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1. 发明申请

US20060141504A1 Molecular technologies for improved risk classification and therapy for acute lymphoblastic leukemia in children and adults 审中-公开
标题翻译：用于改善儿童和成人急性淋巴细胞白血病风险分类和治疗的分子技术
公开(公告)号：US20060141504A1
公开(公告)日：2006-06-29
申请号：US11285976
申请日：2005-11-23
申请人： Cheryl Willman , Edward Bedrick , Huining Kang , Paul Helman , Robert Veroff
发明人： Cheryl Willman , Edward Bedrick , Huining Kang , Paul Helman , Robert Veroff
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to methods for predicting the outcome of therapeutic intervention in cases of leukemia, especially acute lymphoblastic leukemia in children and adults. The present invention evaluates a gene expression profile and identifies prognostic genes of cancers, in particular leukemia, more particularly B-precursor acute lymphoblastic leukemia (ALL). The present invention provides a method of determining prognosis of leukemia, in particular, acute lymphoblastic leukemia, more particularly B-precursor ALL and predicting therapeutic outcome of a patient. The method comprises the steps of first establishing the threshold value of at least three prognostic genes of leukemia, preferably at least eight prognostic genes, or preferably, as many as 26 prognostic genes. Then, the amount of the prognostic gene(s) from a leukemia patient is determined. The amount of the prognostic gene present in that patient is compared with the established threshold value of the prognostic gene(s) which is indicative of therapeutic success or failure, whereby the prognostic outcome of the patient is determined/predicted.
摘要翻译：本发明涉及用于预测儿童和成人白血病尤其是急性淋巴细胞性白血病患者治疗干预结果的方法。本发明评估基因表达谱并鉴定癌症，特别是白血病，特别是B-前体急性成淋巴细胞白血病（ALL）的预后基因。本发明提供了一种确定白血病预后的方法，特别是急性淋巴细胞白血病，特别是B-前体ALL预测患者的治疗结果。该方法包括以下步骤：首先建立至少三种白血病预后基因的阈值，优选至少八个预后基因，或优选多达26个预后基因。然后，确定来自白血病患者的预后基因的量。将该患者中存在的预后基因的量与确定/预测患者的预后结果的预后基因的确定阈值进行比较。

2. 发明申请

US20060063156A1 Outcome prediction and risk classification in childhood leukemia 审中-公开
公开(公告)号：US20060063156A1
公开(公告)日：2006-03-23
申请号：US10729895
申请日：2003-12-05
申请人： Cheryl Willman , Paul Helman , Robert Veroff , Monica Mosquera-Caro , George Davidson , Shawn Martin , Susan Atlas , Erik Andries , Huining Kang , Jonathan Shuster , Xuefei Wang , Richard Harvey , David Haaland , Jeffrey Potter
发明人： Cheryl Willman , Paul Helman , Robert Veroff , Monica Mosquera-Caro , George Davidson , Shawn Martin , Susan Atlas , Erik Andries , Huining Kang , Jonathan Shuster , Xuefei Wang , Richard Harvey , David Haaland , Jeffrey Potter
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N15/09 , C07K14/705
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136
摘要： Genes and gene expression profiles useful for predicting outcome, risk classification, cytogenetics and/or etiology in pediatric acute lymphoblastic leukemia (ALL). OPAL1 is a novel gene associated with outcome and, along with other newly identified genes, represent a novel therapeutic targets.

3. 发明申请

US20090203588A1 Outcome prediction and risk classification in childhood leukemia 审中-公开
标题翻译：儿童期白血病结局预测与风险分类
公开(公告)号：US20090203588A1
公开(公告)日：2009-08-13
申请号：US11811436
申请日：2007-06-08
申请人： Cheryl L. Willman , Paul Helman , Robert Veroff , Monica Mosquera-Caro , George S. Davidson , Shawn B. Martin , Susan R. Atlas , Erik Andries , Huining Kang , Jonathan J. Shuster , Xuefei Wang , Richard C. Harvey , David M. Haaland , Jeffrey W. Potter
发明人： Cheryl L. Willman , Paul Helman , Robert Veroff , Monica Mosquera-Caro , George S. Davidson , Shawn B. Martin , Susan R. Atlas , Erik Andries , Huining Kang , Jonathan J. Shuster , Xuefei Wang , Richard C. Harvey , David M. Haaland , Jeffrey W. Potter
IPC分类号： A61K38/17 , C12N15/12 , C07H21/04 , C07K14/47 , A61K31/711 , A61P35/02 , C12N5/10 , C12N15/85 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136
摘要： Genes and gene expression profiles useful for predicting outcome, risk classification, cytogenetics and/or etiology in pediatric acute lymphoblastic leukemia (ALL). OPAL1 is a novel gene associated with outcome and, along with other newly identified genes, represent a novel therapeutic targets.
摘要翻译：基因和基因表达谱可用于预测儿科急性淋巴细胞白血病（ALL）的结局，风险分类，细胞遗传学和/或病因。 OPAL1是与结果相关的新基因，并与其他新鉴定的基因一起代表了一种新的治疗靶点。

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