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1. 发明申请

US20060264405A1 Phosphorus-containing macrocycles 有权
标题翻译：含磷大环
公开(公告)号：US20060264405A1
公开(公告)日：2006-11-23
申请号：US11429582
申请日：2006-05-05
申请人： Chester Metcalf , Leonard Rozamus , Yihan Wang , R. Thomas , Dong Zou , David Berstein
发明人： Chester Metcalf , Leonard Rozamus , Yihan Wang , R. Thomas , Dong Zou , David Berstein
IPC分类号： A61K31/675 , C07F9/6527
CPC分类号： C07F9/6561 , A61K31/407 , A61K31/4745 , A61K31/675 , C07F9/6527
摘要： This invention concerns a new family of phosphorus-containing macrocycles containing various phosphonate- and phosphonate-containing moieties.
摘要翻译：本发明涉及含有各种含膦酸盐和膦酸盐的部分的含磷大环的新家族。

2. 发明申请

US20050032825A1 Phosphorus-containing compounds and uses thereof 有权
标题翻译：含磷化合物及其用途
公开(公告)号：US20050032825A1
公开(公告)日：2005-02-10
申请号：US10862149
申请日：2004-06-04
申请人： Chester Metcalf , Leonard Rozamus , Yihan Wang , David Berstein
发明人： Chester Metcalf , Leonard Rozamus , Yihan Wang , David Berstein
IPC分类号： A61L27/00 , A61F2/84 , A61K31/661 , A61K31/662 , A61K31/664 , A61K45/00 , A61K45/06 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/10 , A61P35/00 , A61P35/02 , A61P37/00 , C07D498/18 , C07F9/09 , C07F9/22 , C07F9/32 , C07F9/36 , C07F9/40 , C07F9/44 , C07F9/46 , C07F9/53 , C07F9/6561 , A61K31/675 , A61K31/4745
CPC分类号： A61K45/06 , A61K31/675 , C07F9/6561
摘要： This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA— in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; K is O or S; each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P; each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and each occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —C(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H; wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring; each occurrence of G is independently —O—, —S—, —NR2— or (M)X; each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M′ moiety may be saturated or unsaturated; each occurrence of x is independently an integer from 1-6; and the other variables are as defined herein.
摘要翻译：本发明涉及含有部分JQA-的新的含磷化合物族，其中：A不存在或为-O - ， - S-或-NR 2 - 。 Q不存在或（如果A为-O-，-S-或-NR 2 - ），则Q可以是-V-，-OV-，-SV-或-NR 2 V-，其中V为脂族，杂脂族，芳基或杂芳基部分，使得J通过A或通过VA，OVA，SVA或NR 2 VA直接与环己基环连接; K为O或S; 每个出现的Y独立地是-O - ， - S - ， - NR 2 - 或连接R 5部分与P的键; 每个出现的R 2和R 5独立地是脂族，杂脂族，芳基或杂芳基部分，或H; 并且每次出现的R 6独立地是-PK（YR 5）（YR 5），-SO 2（YR 5）或-C（O）（YR 5）; 只要与P直接连接的任何R 2或R 5部分不是H; 其中两个R 2，R 5和/或R 6部分可以彼此化学连接以形成环; 每次出现G独立为-O - ， - S - ， - NR 2 - 或（M）X; 每次出现的M独立地是取代或未取代的亚甲基部分，任何M-M'部分可以是饱和或不饱和的; 每次出现的x独立为1-6的整数; 其他变量如本文所定义。

3. 发明申请

US20070190106A1 Phosphorus-containing compounds & uses thereof 有权
标题翻译：含磷化合物及其用途
公开(公告)号：US20070190106A1
公开(公告)日：2007-08-16
申请号：US11650017
申请日：2007-01-05
申请人： David Berstein , Leonard Rozamus , Yihan Wang , Chester Metcalf
发明人： David Berstein , Leonard Rozamus , Yihan Wang , Chester Metcalf
IPC分类号： A61F2/00 , A61K31/675
CPC分类号： A61K45/06 , A61K31/675 , C07F9/6561
摘要： This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; K is O or S; each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P; each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and each occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —C(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H; wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring; each occurrence of G is independently —O—, —S—, —NR2— or (M)x; each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M′ moiety may be saturated or unsaturated; each occurrence of x is independently an integer from 1-6; and the other variables are as defined herein.
摘要翻译：本发明涉及含有部分JQA-的新的含磷化合物族，其中：A不存在或为-O - ， - S-或-NR 2 - 。 Q不存在或（如果A是-O-，-S-或-NR 2 - ）Q可以是-V-，-OV-，-SV-或-NR 2 V-，其中V是脂族，杂脂族，芳基或杂芳基部分，使得J通过A或通过VA，OVA，SVA或NR 2 O直接与环己基环连接 > VA; K为O或S; 每次出现的Y独立地是-O - ， - S - ， - NR 2 - 或 - 连接R 5部分与P的键; 每个出现的R 2和R 5独立地是脂族，杂脂族，芳基或杂芳基部分，或H; 且每次出现的R 6独立地为-PK（YR 5），（YR 5）， - SO 2 - （YR 5）或-C（O）（YR 5）; 只要与P直接连接的任何R“或R 5”部分不是H; 其中两个R 2，R 5和/或R 6 O 6部分可以彼此化学连接以形成环; 每次出现的G独立地为-O - ， - S - ， - NR 2 - 或（M）x X; 每次出现的M独立地是取代或未取代的亚甲基部分，任何M-M'部分可以是饱和或不饱和的; 每次出现的x独立地为1-6的整数; 其他变量如本文所定义。

4. 发明申请

US20060264456A1 Phosphorus-containing compounds & uses thereof 有权
标题翻译：含磷化合物及其用途
公开(公告)号：US20060264456A1
公开(公告)日：2006-11-23
申请号：US11494418
申请日：2006-07-27
申请人： Chester Metcalf , Leonard Rozamus , Yihan Wang , David Berstein
发明人： Chester Metcalf , Leonard Rozamus , Yihan Wang , David Berstein
IPC分类号： A61K31/4745 , C07D491/14
CPC分类号： A61K45/06 , A61K31/675 , C07F9/6561
摘要： This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; K is O or S; each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P; each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and each occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H; wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring; each occurrence of G is independently —O—, —S—, —NR2— or (M)x; each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M′ moiety may be saturated or unsaturated; each occurrence of x is independently an integer from 1-6; and the other variables are as defined herein.
摘要翻译：本发明涉及含有部分JQA-的新的含磷化合物族，其中：A不存在或为-O - ， - S-或-NR 2 - 。 Q不存在或（如果A是-O-，-S-或-NR 2 - ）Q可以是-V-，-OV-，-SV-或-NR 2 V-，其中V是脂族，杂脂族，芳基或杂芳基部分，使得J通过A或通过VA，OVA，SVA或NR 2 O直接与环己基环连接 > VA; K为O或S; 每次出现的Y独立地是-O - ， - S - ， - NR 2 - 或 - 连接R 5部分与P的键; 每个出现的R 2和R 5独立地是脂族，杂脂族，芳基或杂芳基部分，或H; 且每次出现的R 6独立地为-PK（YR 5），（YR 5）， - SO 2 - （YR 5）或 - （O）（YR 5）; 只要与P直接连接的任何R“或R 5”部分不是H; 其中两个R 2，R 5和/或R 6 O 6部分可以彼此化学连接以形成环; 每次出现的G独立地是-O - ， - S - ， - NR 2 - 或（M）x。每次出现的M独立地是取代或未取代的亚甲基部分，任何M-M'部分可以是饱和或不饱和的; 每次出现的x独立为1-6的整数; 其他变量如本文所定义。

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