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1. 发明授权

US08592193B1 High activity mutants of butyrylcholinesterase for cocaine hydrolysis 有权
标题翻译：用于可卡因水解的丁酰胆碱酯酶的高活性突变体
公开(公告)号：US08592193B1
公开(公告)日：2013-11-26
申请号：US13399406
申请日：2012-02-17
申请人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang , Liu Xue , Shurong Hou
发明人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang , Liu Xue , Shurong Hou
IPC分类号： C12N9/16 , C12N9/18 , A61K38/46 , C07H21/04
CPC分类号： C12N9/18 , A61K38/00 , C12Y301/01008
摘要： Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
摘要翻译：与野生型BChE相比，目前公开的主题的丁酰胆碱酯酶（BChE）多肽变体具有增强（ - ） - 可卡因的催化效率。目前公开的主题的药物组合物包括对（ - ） - 可卡因具有增强的催化效率的BChE多肽变体。用于治疗可卡因诱导的病症的目前公开的主题的方法包括向个体施用有效量的本文所公开的BChE多肽变体以降低可卡因浓度。

2. 发明授权

US08846887B1 High activity mutants of butyrylcholinesterase for cocaine hydrolysis 有权
标题翻译：用于可卡因水解的丁酰胆碱酯酶的高活性突变体
公开(公告)号：US08846887B1
公开(公告)日：2014-09-30
申请号：US13479899
申请日：2012-05-24
申请人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang
发明人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang
IPC分类号： C07H21/04
CPC分类号： A61K38/465 , A61K38/00 , C12N9/18 , C12Y301/01008
摘要： Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
摘要翻译：与野生型BChE相比，目前公开的主题的丁酰胆碱酯酶（BChE）多肽变体具有增强（ - ） - 可卡因的催化效率。目前公开的主题的药物组合物包括对（ - ） - 可卡因具有增强的催化效率的BChE多肽变体。用于治疗可卡因诱导病症的目前公开的主题的方法包括向个体施用有效量的如本文公开的BChE多肽变体以降低可卡因浓度。

3. 发明授权

US08206703B1 High activity mutants of butyrylcholinesterase for cocaine hydrolysis 有权
标题翻译：用于可卡因水解的丁酰胆碱酯酶的高活性突变体
公开(公告)号：US08206703B1
公开(公告)日：2012-06-26
申请号：US13005213
申请日：2011-01-12
申请人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang
发明人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang
IPC分类号： A61K38/46 , C12N9/16
CPC分类号： A61K38/465 , A61K38/00 , C12N9/18 , C12Y301/01008
摘要： Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
摘要翻译：与野生型BChE相比，目前公开的主题的丁酰胆碱酯酶（BChE）多肽变体具有增强（ - ） - 可卡因的催化效率。目前公开的主题的药物组合物包括对（ - ） - 可卡因具有增强的催化效率的BChE多肽变体。用于治疗可卡因诱导病症的目前公开的主题的方法包括向个体施用有效量的如本文公开的BChE多肽变体以降低可卡因浓度。

4. 发明授权

US07892537B1 High activity mutants of butyrylcholinesterase for cocaine hydrolysis 有权
标题翻译：用于可卡因水解的丁酰胆碱酯酶的高活性突变体
公开(公告)号：US07892537B1
公开(公告)日：2011-02-22
申请号：US12767128
申请日：2010-04-26
申请人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang
发明人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang
IPC分类号： A61K38/46 , C12N9/16
CPC分类号： A61K38/465 , A61K38/00 , C12N9/18 , C12Y301/01008
摘要： Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
摘要翻译：与野生型BChE相比，目前公开的主题的丁酰胆碱酯酶（BChE）多肽变体具有增强（ - ） - 可卡因的催化效率。目前公开的主题的药物组合物包括对（ - ） - 可卡因具有增强的催化效率的BChE多肽变体。用于治疗可卡因诱导病症的目前公开的主题的方法包括向个体施用有效量的如本文公开的BChE多肽变体以降低可卡因浓度。

5. 发明授权

US07740840B1 High activity mutants of butyrylcholinesterase for cocaine hydrolysis 有权
标题翻译：用于可卡因水解的丁酰胆碱酯酶的高活性突变体
公开(公告)号：US07740840B1
公开(公告)日：2010-06-22
申请号：US12685341
申请日：2010-01-11
申请人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang
发明人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang
IPC分类号： A61K38/46 , C12N9/16
CPC分类号： A61K38/465 , A61K38/00 , C12N9/18 , C12Y301/01008
摘要： Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
摘要翻译：与野生型BChE相比，目前公开的主题的丁酰胆碱酯酶（BChE）多肽变体具有增强（ - ） - 可卡因的催化效率。目前公开的主题的药物组合物包括对（ - ） - 可卡因具有增强的催化效率的BChE多肽变体。用于治疗可卡因诱导病症的目前公开的主题的方法包括向个体施用有效量的如本文公开的BChE多肽变体以降低可卡因浓度。

6. 发明授权

US08712773B2 Method and system for modeling a common-language speech recognition, by a computer, under the influence of a plurality of dialects 有权
标题翻译：在多个方言的影响下，由计算机对共同语言语音识别进行建模的方法和系统
公开(公告)号：US08712773B2
公开(公告)日：2014-04-29
申请号：US12608191
申请日：2009-10-29
申请人： Fang Zheng , Xi Xiao , Linquan Liu , Zhan You , Wenxiao Cao , Makoto Akabane , Ruxin Chen , Yoshikazu Takahashi
发明人： Fang Zheng , Xi Xiao , Linquan Liu , Zhan You , Wenxiao Cao , Makoto Akabane , Ruxin Chen , Yoshikazu Takahashi
IPC分类号： G10L15/00
CPC分类号： G10L15/187
摘要： The present invention relates to a method for modeling a common-language speech recognition, by a computer, under the influence of multiple dialects and concerns a technical field of speech recognition by a computer. In this method, a triphone standard common-language model is first generated based on training data of standard common language, and first and second monophone dialectal-accented common-language models are based on development data of dialectal-accented common languages of first kind and second kind, respectively. Then a temporary merged model is obtained in a manner that the first dialectal-accented common-language model is merged into the standard common-language model according to a first confusion matrix obtained by recognizing the development data of first dialectal-accented common language using the standard common-language model. Finally, a recognition model is obtained in a manner that the second dialectal-accented common-language model is merged into the temporary merged model according to a second confusion matrix generated by recognizing the development data of second dialectal-accented common language by the temporary merged model. This method effectively enhances the operating efficiency and admittedly raises the recognition rate for the dialectal-accented common language. The recognition rate for the standard common language is also raised.
摘要翻译：本发明涉及一种通过计算机在多种方言的影响下对共同语言语音识别进行建模的方法，并涉及计算机的语音识别技术领域。在这种方法中，首先基于标准通用语言的训练数据生成三通电话标准通用语言模型，第一和第二单音方言重点共同语言模型基于第一种方言重音通用语言的开发数据，第二类。然后按照第一个方言重音的共同语言模型按照第一个混淆矩阵将第一个方言重音的共同语言模型合并到第一个混淆矩阵中的方式获得临时合并模型，该第一混淆矩阵通过使用标准通用语言模型。最后，根据通过临时合并识别第二方言重音的共同语言的开发数据产生的第二混淆矩阵，将第二方言重音的共同语言模型合并到临时合并模型中，获得识别模型模型。这种方法有效提高了运营效率，并且提高了方言重音普通语言的识别率。标准通用语言的识别率也提高了。

7. 发明申请

US20100312552A1 SYSTEMS AND METHODS FOR PREVENTING THE LOSS OF INFORMATION WITHIN A SPEECH FRAME 有权
标题翻译：防止语音信息丢失的系统和方法
公开(公告)号：US20100312552A1
公开(公告)日：2010-12-09
申请号：US12478492
申请日：2009-06-04
申请人： Fang Zheng , Daniel J. Sinder , Anathapadmanabhan A. Kandhadai
发明人： Fang Zheng , Daniel J. Sinder , Anathapadmanabhan A. Kandhadai
IPC分类号： G10L19/00
CPC分类号： H04L1/0009 , G10L19/005 , H04L1/007 , H04L1/0083
摘要： A method for preventing the loss of information within a speech frame is described. A first speech frame to be encoded is selected. A determination is made as to whether or not a second speech frame is a critical speech frame based on the information within the second speech frame and one or more adjacent speech frames. At least a part of an encoded version of the second speech frame is created according to a selected forward error correction (FEC) mode if the second speech frame is a critical speech frame. The first speech frame and the at least a part of the encoded version of the second speech frame are transmitted.
摘要翻译：描述了用于防止语音帧内的信息丢失的方法。选择要编码的第一语音帧。基于第二语音帧内的信息和一个或多个相邻语音帧，确定第二语音帧是否是关键语音帧。如果第二语音帧是关键语音帧，则根据选择的前向纠错（FEC）模式来创建第二语音帧的编码版本的至少一部分。发送第一语音帧和第二语音帧的编码版本的至少一部分。

8. 发明申请

US20100121640A1 METHOD AND SYSTEM FOR MODELING A COMMON-LANGUAGE SPEECH RECOGNITION, BY A COMPUTER, UNDER THE INFLUENCE OF A PLURALITY OF DIALECTS 有权
标题翻译：在大量对话的影响下，由计算机建模常见语音识别的方法和系统
公开(公告)号：US20100121640A1
公开(公告)日：2010-05-13
申请号：US12608191
申请日：2009-10-29
申请人： Fang Zheng , Xi Xiao , Linquan Liu , Zhan You , Wenxiao Cao , Makoto Akabane , Ruxin Chen , Yoshikazu Takahashi
发明人： Fang Zheng , Xi Xiao , Linquan Liu , Zhan You , Wenxiao Cao , Makoto Akabane , Ruxin Chen , Yoshikazu Takahashi
IPC分类号： G10L15/06 , G10L15/00
CPC分类号： G10L15/187
摘要： The present invention relates to a method for modeling a common-language speech recognition, by a computer, under the influence of multiple dialects and concerns a technical field of speech recognition by a computer. In this method, a triphone standard common-language model is first generated based on training data of standard common language, and first and second monophone dialectal-accented common-language models are based on development data of dialectal-accented common languages of first kind and second kind, respectively. Then a temporary merged model is obtained in a manner that the first dialectal-accented common-language model is merged into the standard common-language model according to a first confusion matrix obtained by recognizing the development data of first dialectal-accented common language using the standard common-language model. Finally, a recognition model is obtained in a manner that the second dialectal-accented common-language model is merged into the temporary merged model according to a second confusion matrix generated by recognizing the development data of second dialectal-accented common language by the temporary merged model. This method effectively enhances the operating efficiency and admittedly raises the recognition rate for the dialectal-accented common language. The recognition rate for the standard common language is also raised.
摘要翻译：本发明涉及一种通过计算机在多种方言的影响下对共同语言语音识别进行建模的方法，并涉及计算机的语音识别技术领域。在这种方法中，首先基于标准通用语言的训练数据生成三通电话标准通用语言模型，第一和第二单音方言重点共同语言模型基于第一种方言重音通用语言的开发数据，第二类。然后按照第一个方言重音的共同语言模型按照第一个混淆矩阵将第一个方言重音的共同语言模型合并到第一个混淆矩阵中的方式获得临时合并模型，该第一混淆矩阵通过使用标准通用语言模型。最后，根据通过临时合并识别第二方言重音的共同语言的开发数据产生的第二混淆矩阵，将第二方言重音的共同语言模型合并到临时合并模型中，获得识别模型模型。这种方法有效提高了运营效率，并且提高了方言重音普通语言的识别率。标准通用语言的识别率也提高了。

9. 发明授权

US07654802B2 Reciprocating drive apparatus and method 有权
标题翻译：往复驱动装置及方法
公开(公告)号：US07654802B2
公开(公告)日：2010-02-02
申请号：US11315608
申请日：2005-12-22
申请人： Richard William Crawford, Jr. , Fang Zheng , Charles Edward Beuchat
发明人： Richard William Crawford, Jr. , Fang Zheng , Charles Edward Beuchat
IPC分类号： F04B17/00 , F16H25/08
CPC分类号： F04B23/06 , A61M16/0072 , A61M16/101 , F04B35/04 , Y10T74/18208 , Y10T74/18216 , Y10T74/18224 , Y10T74/18256 , Y10T74/1828 , Y10T74/18296
摘要： A reciprocating drive apparatus has a driving device and a driven device, one of the devices comprising a reciprocating member mounted for movement along a longitudinal axis. At least one rotary member is coupled to one of the devices and a linear bearing assembly has a linear guide rail and a linear slide member with an end coupled to the other device. A connecting link has a first end pivotally connected to the rotary member and a second end pivotally linked to the slide member. Where the reciprocating member is the driven device, rotation of the rotary member will cause the reciprocating member to move back and forth along the longitudinal axis.
摘要翻译：往复式驱动装置具有驱动装置和从动装置，其中一个装置包括安装成沿着纵向轴线运动的往复运动件。至少一个旋转构件联接到所述装置中的一个，并且直线轴承组件具有线性导轨和具有联接到另一装置的端部的线性滑动构件。连接连杆具有枢转地连接到旋转构件的第一端和可枢转地连接到滑动构件的第二端。在往复运动构件是从动装置的情况下，旋转构件的旋转将使往复运动构件沿着纵向轴线前后移动。

10. 发明申请

US20070148016A1 Reciprocating drive apparatus and method 有权
标题翻译：往复驱动装置及方法
公开(公告)号：US20070148016A1
公开(公告)日：2007-06-28
申请号：US11315608
申请日：2005-12-22
申请人： Richard Crawford , Fang Zheng , Charles Beuchat
发明人： Richard Crawford , Fang Zheng , Charles Beuchat
IPC分类号： F04B35/04
CPC分类号： F04B23/06 , A61M16/0072 , A61M16/101 , F04B35/04 , Y10T74/18208 , Y10T74/18216 , Y10T74/18224 , Y10T74/18256 , Y10T74/1828 , Y10T74/18296
摘要： A reciprocating drive apparatus has a driving device and a driven device, one of the devices comprising a reciprocating member mounted for movement along a longitudinal axis. At least one rotary member is coupled to one of the devices and a linear bearing assembly has a linear guide rail and a linear slide member with an end coupled to the other device. A connecting link has a first end pivotally connected to the rotary member and a second end pivotally linked to the slide member. Where the reciprocating member is the driven device, rotation of the rotary member will cause the reciprocating member to move back and forth along the longitudinal axis.
摘要翻译：往复式驱动装置具有驱动装置和从动装置，其中一个装置包括安装成沿着纵向轴线运动的往复运动件。至少一个旋转构件联接到所述装置中的一个，并且直线轴承组件具有线性导轨和具有联接到另一装置的端部的线性滑动构件。连接连杆具有枢转地连接到旋转构件的第一端和可枢转地连接到滑动构件的第二端。在往复运动构件是从动装置的情况下，旋转构件的旋转将使往复运动构件沿着纵向轴线前后移动。

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