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1. 发明申请

US20120309700A1 DEVELOPMENT AND EVALUATION OF NOVEL CHINESE MATERIA MEDICA PREPARATIONS 审中-公开
标题翻译：新型中药材制剂的开发与评价
公开(公告)号：US20120309700A1
公开(公告)日：2012-12-06
申请号：US13499864
申请日：2010-08-24
申请人： Ching Song , Yuan Yi Xie , Lu Wang , Hao Yu , Shu Tsung Liao
发明人： Ching Song , Yuan Yi Xie , Lu Wang , Hao Yu , Shu Tsung Liao
IPC分类号： A61K31/704 , A61K31/58 , C12Q1/68 , A61P37/00 , A61P25/00 , A61P3/10 , A61K31/575 , A61P3/06
CPC分类号： G01N33/6875
摘要： Nuclear receptor LXR is an important member of 49 nuclear receptors in human bodies and has irreplaceable regulatory effects on cholesterol and fat metabolisms. The regulation of the biological activity of LXR may have therapeutic effects to the conditions such as cardiovascular and cerebrovascular obstructions, non-insulin dependent hyperglycemia, immune function disorders, and central nerve functional degeneration. We have developed a group of novel Chinese materia medica preparations targeting nuclear receptor LXR by using a computer-simulated docking technology and a process for determining biological activities of human cells cultured ex vivo. The group of preparations are featured by simple ingredients, low costs, easy to prepare, etc. No significant adverse effects were found in initial acute toxicology analysis which was carried out using mice.
摘要翻译：核受体LXR是人体中49种核受体的重要成员，对胆固醇和脂肪代谢具有不可替代的调节作用。对LXR的生物活性的调节可能对诸如心血管和脑血管障碍，非胰岛素依赖性高血糖症，免疫功能障碍和中枢神经功能退化等疾病具有治疗作用。我们通过使用计算机模拟对接技术和用于测定离体培养的人类细胞的生物活性的方法开发了一组靶向核受体LXR的中药材制剂。该组制剂以简单成分为特征，成本低，易于制备等。在使用小鼠进行的初始急性毒理学分析中未发现明显的不良反应。

2. 发明申请

US20110160174A1 Method Of Treating Disorder Related To High Cholesterol Concentration 审中-公开
标题翻译：治疗高胆固醇浓度相关疾病的方法
公开(公告)号：US20110160174A1
公开(公告)日：2011-06-30
申请号：US13046074
申请日：2011-03-11
申请人： Ching Song , Shutsung Liao , Qing Dai
发明人： Ching Song , Shutsung Liao , Qing Dai
IPC分类号： A61K31/575 , A61P3/06 , A61P9/00 , A61P25/28
CPC分类号： C07J41/0061 , A61K31/56 , A61K31/575 , C07J9/00 , C07J41/00
摘要： A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits, combinations, and compositions for treating a disorder in a subject where an activator of liver X alpha is indicated, such as in, for example, treating a high cholesterol disease.
摘要翻译：一种治疗与高胆固醇浓度相关的病症的方法，包括向有需要的受试者施用式（I）化合物：还公开了用于治疗受试者中的病症的方法，试剂盒，组合和组合物，其中活化剂指示肝Xα，例如在例如治疗高胆固醇疾病中。

3. 发明授权

US07078396B2 Method of treating disorder related to high cholesterol concentration 失效
公开(公告)号：US07078396B2
公开(公告)日：2006-07-18
申请号：US10290997
申请日：2002-11-08
申请人： Ching Song , Shutsung Liao
发明人： Ching Song , Shutsung Liao
IPC分类号： A61K31/56
CPC分类号： A61K31/045 , A61K31/13 , A61K31/56 , C07J9/00 , C07J41/00 , C07J53/00 , Y10S514/824
摘要： A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits, combinations, and compositions for treating a disorder in a subject where an activator of liver X alpha is indicated, such as in, for example, treating a high cholesterol disease.

4. 发明授权

US5639616A Isolated nucleic acid encoding a ubiquitous nuclear receptor 失效
标题翻译：分离的核酸编码普遍存在的核受体
公开(公告)号：US5639616A
公开(公告)日：1997-06-17
申请号：US342411
申请日：1994-11-18
申请人： Shutsung Liao , Ching Song
发明人： Shutsung Liao , Ching Song
IPC分类号： C07K14/705 , C12N15/12 , C12N5/10
CPC分类号： C07K14/70567 , C07K2319/00
摘要： The invention relates generally to compositions of and methods for obtaining ubiquitous, nuclear receptor (UR) polypeptides. The invention also relates to polynucleotides encoding UR polypeptides, recombinant host cells and vectors containing UR-encoding polynucleotide sequences, and recombinant UR polypeptides. By way of example, the invention discloses the cloning and functional expression of at least two different UR polypeptides. The invention also includes methods for using the isolated, recombinant receptor polypeptides in assays designed to select substances which interact with UR polypeptides for use in diagnostic, drug design and therapeutic applications.
摘要翻译：本发明一般涉及获得普遍存在的核受体（UR）多肽的组合物和方法。本发明还涉及编码UR多肽的多核苷酸，重组宿主细胞和含有编码UR的多核苷酸序列的载体和重组UR多肽。举例来说，本发明公开了至少两种不同的UR多肽的克隆和功能表达。本发明还包括在分析设计用于选择与UR多肽相互作用以用于诊断，药物设计和治疗应用的物质的测定中使用分离的重组受体多肽的方法。

5. 发明申请

US20100093687A1 Method Of Treating Disorder Related To High Cholesterol Concentration 审中-公开
标题翻译：治疗高胆固醇浓度相关疾病的方法
公开(公告)号：US20100093687A1
公开(公告)日：2010-04-15
申请号：US12637165
申请日：2009-12-14
申请人： Ching Song , Shutsung Liao , Qing Dai
发明人： Ching Song , Shutsung Liao , Qing Dai
IPC分类号： A61K31/575 , A61P7/00 , A61P25/00 , A61P9/10 , A61P25/28 , C07J9/00
CPC分类号： C07J41/0061 , A61K31/56 , A61K31/575 , C07J9/00 , C07J41/00
摘要： A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits, combinations, and compositions for treating a disorder in a subject where an activator of liver X alpha is indicated, such as in, for example, treating a high cholesterol disease.
摘要翻译：一种治疗与高胆固醇浓度相关的病症的方法，包括向有需要的受试者施用式（I）化合物：还公开了用于治疗受试者中的病症的方法，试剂盒，组合和组合物，其中活化剂指示肝Xα，例如在例如治疗高胆固醇疾病中。

6. 发明申请

US20070197484A1 Method of treating disorder related to high cholesterol concentration 审中-公开
标题翻译：治疗高胆固醇浓度相关疾病的方法
公开(公告)号：US20070197484A1
公开(公告)日：2007-08-23
申请号：US11488450
申请日：2006-07-18
申请人： Ching Song , Shutsung Liao , Qing Dai
发明人： Ching Song , Shutsung Liao , Qing Dai
IPC分类号： A61K31/56 , C07J41/00
CPC分类号： C07J41/0061 , A61K31/56 , A61K31/575 , C07J9/00 , C07J41/00
摘要： A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits, combinations, and compositions for treating a disorder in a subject where an activator of liver X alpha is indicated, such as in, for example, treating a high cholesterol disease.
摘要翻译：一种治疗与高胆固醇浓度相关的病症的方法，包括向有需要的受试者施用式（I）化合物：还公开了用于治疗受试者中的病症的方法，试剂盒，组合和组合物，其中活化剂指示肝Xα，例如在例如治疗高胆固醇疾病中。

7. 发明授权

US07012069B2 Liver X receptor agonists 失效
标题翻译：肝X受体激动剂
公开(公告)号：US07012069B2
公开(公告)日：2006-03-14
申请号：US10137695
申请日：2002-05-02
申请人： Ching Song , Shutsung Liao
发明人： Ching Song , Shutsung Liao
IPC分类号： A61K31/56 , C07J9/00
CPC分类号： C07J9/00 , C07J1/00 , C07J31/00 , C07J41/00
摘要： A compound of formula (I): Each of R1, R2, R3, R4, R4′, R5, R6, R7, R11, R12, R15, R16, and R17, independently, is hydrogen, halo, alkyl, haloalkyl, hydroxy, amino, carboxyl, oxo, sulfonic acid, or alkyl that is optionally inserted with —NH—, —N(alkyl)—, —O—, —S—, —SO—, —SO2—, —O—SO2—, —SO2—O—, —SO3—O—, —CO—, —CO—O—, —O—CO—, —CO—NR′—, or —NR′—CO—; or R3 and R4 together, R4 and R5 together, R5 and R6 together, or R6 and R7 together are eliminated so that a C═C bond is formed between the carbons to which they are attached; each of R8, R9, R10, R13, and R14, independently, is hydrogen, halo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, or amino; n is 0, 1, or 2; A is alkylene, alkenylene, or alkynylene; and each of X, Y, and Z, independently, is alkyl, haloalkyl, —OR′, —SR′, —NR′R″, —N(OR′)R″, or —N(SR′)R″; or X and Y together are ═O, ═S, or ═NR′; wherein each of R′ and R″, independently, is hydrogen, alkyl, or haloalkyl.
摘要翻译：式（I）的化合物：R 1，R 2，R 3，R 4， R 4'，R 5，R 6，R 7，R 11， R 12，R 15，R 16和R 17独立地是氢，卤素，烷基，卤代烷基，羟基，氨基，羧基，氧代，磺酸或任选地被-NH-， - N（烷基） - ， - O - ， - S - ， - SO - ， - SO 2 -O - SO 2 - ， - SO 2 -O - ， - SO 3 -O - ， - CO - ，-CO-O-，-O-CO-，-CO-NR'-或-NR'-CO-; 或R 3和R 4一起为R 4和R 5一起为R 5， SUB>和R 6一起，或R 6和R 7一起被除去，使得在它们之间的碳之间形成CC键附上 R 8，R 9，R 10，R 13和R 14中的每一个，独立地是氢，卤素，烷基，卤代烷基，羟烷基，烷氧基，羟基或氨基; n为0,1或2; A是亚烷基，亚烯基或亚炔基; 并且X，Y和Z各自独立地是烷基，卤代烷基，-OR'，-SR'，-NR'R“， - N（OR'）R”或-N（SR'）R “” 或X和Y一起为-O，-S或-NR'; 其中R'和R“各自独立地是氢，烷基或卤代烷基。

8. 发明授权

US06645955B1 3,6-dihydroxy-24-amidyl steroid derivatives 失效
标题翻译： 3,6-二羟基-24-酰氨基类固醇衍生物
公开(公告)号：US06645955B1
公开(公告)日：2003-11-11
申请号：US09560236
申请日：2000-04-28
申请人： Shutsung Liao , Ching Song
发明人： Shutsung Liao , Ching Song
IPC分类号： A61K3156
CPC分类号： C07J17/00 , A61K31/565 , A61K31/57 , A61K31/575 , A61K31/585 , C07J3/00 , C07J9/00 , C07J41/00
摘要： Steroid derivatives of this invention interact with nuclear liver X receptor (LXR) and ubiquitous receptor (UR) and can be used to treat a variety of LXR- or UR-mediated disorders.
摘要翻译：本发明的类固醇衍生物与核肝X受体（LXR）和普遍存在的受体（UR）相互作用，可用于治疗各种LXR或UR介导的疾病。

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