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    • 1. 发明授权
    • Oral immunization with transgenic plants
    • 用转基因植物进行口服免疫
    • US06194560B1
    • 2001-02-27
    • US09191852
    • 1998-11-12
    • Charles J. ArntzenHugh S. MasonTariq A. Haq
    • Charles J. ArntzenHugh S. MasonTariq A. Haq
    • A61K39108
    • C07K14/005A61K39/00C07K14/245C12N15/8258C12N2770/16022Y02A50/472
    • The oral vaccines and oral vaccine adjuvants of the present invention are produced in transgenic plants and then administered through the consumption of the transgenic plant. DNA sequences both natural and synthetic encoding for the expression of immunogenic agents which are capable of causing an immune response in animals when fed in edible plants, plant tissues, or derived plant materials are constructed and plants transformed for stable or transient expression in plant cells. The present invention provides the first known functional method for immunizing animals via transgenic plants, where the plants express bacterial antigens that act as both immunogens and adjuvants when the transgenic plant material expressing the antigens is fed to animals.
    • 本发明的口服疫苗和口服疫苗佐剂在转基因植物中生产,然后通过消耗转基因植物来施用。 构建天然和合成编码免疫原性试剂表达的DNA序列,其在饲喂可食用植物,植物组织或衍生植物材料时能够在动物中引起免疫应答,植物转化以在植物细胞中稳定或短暂表达。 本发明提供了用于通过转基因植物免疫动物的第一已知功能方法,其中当将表达抗原的转基因植物材料供给动物时,植物表达作为免疫原和佐剂的细菌抗原。