专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08623348B2 Interferon-α (IFN-α) fused proteins comprising IFN-α and a cytoplasmic transduction peptide (CTP) 有权
标题翻译：包含IFN-α和细胞质转导肽（CTP）的干扰素-α（IFN-α）融合蛋白
公开(公告)号：US08623348B2
公开(公告)日：2014-01-07
申请号：US13260490
申请日：2009-03-27
申请人： Chan Kyu Lee , Seonyoung Yang , Eun Ju Kang , Kang Ryu , Hyun Soo Lee , Yong Soo Bae
发明人： Chan Kyu Lee , Seonyoung Yang , Eun Ju Kang , Kang Ryu , Hyun Soo Lee , Yong Soo Bae
IPC分类号： A61K38/21 , A61K39/00 , A61K39/385 , C07K14/56 , C12P21/04
CPC分类号： C07K14/56 , A61K38/00 , C07K2319/00 , C07K2319/10
摘要： Disclosed is an interferon-α (IFN-α) fused protein having IFN-α fused to a cytoplasmic transduction peptide (CTP). The disclosure relates to a fused protein wherein a CTP, which binds well to cell-membrane barriers and enables translocation into the liver, is genetically fused to a human IFN-α, thereby enhancing the conjugation capacity of cell membranes and antiviral activity, inhibiting CTP transport into the cell nucleus, and enhancing the translocation and settlement of the fused protein into the liver and of transduction to the liver tissue. Accordingly, it is possible to develop protein-based medicines effective for preventing or treating various liver diseases associated with viral infection at low doses.
摘要翻译：公开了具有与细胞质转导肽（CTP）融合的IFN-α的干扰素-α（IFN-α）融合蛋白。本公开涉及融合蛋白，其中与细胞膜屏障良好结合并能够转运到肝脏中的CTP与人IFN-α遗传融合，从而增强细胞膜的共轭能力和抗病毒活性，抑制CTP 运输到细胞核，并增强融合蛋白的转运和沉降进入肝脏和向肝组织转导。因此，可以开发有效预防或治疗与低剂量病毒感染相关的各种肝脏疾病的蛋白质类药物。

2. 发明申请

US20120134961A1 Interferon-alpha (IFN-alpha) Fused Protein Having IFN-alpha and Cytoplasmic Transduction Peptide (CTP) 有权
标题翻译：具有IFN-α和细胞质转导肽（CTP）的干扰素-α（IFN-α）融合蛋白
公开(公告)号：US20120134961A1
公开(公告)日：2012-05-31
申请号：US13260490
申请日：2009-03-27
申请人： Chan Kyu Lee , Seonyoung Yang , Ju Kang , Kang Ryu , Hyun Soo Lee , Yong Soo Bae
发明人： Chan Kyu Lee , Seonyoung Yang , Ju Kang , Kang Ryu , Hyun Soo Lee , Yong Soo Bae
IPC分类号： A61K38/21 , C12N15/21 , C12N15/63 , A61P35/00 , C12N1/19 , C12N5/10 , C12P21/00 , A61P1/16 , C07K14/56 , C12N1/21
CPC分类号： C07K14/56 , A61K38/00 , C07K2319/00 , C07K2319/10
摘要： Disclosed is an interferon-α (IFN-α) fused protein having IFN-α fused to a cytoplasmic transduction peptide (CTP). The disclosure relates to a fused protein wherein a CTP, which binds well to cell-membrane barriers and enables translocation into the liver, is genetically fused to a human IFN-α, thereby enhancing the conjugation capacity of cell membranes and antiviral activity, inhibiting CTP transport into the cell nucleus, and enhancing the translocation and settlement of the fused protein into the liver and of transduction to the liver tissue. Accordingly, it is possible to develop protein-based medicines effective for preventing or treating various liver diseases associated with viral infection at low doses.
摘要翻译：公开了具有与细胞质转导肽（CTP）融合的IFN-α的干扰素-α（IFN-α）融合蛋白。本公开涉及融合蛋白，其中与细胞膜屏障良好结合并能够转运到肝脏中的CTP与人IFN-α遗传融合，从而增强细胞膜的共轭能力和抗病毒活性，抑制CTP 运输到细胞核，并增强融合蛋白的转运和沉降进入肝脏和向肝组织转导。因此，可以开发有效预防或治疗与低剂量病毒感染相关的各种肝脏疾病的蛋白质类药物。

3. 发明授权

US08513028B2 Use of MLN51 gene and protein 有权
标题翻译：使用MLN51基因和蛋白质
公开(公告)号：US08513028B2
公开(公告)日：2013-08-20
申请号：US12299919
申请日：2007-05-08
申请人： Jin Ah Jang , Dae Seog Lim , Hyun Soo Lee , Yong Soo Bae
发明人： Jin Ah Jang , Dae Seog Lim , Hyun Soo Lee , Yong Soo Bae
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/544 , G01N33/567 , G01N33/574 , A61K31/70 , A61K39/395 , C07K16/18 , C12P21/08
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to novel uses of the MLN 51 gene or protein. The MLN 51 gene and protein is closely related to the development of rheumatoid arthritis and serve as biomarker and therapeutic target for rheumatoid arthritis, particularly chronic synovitis.
摘要翻译：本发明涉及MLN 51基因或蛋白质的新用途。 MLN 51基因和蛋白质与类风湿性关节炎的发展密切相关，作为类风湿性关节炎，特别是慢性滑膜炎的生物标志物和治疗靶点。

4. 发明申请

US20100055076A1 Mesenchymal stem cell-mediated autologous dendritic cells with increased immunosuppression 审中-公开
标题翻译：间充质干细胞介导的自体树突细胞增加免疫抑制
公开(公告)号：US20100055076A1
公开(公告)日：2010-03-04
申请号：US12461694
申请日：2009-08-20
申请人： Dae Seog Lim , Ju Ah Jeong , Mi-Sun Kang , Hyun Soo Lee , Yong Soo Bae
发明人： Dae Seog Lim , Ju Ah Jeong , Mi-Sun Kang , Hyun Soo Lee , Yong Soo Bae
IPC分类号： A61K35/12 , C12N5/00 , C12N5/02
CPC分类号： C12N5/064 , A61K2035/122 , C12N2502/1358
摘要： A method for preparing dendritic cells which have an enhanced potential to suppress immune responses, method for suppressing immune response by comprising administering them, dendritic cells carrying a potential to suppress immune responses, and a pharmaceutical composition comprising the dendritic cells capable of inducing immunosuppressive responses. The present dendritic cells having an enhanced potential to suppress immune responses can be utilized for treating or preventing various diseases or disorders through the suppression of immune responses. In addition, the enhanced immunotolerance potential of the dendritic cells ensures the cells to be effectively used as an immunosuppressive agent.
摘要翻译：一种制备具有增强的抑制免疫应答潜力的树突细胞的方法，包括施用它们来抑制免疫应答的方法，具有抑制免疫应答潜力的树突状细胞，以及包含能诱导免疫抑制反应的树突状细胞的药物组合物。具有增强的抑制免疫应答潜力的本发明的树突状细胞可用于通过抑制免疫应答来治疗或预防各种疾病或病症。此外，树突状细胞的增强的免疫耐受潜力确保细胞被有效地用作免疫抑制剂。

5. 发明申请

US20090131361A1 Novel Use of MLN51 Gene and Protein 有权
标题翻译：新的使用MLN51基因和蛋白质
公开(公告)号：US20090131361A1
公开(公告)日：2009-05-21
申请号：US12299919
申请日：2007-05-08
申请人： Jin Ah Jang , Dae Seog Lim , Hyun Soo Lee , Yong Soo Bae
发明人： Jin Ah Jang , Dae Seog Lim , Hyun Soo Lee , Yong Soo Bae
IPC分类号： A61K31/7052 , C12Q1/68 , C12Q1/02 , A61P37/00 , A61P19/02 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to novel uses of the MLN 51 gene or protein. The MLN 51 gene and protein is closely related to the development of rheumatoid arthritis, particularly chronic synovitis.
摘要翻译：本发明涉及MLN 51基因或蛋白质的新用途。 MLN 51基因和蛋白质与类风湿性关节炎的发展密切相关，特别是慢性滑膜炎。

6. 发明授权

US07836269B2 Systems and methods for access violation management of secured memory 有权
标题翻译：安全内存访问违规管理的系统和方法
公开(公告)号：US07836269B2
公开(公告)日：2010-11-16
申请号：US11618075
申请日：2006-12-29
申请人： Willy Obereiner , Venkat Natarajan , Jeremy Isaac Nathaniel Werner , Joe Yuen Tom , Hyun Soo Lee
发明人： Willy Obereiner , Venkat Natarajan , Jeremy Isaac Nathaniel Werner , Joe Yuen Tom , Hyun Soo Lee
IPC分类号： G06F13/16
CPC分类号： G06F12/1483 , G06F21/53
摘要： Systems and methods that facilitate processing data and securing data written to or read from memory. A processor can include a host memory interface that monitors all bus traffic between a host processor and memory. The host memory interface can analyze commands generated by the host processor and determine the validity of the commands. Valid commands can proceed for further analysis; invalid commands can be aborted, for example, with the host memory interface and memory each set to an idle state. The host memory interface can analyze authentication information obtained via an authentication component, and information regarding memory partition rights, to determine whether a command partition violation exists as to the command. If a violation exists, the host memory interface can prevent the improper command from executing in the memory, and can cause a different operation to occur thereby allowing the memory to be placed in a known state.
摘要翻译：便于处理数据并保护写入或读取内存的数据的系统和方法。处理器可以包括主机存储器接口，其监视主处理器和存储器之间的所有总线流量。主机存储器接口可以分析主机处理器产生的命令，并确定命令的有效性。有效的命令可以进行进一步分析; 无效命令可以被中止，例如，主机存储器接口和存储器都设置为空闲状态。主机存储器接口可以分析通过认证组件获得的认证信息和关于存储器分区权限的信息，以确定是否存在关于该命令的命令分区违例。如果存在违规，则主机存储器接口可以防止不正确的命令在存储器中执行，并且可能导致不同的操作发生，从而允许将存储器置于已知状态。

7. 发明申请

US20120127698A1 CONDENSING TYPE OPTICAL SHEET 有权
标题翻译：冷凝型光学片
公开(公告)号：US20120127698A1
公开(公告)日：2012-05-24
申请号：US13386606
申请日：2010-07-28
申请人： Hyun Soo Lee , Chang Pyo Hong , Chung Seock Kang
发明人： Hyun Soo Lee , Chang Pyo Hong , Chung Seock Kang
IPC分类号： G02F1/13357 , G02B27/10 , G02B19/00
CPC分类号： G02B5/045 , G02B5/0215 , G02F2001/133607
摘要： Disclosed is a condensing type optical sheet for use in a liquid crystal display, which prevents the generation of a yellow band or a rainbow phenomenon without using a protective sheet.
摘要翻译：公开了一种用于液晶显示器的聚光型光学片，其在不使用保护片的情况下防止产生黄色带或彩虹现象。

8. 发明授权

US07642255B2 Compounds and compositions as protein kinase inhibitors 失效
标题翻译：化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：US07642255B2
公开(公告)日：2010-01-05
申请号：US12099708
申请日：2008-04-08
申请人： Taebo Sim , Hyun Soo Lee , Pingda Ren , Qiang Ding , Yi Liu , Bing Li , Lintong Li , Xia Wang , Tetsuo Uno , Guobao Zhang , Nathanael Schiander Gray , Shuli You
发明人： Taebo Sim , Hyun Soo Lee , Pingda Ren , Qiang Ding , Yi Liu , Bing Li , Lintong Li , Xia Wang , Tetsuo Uno , Guobao Zhang , Nathanael Schiander Gray , Shuli You
IPC分类号： C07D413/14 , C07D471/04 , C07D487/04 , A61K31/535 , A61K31/497 , A61K31/519 , C07D251/12 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症，Bmx，c-Raf，Csk，Fes，FGFR，Flt3，Ikk，IR，JNK，Lck，Mkk，PKC，PKD，Rsk，SAPK，Syk，Trk，BTK，Src，EGFR，IGF，Mek，Ros和Tie2 激酶。

9. 发明授权

US07620752B1 Circuit for and method of processing data input to a first-in first-out memory 有权
标题翻译：用于处理输入到先进先出存储器的数据的电路和方法
公开(公告)号：US07620752B1
公开(公告)日：2009-11-17
申请号：US11218410
申请日：2005-09-01
申请人： Hyun Soo Lee
发明人： Hyun Soo Lee
IPC分类号： G06F3/00
CPC分类号： G06F13/4059
摘要： A method of processing data input to a first-in first-out memory is disclosed. The method comprises steps of receiving input data words from a pipeline stage at an input of the first-in first-out memory; receiving data valid bits associated with the pipeline stage; generating a count associated with the data valid bits; and coupling the count to the first-in first-out memory. The step of generating a count associated with the data valid bits may comprise encoding the data valid bits to generate a valid data word representing the number of pipeline stages having valid data. The method of further comprises a step of generating an almost full signal based upon the count, and in particular generating an almost full signal when a read pointer incremented by the count of valid bits in the pipeline stages equals a write pointer. A circuit for processing data is also disclosed.
摘要翻译：公开了一种处理输入到先进先出存储器的数据的方法。该方法包括以下步骤：在先入先出存储器的输入处从流水线级接收输入数据字; 接收与流水线级相关联的数据有效位; 生成与数据有效位相关联的计数; 并将计数耦合到先进先出存储器。产生与数据有效位相关联的计数的步骤可以包括对数据有效位进行编码，以生成表示具有有效数据的流水线级数的有效数据字。所述方法还包括基于所述计数产生几乎全信号的步骤，并且特别是当通过所述流水线级中的有效位的计数增加的读指针等于写指针时，产生几乎全信号。还公开了一种用于处理数据的电路。

10. 发明申请

US20080162784A1 SYSTEMS AND METHODS FOR ACCESS VIOLATION MANAGEMENT OF SECURED MEMORY 有权
标题翻译：安全存储器访问管理的系统和方法
公开(公告)号：US20080162784A1
公开(公告)日：2008-07-03
申请号：US11618075
申请日：2006-12-29
申请人： Willy Obereiner , Venkat Natarajan , Jeremy Isaac Nathaniel Werner , Joe Yuen Tom , Hyun Soo Lee
发明人： Willy Obereiner , Venkat Natarajan , Jeremy Isaac Nathaniel Werner , Joe Yuen Tom , Hyun Soo Lee
IPC分类号： G06F12/14 , G06F12/02
CPC分类号： G06F12/1483 , G06F21/53
摘要： Systems and methods that facilitate processing data and securing data written to or read from memory. A processor can include a host memory interface that monitors all bus traffic between a host processor and memory. The host memory interface can analyze commands generated by the host processor and determine the validity of the commands. Valid commands can proceed for further analysis; invalid commands can be aborted, for example, with the host memory interface and memory each set to an idle state. The host memory interface can analyze authentication information obtained via an authentication component, and information regarding memory partition rights, to determine whether a command partition violation exists as to the command. If a violation exists, the host memory interface can prevent the improper command from executing in the memory, and can cause a different operation to occur thereby allowing the memory to be placed in a known state.
摘要翻译：便于处理数据并保护写入或读取内存的数据的系统和方法。处理器可以包括主机存储器接口，其监视主处理器和存储器之间的所有总线流量。主机存储器接口可以分析主机处理器产生的命令，并确定命令的有效性。有效的命令可以进行进一步分析; 无效命令可以被中止，例如，主机存储器接口和存储器都设置为空闲状态。主机存储器接口可以分析通过认证组件获得的认证信息和关于存储器分区权限的信息，以确定是否存在关于该命令的命令分区违例。如果存在违规，则主机存储器接口可以防止不正确的命令在存储器中执行，并且可能导致不同的操作发生，从而允许将存储器置于已知状态。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式