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1. 发明授权

US07663081B2 Apparatus for digital imaging photodetector using gas electron multiplier 失效
标题翻译：用于使用气体电子倍增器的数字成像光电检测器的装置
公开(公告)号：US07663081B2
公开(公告)日：2010-02-16
申请号：US12094985
申请日：2006-11-23
申请人： Chang Hie Hahn , Il-Gon Kim , Won-Jeong Kim , Jaehoon Yu
发明人： Chang Hie Hahn , Il-Gon Kim , Won-Jeong Kim , Jaehoon Yu
IPC分类号： G01T1/18
CPC分类号： H01J47/02
摘要： The present invention provides a digital imaging photodetector with a gas electron multiplier. The digital imaging photodetector comprises a gas electron multiplier detector. The gas electron multiplier detector includes a photoelectric converter for converting incident light into photoelectrons or Compton electrons; a gas electron multiplier (GEM) for receiving the photoelectrons or Compton electrons from the photoelectric converter and multiplying them; and a readout unit for receiving an electrical signal indicating a position where an electron cloud multiplied in the gas electron multiplier arrives on an anode, recognizing coordinates of the electron cloud based on the received signal, and outputting the coordinates of the electron cloud. According to the digital imaging photodetector of the present invention, real-time imaging of image information can be achieved by multiplying photoelectrons or Compton electrons, which are discharged due to a photoelectric effect or a Compton effect induced by visible rays, ultraviolet rays or X-rays, using the gas electron multiplier.
摘要翻译：本发明提供一种具有气体电子倍增器的数字成像光电检测器。数字成像光电检测器包括气体电子倍增器检测器。气体电子倍增器检测器包括用于将入射光转换成光电子或康普顿电子的光电转换器; 用于从光电转换器接收光电子或康普顿电子并将它们相乘的气体电子倍增器（GEM）; 以及读出单元，用于接收指示在气体电子倍增器中乘以的电子云到达阳极的位置的电信号，基于接收信号识别电子云的坐标，并输出电子云的坐标。根据本发明的数字成像光电检测器，可以通过将由于光电效应或由可见光，紫外线或X射线引起的康普顿效应而放电的光电子或康普顿电子相乘来实现图像信息的实时成像，使用气体电子倍增器。

2. 发明申请

US20080283725A1 Apparatus for Digital Imaging Photodetector Using Gas Electron Multiplier 失效
标题翻译：使用气体电子倍增器的数字成像光电探测器的设备
公开(公告)号：US20080283725A1
公开(公告)日：2008-11-20
申请号：US12094985
申请日：2006-11-23
申请人： Chang Hie Hahn , Il-Gon Kim , Won-Jeong Kim , Jaehoon Yu
发明人： Chang Hie Hahn , Il-Gon Kim , Won-Jeong Kim , Jaehoon Yu
IPC分类号： H01J40/14
CPC分类号： H01J47/02
摘要： The present invention provides a digital imaging photodetector with a gas electron multiplier. The digital imaging photodetector comprises a gas electron multiplier detector. The gas electron multiplier detector includes a photoelectric converter for converting incident light into photoelectrons or Compton electrons; a gas electron multiplier (GEM) for receiving the photoelectrons or Compton electrons from the photoelectric converter and multiplying them; and a readout unit for receiving an electrical signal indicating a position where an electron cloud multiplied in the gas electron multiplier arrives on an anode, recognizing coordinates of the electron cloud based on the received signal, and outputting the coordinates of the electron cloud. According to the digital imaging photodetector of the present invention, real-time imaging of image information can be achieved by multiplying photoelectrons or Compton electrons, which are discharged due to a photoelectric effect or a Compton effect induced by visible rays, ultraviolet rays or X-rays, using the gas electron multiplier.
摘要翻译：本发明提供一种具有气体电子倍增器的数字成像光电检测器。数字成像光电检测器包括气体电子倍增器检测器。气体电子倍增器检测器包括用于将入射光转换成光电子或康普顿电子的光电转换器; 用于从光电转换器接收光电子或康普顿电子并将它们相乘的气体电子倍增器（GEM）; 以及读出单元，用于接收指示在气体电子倍增器中乘以的电子云到达阳极的位置的电信号，基于接收信号识别电子云的坐标，并输出电子云的坐标。根据本发明的数字成像光电检测器，可以通过将由于光电效应或由可见光，紫外线或X射线引起的康普顿效应而放电的光电子或康普顿电子相乘来实现图像信息的实时成像，使用气体电子倍增器。

3. 发明申请

US20090261265A1 APPARATUS AND METHOD FOR ARRAY GEM DIGITAL IMAGING RADIATION DETECTOR 审中-公开
标题翻译：阵列数位成像辐射探测器的设备和方法
公开(公告)号：US20090261265A1
公开(公告)日：2009-10-22
申请号：US12097755
申请日：2006-02-24
申请人： Chang Hie Hahn , Ii-Gon Kim , Seongtae Park , Jaehoon Yu
发明人： Chang Hie Hahn , Ii-Gon Kim , Seongtae Park , Jaehoon Yu
IPC分类号： H01J47/00 , G01N23/04
CPC分类号： G01N23/227 , G01T1/2935
摘要： An array gas electron multiplier (GEM) digital imaging radiation detector and a control method thereof are disclosed. The array gas electron multiplier (GEM) digital imaging radiation detector includes an array GEM detector. The array GEM detector includes: an ionized electron generation unit for generating ionized electrons in internal filling gas by incident X-rays or gamma rays or by incident charged particles; a gas electron multiplication unit for multiplying the ionized electrons of the ionized electron generation unit in filling gas inside hole of a gas electron multiplier (GEM), through electron avalanche effect, using the GEM, to form electron clouds; a readout for detecting and outputting coordinates of the electron clouds as the readout receives positions through electrical signals, in which the positions of the electron clouds, being multiplied and formed in the gas electron multiplication unit, reach output electrodes. Therefore, the present invention can multiply ionized electrons of internal filling gas as a gas electron multiplier (GEM) generates an electron avalanche effect in the hole thereof, in which the ionized electrons are generated as a photo-electron effect or a Compton effect is induced by high energy incident light, such as X-rays or gamma rays, or which are directly generated by incident charged particles, and can convert image information of the inside or outside of an target object into images of two-dimensions, in real time, such that the detector can be properly used as a security search apparatus in a harbor or an airport, or can be adapted as a core part of industrial nondestructive testing apparatus.
摘要翻译：公开了阵列气体电子倍增器（GEM）数字成像放射线检测器及其控制方法。阵列气体电子倍增器（GEM）数字成像辐射检测器包括阵列GEM检测器。阵列GEM检测器包括：离子化电子产生单元，用于通过入射的X射线或γ射线或入射的带电粒子在内部填充气体中产生离子化的电子; 一种气体电子倍增单元，用于通过使用GEM的电子雪崩效应将气体电子倍增器（GEM）中的填充气体中的离子化电子发生单元的离子化电子乘以电子云; 读出装置，当读出器通过电信号接收位置时，用于检测和输出电子云的坐标，其中在气体电子倍增单元中倍增并形成的电子云的位置到达输出电极。因此，本发明可以将作为气体电子倍增器（GEM）的内部填充气体的离子化电子乘以其空穴中产生电子雪崩效应，其中产生电离电子作为光电子效应或产生康普顿效应通过诸如X射线或γ射线的高能入射光，或由入射的带电粒子直接产生的能量入射光，并且可以实时地将目标物体的内部或外部的图像信息转换为二维的图像，使得检测器可以适当地用作港口或机场中的安全检索装置，或者可以适用于工业无损检测装置的核心部分。

4. 发明申请

US20120270771A1 APOLIPOPROTEIN A-1 MIMIC PEPTIDES, AND THERAPEUTIC AGENT FOR TREATING HYPERLIPIDEMIA AND DISEASES RELATED TO HYPERLIPIDEMIA COMPRISING SAME 审中-公开
标题翻译： APOLIPOPROTEIN A-1 MIMIC PEPTIDES和用于治疗与包含其中的高脂血素相关的高脂血症和疾病的治疗剂
公开(公告)号：US20120270771A1
公开(公告)日：2012-10-25
申请号：US13499357
申请日：2009-09-30
申请人： Jaehoon Yu
发明人： Jaehoon Yu
IPC分类号： C40B40/10 , A61P9/10 , A61P9/00 , C40B30/06 , A61P25/28 , A61P25/00 , A61P3/04 , A61P3/06 , A61K38/10 , A61P3/10
CPC分类号： C07K14/775 , A61K38/00 , G01N33/6893 , G01N33/92 , G01N2800/044
摘要： The present invention relates to apolipoprotein A-1 mimic peptides, and therapeutic agent for treating hyperlipidemia and diseases related to hyperlipidemia comprising the same. More specifically, the apolipoprotein A-1 mimic peptides of the present invention were manufactured by modifying hydrophilic or hydrophobic face of existing 4F amphipathic peptides to produce Apo A-I mimic peptides which specifically bind with cholesterol ester to allow high density lipoprotein content to increase, and the peptide of which phenylalanine in hydrophobic face of 4F is substituted with 2-naphthylalanine has superior cholesterol efflux capability and cognitive function for lipids to the existing 4F peptides, among the mimic peptides. Thus, the Apo A-I mimic peptides of the present invention can be used as Apo A-I mimic peptides and as a therapeutic agent for treating hyperlipidemia and diseases related to hyperlipidemia.
摘要翻译：本发明涉及载脂蛋白A-1模拟肽，以及用于治疗高脂血症的治疗剂和与其相关的高脂血症相关疾病。更具体地说，本发明的载脂蛋白A-1模拟肽是通过改变现有4F两亲肽的亲水或疏水面来制备产生与胆固醇酯特异性结合以允许高密度脂蛋白含量增加的Apo AI模拟肽，其中4F的疏水性面中的苯丙氨酸被2-萘基丙氨酸取代的肽在模拟肽中具有优异的胆固醇流出能力和对现有4F肽的脂质的认知功能。因此，本发明的Apo A-I模拟肽可用作Apo A-I模拟肽，并用作治疗高脂血症和与高脂血症有关的疾病的治疗剂。

5. 发明申请

US20050222055A1 Heterodimeric conjugates of neomycin-oxazolidinone, their preparation and their use 审中-公开
标题翻译：新霉素 - 恶唑烷酮的异二聚体共轭物，其制备及其应用
公开(公告)号：US20050222055A1
公开(公告)日：2005-10-06
申请号：US10502539
申请日：2002-07-04
申请人： Jaehoon Yu , Jongkook Lee , Miyun Kwon , Ae Pae , Hun Koh
发明人： Jaehoon Yu , Jongkook Lee , Miyun Kwon , Ae Pae , Hun Koh
IPC分类号： C07H15/22 , C07H15/232 , C07H15/20 , A61K31/704
CPC分类号： C07H15/232
摘要： The present invention relates to novel oxazolidinone derivatives represented as following compound I and a process for the preparation thereof. The compounds of the present invention have wide antibacterial spectrums superior antibacterial activity and low toxicity. Therefore, it can be expected to use as novel antibacterial agent. wherein, R1 is alkylcarboxyl group or —CH2R2 (wherein, R2 is OH, argido group, —OR3 (wherein, R3 is C1-4 alkyl, methansulfonyl, p-toluensulfonyl, carboxyl, C1-4 alkylcarboxyl, C1-4 alkylcarbonyl, benzyloxycarbonyl, or imidazolylcarbonyl), or —NHR4).
摘要翻译：本发明涉及以下述化合物I表示的新型恶唑烷酮衍生物及其制备方法。本发明的化合物具有广泛的抗菌谱，抗菌活性和毒性低。因此，可以预期用作新型抗菌剂。其中R 1是烷基羧基或-CH 2 R 2 R 2（其中R 2是OH，argido 基团，-OR 3（其中R 3是C 1-4烷基，甲磺酰基，对甲苯磺酰基，羧基，C 1 -C 4烷基， 1-4烷基羧基，C 1-4烷基羰基，苄氧基羰基或咪唑基羰基）或-NHR 4）。

6. 发明授权

US08084399B2 Process for screening of a binding amphiphilic peptides specific for hairpin RNA 有权
标题翻译：用于筛选发夹RNA特异性结合两亲肽的方法
公开(公告)号：US08084399B2
公开(公告)日：2011-12-27
申请号：US12540246
申请日：2009-08-12
申请人： Jaehoon Yu , Jeffrey Kieft , Su Jin Lee
发明人： Jaehoon Yu , Jeffrey Kieft , Su Jin Lee
IPC分类号： C40B30/04 , A61K38/00
CPC分类号： C07K7/08
摘要： The present invention relates to a screening method of an amphiphilic peptide specifically binding to hairpin RNA, more precisely a screening method of an amphiphilic peptide having specificity and strong binding strength to target hairpin RNA using peptide library comprising those peptides having modifications of both hydrophilic face and hydrophobic face. The method of the present invention provides a screening method of an amphiphilic peptide which is specific to hairpin RNA. So, the peptide selected by the method of the present invention can be effectively used for the study of hairpin RNA functions and for the production of a novel drug using an artificial peptide binding to a hairpin RNA target.
摘要翻译：本发明涉及特异性结合发夹RNA的两亲性肽的筛选方法，更确切地说，使用肽文库的具有特异性和对靶发夹RNA的强结合强度的两亲肽的筛选方法，所述肽文库包括具有亲水性面部和疏水面。本发明的方法提供了对发夹RNA特异性的两亲肽的筛选方法。因此，通过本发明的方法选择的肽可以有效地用于研究发夹RNA功能，并且可以使用结合发夹RNA靶的人工肽来生产新药。

7. 发明授权

US07999070B2 Process for screening of a binding peptide specific for specific RNA and RNA binding peptides therefrom 有权
标题翻译：筛选特异性RNA和RNA结合肽的结合肽的方法
公开(公告)号：US07999070B2
公开(公告)日：2011-08-16
申请号：US11457773
申请日：2006-07-14
申请人： Jaehoon Yu
发明人： Jaehoon Yu
IPC分类号： A61K38/00 , C07K7/00 , C40B40/10 , C40B30/04 , C12Q1/68 , G01N33/53
CPC分类号： C07K7/08 , G01N2500/04
摘要： The present invention relates to a screening method for RNA specific binding peptide using alpha-helical peptides. The screening method for RNA specific binding peptide of the present invention using alpha-helical peptides enables the selection of a peptide having strong binding capacity to a specific RNA having particular morphology and nucleotide sequence and the investigation of functions of RNA using the selected peptides, and is very useful for the production of a new drug using synthetic peptide having more powerful and specific binding capacity to RNA than those of natural peptides.
摘要翻译：本发明涉及使用α-螺旋肽的RNA特异性结合肽的筛选方法。使用α-螺旋肽的本发明的RNA特异性结合肽的筛选方法使得能够选择对具有特定形态和核苷酸序列的特异性RNA具有强结合能力的肽，以及使用所选择的肽对RNA功能的研究，以及对于使用具有比天然肽更强大和特异的RNA结合能力的合成肽来生产新药物是非常有用的。

8. 发明授权

US07799830B2 Cinnamic acid dimers, their preparation and the use thereof for treating neurodegenerative disease 失效
标题翻译：肉桂酸二聚体，其制备及其用于治疗神经变性疾病的用途
公开(公告)号：US07799830B2
公开(公告)日：2010-09-21
申请号：US10515560
申请日：2002-06-25
申请人： Dong-Jin Kim , Kye-Jung Shin , Jaehoon Yu , Hee-Sul Lee
发明人： Dong-Jin Kim , Kye-Jung Shin , Jaehoon Yu , Hee-Sul Lee
IPC分类号： A61K31/235 , A61K31/19 , C07C69/00 , C07C229/00 , C07C62/00 , C07C55/28
CPC分类号： C07C229/44 , C07C45/71 , C07C47/575 , C07C59/68 , C07C67/343 , C07C69/734
摘要： The present invention relates to cinnamic acid dimers, their preparation and the use thereof for treating neurodegenerative disease, which have excellent effect on enhancing the learning and memory-retention ability in vivo and have fewer side-effects by showing no hormone properties, even when administered for a long period of time, and thus which can be used for neurodegenerative disease including dementia.
摘要翻译：本发明涉及肉桂酸二聚体及其制备方法及其用于治疗神经变性疾病的用途，其对于增强体内的学习和记忆保持能力具有优异的效果，并且即使在施用时也显示出不具有激素特性的副作用较少长时间，因此可用于包括痴呆的神经变性疾病。

9. 发明申请

US20050203180A1 Cinnamic acid dimers, their preparation and the use thereof for treating neurodegenerative disease 失效
标题翻译：肉桂酸二聚体，其制备及其用于治疗神经变性疾病的用途
公开(公告)号：US20050203180A1
公开(公告)日：2005-09-15
申请号：US10515560
申请日：2002-06-25
申请人： Dong-Jin Kim , Kye-Jung Shin , Jaehoon Yu , Hee-Sul Lee
发明人： Dong-Jin Kim , Kye-Jung Shin , Jaehoon Yu , Hee-Sul Lee
IPC分类号： A61P25/28 , A61K31/194 , A61K31/195 , A61K31/216 , C07C45/70 , C07C45/71 , C07C47/575 , C07C51/38 , C07C59/68 , C07C67/32 , C07C67/343 , C07C69/734 , C07C69/736 , C07C227/02 , C07C229/44 , A61K31/235 , A61K31/192 , A61K31/205
CPC分类号： C07C229/44 , C07C45/71 , C07C47/575 , C07C59/68 , C07C67/343 , C07C69/734
摘要： The present invention relates to cinnamic acid dimers, their preparation and the use thereof for treating neurodegenerative disease, which have excellent effect on enhancing the learning and memory-retention ability in vivo and have fewer side-effects by showing no hormone properties, even when administered for a long period of time, and thus which can be used for neurodegenerative disease including dementia.
摘要翻译：本发明涉及肉桂酸二聚体及其制备方法及其用于治疗神经变性疾病的用途，其对于增强体内的学习和记忆保持能力具有优异的效果，并且即使在施用时也显示出不具有激素特性的副作用较少长时间，因此可用于包括痴呆的神经变性疾病。

10. 发明申请

US20050009765A1 Heterodimeric conjugates of neomycin-chloramphenicol having an enhanced specificity against rna targets and its preparation 失效
标题翻译：具有增强的rna靶标特异性的新霉素 - 氯霉素的异二聚体结合物及其制备
公开(公告)号：US20050009765A1
公开(公告)日：2005-01-13
申请号：US10496275
申请日：2001-12-05
申请人： Jaehoon Yu , Jongkook Lee , Miyun Kwon , Kye-Jung Shin
发明人： Jaehoon Yu , Jongkook Lee , Miyun Kwon , Kye-Jung Shin
IPC分类号： C07H5/10 , C07H15/232 , A61K31/704 , C07H15/20 , C07H15/22
CPC分类号： C07H5/10 , C07H15/232
摘要： The present invention relates to heterodimeric conjugates of neomycin-chloramphenicol of formula 1, their preparation and their use. Because of their heterodimeric structure, they can recognize both stem and loop of RNA motif and show binding ability to a certain RNA such that they have an enhanced pharmaceutical efficacy and reduced side effect which can be caused by non-specific drugs. For these reasons, the can be effectively used as an antiviral agent, an antibacterial agent or an anti cancer drugs.
摘要翻译：本发明涉及式1的新霉素 - 氯霉素的异二聚体缀合物，其制备及其用途。由于它们的异二聚体结构，它们可以识别RNA基序的茎和环，并且显示出对某些RNA的结合能力，使得它们具有增强的药物功效并且可以由非特异性药物引起的副作用降低。由于这些原因，可以有效地用作抗病毒剂，抗菌剂或抗癌药物。

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