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    • 2. 发明申请
    • Metal Complexes of Thiourea and Derivatives as Metal Delivering Anti-Cancer and Anti-Inflammatory Agents
    • 硫脲和衍生物金属配合物作为金属提供抗癌和抗炎剂
    • US20110269730A1
    • 2011-11-03
    • US13091625
    • 2011-04-21
    • Chi Ming Che
    • Chi Ming Che
    • A61K31/555A61P35/00C07F1/08A61P29/00C07F1/12C07F1/10
    • C07F1/12C07F1/005C07F1/08C07F1/10
    • The present invention relates to metal thiourea complexes comprising N-substituted thiourea ligands and sulfur-coordinated metal ions, and methods for using the metal thiourea complexes for delivering otherwise unstable or impermeable metal ions to mammalian cells, for inhibiting cancer cell growth and inflammation, and for inhibiting the activities of associated drug targets under in vitro and in vivo conditions. The metal complexes of N-substituted thiourea are defined by the following formula (Ia or Ib) wherein R1 can be H, alkyl, alkenyl, alkynyl, aryl or heterocyclic groups; R2 can be H, alkyl, alkenyl, alkynyl or aryl groups; n=1 to 4; X− is a pharmaceutically acceptable anion (chloride, bromide, iodide, hexafluorophosphate, or triflate) and M is a coinage metal (Au, Ag, or Cu).
    • 本发明涉及包含N-取代的硫脲配位体和硫配位金属离子的金属硫脲配合物,以及使用金属硫脲络合物向哺乳动物细胞递送不稳定或不渗透的金属离子,抑制癌细胞生长和炎症的方法,以及 用于在体外和体内条件下抑制相关药物靶标的活性。 N-取代的硫脲的金属络合物由下式(Ia或Ib)定义,其中R 1可以是H,烷基,烯基,炔基,芳基或杂环基; R2可以是H,烷基,烯基,炔基或芳基; n = 1〜4; X-是药学上可接受的阴离子(氯化物,溴化物,碘化物,六氟磷酸盐或三氟甲磺酸盐),M是造币金属(Au,Ag或Cu)。
    • 5. 发明授权
    • Metal complexes of thiourea and derivatives as metal delivering anti-cancer and anti-inflammatory agents
    • 硫脲和衍生物的金属络合物作为递送抗癌和抗炎剂的金属
    • US08722897B2
    • 2014-05-13
    • US13091625
    • 2011-04-21
    • Chi Ming Che
    • Chi Ming Che
    • C07F1/12C07F1/08C07F1/10C07F1/00
    • C07F1/12C07F1/005C07F1/08C07F1/10
    • The present invention relates to metal thiourea complexes comprising N-substituted thiourea ligands and sulfur-coordinated metal ions, and methods for using the metal thiourea complexes for delivering otherwise unstable or impermeable metal ions to mammalian cells, for inhibiting cancer cell growth and inflammation, and for inhibiting the activities of associated drug targets under in vitro and in vivo conditions. The metal complexes of N-substituted thiourea are defined by the following formula (Ia or Ib) wherein R1 can be H, alkyl, alkenyl, alkynyl, aryl or heterocyclic groups; R2 can be H, alkyl, alkenyl, alkynyl or aryl groups; n=1 to 4; X− is a pharmaceutically acceptable anion (chloride, bromide, iodide, hexafluorophosphate, or triflate) and M is a coinage metal (Au, Ag, or Cu).
    • 本发明涉及包含N-取代的硫脲配位体和硫配位金属离子的金属硫脲配合物,以及使用金属硫脲络合物向哺乳动物细胞递送不稳定或不渗透的金属离子,抑制癌细胞生长和炎症的方法,以及 用于在体外和体内条件下抑制相关药物靶标的活性。 N-取代的硫脲的金属络合物由下式(Ia或Ib)定义,其中R 1可以是H,烷基,烯基,炔基,芳基或杂环基; R2可以是H,烷基,烯基,炔基或芳基; n = 1〜4; X-是药学上可接受的阴离子(氯化物,溴化物,碘化物,六氟磷酸盐或三氟甲磺酸盐),M是造币金属(Au,Ag或Cu)。