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1. 发明申请

US20060233794A1 Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders 有权
标题翻译：抗cd70抗体 - 药物偶联物及其用于治疗癌症和免疫疾病的用途
公开(公告)号：US20060233794A1
公开(公告)日：2006-10-19
申请号：US10546304
申请日：2004-02-20
申请人： Che-Leung Law , Alan Wahl , Nathalie Scholler , Linda Pestano
发明人： Che-Leung Law , Alan Wahl , Nathalie Scholler , Linda Pestano
IPC分类号： A61K39/395
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译：公开了与细胞毒性，免疫抑制或其它治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物共轭物的药物组合物和试剂盒。还公开了用于治疗表达CD70的癌症和免疫学疾病的方法，包括向受试者施用所公开的药物组合物。

2. 发明申请

US20120251559A1 Treatment of B-Cell Cancers With Anti-CD70 Antibody-Drug Conjugates 有权
标题翻译：用抗CD70抗体药物偶联物治疗B细胞癌
公开(公告)号：US20120251559A1
公开(公告)日：2012-10-04
申请号：US13491475
申请日：2012-06-07
申请人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
发明人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
IPC分类号： A61K39/395 , A61P35/02 , A61P35/00
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of a CD70-expressing cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译：公开了与细胞毒性治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。还公开了用于治疗表达CD70的癌症的方法，包括向受试者施用所公开的药物组合物。

3. 发明申请

US20100158910A1 TREATMENT OF RENAL CELL CARCINOMA WITH ANTI-CD70 ANTIBODY-DRUG CONJUGATES 有权
标题翻译：用抗CD70抗体药物联合治疗肾细胞癌
公开(公告)号：US20100158910A1
公开(公告)日：2010-06-24
申请号：US12635607
申请日：2009-12-10
申请人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
发明人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing a cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译：公开了与细胞毒性，治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。还公开了用于治疗表达癌症的CD70的方法，包括向受试者施用所公开的药物组合物。

4. 发明授权

US09345785B2 Treatment of renal cell carcinoma with anti-CD70 antibody-drug conjugates 有权
标题翻译：用抗CD70抗体 - 药物偶联物治疗肾细胞癌
公开(公告)号：US09345785B2
公开(公告)日：2016-05-24
申请号：US12635607
申请日：2009-12-10
申请人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
发明人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
IPC分类号： A61K39/395 , A61K47/48 , A61K49/00 , C07K16/28
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing a cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译：公开了与细胞毒性，治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。还公开了用于治疗表达癌症的CD70的方法，包括向受试者施用所公开的药物组合物。

5. 发明申请

US20120288512A1 Anti-CD70 Antibody-Drug Conjugates and Their Use for the Treatment of Cancer and Immune Disorders 有权
标题翻译：抗CD70抗体 - 药物偶联物及其用于治疗癌症和免疫疾病的用途
公开(公告)号：US20120288512A1
公开(公告)日：2012-11-15
申请号：US13485536
申请日：2012-05-31
申请人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
发明人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
IPC分类号： A61K39/44 , A61P29/00 , A61P31/06 , A61P17/06 , A61P5/16 , A61P1/16 , A61P37/06 , A61P25/00
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译：公开了与细胞毒性，免疫抑制或其它治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物共轭物的药物组合物和试剂盒。还公开了用于治疗表达CD70的癌症和免疫学疾病的方法，包括向受试者施用所公开的药物组合物。

6. 发明申请

US20100150925A1 TREATMENT OF B-CELL CANCERS WITH ANTI-CD70 ANTIBODY-DRUG CONJUGATES 审中-公开
标题翻译：用抗CD70抗体药物联合治疗B细胞癌
公开(公告)号：US20100150925A1
公开(公告)日：2010-06-17
申请号：US12635571
申请日：2009-12-10
申请人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
发明人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02
CPC分类号： A61K47/6803 , A61K47/65 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of a CD70-expressing cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译：公开了与细胞毒性治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。还公开了用于治疗表达CD70的癌症的方法，包括向受试者施用所公开的药物组合物。

7. 发明授权

US07662387B2 Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders 有权
标题翻译：抗cd70抗体 - 药物偶联物及其用于治疗癌症和免疫疾病的用途
公开(公告)号：US07662387B2
公开(公告)日：2010-02-16
申请号：US10546304
申请日：2004-02-20
申请人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
发明人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
IPC分类号： A61K39/00
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译：公开了与细胞毒性，免疫抑制或其它治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物共轭物的药物组合物和试剂盒。还公开了用于治疗表达CD70的癌症和免疫学疾病的方法，包括向受试者施用所公开的药物组合物。

8. 发明申请

US20070128593A1 Sga-1m, a cancer associated antigen, and uses thereof 审中-公开
标题翻译： Sga-1m，癌相关抗原及其用途
公开(公告)号：US20070128593A1
公开(公告)日：2007-06-07
申请号：US10503462
申请日：2003-02-03
申请人： Joseph Petroziello , Che-Leung Law , Alan Wahl
发明人： Joseph Petroziello , Che-Leung Law , Alan Wahl
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C07K14/47 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/5011 , G01N33/57484 , G01N2500/00
摘要： The present invention relates to a gene and gene product, SGA-1M that is differentially expressed in cancer tissues and cell lines. Suppression Subtractive Hybridization and microarray screening were used to screen for differential expression of SGA-1M in cancer tissues and cell lines. Expression analysis has demonstrated overexpression of SGA-1M in breast cancer tissue and breast cancer derived cell lines, in ovarian cancer, skin cancer, a cancer of the lymphoid system, thyroid cancer, pancreatic cancer, stomach cancer, and lung cancer. The gene is expressed as a 1.95 kb mRNA. The full length cDNA comprises two open reading frames encoding polypeptides of 221 and 75 amino acids, respectively. Monitoring expression levels of SGA-1M is useful for the diagnosis and prognosis of cancer as well as for evaluating the risk of developing certain types of cancers and the risk of metastasis of cancer. Reagents that target SGA-1M are useful for the treatment of cancer.
摘要翻译：本发明涉及在癌组织和细胞系中差异表达的基因和基因产物SGA-1M。抑制消减杂交和微阵列筛选用于筛选癌组织和细胞系中SGA-1M的差异表达。表达分析已经证明SGA-1M在乳腺癌组织和乳腺癌衍生细胞系，卵巢癌，皮肤癌，淋巴系统癌症，甲状腺癌，胰腺癌，胃癌和肺癌中的过度表达。该基因表达为1.95kb的mRNA。全长cDNA分别包含编码221和75个氨基酸的多肽的两个开放阅读框。监测SGA-1M的表达水平对于癌症的诊断和预后以及评估发展某些类型癌症的风险和癌症转移的风险是有用的。靶向SGA-1M的试剂可用于治疗癌症。

9. 发明申请

US20050123536A1 Treatment of immunological disorders using anti-dc30 antibodies 审中-公开
标题翻译：使用抗dc30抗体治疗免疫疾病
公开(公告)号：US20050123536A1
公开(公告)日：2005-06-09
申请号：US10496628
申请日：2002-11-20
申请人： Che-Leung Law , Kerry Klussman , Alan Wahl , Peter Senter , Svetlana Doronina , Brian Toki
发明人： Che-Leung Law , Kerry Klussman , Alan Wahl , Peter Senter , Svetlana Doronina , Brian Toki
IPC分类号： A61K48/00 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K47/48 , A61P1/16 , A61P5/14 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P27/14 , A61P27/16 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , C07K16/28
CPC分类号： C07K16/2878 , A61K39/39541 , A61K47/6849 , A61K2039/505 , C07K16/2809 , C07K2317/24 , C07K2317/31 , C07K2317/565 , A61K2300/00
摘要： The present invention relates to methods for the treatment of immunological disorders other than cancer, comprising administering proteins characterized by their ability to bind to CD30 and exert a cytostatic or cytotoxic effect on an activated lymphocyte. Such proteins include monoclonal antibodies AC10 and IleFi1. AC10 and HeFi-1 derivatives, and antibodies that compete with AC10 and HeFi-1 for binding to CD30. Other such proteins include multivalent anti-CD30 antibodies and anti-CD30 antibodies conjugated to cytotoxic agents. Treatment modalities with antibodies of the invention are also provided.
摘要翻译：本发明涉及用于治疗除癌症以外的免疫学疾病的方法，其包括施用以其结合CD30的能力为特征的蛋白质，并对活化的淋巴细胞施加细胞抑制或细胞毒性作用。这些蛋白质包括单克隆抗体AC10和IleFi1。 AC10和HeFi-1衍生物，以及与AC10和HeFi-1竞争结合CD30的抗体。其他这样的蛋白质包括多价抗CD30抗体和与细胞毒性剂缀合的抗-CD30抗体。还提供了与本发明的抗体的治疗方式。

10. 发明申请

US20070292422A1 ANTI-CD70 ANTIBODY AND ITS USE FOR THE TREATMENT AND PREVENTION OF CANCER AND IMMUNE DISORDERS 有权
标题翻译：抗CD70抗体及其用于治疗和预防癌症和免疫缺陷病毒
公开(公告)号：US20070292422A1
公开(公告)日：2007-12-20
申请号：US11735365
申请日：2007-04-13
申请人： Che-Leung Law , Julie McEarchern , Alan Wahl
发明人： Che-Leung Law , Julie McEarchern , Alan Wahl
IPC分类号： A61K39/395 , A61P25/28 , A61P31/06 , A61P35/00 , A61P37/00
CPC分类号： C07K16/2875 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要： Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunomodulatory without conjugation to a therapeutic agents as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering the CD70 binding agents to a subject.
摘要翻译：公开了CD70结合剂，例如抗CD70抗体和衍生物，其诱导细胞毒性，细胞抑制或免疫调节而不与治疗剂缀合，以及包含抗体或衍生物的药物组合物和试剂盒。还公开了用于治疗和预防CD70表达的癌症和免疫学障碍的方法，其包括向受试者施用CD70结合剂。

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