类号： C07H2102
CPC分类号： C12N15/1135 , C07H21/00 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Q1/6876 , C12Q2600/158 , C12N2310/3525
摘要： Compositions and methods are provided for the modulation of expression of the human ras gene in both the normal and activated forms. Oligonucleotides are provided that have methylene(methylimino) linkages alternating with phosphorothioate or phosphodiester linkages. Further oligonucleotides are provide that have a first region having a methylene(methylimino) linkage alternating with a phosphorothioate or phosphodiester linkage and a second region having phosphorothioate linkages. Such oligonucleotides can be used for diagnostics as well as for research purposes including methods for diagnosis, detection and treatment of conditions arising from the activation of the H-ras gene.
摘要翻译：提供组合物和方法用于调节正常和活化形式的人ras基因的表达。提供了具有与硫代磷酸酯或磷酸二酯键交替的亚甲基（甲基亚氨基）键的寡核苷酸。提供另外的寡核苷酸，其具有与硫代磷酸酯或磷酸二酯键交替的亚甲基（甲基亚氨基）键的第一区域和具有硫代磷酸酯键的第二区域。这样的寡核苷酸可用于诊断以及研究目的，包括用于诊断，检测和治疗由H-ras基因激活产生的病症的方法。

10. 发明授权

US06001993A Random oligonucleotide libraries and methods of making the same 失效
标题翻译：随机寡核苷酸文库及其制作方法
公开(公告)号：US06001993A
公开(公告)日：1999-12-14
申请号：US768102
申请日：1996-12-16
申请人： Phillip Dan Cook , David J. Ecker , Oscar L. Acevedo , Peter Davis
发明人： Phillip Dan Cook , David J. Ecker , Oscar L. Acevedo , Peter Davis
IPC分类号： C07B61/00 , C07H21/00 , C07K1/04
CPC分类号： C07K1/047 , C07H21/00 , C40B40/00
摘要： The present invention provides methods of analyzing and evaluating phosphorus bearing monomeric units as to their suitability for use in preparing randomer oligomer libraries. The invention further provides methods for preparing such randomer oligomer libraries from the selected monomers.
摘要翻译：本发明提供了分析和评价含磷单体单元在适用于制备兰德莫尔低聚物文库时的方法。本发明还提供从所选择的单体制备这种兰定糖低聚物文库的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式