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1. 发明授权

US07972378B2 Stents for prosthetic heart valves 有权
标题翻译：假体心脏瓣膜支架
公开(公告)号：US07972378B2
公开(公告)日：2011-07-05
申请号：US12321760
申请日：2009-01-23
申请人： Charles Tabor , Carol E. Eberhardt , Timothy G. Laske , Timothy R. Ryan , Joseph C. Morrow , Tammy Y. Tam , Brian A. Glynn , Anne L. Brody Rubin , J. Michael Tuchek
发明人： Charles Tabor , Carol E. Eberhardt , Timothy G. Laske , Timothy R. Ryan , Joseph C. Morrow , Tammy Y. Tam , Brian A. Glynn , Anne L. Brody Rubin , J. Michael Tuchek
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2418 , A61F2/013 , A61F2/07 , A61F2/2433 , A61F2/2436 , A61F2/89 , A61F2/90 , A61F2002/016 , A61F2220/0058 , A61F2220/0075 , A61F2220/0091 , A61F2230/0006 , A61F2230/0054 , A61F2230/008 , A61F2250/0018 , A61F2250/003 , A61F2250/0039
摘要： A stented valve including a stent structure including a generally tubular body portion that has a first end and a second end, wherein an area adjacent the first end has a first stiffness, an area adjacent the second end has a second stiffness, and a central region between the areas at the first and second ends has a third stiffness that is less than the stiffness adjacent the first and second ends, wherein the stent structure can be reconfigured in its central area to match a curved patient anatomical region. The stented valve further includes a valve structure attached within the generally tubular portion.
摘要翻译：一种支架式阀，包括支架结构，其包括具有第一端和第二端的大体管状体部，其中与第一端相邻的区域具有第一刚度，与第二端相邻的区域具有第二刚度，以及中心区域在第一和第二端之间的区域之间具有小于邻近第一和第二端的刚度的第三刚度，其中支架结构可以在其中心区域重新配置以匹配弯曲的患者解剖区域。支架瓣膜还包括附接在大致管状部分内的阀结构。

2. 发明授权

US08673000B2 Stents for prosthetic heart valves 有权
标题翻译：假体心脏瓣膜支架
公开(公告)号：US08673000B2
公开(公告)日：2014-03-18
申请号：US13112656
申请日：2011-05-20
申请人： Charles Tabor , Carol E. Eberhardt , Timothy G. Laske , Timothy R. Ryan , Joseph C. Morrow , Tammy Y. Tam , Brian A. Glynn , Anne L. Brody Rubin , J. Michael Tuchek
发明人： Charles Tabor , Carol E. Eberhardt , Timothy G. Laske , Timothy R. Ryan , Joseph C. Morrow , Tammy Y. Tam , Brian A. Glynn , Anne L. Brody Rubin , J. Michael Tuchek
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/013 , A61F2/07 , A61F2/2433 , A61F2/2436 , A61F2/89 , A61F2/90 , A61F2002/016 , A61F2220/0058 , A61F2220/0075 , A61F2220/0091 , A61F2230/0006 , A61F2230/0054 , A61F2230/008 , A61F2250/0018 , A61F2250/003 , A61F2250/0039
摘要： A stented valve including a generally tubular stent structure that has a longitudinal axis, first and second opposite ends, a plurality of commissure support structures spaced from the first and second ends and extending generally parallel to the longitudinal axis, at least one structural wire positioned between each two adjacent commissure support structures, and at least one wing portion extending from two adjacent commissure support structures and toward one of the first and second ends of the stent structure. The stented valve further includes a valve structure attached within the generally tubular stent structure to the commissure support structures.
摘要翻译：一种支架式阀，包括大致管状的支架结构，其具有纵向轴线，第一和第二相对端部，与第一和第二端部间隔开并且大致平行于纵向轴线延伸的多个连合支撑结构，至少一个结构线定位在每个两个相邻的连合支撑结构，以及从两个相邻的合金支撑结构延伸并且朝向支架结构的第一和第二端中的一个延伸的至少一个翼部。支架瓣膜还包括附接在大致管状支架结构内的连接支撑结构的瓣膜结构。

3. 发明申请

US20090287299A1 Stents for prosthetic heart valves 有权
标题翻译：假体心脏瓣膜支架
公开(公告)号：US20090287299A1
公开(公告)日：2009-11-19
申请号：US12321760
申请日：2009-01-23
申请人： Charles Tabor , Carol E. Eberhardt , Timothy G. Laske , Timothy R. Ryan , Joseph C. Morrow , Tammy Y. Tam , Brian A. Glynn , Anne L. Brody Rubin , J. Michael Tuchek
发明人： Charles Tabor , Carol E. Eberhardt , Timothy G. Laske , Timothy R. Ryan , Joseph C. Morrow , Tammy Y. Tam , Brian A. Glynn , Anne L. Brody Rubin , J. Michael Tuchek
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/013 , A61F2/07 , A61F2/2433 , A61F2/2436 , A61F2/89 , A61F2/90 , A61F2002/016 , A61F2220/0058 , A61F2220/0075 , A61F2220/0091 , A61F2230/0006 , A61F2230/0054 , A61F2230/008 , A61F2250/0018 , A61F2250/003 , A61F2250/0039
摘要： A stented valve including a stent structure including a generally tubular body portion that has a first end and a second end, wherein an area adjacent the first end has a first stiffness, an area adjacent the second end has a second stiffness, and a central region between the areas at the first and second ends has a third stiffness that is less than the stiffness adjacent the first and second ends, wherein the stent structure can be reconfigured in its central area to match a curved patient anatomical region. The stented valve further includes a valve structure attached within the generally tubular portion.
摘要翻译：一种支架式阀，包括支架结构，其包括具有第一端和第二端的大体管状体部，其中与第一端相邻的区域具有第一刚度，与第二端相邻的区域具有第二刚度，以及中心区域在第一和第二端之间的区域之间具有小于邻近第一和第二端的刚度的第三刚度，其中支架结构可以在其中心区域重新配置以匹配弯曲的患者解剖区域。支架瓣膜还包括附接在大致管状部分内的阀结构。

4. 发明申请

US20110224780A1 STENTS FOR PROSTHETIC HEART VALVES 有权
标题翻译：前驱心脏瓣膜手术
公开(公告)号：US20110224780A1
公开(公告)日：2011-09-15
申请号：US13112656
申请日：2011-05-20
申请人： Charles Tabor , Carol E. Eberhardt , Timothy G. Laske , Timothy R. Ryan , Joseph C. Morrow , Tammy Y. Tam , Brian A. Glynn , Anne L. Brody Rubin , Imichael Tuchek
发明人： Charles Tabor , Carol E. Eberhardt , Timothy G. Laske , Timothy R. Ryan , Joseph C. Morrow , Tammy Y. Tam , Brian A. Glynn , Anne L. Brody Rubin , Imichael Tuchek
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/013 , A61F2/07 , A61F2/2433 , A61F2/2436 , A61F2/89 , A61F2/90 , A61F2002/016 , A61F2220/0058 , A61F2220/0075 , A61F2220/0091 , A61F2230/0006 , A61F2230/0054 , A61F2230/008 , A61F2250/0018 , A61F2250/003 , A61F2250/0039
摘要： A stented valve including a generally tubular stent structure that has a longitudinal axis, first and second opposite ends, a plurality of commissure support structures spaced from the first and second ends and extending generally parallel to the longitudinal axis, at least one structural wire positioned between each two adjacent commissure support structures, and at least one wing portion extending from two adjacent commissure support structures and toward one of the first and second ends of the stent structure. The stented valve further includes a valve structure attached within the generally tubular stent structure to the commissure support structures.
摘要翻译：一种支架式阀，包括大致管状的支架结构，其具有纵向轴线，第一和第二相对端部，与第一和第二端部间隔开并且大致平行于纵向轴线延伸的多个连合支撑结构，至少一个结构线定位在每个两个相邻的连合支撑结构，以及从两个相邻的合金支撑结构延伸并且朝向支架结构的第一和第二端中的一个延伸的至少一个翼部。支架瓣膜还包括附接在大致管状支架结构内的连接支撑结构的瓣膜结构。

5. 发明申请

US20100036479A1 Stented Heart Valve Devices 有权
标题翻译：心脏瓣膜装置
公开(公告)号：US20100036479A1
公开(公告)日：2010-02-11
申请号：US12428737
申请日：2009-04-23
申请人： Alexander J. Hill , Mark J. Capps , Carol E. Eberhardt , Morgan M. House , Stuart R. MacDonald , Joseph C. Morrow , Jerald Redmond , Janice L. Shay , Timothy R. Ryan
发明人： Alexander J. Hill , Mark J. Capps , Carol E. Eberhardt , Morgan M. House , Stuart R. MacDonald , Joseph C. Morrow , Jerald Redmond , Janice L. Shay , Timothy R. Ryan
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2412 , A61F2/2487 , A61F2210/0014 , A61F2220/0016 , A61F2230/001 , A61F2230/0045 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0076 , A61F2230/008 , A61F2250/0039
摘要： A stent frame including an annular portion having first and second ends, a central longitudinal axis, and a wire portion with at least two extending posts and a generally sinusoidal series of peaks and valleys between each of the at least two extending posts; an atrial portion extending from the first end of the annular portion, wherein the atrial portion includes a plurality of flares that extend radially outward relative to the longitudinal axis of the annular portion; and a ventricular portion extending from the second end of the annular portion, wherein the ventricular portion includes at least one flare that extends radially outward relative to the longitudinal axis of the annular portion.
摘要翻译：一种支架框架，包括具有第一端和第二端的环形部分，中心纵向轴线和具有至少两个延伸柱的线部分，以及在所述至少两个延伸柱中的每一个之间的大致正弦系列的峰和谷; 从所述环形部分的第一端延伸的心房部分，其中所述心房部分包括相对于所述环形部分的纵向轴线径向向外延伸的多个喇叭口; 以及从所述环形部分的第二端延伸的心室部分，其中所述心室部分包括相对于所述环形部分的纵向轴线径向向外延伸的至少一个耀斑。

6. 发明授权

US09173737B2 Stented heart valve devices 有权
标题翻译：支架心脏瓣膜装置
公开(公告)号：US09173737B2
公开(公告)日：2015-11-03
申请号：US12428737
申请日：2009-04-23
申请人： Alexander J. Hill , Mark J. Capps , Carol E. Eberhardt , Morgan M. House , Stuart R. MacDonald , Joseph C. Morrow , Jerald Redmond , Janice L. Shay , Timothy R. Ryan
发明人： Alexander J. Hill , Mark J. Capps , Carol E. Eberhardt , Morgan M. House , Stuart R. MacDonald , Joseph C. Morrow , Jerald Redmond , Janice L. Shay , Timothy R. Ryan
IPC分类号： A61F2/82 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2412 , A61F2/2487 , A61F2210/0014 , A61F2220/0016 , A61F2230/001 , A61F2230/0045 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0076 , A61F2230/008 , A61F2250/0039
摘要： A stent frame including an annular portion having first and second ends, a central longitudinal axis, and a wire portion with at least two extending posts and a generally sinusoidal series of peaks and valleys between each of the at least two extending posts; an atrial portion extending from the first end of the annular portion, wherein the atrial portion includes a plurality of flares that extend radially outward relative to the longitudinal axis of the annular portion; and a ventricular portion extending from the second end of the annular portion, wherein the ventricular portion includes at least one flare that extends radially outward relative to the longitudinal axis of the annular portion.
摘要翻译：一种支架框架，包括具有第一端和第二端的环形部分，中心纵向轴线和具有至少两个延伸柱的线部分，以及在所述至少两个延伸柱中的每一个之间的大致正弦系列的峰和谷; 从所述环形部分的第一端延伸的心房部分，其中所述心房部分包括相对于所述环形部分的纵向轴线径向向外延伸的多个喇叭口; 以及从所述环形部分的第二端延伸的心室部分，其中所述心室部分包括相对于所述环形部分的纵向轴线径向向外延伸的至少一个耀斑。

7. 发明申请

US20090198323A1 Prosthetic Heart Valve System 有权
标题翻译：假心脏瓣膜系统
公开(公告)号：US20090198323A1
公开(公告)日：2009-08-06
申请号：US12372115
申请日：2009-02-17
申请人： Keith M. Johnson , Jack D. Lemmon , Joseph C. Morrow , Timothy R. Ryan
发明人： Keith M. Johnson , Jack D. Lemmon , Joseph C. Morrow , Timothy R. Ryan
IPC分类号： A61F2/24
CPC分类号： A61F2/2439 , A61F2/2412 , A61F2/2427
摘要： A prosthetic heart valve system including a prosthetic heart valve and a deflection device. The deflection device includes a line and a connector assembly including a tensioning component. The line interconnects and passes through free ends of stent posts associated with the heart valve, and is further connected to the tensioning component. The tensioning component is transitionable to a tensioning state in which the line is tensioned to inwardly deflect the stent posts. In this regard, the tensioning component is self-locking relative to the line in the tensioning state, and an entirety of the line extending distal the tensioning device does not extend beyond a stent portion of the heart valve opposite the stent posts. In a preferred embodiment, a holder body is further included, coupled to the heart valve apart from the deflection device.
摘要翻译：一种假体心脏瓣膜系统，包括假体心脏瓣膜和偏转装置。偏转装置包括线和包括张紧部件的连接器组件。线路连接并穿过与心脏瓣膜相关联的支架支柱的自由端，并进一步连接到张紧部件。张紧部件可转换到张紧状态，其中线被张紧以使支架柱向内偏转。在这方面，张紧部件相对于处于张紧状态的线是自锁的，并且延伸远离张紧装置的线的整体不延伸超过与支架柱相对的心脏瓣膜的支架部分。在优选实施例中，进一步包括保持器主体，其与偏转装置相连接到心脏瓣膜。

8. 发明申请

US20080183284A1 Annuloplasty Band and Method 有权
标题翻译：瓣膜成形术和方法
公开(公告)号：US20080183284A1
公开(公告)日：2008-07-31
申请号：US12059495
申请日：2008-03-31
申请人： Timothy R. Ryan , Joseph C. Morrow
发明人： Timothy R. Ryan , Joseph C. Morrow
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2448 , A61F2/2466 , A61F2/2496
摘要： An annuloplasty band comprising a sheath, and a generally arcuate stiffening element disposed within the sheath. The stiffening element extends from a first end to a second end, and preferably includes eyelets at its first and second ends adapted to receive sutures to secure the annuloplasty band to a valve annulus. The annuloplasty band preferably has a low profile (e.g., a thickness less than 3 mm). In embodiments intended for mitral valve repair, the eyelets are particularly adapted to receive sutures to secure the annuloplasty band to the antero-lateral trigone and postero-medial trigone. A holder and sizer device useful with the annuloplasty band are also provided.
摘要翻译：包括鞘的瓣膜成形带和设置在护套内的大致弓形的加强元件。加强元件从第一端延伸到第二端，并且优选地包括其第一端和第二端处的孔眼，其适于接收缝合线以将瓣膜成形术带固定到瓣膜环。瓣膜成形术带优选地具有低轮廓（例如，厚度小于3mm）。在旨在用于二尖瓣修复的实施例中，孔眼特别适于接收缝合线以将瓣膜成形术带固定到前后三角区和后内侧三角区。还提供了一种与瓣环成形术带有用的夹持器和分级器装置。

9. 发明授权

US07503929B2 Prosthetic heart valve system 有权
标题翻译：假心脏瓣膜系统
公开(公告)号：US07503929B2
公开(公告)日：2009-03-17
申请号：US11337422
申请日：2006-01-23
申请人： Keith M. Johnson , Jack D. Lemmon , Joseph C. Morrow , Timothy R. Ryan
发明人： Keith M. Johnson , Jack D. Lemmon , Joseph C. Morrow , Timothy R. Ryan
IPC分类号： A61F2/24
CPC分类号： A61F2/2439 , A61F2/2412 , A61F2/2427
摘要： A prosthetic heart valve system including a prosthetic heart valve and a deflection device. The deflection device includes a line and a connector assembly including a tensioning component. The line interconnects and passes through free ends of stent posts associated with the heart valve, and is further connected to the tensioning component. The tensioning component is transitionable to a tensioning state in which the line is tensioned to inwardly deflect the stent posts. In this regard, the tensioning component is self-locking relative to the line in the tensioning state, and an entirety of the line extending distal the tensioning device does not extend beyond a stent portion of the heart valve opposite the stent posts. In a preferred embodiment, a holder body is further included, coupled to the heart valve apart from the deflection device.
摘要翻译：一种假体心脏瓣膜系统，包括假体心脏瓣膜和偏转装置。偏转装置包括线和包括张紧部件的连接器组件。线路连接并穿过与心脏瓣膜相关联的支架支柱的自由端，并进一步连接到张紧部件。张紧部件可转换到张紧状态，其中线被张紧以使支架柱向内偏转。在这方面，张紧部件相对于处于张紧状态的线是自锁的，并且延伸远离张紧装置的线的整体不延伸超过与支架柱相对的心脏瓣膜的支架部分。在优选实施例中，进一步包括保持器主体，其与偏转装置相连接到心脏瓣膜。

10. 发明申请

US20080215144A1 Replacement prosthetic heart valves and methods of implantation 有权
标题翻译：替代假体心脏瓣膜和植入方法
公开(公告)号：US20080215144A1
公开(公告)日：2008-09-04
申请号：US12070347
申请日：2008-02-15
申请人： Timothy R. Ryan , Joseph C. Morrow
发明人： Timothy R. Ryan , Joseph C. Morrow
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2409 , A61F2/2433 , A61F2/2436 , A61F2/958 , A61F2210/0014 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , A61F2230/0069 , A61F2310/00023
摘要： A replacement prosthetic heart valve for engagement with a structure of a previously implanted prosthetic heart valve, the replacement heart valve including a stent structure and at least two leaflets attached within the interior area of a tubular body portion of the stent structure. The stent structure includes a generally tubular body portion having an interior area, at least two upper flange portions for positioning at an outflow end of the previously implanted heart valve, wherein the upper flange portions extend radially outward from the tubular body portion and are biased toward an inflow end of the replacement heart valve, and at least one lower flange portion for positioning at an inflow end of the previously implanted heart valve, wherein the lower flange portions extend radially outward from the tubular body portion and are biased toward an outflow end of the replacement heart valve.
摘要翻译：一种替代假体心脏瓣膜，用于与先前植入的假体心脏瓣膜的结构接合，所述置换心脏瓣膜包括支架结构和附接在支架结构的管状主体部分的内部区域内的至少两个小叶。支架结构包括具有内部区域的大致管状的本体部分，用于定位在先前植入的心脏瓣膜的流出端处的至少两个上凸缘部分，其中上凸缘部分从管状体部分径向向外延伸并被偏压朝向置换心脏瓣膜的流入端，以及用于定位在先前植入的心脏瓣膜的流入端的至少一个下凸缘部分，其中下凸缘部分从管状体部分径向向外延伸，并且朝向更换心脏瓣膜。

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