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    • 3. 发明申请
    • METHODS AND COMPOSITIONS FOR THE DELIVERY OF BIOACTIVE COMPOUNDS
    • 用于提供生物化合物的方法和组合物
    • US20110117026A1
    • 2011-05-19
    • US12993424
    • 2009-05-01
    • Yu-Chen TsengSang Kyoon KimMichael HackettSumio ChonoLeaf HuangShyh-dar Li
    • Yu-Chen TsengSang Kyoon KimMichael HackettSumio ChonoLeaf HuangShyh-dar Li
    • A61K9/127C12Q1/02C12N5/071A61K31/713A61K49/00A61P35/00
    • C07C279/10A61K9/1271A61K9/1272A61K47/6911C07C279/20C12N15/88
    • The present invention provides compositions comprising delivery systems comprising a lipid vehicle, a bioactive compound, and a polyanionic carrier macromolecule that is not a carrier polynucleotide, wherein the lipid vehicle encapsulates the polynucleotide of interest and the polyanionic carrier macromolecule, and wherein the delivery system is essentially free of carrier polynucleotides. Compositions also include delivery systems comprising a lipid vehicle and a bioactive agent, wherein the lipid vehicle encapsulates the bioactive agent, and wherein the lipid vehicle comprises a covalent bilayer or a core supported bilayer comprising polycationic lipids. Other compositions provided herein comprise a delivery system comprising a polypeptide of interest and a means for delivering the polypeptide into a cell. Also provided herein are methods for making the delivery systems, methods for delivering bioactive compounds, methods for treating a disease or unwanted condition in a subject with the delivery systems, and methods for detecting apoptosis in a cell.
    • 本发明提供包含递送系统的组合物,其包含脂质载体,生物活性化合物和不是载体多核苷酸的聚阴离子载体大分子,其中所述脂质载体包封感兴趣的多核苷酸和聚阴离子载体大分子,并且其中递送系统是 基本上不含载体多核苷酸。 组合物还包括包含脂质载体和生物活性剂的递送系统,其中所述脂质载体包封所述生物活性剂,并且其中所述脂质载体包含共价双层或包含聚阳离子脂质的核心负载双层。 本文提供的其它组合物包含包含感兴趣多肽的递送系统和用于将多肽递送至细胞的手段。 本文还提供了制备递送系统的方法,用于递送生物活性化合物的方法,用于用递送系统治疗受试者的疾病或不需要的病症的方法,以及用于检测细胞凋亡的方法。