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    • 1. 发明授权
    • Apparatus and method for comparing protein structure using 3D RDA and Fourier descriptor
    • 使用3D RDA和傅里叶描述符比较蛋白质结构的装置和方法
    • US08805621B2
    • 2014-08-12
    • US11928672
    • 2007-10-30
    • Chan-Yong ParkSung-Hee ParkDae-Hee KimSoo-Jun ParkSeon-Hee Park
    • Chan-Yong ParkSung-Hee ParkDae-Hee KimSoo-Jun ParkSeon-Hee Park
    • G01N31/00G06F19/16G06F19/10
    • G06F19/16G06F19/10
    • Provided is an apparatus and method for comparing a protein structure, which can search a protein similar to an inquiry protein in a 3D protein database in real time by describing a feature of a protein structure by using a three-dimensional (3D) relative directional angle (RDA) and a Fourier descriptor. The apparatus includes: a 3D RDA coder configured to code a 3D RDA of a target protein data or an inquiry protein data inputted from the outside; a Fourier transformer configured to obtain Fourier coefficients by Fourier transforming 3D RDA coding values coded by the 3D RDA coder; a comparator configured to compare the obtained Fourier coefficient of the target protein data with the obtained Fourier coefficient of the inquiry protein data; and a data generator configured to output protein data in order from high similarity to low similarity according to the comparison result of the comparator.
    • 提供了一种用于比较蛋白质结构的装置和方法,其可以通过使用三维(3D)相对方向角度描述蛋白质结构的特征来实时搜索与3D蛋白质数据库中的查询蛋白质相似的蛋白质 (RDA)和傅立叶描述符。 该装置包括:3D RDA编码器,被配置为对目标蛋白质数据的3D RDA或从外部输入的查询蛋白质数据进行编码; 傅立叶变换器,被配置为通过傅里叶变换来获得傅里叶系数,所述三维RDA编码值由3D RDA编码器编码; 比较器,将获得的目标蛋白质数据的傅立叶系数与所求得的蛋白质数据的傅里叶系数进行比较; 以及数据生成器,其被配置为根据比较器的比较结果从高相似性到低相似性的顺序输出蛋白质数据。
    • 2. 发明申请
    • APPARATUS AND METHOD FOR COMPARING PROTEIN STRUCTURE USING 3D RDA AND FOURIER DESCRIPTOR
    • 使用3D RDA和FOURIER描述符比较蛋白质结构的装置和方法
    • US20080140659A1
    • 2008-06-12
    • US11928672
    • 2007-10-30
    • Chan-Yong ParkSung-Hee ParkDae-Hee KimSoo-Jun ParkSeon-Hee Park
    • Chan-Yong ParkSung-Hee ParkDae-Hee KimSoo-Jun ParkSeon-Hee Park
    • G06F7/04G06F17/14
    • G06F19/16G06F19/10
    • Provided is an apparatus and method for comparing a protein structure, which can search a protein similar to an inquiry protein in a 3D protein database in real time by describing a feature of a protein structure by using a three-dimensional (3D) relative directional angle (RDA) and a Fourier descriptor. The apparatus includes: a 3D RDA coder configured to code a 3D RDA of a target protein data or an inquiry protein data inputted from the outside; a Fourier transformer configured to obtain Fourier coefficients by Fourier transforming 3D RDA coding values coded by the 3D RDA coder; a comparator configured to compare the obtained Fourier coefficient of the target protein data with the obtained Fourier coefficient of the inquiry protein data; and a data generator configured to output protein data in order from high similarity to low similarity according to the comparison result of the comparator.
    • 提供了一种用于比较蛋白质结构的装置和方法,其可以通过使用三维(3D)相对方向角度描述蛋白质结构的特征来实时搜索与3D蛋白质数据库中的查询蛋白质相似的蛋白质 (RDA)和傅立叶描述符。 该装置包括:3D RDA编码器,被配置为对目标蛋白质数据的3D RDA或从外部输入的查询蛋白质数据进行编码; 傅立叶变换器,被配置为通过傅里叶变换来获得傅里叶系数,所述三维RDA编码值由3D RDA编码器编码; 比较器,将获得的目标蛋白质数据的傅立叶系数与所求得的蛋白质数据的傅里叶系数进行比较; 以及数据生成器,其被配置为根据比较器的比较结果从高相似性到低相似性的顺序输出蛋白质数据。
    • 3. 发明申请
    • Apparatus and method for detecting ligand by using automatic specific site extraction
    • 通过自动特异性位点提取检测配体的装置和方法
    • US20080133199A1
    • 2008-06-05
    • US11978830
    • 2007-10-30
    • Sung-Hee ParkChan-Yong ParkDae-Hee KimSoo-Jun ParkSeon-Hee Park
    • Sung-Hee ParkChan-Yong ParkDae-Hee KimSoo-Jun ParkSeon-Hee Park
    • G06G7/48
    • G16B15/00G16B30/00
    • Provided is an apparatus and method for detecting a ligand through automatic specific site extraction and allow a convenient and speedy protein structure-based drug design by detecting sequences and structures of protein binding sites or detecting structures of protein binding sites, and then automatically extracting a specific site to detect a ligand. The ligand detecting apparatus includes: an input data processing unit for processing input data; a binding site extraction unit for extracting a binding site from the data; a user input unit for allowing a user to select a comparison type; a manual like-binding-site comparison unit for manually comparing a binding site of a target protein with a like binding site of a protein of a database to extract a specific site; an automatic like-binding-site comparison unit; and a ligand detection unit for performing virtual screening on the specific site.
    • 提供一种通过自动特异性位点提取检测配体的装置和方法,通过检测蛋白质结合位点的序列和结构或检测蛋白质结合位点的结构,从而方便快捷的基于蛋白质结构的药物设计,然后自动提取特异性 检测配体的位点。 配体检测装置包括:输入数据处理单元,用于处理输入数据; 用于从数据中提取结合位点的结合位点提取单元; 用户输入单元,用于允许用户选择比较类型; 用于手动比较目标蛋白质的结合位点与数据库的蛋白质的类似结合位点以提取特定位点的手动样品结合位点比较单元; 自动比对结合位点比较单元; 以及用于在特定位点进行虚拟筛选的配体检测单元。
    • 4. 发明申请
    • LAYOUT METHOD FOR PROTEIN-PROTEIN INTERACTION NETWORKS BASED ON SEED PROTEIN
    • 基于种子蛋白的蛋白质 - 蛋白质相互作用网络的布局方法
    • US20080133197A1
    • 2008-06-05
    • US11932880
    • 2007-10-31
    • Sun-Lee BangJae-Hun ChoiJong-Min ParkYong-Ho LeeSoo-Jun ParkSeon-Hee Park
    • Sun-Lee BangJae-Hun ChoiJong-Min ParkYong-Ho LeeSoo-Jun ParkSeon-Hee Park
    • G06G7/48
    • G16B45/00G16B5/00
    • Provided is a layout method for protein-protein interaction networks based on a seed protein, which is for performing multiple stages of nesting centered on a node having a high degree of physical relationship, and performing multiple stages of extension and force directed placement (FDP) with respect to a final nest graph. The layout method includes the steps of: a) extracting a node list of each sub-graph constituting a protein-protein interaction network, and aligning the node list according to adjacency of nodes; b) selecting a seed protein from the aligned node list according to node priority and nest relationship with another node; c) nesting adjacent nodes centered on the selected seed protein to generate a nested node; and d) selecting an initial position of the generated nested node, placing the nodes of the nested nodes on respective division points, centered on the seed protein, and then performing layout.
    • 提供了一种基于种子蛋白的蛋白质 - 蛋白质相互作用网络的布局方法,其用于以具有高度物理关系的节点为中心执行多个嵌套阶段,并且执行多个延伸阶段和力定向放置(FDP) 关于最终的巢图。 布局方法包括以下步骤:a)提取构成蛋白质 - 蛋白质相互作用网络的每个子图的节点列表,并根据节点的邻接对齐该节点列表; b)根据节点优先级和与另一节点的嵌套关系从对齐的节点列表中选择种子蛋白; c)嵌套以所选种子蛋白为中心的相邻节点以产生嵌套节点; 以及d)选择生成的嵌套节点的初始位置,将嵌套节点的节点放置在以种子蛋白为中心的相应分割点上,然后执行布局。
    • 9. 发明授权
    • Non-linear quantization and similarity matching methods for retrieving image data
    • 用于检索图像数据的非线性量化和相似度匹配方法
    • US07295718B2
    • 2007-11-13
    • US09978668
    • 2001-10-18
    • Soo-Jun ParkChee Sun WonDong-Kwon ParkHyunjin KimSung Hee ParkMyung Gil Jang
    • Soo-Jun ParkChee Sun WonDong-Kwon ParkHyunjin KimSung Hee ParkMyung Gil Jang
    • G06K9/54G06K9/00
    • G06F17/30259H04N19/98
    • A method for constructing a database having image information representing a plurality of images including the steps of: a) calculating L×5 number of normalized edge histogram bins to generate L number of edge histograms of a target image, wherein each edge histogram has five normalized edge histogram bins and represents a spatial distribution of five reference edges in a sub-image and L is a positive integer, wherein the reference edges include four directional edges and a non-directional edge; b) non-linearly quantizing the L×5 number of normalized edge histogram bins to generate L×5 number of quantization index values for the target image; c) storing the L×5 number of quantization index values to the database; and d) repeating the steps a) to c) until all of the stored images are processed to thereby construct the database having the image information.
    • 一种用于构建具有表示多个图像的图像信息的数据库的方法,包括以下步骤:a)计算Lx5个归一化边缘直方图区块数,以产生目标图像的L个边缘直方图,其中每个边缘直方图具有五个归一化边缘直方图 并且表示子图像中的五个参考边缘的空间分布,并且L是正整数,其中所述参考边缘包括四个方向边缘和非定向边缘; b)非线性量化归一化边缘直方图区间的Lx5数量,以产生目标图像的L×5个量化量化索引值; c)将Lx5数量的量化索引值存储到数据库; 以及d)重复步骤a)至c),直到所有存储的图像被处理,从而构建具有图像信息的数据库。