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1. 发明授权

US08841120B2 Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity 有权
标题翻译：包含复合衣壳氨基酸序列以增强交叉反应性的病毒样颗粒
公开(公告)号：US08841120B2
公开(公告)日：2014-09-23
申请号：US13023363
申请日：2011-02-08
申请人： Charles Richardson , Robert F. Bargatze , Joel Haynes , Bryan Steadman
发明人： Charles Richardson , Robert F. Bargatze , Joel Haynes , Bryan Steadman
IPC分类号： C12N15/40 , C07K14/005 , A61K39/12 , C12N13/00 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K47/36 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55572 , A61K2039/55583 , A61K2039/70 , C12N7/00 , C12N2770/16022 , C12N2770/16023 , C12N2770/16034 , Y02A50/467
摘要： The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the invention provides virus-like particles comprising at least one composite polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of a non-enveloped virus and produce an increase in antisera cross-reactivity to one or more circulating strains of the non-enveloped virus. Methods of making composite virus-like particles and vaccine formulations comprising composite virus-like particles are also disclosed.
摘要翻译：本发明提供具有衍生自代表非包膜病毒的两个或更多个循环株的衣壳蛋白的共有序列的复合氨基酸序列的多肽。特别地，本发明提供包含至少一种复合多肽的病毒样颗粒。这种病毒样颗粒具有两个或更多个非包膜病毒的循环株的抗原表位，并且对一个或多个非包膜病毒的循环株产生抗血清交叉反应性的增加。还公开了制备复合病毒样颗粒和包含复合病毒样颗粒的疫苗制剂的方法。

2. 发明授权

US08481693B2 Virus like particle purification 有权
标题翻译：病毒样颗粒净化
公开(公告)号：US08481693B2
公开(公告)日：2013-07-09
申请号：US12531248
申请日：2008-03-14
申请人： Thomas S. Vedvick , Bryan Steadman , Charles Richardson , Thomas R. Foubert , Charles R. Petrie
发明人： Thomas S. Vedvick , Bryan Steadman , Charles Richardson , Thomas R. Foubert , Charles R. Petrie
IPC分类号： C07K1/00 , C12N7/00
CPC分类号： A61K39/12 , C07K1/18 , C07K14/005 , C12N7/00 , C12N2770/16023 , C12N2770/16034 , C12N2770/16051
摘要： Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.
摘要翻译：公开了纯化人类软骨病毒的方法，包括诺如病毒和滑叶病毒。

3. 发明申请

US20100150961A1 VIRUS LIKE PARTICLE PURIFICATION 有权
标题翻译：病毒样颗粒净化
公开(公告)号：US20100150961A1
公开(公告)日：2010-06-17
申请号：US12531248
申请日：2008-03-14
申请人： Thomas S. Vedvick , Bryan Steadman , Charles Richardson , Thomas R. Foubert , Charles R. Petrie
发明人： Thomas S. Vedvick , Bryan Steadman , Charles Richardson , Thomas R. Foubert , Charles R. Petrie
IPC分类号： A61K39/125 , C12N7/02
CPC分类号： A61K39/12 , C07K1/18 , C07K14/005 , C12N7/00 , C12N2770/16023 , C12N2770/16034 , C12N2770/16051
摘要： Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.
摘要翻译：公开了纯化人类软骨病毒的方法，包括诺如病毒和滑叶病毒。

4. 发明授权

US06355776B1 Peptides comprising repetitive units of amino acids and DNA sequences encoding the same 失效
标题翻译：包含氨基酸重复单元和编码氨基酸的DNA序列的肽
公开(公告)号：US06355776B1
公开(公告)日：2002-03-12
申请号：US09444791
申请日：1999-11-22
申请人： Franco A. Ferrari , Charles Richardson , James Chambers , Stuart Causey , Thomas J. Pollock , Joseph Cappello , John W. Crissman
发明人： Franco A. Ferrari , Charles Richardson , James Chambers , Stuart Causey , Thomas J. Pollock , Joseph Cappello , John W. Crissman
IPC分类号： C07K1300
CPC分类号： C07K14/43586 , C07K14/78 , C07K2319/00 , C07K2319/02 , C07K2319/33 , C07K2319/61 , C12N1/06 , C12N15/11 , C12N15/62 , C12N15/66 , C12N15/70 , C12N15/75
摘要： Novel polypeptides comprising repetitive units of amino acids, as well as synthetic genes encoding the subject polypeptides are provided. The subject polypeptides are characterized by comprising repetitive units of amino acids, where the repetitive units are present in naturally occurring proteins, particularly naturally occurring structural proteins. The subject polypeptides find use in a variety of applications, such as structural components of prosthetic devices, synthetic fibers, and the like.
摘要翻译：提供了包含氨基酸重复单元的新型多肽，以及编码本发明多肽的合成基因。主题多肽的特征在于包含氨基酸的重复单元，其中重复单元存在于天然存在的蛋白质中，特别是天然存在的结构蛋白质中。主题多肽可用于各种应用，例如假体装置的结构部件，合成纤维等。

5. 发明授权

US5243038A Construction of synthetic DNA and its use in large polypeptide synthesis 失效
标题翻译：合成DNA的构建及其在大多肽合成中的应用
公开(公告)号：US5243038A
公开(公告)日：1993-09-07
申请号：US114618
申请日：1987-10-29
申请人： Franco A. Ferrari , Charles Richardson , James Chambers , Stuart C. Causey , Thomas J. Pollock , Joseph Capello , John W. Crissman
发明人： Franco A. Ferrari , Charles Richardson , James Chambers , Stuart C. Causey , Thomas J. Pollock , Joseph Capello , John W. Crissman
IPC分类号： C07K14/435 , C07K14/78 , C12N1/06 , C12N15/11 , C12N15/62 , C12N15/70 , C12N15/75
CPC分类号： C07K14/78 , C07K14/43586 , C12N1/06 , C12N15/11 , C12N15/62 , C12N15/70 , C12N15/75 , C07K2319/00 , C07K2319/02 , C07K2319/61
摘要： Methods are provided for the production of large polypeptides containing repeating sequences of amino acids utilizing biochemical techniques, specifically DNA sequences coding for the expression of the large polypeptides. Systems utilizing exogenous transcriptional and translational regions to control the production of the large polypeptides are also provided.
摘要翻译：提供了使用生化技术生产含有氨基酸重复序列的大多肽的方法，特别是编码大多肽表达的DNA序列。还提供了利用外源转录和翻译区以控制大多肽的产生的系统。

6. 发明申请

US20110260013A1 BAG MASTER SYSTEM 审中-公开
标题翻译：袋主系统
公开(公告)号：US20110260013A1
公开(公告)日：2011-10-27
申请号：US13092125
申请日：2011-04-21
申请人： Charles Richardson
发明人： Charles Richardson
IPC分类号： B65B67/04 , B23P19/04
CPC分类号： B65B67/04 , B65B67/12 , Y10T29/49815 , Y10T29/49826
摘要： A debris collection device comprising: a graduated columnar member having, a first open end located in a top rim, a second open end located in a bottom rim, an inner surface, and an outer surface. First open end and second open end of the graduated columnar member oppose each other to form a through-hole between the top rim and the bottom rim defined by the inner surface having an inner volume of the graduated columnar member (creating a funnel profile.) The outer surface may comprise a flat portion such that the debris collection device can be laid in a debris collection orientation on a ground surface (parallel to) suitable to convey refuse from the ground surface into the top rim, though the graduated columnar member, and into a flexible bag removably-coupled to the bag holding periphery of the bottom rim to storably-contain said refuse for transport to another location.
摘要翻译：一种碎片收集装置，包括：分级柱状构件，其具有位于顶部边缘中的第一开口端，位于底部边缘中的第二开口端，内表面和外表面。刻度柱状构件的第一开口端和第二开口端彼此相对以在由具有分级柱状构件的内部容积的内表面限定的顶部边缘和底部边缘之间形成通孔（产生漏斗形状）。外表面可以包括平坦部分，使得碎屑收集装置可以在地面（平行于）适于将垃圾从地面传送到顶部边缘的地面（平行于）通过分级柱状构件放置在碎片收集方向上，以及成为可移除地联接到底部边缘的袋保持周边的柔性袋，以可存储地容纳所述垃圾以运送到另一位置。

7. 发明授权

US07955603B2 Norovirus vaccine formulations 有权
标题翻译：诺如病毒疫苗制剂
公开(公告)号：US07955603B2
公开(公告)日：2011-06-07
申请号：US12093921
申请日：2007-09-28
申请人： Charles Richardson , Thomas S. Vedvick , Thomas R. Foubert , William T. Tino
发明人： Charles Richardson , Thomas S. Vedvick , Thomas R. Foubert , William T. Tino
IPC分类号： A61K35/00 , C12Q1/70
CPC分类号： A61K39/12 , A61K39/125 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/543 , A61K2039/55572 , A61K2039/70 , C07K16/10 , C12N7/00 , C12N2770/16023 , C12N2770/16034
摘要： The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.
摘要翻译：本发明涉及包含诺如病毒抗原和佐剂的抗原性和疫苗组合物，特别是单价VLP和多价VLP的混合物的混合物，以及用于生产单价和多价VLP的方法，VLP包含来自一种或多种VLP的衣壳蛋白更多的诺如病毒基因组。

8. 发明授权

US5881490A Fishing rig 失效
标题翻译：钓鱼架
公开(公告)号：US5881490A
公开(公告)日：1999-03-16
申请号：US989244
申请日：1997-12-12
申请人： Charles Richardson
发明人： Charles Richardson
IPC分类号： A01K83/06 , A01K91/04
CPC分类号： A01K83/06 , A01K91/04
摘要： A leader wire made from a more flexible 7.times.19 stainless steel cable rather than the standard 7.times.7 cable leader wire includes a loop at one end and a swivel at the other. A first hook is attached to the loop at the end of the leader. Intermediate the two ends is a second hook which is movable along the length of the leader. A length of thin copper wire is twisted around the leader at a position between the second hook and the swivel and is movable therealong. The copper wire can be held in place, however, by a small sleeve that passes over the same. The wire is utilized to hold the mouth of the bait fish closed and to hold the bait fish in place by wrapping the wire around the same.
摘要翻译：由更灵活的7x19不锈钢电缆制成的导线，而不是标准的7x7电缆引线，其一端包括一个环，另一端有一个回转。第一个钩子连接到领导者末端的循环。中间的两端是第二个钩子，它可以沿着引导件的长度移动。在第二个钩子和旋转件之间的一个位置上，细长的铜线长度围绕引导件扭转，并且可以沿其移动。然而，铜线可以保持在适当的位置，而通过一个穿过它的小套管。电线用于将诱饵鱼的口闭合并通过将线缠绕在一起将饵鱼保持在适当的位置。

9. 发明授权

US10130696B2 Method of conferring a protective immune response to norovirus 有权
公开(公告)号：US10130696B2
公开(公告)日：2018-11-20
申请号：US12678813
申请日：2008-09-18
申请人： Charles Richardson , Thomas S. Vedvick , Thomas R. Foubert , William Tino
发明人： Charles Richardson , Thomas S. Vedvick , Thomas R. Foubert , William Tino
IPC分类号： A61K39/12 , C12N7/00 , A61K39/00
摘要： The present invention relates to vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to methods of conferring protective immunity to Norovirus infections in a human subject.

10. 发明申请

US20070191722A1 SYSTEM AND METHOD FOR HEART MONITORING 审中-公开
标题翻译：用于心脏监测的系统和方法
公开(公告)号：US20070191722A1
公开(公告)日：2007-08-16
申请号：US11738962
申请日：2007-04-23
申请人： Charles Richardson , Michael Smith , Franz Kellar
发明人： Charles Richardson , Michael Smith , Franz Kellar
IPC分类号： A61B5/04
CPC分类号： A61B5/04525 , A61B5/0006 , A61B5/413 , A61N1/3702 , A61N1/37211 , A61N1/37247 , A61N1/37282
摘要： The present invention provides systems and methods for monitoring a heart. According to one embodiment, the system includes an implantable registering unit for registering an electrical signal from the heart. The system includes a local data unit in operable communication with registering unit. The local data unit may be placed in communication with a computer, which may be at a location remote from the local data unit. The computer is adapted to receive the data from the local data unit corresponding to the registered electrical signal and to compare the registered electrical signal to a reference electrical signal to determine whether the heart is functioning properly.
摘要翻译：本发明提供了用于监测心脏的系统和方法。根据一个实施例，该系统包括用于记录来自心脏的电信号的可植入记录单元。该系统包括与注册单元可操作地通信的本地数据单元。本地数据单元可以被放置成与计算机通信，计算机可以位于远离本地数据单元的位置。计算机适于从与注册的电信号对应的本地数据单元接收数据，并将注册的电信号与参考电信号进行比较，以确定心脏是否正常工作。

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