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1. 发明授权

US09428808B2 Markers, biochips and kits for milk quality detection 有权
标题翻译：牛奶质量检测标记，生物芯片和试剂盒
公开(公告)号：US09428808B2
公开(公告)日：2016-08-30
申请号：US13509433
申请日：2010-05-27
申请人： Chengyu Zhang , Ke Zeng , Junfeng Zhang , Chunliang Tian , Haijin Li
发明人： Chengyu Zhang , Ke Zeng , Junfeng Zhang , Chunliang Tian , Haijin Li
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q2600/178
摘要： This invention provides markers, methods, biochips and kits for milk quality detection. The present invention particularly provides a method for milk quality detection by means of detecting the particular microRNAs in milk, so as to establish the standard of raw milk content.
摘要翻译：本发明提供用于牛奶质量检测的标记，方法，生物芯片和试剂盒。本发明特别提供一种通过检测牛奶中特定微小RNA的乳品质量检测方法，以确定生奶量的标准。

2. 发明申请

US20120252694A1 MARKERS, METHODS, BIOCHIPS AND KITS FOR MILK QUALITY DETECTION 有权
标题翻译：标记，方法，生物柴油和奶酪的质量检测
公开(公告)号：US20120252694A1
公开(公告)日：2012-10-04
申请号：US13509433
申请日：2010-05-27
申请人： Chengyu Zhang , Ke Zeng , Junfeng Zhang , Chunliang Tian , Haijin Li
发明人： Chengyu Zhang , Ke Zeng , Junfeng Zhang , Chunliang Tian , Haijin Li
IPC分类号： C40B30/04 , C40B20/00 , G01N21/64 , C40B40/06
CPC分类号： C12Q1/6876 , C12Q2600/178
摘要： This invention provides markers, methods, biochips and kits for milk quality detection. The present invention particularly provides a method for milk quality detection by means of detecting the particular microRNAs in milk, so as to establish the standard of raw milk content.
摘要翻译：本发明提供用于牛奶质量检测的标记，方法，生物芯片和试剂盒。本发明特别提供一种通过检测牛奶中特定微小RNA的乳品质量检测方法，以确定生奶量的标准。

3. 发明申请

US20110117565A1 SERUM OR PLASMA MICRORNA AS BIOMARKERS FOR NON-SMALL CELL LUNG CANCER 有权
标题翻译：血清或血浆MICRORNA作为非小细胞肺癌的生物标志物
公开(公告)号：US20110117565A1
公开(公告)日：2011-05-19
申请号：US12996967
申请日：2009-12-14
申请人： Chenyu Zhang , Ke Zeng , Junfeng Zhang , Yi Ba , Xi Chen , Haijin Li
发明人： Chenyu Zhang , Ke Zeng , Junfeng Zhang , Yi Ba , Xi Chen , Haijin Li
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： The present invention provides non-small cell lung cancer markers and the use thereof. The non-small cell lung cancer markers in the present invention include at least one of the 26 selected detectable mature microRNAs existing stably in human serum or plasma. The invention also provides a probe combination, kit and biochip for detecting the non-small cell lung cancer markers. The invention further provides a method for detecting microRNAs in the serum of lung cancer patients. By detecting the variations of microRNAs in the serum of lung cancer patients, the disease can be diagnosed in vitro; the progression course of the disease can be predicted; the occurrence of complications, the rate of relapse and the prognosis of the disease can be monitored; the drug efficacy and therapeutic effects can be analyzed. The method in the present invention enables extensive detection spectrum, high sensitivity, low cost, convenient sample taking and preservation. The method can be applied in the general survey of disease, solves problems of the low specificity and sensitivity encountered with previous single markers, and increases significantly the clinical detection rate of diseases, all of which make it an effective means for diagnosing diseases at an early stage.
摘要翻译：本发明提供非小细胞肺癌标志物及其用途。本发明中的非小细胞肺癌标志物包括稳定存在于人血清或血浆中的26种选择的可检测的成熟微RNA中的至少一种。本发明还提供了用于检测非小细胞肺癌标志物的探针组合，试剂盒和生物芯片。本发明还提供了一种检测肺癌患者血清中微小RNA的方法。通过检测肺癌患者血清中microRNAs的变化，可以在体外诊断该疾病; 可以预测疾病的进展过程; 可以监测并发症的发生，复发率和预后; 可以分析药物的疗效和治疗效果。本发明的方法能够广泛的检测光谱，高灵敏度，低成本，便于取样和保存。该方法可应用于疾病综合调查，解决了以前单个标记物所遇到的低特异性和敏感性问题，并大大增加了疾病的临床检出率，这些都成为早期诊断疾病的有效手段阶段。

4. 发明申请

US20130078225A1 Method for Modulating MicroRNA Content in Living Beings and the Use Thereof 有权
标题翻译：调节生物中微RNA含量的方法及其用途
公开(公告)号：US20130078225A1
公开(公告)日：2013-03-28
申请号：US13641074
申请日：2010-04-13
申请人： Ke Zeng , Chenyu Zhang , Junfeng Zhang , Haijin Li
发明人： Ke Zeng , Chenyu Zhang , Junfeng Zhang , Haijin Li
IPC分类号： A61K35/14 , A61K35/28 , A61K35/36
CPC分类号： A61K35/14 , A61K35/28 , A61K35/36 , C12N15/111 , C12N15/88 , C12N2310/141 , C12N2320/32
摘要： The present invention relates to a method for modulating miRNA content in living beings and the use thereof, whereof the miRNAs are delivered initiatively and selectively by microparticles/MVs/exosomes to the circulatory system and target cells/tissues to perform various functions. The invention provides a novel combination of molecules that mediates the inter-cellular communication: the miRNAs secreted by cells through cellular MVs. Meanwhile, the present invention also provides a method for preparing cellular MVs entrapping certain miRNAs, and, according to the regulation and modification of gene expression in cells and tissues with the miRNA-entrapping cellular MVs, provides a novel method for modulating miRNA content in living beings, which is effective and adoptable to all cell types.
摘要翻译：本发明涉及一种用于调节生物中miRNA含量的方法及其用途，其中miRNA通过微粒/ MV /外来体主动和选择性递送至循环系统和靶细胞/组织以执行各种功能。本发明提供介导细胞间通讯的分子的新型组合：通过细胞MV分泌细胞的miRNA。同时，本发明还提供了一种制备截留某些miRNA的细胞MV的方法，并且根据miRNA携带细胞MV对细胞和组织中基因表达的调节和修饰，提供了调节生物中miRNA含量的新方法生物，对所有细胞类型有效和可应用。

5. 发明授权

US09821009B2 Method for modulating microRNA content in living beings and the use thereof 有权
公开(公告)号：US09821009B2
公开(公告)日：2017-11-21
申请号：US13641074
申请日：2010-04-13
申请人： Ke Zeng , Chenyu Zhang , Junfeng Zhang , Haijin Li
发明人： Ke Zeng , Chenyu Zhang , Junfeng Zhang , Haijin Li
IPC分类号： C12N15/11 , A61K35/14 , A61K35/28 , A61K35/36 , C12N15/88
CPC分类号： A61K35/14 , A61K35/28 , A61K35/36 , C12N15/111 , C12N15/88 , C12N2310/141 , C12N2320/32
摘要： The present invention relates to a method for modulating miRNA content in living beings and the use thereof, whereof the miRNAs are delivered initiatively and selectively by microparticles/MVs/exosomes to the circulatory system and target cells/tissues to perform various functions. The invention provides a novel combination of molecules that mediates the inter-cellular communication: the miRNAs secreted by cells through cellular MVs. Meanwhile, the present invention also provides a method for preparing cellular MVs entrapping certain miRNAs, and, according to the regulation and modification of gene expression in cells and tissues with the miRNA-entrapping cellular MVs, provides a novel method for modulating miRNA content in living beings, which is effective and adoptable to all cell types.

6. 发明授权

US09388470B2 Serum or plasma microRNA as biomarkers for non-small cell lung cancer 有权
标题翻译：血清或血浆microRNA作为非小细胞肺癌的生物标志物
公开(公告)号：US09388470B2
公开(公告)日：2016-07-12
申请号：US12996967
申请日：2009-12-14
申请人： Chenyu Zhang , Ke Zeng , Junfeng Zhang , Yi Ba , Xi Chen , Haijin Li
发明人： Chenyu Zhang , Ke Zeng , Junfeng Zhang , Yi Ba , Xi Chen , Haijin Li
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： The present invention provides non-small cell lung cancer markers and the use thereof in diagnosing and monitoring diseases in vitro. The non-small cell lung cancer markers include at least one of the 26 selected detectable mature microRNAs existing stably in human serum or plasma. The invention also provides probe combinations, a kit and biochip for detecting the non-small cell lung cancer markers. The invention further provides a method for detecting the said lung cancer markers. The method in the present invention enables extensive detection spectrum, high sensitivity, low cost, convenient sample taking and preservation. The method can be applied in the general survey of disease, solves problems of the low specificity and sensitivity encountered with previous single markers, and increases significantly the clinical detection rate of diseases; it forms an effective means for diagnosing diseases at an early stage.
摘要翻译：本发明提供非小细胞肺癌标志物及其在体外诊断和监测疾病中的应用。非小细胞肺癌标志物包括稳定存在于人血清或血浆中的26种选择的可检测的成熟微RNA中的至少一种。本发明还提供探针组合，用于检测非小细胞肺癌标志物的试剂盒和生物芯片。本发明还提供了一种用于检测所述肺癌标志物的方法。本发明的方法能够广泛的检测光谱，高灵敏度，低成本，便于取样和保存。该方法可应用于疾病一般调查，解决了以前单个标记物遇到的低特异性和敏感性问题，大大提高了疾病的临床检出率; 它是早期诊断疾病的有效手段。

7. 发明申请

US20100173288A1 SERUM/PLASMA MICRONAS AND USES THEREOF 审中-公开
公开(公告)号：US20100173288A1
公开(公告)日：2010-07-08
申请号：US12302196
申请日：2007-12-06
申请人： Chenyu Zhang , Junfeng Zhang , Xi Chen , Yi Ba , Jiangning Chen , Jin Wang , Ke Zeng , Hongjie Zhang
发明人： Chenyu Zhang , Junfeng Zhang , Xi Chen , Yi Ba , Jiangning Chen , Jin Wang , Ke Zeng , Hongjie Zhang
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q1/6876 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , C12Q2525/207
摘要： This invention provides a combination of microRNAs for evaluating the physiological and/or pathological condition of a subject, wherein the combination comprises all detectable microRNAs stably existing in the serum/plasma of a subject; and a method for evaluating the physiological and/or pathological condition of a subject, wherein the method includes determining all detectable microRNAs stably existing in the serum/plasma of a subject; and a kit for evaluating the physiological and/or pathological condition of a subject, wherein the kit contains the tools for determining all detectable microRNAs that stably existing in the serum/plasma of a subject; and a biochip for evaluating the physiological and/or pathological condition of a subject, wherein the biochip contains the components for determining all detectable microRNAs stably existing in the serum/plasma of a subject. The aforementioned combination, method, kit and biochip can be used for diagnosis as well as differentially diagnosis of diseases including various tumors; various acute/chronic infectious diseases, e.g. viral diseases such as viral influenza, viral hepatitis, AIDS, SARS, bacterial diseases such as tuberculosis, bacterial pneumonia, and other acute/chronic infectious diseases caused by various pathogenic microorganisms; other acute/chronic diseases such as diseases of respiratory system, diseases of immune system, diseases of blood and hematopoietic system, diseases of circulatory system such as cardio-cerebrovascular diseases, metabolic diseases of endocrine system, diseases of digestive system, diseases of nervous system, diseases of urinary system, diseases of reproductive system and diseases of locomotor system, prediction of complications occurrence and malignant diseases relapse, evaluation of therapeutic effects, screening of pharmaceutical active ingredients, assessment of drug efficacy as well as forensic authentication and prohibited drug inspection and the like, possessing a number of advantages such as extensive detection spectrum, high sensitivity, low cost, convenience for sampling, ease for sample preservation, etc. The said method can be widely used in work related to general survey of diseases and so on, improve the low-specificity and low-sensitivity caused by individual differences which single markers are difficult to overcome, significantly increasing the clinical detection rate of diseases, all of which make it become an effective means for diagnosing diseases in an early phase.

8. 发明授权

US09590749B2 Terminal and method for calculating channel quality indication information 有权
标题翻译：终端和计算信道质量指示信息的方法
公开(公告)号：US09590749B2
公开(公告)日：2017-03-07
申请号：US14400603
申请日：2011-12-21
申请人： Yijian Chen , Jun Xu , Yu Ngok Li , Bo Dai , Junfeng Zhang
发明人： Yijian Chen , Jun Xu , Yu Ngok Li , Bo Dai , Junfeng Zhang
IPC分类号： H04B7/06 , H04B17/309 , H04L1/00 , H04B7/04 , H04L25/02
CPC分类号： H04B17/309 , H04B7/0452 , H04B7/0456 , H04B7/046 , H04B7/0486 , H04B7/063 , H04B7/0632 , H04B7/0639 , H04B7/0689 , H04L1/0026 , H04L25/0202
摘要： Disclosed in the present document are a method and terminal for calculating channel quality indication information. The method includes: a terminal performing a channel measurement according to a received cell state information-reference signal (CSI-RS) or cell reference signal (CRS), determining a channel state information (CSI) reference resource, and determining channel quality indication (CQI) calculation conditions, then the terminal calculating a CQI value corresponding to the CSI reference resource according to the determined conditions and the measurement result. The present document makes a reasonable setting of the CQI calculation conditions, and ensures performance and effectiveness of system link self-adaptation.
摘要翻译：在本文档中公开了一种用于计算信道质量指示信息的方法和终端。该方法包括：根据接收到的小区状态信息参考信号（CSI-RS）或小区参考信号（CRS）执行信道测量的终端，确定信道状态信息（CSI）参考资源，以及确定信道质量指示（ CQI）计算条件，则终端根据确定的条件和测量结果来计算与CSI参考资源相对应的CQI值。本文档对CQI计算条件进行合理设置，确保系统链路自适应的性能和有效性。

9. 发明授权

US09491649B2 Method and apparatus for transmitting periodic feedback report 有权
标题翻译：发送定期反馈报告的方法和装置
公开(公告)号：US09491649B2
公开(公告)日：2016-11-08
申请号：US13877165
申请日：2011-06-24
申请人： Yijian Chen , Jun Xu , YuNgok Li , Junfeng Zhang
发明人： Yijian Chen , Jun Xu , YuNgok Li , Junfeng Zhang
IPC分类号： H04W24/10 , H04L1/00
CPC分类号： H04W24/10 , H04L1/0026 , H04L1/0027 , H04L1/0028 , H04L1/0071 , H04L1/0072
摘要： Disclosed in the present invention are a method and an apparatus for transmitting a periodic feedback report. In this case, the method includes: coding a periodic feedback report to be transmitted and data information corresponding to a transmission block respectively, wherein the periodic feedback report includes one of the following information: a combined coding index of rank indicator (RI) information and first pre-coding matrix indicator (PMI-1) information, a combined coding index of the RI and pre-coding type indication (PTI) information, and the PMI-1; intercepting correspondingly coded information according to the target length; and when a transmission block corresponds to a single layer or multiple layers, carrying out channel interleave on the coded information on the single layer or multiple layers to be transmitted on the transmission block, and transmitting the interleaved information on a layer corresponding to a physical uplink shared channel (PUSCH).
摘要翻译：在本发明中公开了一种用于发送周期性反馈报告的方法和装置。在这种情况下，该方法包括：分别编码要发送的周期性反馈报告和对应于传输块的数据信息，其中周期性反馈报告包括以下信息之一：秩指示符（RI）信息的组合编码索引和第一预编码矩阵指示符（PMI-1）信息，RI和预编码类型指示（PTI）信息的组合编码索引和PMI-1; 根据目标长度拦截相应的编码信息; 并且当传输块对应于单层或多层时，对传输块上要发送的单层或多层上的编码信息进行信道交织，并将交织信息发送到与物理上行链路相对应的层上共享信道（PUSCH）。

10. 发明授权

US09236980B2 Control channel transmitting, receiving method, base station and terminal 有权
标题翻译：控制信道发射，接收方式，基站和终端
公开(公告)号：US09236980B2
公开(公告)日：2016-01-12
申请号：US14348920
申请日：2013-05-31
申请人： Senbao Guo , Yijian Chen , Bo Dai , Yunfeng Sun , Junfeng Zhang
发明人： Senbao Guo , Yijian Chen , Bo Dai , Yunfeng Sun , Junfeng Zhang
IPC分类号： H04W4/00 , H04L5/00 , H04W72/04
CPC分类号： H04L5/003 , H04L1/1893 , H04L5/0053 , H04L5/0091 , H04W72/042
摘要： A method for transmitting and receiving a control channel, a base station and a terminal relate to a long term evolution advanced system. The method for transmitting a control channel disclosed by the present document includes: a base station side configuring, for a terminal side, detection-limited subframe cluster information of a control channel, so as to notify the terminal side of the manner by which the base station side transmits the control channel. The present document also discloses a method for receiving a control channel, a base station and a terminal.
摘要翻译：用于发送和接收控制信道的方法，基站和终端涉及长期演进高级系统。用于发送由本文件公开的控制信道的方法包括：基站侧，对于终端侧，配置控制信道的检测受限子帧集合信息，以便向终端侧通知基站站侧发送控制信道。本文件还公开了一种用于接收控制信道，基站和终端的方法。

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