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1. 发明授权

US5925054A Perfusion device for maintaining blood flow in a vessel while isolating an anastomosis 失效
公开(公告)号：US5925054A
公开(公告)日：1999-07-20
申请号：US790827
申请日：1997-01-23
申请人： Charles S. Taylor , Alfredo R. Cantu , Son M. Gia , Jeff A. Krolic , Robert G. Matheny , Amr Salahieh , Ivan Sepetka
发明人： Charles S. Taylor , Alfredo R. Cantu , Son M. Gia , Jeff A. Krolic , Robert G. Matheny , Amr Salahieh , Ivan Sepetka
IPC分类号： A61B17/00 , A61B17/04 , A61B17/11 , A61B17/12 , A61B17/08
CPC分类号： A61B17/11 , A61B17/12045 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B17/1219 , A61B17/0469 , A61B2017/1135 , A61B2017/12127
摘要： A plurality of embodiments of a distal perfusion device are disclosed, which device facilitates anastomosis constructions by maintaining a dry anastomosis site while simultaneously maintaining blood flow distally in the blood vessel to prevent ischemia and reduce overall patient trauma. The perfusion device is configured for installation into a blood vessel such as a left anterior descending coronary artery through an incision therein, to which is to be grafted a distal end of a blood vessel such as an internal mammary artery. The device includes a central member of selected configuration and material, terminating at either end thereof in respective selectively tapered end members. A lumen extending through the central member and end members, and selected perforations in the end members, maintain blood flow through the perfusion device. A selected portion or portions of the device's outer circumference fit snugly within the artery in the regions beyond and/or at the anastomosis site, to maintain the latter free of blood. Several methods for deploying and removing respective embodiments of the device also are illustrated.

2. 发明授权

US06214022B1 Perfusion device for maintaining blood flow in a vessel while isolating an anastomosis 失效
标题翻译：用于在分离吻合期间维持血管中的血液流动的灌注装置
公开(公告)号：US06214022B1
公开(公告)日：2001-04-10
申请号：US09301019
申请日：1999-04-28
申请人： Charles S. Taylor , Alfredo R. Cantu , Son M. Gia , Jeff A. Krolic , Robert G. Matheny , Amr Salahieh , Ivan Sepetka
发明人： Charles S. Taylor , Alfredo R. Cantu , Son M. Gia , Jeff A. Krolic , Robert G. Matheny , Amr Salahieh , Ivan Sepetka
IPC分类号： A61B1708
CPC分类号： A61B17/11 , A61B17/0469 , A61B17/12045 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B17/1219 , A61B2017/1135 , A61B2017/12127
摘要： A plurality of embodiments of a distal perfusion device are disclosed, which device facilitates anastomosis constructions by maintaining a dry anastomosis site while simultaneously maintaining blood flow distally in the blood vessel to prevent ischemia and reduce overall patient trauma. The perfusion device is configured for installation into a blood vessel such as a left anterior descending coronary artery through an incision therein, to which is to be grafted a distal end of a blood vessel such as an internal mammary artery. The device includes a central member of selected configuration and material, terminating at either end thereof in respective selectively tapered end members. A lumen extending through the central member and end members, and selected perforations in the end members, maintain blood flow through the perfusion device. A selected portion or portions of the device's outer circumference fit snugly within the artery in the regions beyond and/or at the anastomosis site, to maintain the latter free of blood. Several methods for deploying and removing respective embodiments of the device also are illustrated.
摘要翻译：公开了一种远端灌注装置的多个实施例，该装置通过维持干吻合部位来促进吻合结构，同时在血管中保持血液向远端流动以防止局部缺血并减少总的患者创伤。灌注装置被构造成通过其中的切口安装到诸如左前降支冠状动脉的血管中，其将被移植到诸如内部乳腺动脉的血管的远端。该装置包括选定构型和材料的中心构件，其终端位于相应的选择性锥形端构件的任一端。延伸穿过中心构件和端构件的内腔以及端构件中选择的穿孔保持血流通过灌注装置。装置的外周的选定部分或部分适合紧贴在吻合部位之外和/或处于吻合部位的区域内的动脉内，以保持后者无血液。还示出了用于部署和移除设备的各个实施例的几种方法。

3. 发明授权

US06071297A Perfusion device for maintaining blood flow in a vessel while isolating an anastomosis 失效
标题翻译：用于在分离吻合期间维持血管中的血液流动的灌注装置
公开(公告)号：US06071297A
公开(公告)日：2000-06-06
申请号：US956164
申请日：1997-10-22
申请人： Amr Salahieh , Charles S. Taylor , Alfredo R. Cantu , Ivan Sepetka , Robert G. Matheny
发明人： Amr Salahieh , Charles S. Taylor , Alfredo R. Cantu , Ivan Sepetka , Robert G. Matheny
IPC分类号： A61B17/11 , A61B17/12 , A61M29/00
CPC分类号： A61B17/12045 , A61B17/11 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B2017/12127
摘要： A plurality of embodiments of a distal perfusion device are disclosed, which device facilitates anastomosis constructions by maintaining a dry anastomosis site while simultaneously maintaining blood flow distally in the blood vessel to prevent ischemia and reduce overall patient trauma. The perfusion device is configured for installation into a blood vessel such as a left anterior descending coronary artery through an incision therein, to which is to be grafted a distal end of a blood vessel such as an internal mammary artery. The device includes a central member of selected configuration and material, terminating at either end thereof in respective selectively tapered end members. A lumen extending through the central member and end members, and selected perforations in the end members, maintain blood flow through the perfusion device. A selected portion or portions of the device's outer circumference fit snugly within the artery in the regions beyond and/or at the anastomosis site, to maintain the latter free of blood. Several methods for deploying and removing respective embodiments of the device also are illustrated.
摘要翻译：公开了一种远端灌注装置的多个实施例，该装置通过维持干吻合部位来促进吻合结构，同时在血管中保持血液向远端流动以防止局部缺血并减少总的患者创伤。灌注装置被构造成通过其中的切口安装到诸如左前降支冠状动脉的血管中，其将被移植到诸如内部乳腺动脉的血管的远端。该装置包括选定构型和材料的中心构件，其终端位于相应的选择性锥形端构件的任一端。延伸穿过中心构件和端构件的内腔以及端构件中选择的穿孔保持血流通过灌注装置。装置的外周的选定部分或部分适合紧贴在吻合部位之外和/或处于吻合部位的区域内的动脉内，以保持后者无血液。还示出了用于部署和移除设备的各个实施例的几种方法。

4. 发明授权

US5769870A Perfusion device for maintaining blood flow in a vessel while isolating an anastomosis 失效
公开(公告)号：US5769870A
公开(公告)日：1998-06-23
申请号：US603415
申请日：1996-02-20
申请人： Amr Salahieh , Charles S. Taylor , Alfredo R. Cantu , Ivan Sepetka , Robert G. Matheny
发明人： Amr Salahieh , Charles S. Taylor , Alfredo R. Cantu , Ivan Sepetka , Robert G. Matheny
IPC分类号： A61B17/11 , A61B17/12 , A61M29/00
CPC分类号： A61B17/12045 , A61B17/11 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B2017/12127
摘要： A plurality of embodiments of a distal perfusion device are disclosed, which device facilitates anastomosis constructions by maintaining a dry anastomosis site while simultaneously maintaining blood flow distally in the blood vessel to prevent ischemia and reduce overall patient trauma. The perfusion device is configured for installation into a blood vessel such as a left anterior descending coronary artery through an incision therein, to which is to be grafted a distal end of a blood vessel such as an internal mammary artery. The device includes a central member of selected configuration and material, terminating at either end thereof in respective selectively tapered end members. A lumen extending through the central member and end members, and selected perforations in the end members, maintain blood flow through the perfusion device. A selected portion or portions of the device's outer circumference fit snugly within the artery in the regions beyond and/or at the anastomosis site, to maintain the latter free of blood. Several methods for deploying and removing respective embodiments of the device also are illustrated.

5. 发明授权

US06602189B1 Access platform for internal mammary dissection 有权
标题翻译：内部乳腺切开手术平台
公开(公告)号：US06602189B1
公开(公告)日：2003-08-05
申请号：US09480830
申请日：2000-01-10
申请人： Federico J. Bennetti , Charles S. Taylor , William N. Aldrich , Ivan Sepetka , Robert G. Matheny , Eugene E. Reis , Brent Regan , Richard M. Ferrari
发明人： Federico J. Bennetti , Charles S. Taylor , William N. Aldrich , Ivan Sepetka , Robert G. Matheny , Eugene E. Reis , Brent Regan , Richard M. Ferrari
IPC分类号： A61B1728
CPC分类号： A61B17/3423 , A61B17/0206 , A61B17/025 , A61B17/3476 , A61B90/50 , A61B2017/349
摘要： An access platform having a first and a second blade interconnected to a spreader member that laterally drives the blades apart or together and a sternal pad interconnected to a blade. The superior blade is preferably pivotally coupled to the spreader member such that it naturally rises as the blades are separated. Alternatively, a vertical displacement member is operably interconnected to a blade and the spreader member and is used to vertically displace the interconnected superior blade and, thus, increase a surgeon's working space and visual access for the dissection of an internal mammary artery. A tissue retractor is interconnected to the blades to draw the soft tissue around an incision away from the surgeon's working area.
摘要翻译：一种进入平台，具有互连到扩张器构件的第一和第二刀片，所述第二和第二刀片横向地驱动刀片彼此分开或一起，以及与刀片互连的胸骨垫。优选的叶片优选地枢转地联接到扩展器构件，使得其随着叶片分离而自然地上升。或者，垂直移位构件可操作地连接到叶片和吊架构件，并且用于垂直地移位互连的上叶片，并且因此增加外科医生的工作空间和用于解剖内部乳房动脉的视觉进入。组织牵缩器与刀片相互连接以将软组织围绕切口远离外科医生的工作区域。

6. 发明授权

US5730757A Access platform for internal mammary dissection 失效
标题翻译：内部乳腺切开手术平台
公开(公告)号：US5730757A
公开(公告)日：1998-03-24
申请号：US604161
申请日：1996-02-20
申请人： Federico J. Benetti , Charles S. Taylor , William N. Aldrich , Ivan Sepetka , Robert G. Matheny , Eugene E. Reis , Brent Regan , Richard M. Ferrari
发明人： Federico J. Benetti , Charles S. Taylor , William N. Aldrich , Ivan Sepetka , Robert G. Matheny , Eugene E. Reis , Brent Regan , Richard M. Ferrari
IPC分类号： A61B17/02 , A61B17/34 , A61B19/00
CPC分类号： A61B17/3423 , A61B17/0206 , A61B90/50 , A61B17/025 , A61B2017/3427 , A61B2017/349
摘要： An access platform having a first and a second blade interconnected to a spreader member that laterally drives the blades apart or together and support pads interconnected to the first blade. A torsional member is operably interconnected to the first blade and the spreader member and is used to vertically displace the first blade in either direction and, thus, increase a surgeon's working space and visual access for the dissection of an internal mammary artery. A tissue retractor interconnected to the blades is used to draw the soft tissue around an incision away from the surgeon's working area.
摘要翻译：一种进入平台，其具有与扩展构件相互连接的第一和第二叶片，所述第一和第二叶片横向地驱动叶片彼此分离或一起，并且支撑与第一叶片互连的垫。扭转构件可操作地连接到第一叶片和展开构件，并且用于沿任一方向垂直地移位第一叶片，并且因此增加外科医生的工作空间和用于内部乳房动脉解剖的视觉进入。使用与叶片互连的组织牵开器将软组织围绕切口远离外科医生的工作区域。

7. 发明授权

US6001111A Low profile vessel occluder with and without detachable applicator 失效
标题翻译：具有和不具有可拆卸涂抹器的低轮廓血管封堵器
公开(公告)号：US6001111A
公开(公告)日：1999-12-14
申请号：US8113
申请日：1998-01-16
申请人： Ivan Sepetka , Robert G. Matheny , James A. Magovern , Dwight P. Morejohn , Robert C. Glines
发明人： Ivan Sepetka , Robert G. Matheny , James A. Magovern , Dwight P. Morejohn , Robert C. Glines
IPC分类号： A61B17/04 , A61B17/06 , A61B17/064 , A61B17/122 , A61B17/128 , A61B17/00
CPC分类号： A61B17/122 , A61B17/0487 , A61B17/06 , A61B17/0643 , A61B17/128 , A61B2017/0461 , A61B2017/0464
摘要： A low profile unobtrusive occluder device is disclosed which is particularly applicable for occluding blood vessels in minimally invasive beating heart CABG surgical procedures, wherein relatively small surgical openings are provided. At least one flexible member is provided on the occluder, which is placed against the vessel. A suture thread is passed under the vessel to encompass the vessel between the occluder and suture thread. The suture thread is selectively attached to the occluder such that the flexible member, when deformed, applies continuous selected tension on the suture thread to apply a corresponding compression on the vessel which occludes the flow of blood. An applicator is attached to the occluder to enable installation thereof, but is detachable after installation such that only the low profile occluder remains on the heart surface during surgery. The applicator is re-attached to the occluder to facilitate removal of the latter. In an alternative embodiment, the occluder is formed as an adjustable part of a heart contacting member of a thoracotomy stabilizer apparatus.
摘要翻译：公开了一种低调的不引人注意的闭塞器装置，其特别适用于在微创搏动心脏CABG外科手术中闭塞血管，其中提供了相对较小的手术开口。至少一个柔性构件设置在封闭器上，其抵靠容器放置。缝合线在血管下方通过封闭器和缝合线之间的容器。缝合线选择性地附接到闭塞器，使得当变形时，柔性构件在缝合线上施加连续的选定张力，以在封闭血流的血管上施加相应的压缩。敷贴器附接到封堵器以使其能够安装，但是在安装之后可拆卸，使得在外科手术期间只有低轮廓的封堵器保留在心脏表面上。将施用器重新连接到封堵器以便于去除封堵器。在替代实施例中，封堵器形成为开胸稳定器装置的心脏接触构件的可调部分。

8. 发明授权

US06381499B1 Method and apparatus for using vagus nerve stimulation in surgery 失效
标题翻译：手术中使用迷走神经刺激的方法和装置
公开(公告)号：US06381499B1
公开(公告)日：2002-04-30
申请号：US09574586
申请日：2000-05-17
申请人： Charles S. Taylor , Robert G. Matheny , Dwight P. Morejohn
发明人： Charles S. Taylor , Robert G. Matheny , Dwight P. Morejohn
IPC分类号： A61N132
CPC分类号： A61B17/122 , A61B17/1227 , A61B2017/0243 , A61N1/36014
摘要： A method and apparatus for facilitating coronary surgery on the beating heart wherein the vagus nerve is electrically stimulated to purposely temporarily stop or substantially reduce the beating of the heart under precisely controlled conditions. The apparatus controllably applies electrical stimulus to pre-selected locations along the vagus nerve and to pre-selected nerve branches related to the heart. The apparatus includes several clip and probe configurations for establishing electrical contact with the vagus nerve. Such purposely caused temporary stoppage or substantial reduction of the beating of the heart facilitates procedures such as suturing of an anastomosis which would otherwise be more difficult because of the motion induced by the beating heart.
摘要翻译：一种用于促进搏动心脏的冠状动脉手术的方法和装置，其中电刺激迷走神经以故意暂时地停止或基本上减少在精确控制的条件下的心跳。该装置可控制地将电刺激应用于沿着迷走神经的预先选择的位置和与心脏相关的预先选择的神经分支。该装置包括用于建立与迷走神经的电接触的多个夹子和探针配置。这样有意地引起临时停止或大幅度减少心脏搏动的方法有助于诸如缝合吻合术的过程，否则由于跳动心脏引起的运动将更加困难。

9. 发明授权

US5727569A Surgical devices for imposing a negative pressure to fix the position of cardiac tissue during surgery 失效
标题翻译：用于施加负压以固定手术期间心脏组织位置的手术装置
公开(公告)号：US5727569A
公开(公告)日：1998-03-17
申请号：US603328
申请日：1996-02-20
申请人： Federico J. Benetti , Robert G. Matheny , Charles S. Taylor
发明人： Federico J. Benetti , Robert G. Matheny , Charles S. Taylor
IPC分类号： A61B17/00 , A61B17/02 , A61B17/30 , A61B17/34 , A61B19/00
CPC分类号： A61B17/00 , A61B2017/00243 , A61B2017/00703 , A61B2017/0243 , A61B2017/306 , A61B2017/3488 , A61B90/40
摘要： The invention is devices and techniques which use a negative (suction) pressure or vacuum, applied through a surgical instrument, to fix the position of a portion of the surface of a beating heart so that a surgical procedure can be more easily performed. The devices apply a negative pressure at several points on the outer surface of the heart such that a portion of the heart is fixed in place by the suction imposed through the surgical instrument. Because the instrument fixes the position of the tissue, and because the instruments remain at a constant distance from the particular portion of the heart where the surgery is being performed, the device may also serve as a support or platform so that other surgical instruments or devices can be advantageously used at the site. In certain preferred embodiments, the devices described herein have structures to facilitate the use of additional surgical instruments such that the placement of negative pressure device permit the surgeon to advantageously manipulate the other instruments during surgery. The negative pressure is preferably imposed through a plurality of ports which may be disposed in a substantially planar surface of the instrument which contacts the cardiac tissue.
摘要翻译：本发明是使用通过外科器械施加的负（吸力）压力或真空来固定跳动心脏表面的一部分的位置使得外科手术可以更容易地进行的装置和技术。这些装置在心脏的外表面上的几个点处施加负压，使得心脏的一部分通过通过手术器械施加的抽吸被固定就位。因为仪器固定组织的位置，并且因为仪器保持与正在执行手术的心脏的特定部分恒定的距离，所以该装置还可以用作支撑或平台，使得其它手术器械或装置可以有利地在现场使用。在某些优选实施例中，本文所述的装置具有便于使用额外外科器械的结构，使得负压装置的放置允许外科医生在手术期间有利地操纵其他器械。负压优选通过多个端口施加，所述多个端口可以设置在与心脏组织接触的仪器的基本平坦的表面中。

10. 发明授权

US06308104B1 Method and apparatus for using vagus nerve stimulation in surgery 失效
标题翻译：手术中使用迷走神经刺激的方法和装置
公开(公告)号：US06308104B1
公开(公告)日：2001-10-23
申请号：US09338303
申请日：1999-06-22
申请人： Charles S. Taylor , Robert G. Matheny , Dwight P. Morejohn
发明人： Charles S. Taylor , Robert G. Matheny , Dwight P. Morejohn
IPC分类号： A61N105
CPC分类号： A61B17/122 , A61B17/1227 , A61B2017/0243 , A61N1/36014
摘要： A method and apparatus for facilitating coronary surgery on the beating heart wherein the vagus nerve is electrically stimulated to purposely temporarily stop or substantially reduce the beating of the heart under precisely controlled conditions. The apparatus controllably applies the electrical stimulus to preselected locations along the vagus nerve and thus to preselected nerve branches related to the heart. The apparatus includes several clip and probe configurations for establishing electrical contact with the vagus nerve. Such purposely caused temporary stoppage or substantial reduction of the beating of the heart facilitates procedures such as suturing of an anastomosis which would otherwise be more difficult because of the motion induced by the beating heart.
摘要翻译：一种用于促进搏动心脏的冠状动脉手术的方法和装置，其中电刺激迷走神经以故意暂时地停止或基本上减少在精确控制的条件下的心跳。该装置可控制地将电刺激应用于沿着迷走神经的预选位置，并因此应用于与心脏相关的预选神经分支。该装置包括用于建立与迷走神经的电接触的多个夹子和探针配置。这样有意地引起临时停止或大幅度减少心脏搏动的方法有助于诸如缝合吻合术的过程，否则由于跳动心脏引起的运动将更加困难。

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