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1. 发明授权

US08636001B2 Dry powder inhaler and system for drug delivery 有权
公开(公告)号：US08636001B2
公开(公告)日：2014-01-28
申请号：US12484129
申请日：2009-06-12
申请人： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfileld , Anthony Bryant , Tom He , Alfred Mann
发明人： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfileld , Anthony Bryant , Tom He , Alfred Mann
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61K9/0075 , A61K38/00 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/22 , A61M15/0021 , A61M15/0023 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0086 , A61M15/0091 , A61M2202/064 , A61M2205/6081 , A61M2206/20
摘要： A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

2. 发明申请

US20090308390A1 Dry Powder Inhaler and System for Drug Delivery 有权
公开(公告)号：US20090308390A1
公开(公告)日：2009-12-17
申请号：US12484125
申请日：2009-06-12
申请人： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfield , Anthony Bryant , Tom He , Alfred Mann
发明人： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfield , Anthony Bryant , Tom He , Alfred Mann
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61K9/0075 , A61K38/00 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/22 , A61M15/0021 , A61M15/0023 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0086 , A61M15/0091 , A61M2202/064 , A61M2205/6081 , A61M2206/20
摘要： A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

3. 发明申请

US20090308391A1 Dry Powder Inhaler and System for Drug Delivery 有权
标题翻译：干粉吸入器和药物输送系统
公开(公告)号：US20090308391A1
公开(公告)日：2009-12-17
申请号：US12484129
申请日：2009-06-12
申请人： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfield , Anthony Bryant , Tom He , Alfred Mann
发明人： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfield , Anthony Bryant , Tom He , Alfred Mann
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61K9/0075 , A61K38/00 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/22 , A61M15/0021 , A61M15/0023 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0086 , A61M15/0091 , A61M2202/064 , A61M2205/6081 , A61M2206/20
摘要： A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
摘要翻译：提供了一种呼吸动力的干粉吸入器，药筒和肺部药物递送系统。干粉吸入器可以配备有或不带有与吸入器一起使用的单位剂量盒。吸入器和/或药筒可以具有药物递送制剂，其包含例如二酮哌嗪和活性成分，包括肽和蛋白质，例如用于治疗糖尿病和/或肥胖症的胰岛素和胰高血糖素样肽1。干粉吸入器紧凑; 可以以各种形状和尺寸，颜色提供，并且包括壳体，接口管，盒放置区域和用于打开和关闭药剂盒的机构。该设备易于制造，提供预单位单位剂量，相对易于使用，并且可重复使用或一次性使用。

4. 发明申请

US20070112404A1 Implantable stimulator 有权
标题翻译：植入式刺激器
公开(公告)号：US20070112404A1
公开(公告)日：2007-05-17
申请号：US11280620
申请日：2005-11-16
申请人： Alfred Mann , Tom He
发明人： Alfred Mann , Tom He
IPC分类号： A61N1/32
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/37205 , A61N1/3756
摘要： An implantable stimulator includes a tube assembly that is configured to house a number of components that are configured to apply at least one stimulus to at least one stimulation site within a patient. The tube assembly has a shape that allows the stimulator to be implanted within said patient in a pre-determined orientation. Exemplary methods of stimulating a stimulation site within a patient include applying an electrical stimulation current to a stimulation site via one or more electrodes extending along one or more sides of a stimulator. The stimulator has a shape allowing the stimulator to be implanted within the patient in a pre-determined orientation.
摘要翻译：可植入刺激器包括管组件，其被配置为容纳多个部件，所述部件被配置为将至少一个刺激应用于患者内的至少一个刺激部位。管组件具有允许刺激器以预定方向植入所述患者体内的形状。刺激患者内的刺激部位的示例性方法包括通过沿刺激器的一侧或多侧延伸的一个或多个电极将电刺激电流施加到刺激部位。刺激器具有允许刺激器以预定方向植入患者体内的形状。

5. 发明申请

US20070066997A1 Methods and systems for placing an implanted stimulator for stimulating tissue 失效
标题翻译：放置刺激器刺激组织的方法和系统
公开(公告)号：US20070066997A1
公开(公告)日：2007-03-22
申请号：US11232540
申请日：2005-09-21
申请人： Tom He , Todd Whitehurst , Alfred Mann , Peter Johnson
发明人： Tom He , Todd Whitehurst , Alfred Mann , Peter Johnson
IPC分类号： A61N1/36
CPC分类号： A61N1/372 , A61N1/37205
摘要： Systems for providing stimulation with an implantable system control unit and for optimally positioning that system control unit include a system control unit configured to provide a stimulus to a patient with a member attached to the system control unit for pulling the system control unit into position within the patient. Methods of optimally positioning the implantable system control unit within a patient such that the system control unit is proximal to target tissue that is to be stimulated by the system control unit include threading a member through a patient's body using a needle, the member passing proximal to the target tissue and being attached to the system control unit, and pulling the system control unit into place with the member.
摘要翻译：用于用可植入系统控制单元提供刺激并且用于最佳地定位该系统控制单元的系统包括系统控制单元，该系统控制单元被配置为向患者提供具有连接到系统控制单元的构件的刺激，用于将系统控制单元牵引到患者。将可植入系统控制单元最佳地定位在患者体内的方法，使得系统控制单元靠近要由系统控制单元刺激的目标组织，包括使用针穿过患者身体的部件，目标组织并附接到系统控制单元，并且将系统控制单元拉到构件的适当位置。

6. 发明申请

US20070021800A1 CAVERNOUS NERVE STIMULATION VIA UNIDIRECTIONAL PROPAGATION OF ACTION POTENTIALS 有权
标题翻译：通过行动潜力的联合传播促进神经刺激
公开(公告)号：US20070021800A1
公开(公告)日：2007-01-25
申请号：US11536565
申请日：2006-09-28
申请人： Todd Whitehurst , James McGivern , Rafael Carbunaru , Matthew Haller , Tom He , Kerry Bradley
发明人： Todd Whitehurst , James McGivern , Rafael Carbunaru , Matthew Haller , Tom He , Kerry Bradley
IPC分类号： A61N1/00
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/37205
摘要： Methods of using unidirectionally propagating action potentials (UPAPs) for cavernous nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., microstimulators), possibly with programmably configurable electrodes.
摘要翻译：提供了使用单向传播动作电位（UPAP）用于海绵神经刺激和某些疾病的方法。能够产生这种UPAP的刺激器包括但不限于微型可植入刺激器（即，微型刺激器），可能具有可编程配置的电极。

7. 发明申请

US20050267555A1 Engagement tool for implantable medical devices 审中-公开
标题翻译：可植入医疗器械的接合工具
公开(公告)号：US20050267555A1
公开(公告)日：2005-12-01
申请号：US11136938
申请日：2005-05-24
申请人： Goran Marnfeldt , Rafael Carbunaru , Kelly McClure , Matthew Haller , Tom He , Todd Whitehurst , Meredith Anderson , James Makous , Kristen Jaax , Peter Johnson
发明人： Goran Marnfeldt , Rafael Carbunaru , Kelly McClure , Matthew Haller , Tom He , Todd Whitehurst , Meredith Anderson , James Makous , Kristen Jaax , Peter Johnson
IPC分类号： A61B17/22 , A61B17/32 , A61B17/34 , A61B19/00 , A61N1/00 , A61N1/05 , A61N1/08
CPC分类号： A61B17/3417 , A61B17/221 , A61B17/32056 , A61B17/3468 , A61B90/30 , A61B2017/00358 , A61B2017/22035 , A61B2017/2215 , A61B2017/320044 , A61N1/05 , A61N1/08
摘要： Systems for adjusting a position of an implanted medical device within a patient include an engagement tool configured to couple to the implanted medical device. The engagement tool adjusts the position of the medical device when coupled to the implanted medical device. Methods of adjusting a position of an implanted medical device within a patient include locating the implanted medical device, coupling an engagement tool to the medical device, and adjusting a position of the engagement tool to adjust the position of the medical device.
摘要翻译：用于调整患者内植入的医疗装置的位置的系统包括被配置为耦合到植入的医疗装置的接合工具。接合工具当耦合到植入的医疗装置时调节医疗装置的位置。调整患者内的植入医疗装置的位置的方法包括定位植入的医疗装置，将接合工具联接到医疗装置，以及调整接合工具的位置以调整医疗装置的位置。

8. 发明申请

US20070219595A1 Stimulator system with electrode array and the method of making the same 有权
标题翻译：具有电极阵列的刺激器系统及其制造方法
公开(公告)号：US20070219595A1
公开(公告)日：2007-09-20
申请号：US11375638
申请日：2006-03-14
申请人： Tom He
发明人： Tom He
IPC分类号： A61N1/00
CPC分类号： A61N1/375 , A61N1/37205 , A61N1/3756
摘要： An implantable microstimulator can include a housing with a surface containing a metal region. The housing defines an exterior and an interior. At least one conductive electrode is disposed on the exterior of the housing over the metal region of the housing. Adhesive is disposed between the metal region of the housing and the conductive electrodes. An electronic subassembly is disposed in the interior of the housing and coupled to the conductive electrodes through the housing.
摘要翻译：可植入微型刺激器可以包括具有包含金属区域的表面的壳体。壳体限定外部和内部。至少一个导电电极设置在壳体的外部的壳体的金属区域上。粘合剂设置在壳体的金属区域和导电电极之间。电子组件设置在外壳的内部，并通过外壳与导电电极连接。

9. 发明申请

US20060167521A1 Casings for implantable stimulators and methods of making the same 有权
标题翻译：用于植入式刺激器的壳体及其制造方法
公开(公告)号：US20060167521A1
公开(公告)日：2006-07-27
申请号：US11043399
申请日：2005-01-26
申请人： Tom He , Matthew Haller
发明人： Tom He , Matthew Haller
IPC分类号： A61N1/375
CPC分类号： A61N1/375 , A61N1/3756 , A61N1/3758
摘要： An implantable stimulator includes a device for delivering a stimulus and a casing having a first, metal portion and a second, portion which is formed from a plastic or polymer. A method of forming an implantable stimulator includes preparing a coil on a ferrite tube and molding a casing body on the coil, such that the coil is embedded in a wall of the casing which is formed of a plastic or polymer. Another method of forming an implantable stimulator includes forming an annular metal connector and molding a plastic or polymer casing body on the metal connector.
摘要翻译：可植入刺激器包括用于输送刺激的装置和具有由塑料或聚合物形成的第一金属部分和第二部分的壳体。形成可植入刺激器的方法包括在铁氧体管上制备线圈并在线圈上成型壳体，使得线圈嵌入由塑料或聚合物形成的壳体的壁中。形成可植入刺激器的另一种方法包括形成环形金属连接器并在金属连接器上模制塑料或聚合物壳体。

10. 发明申请

US20050057905A1 Electronic module design to maximize the volume efficiency in a miniature medical device 有权
标题翻译：电子模块设计，以最大限度地提高微型医疗设备的体积效率
公开(公告)号：US20050057905A1
公开(公告)日：2005-03-17
申请号：US10609452
申请日：2003-06-27
申请人： Tom He , Matthew Haller , Jordi Parramon , Goran Marnfeldt
发明人： Tom He , Matthew Haller , Jordi Parramon , Goran Marnfeldt
IPC分类号： A61N1/36 , A61N1/372 , A61N1/375 , A61N1/378 , H01Q1/24 , H01Q7/08 , H02J7/00 , H02J17/00 , H05K7/06
CPC分类号： A61N1/37276 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/3727 , A61N1/375 , A61N1/3787 , H01L2224/45144 , H01L2224/45147 , H01L2224/48465 , H01L2224/49175 , H01L2924/00011 , H01L2924/1461 , H01L2924/19105 , H01L2924/19107 , H01L2924/3011 , H01L2924/30111 , H02J7/025 , H02J7/345 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10 , Y10T29/4902 , Y10T29/49071 , Y10T29/49073 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49169 , Y10T29/49826 , Y10T29/49945 , Y10T29/49968 , Y10T428/12264 , Y10T428/12271 , Y10T428/12347 , Y10T428/12375 , Y10T428/12396 , Y10T428/12535 , Y10T428/12806 , H01L2924/00 , H01L2924/01005 , H01L2924/01033
摘要： Compact electronic modules, which may be used with implantable microstimulators and other medical and non-medical devices, and manufacture/assembly of such modules are described. Component and circuitry designs utilize unique redistribution techniques and attachment methods. A number of component designs and packaging configurations maximize the volume efficiency of electronic modules. Also included are improved processes and systems enabling the manufacture and assembly of such compact packages.
摘要翻译：描述了可与可植入微型刺激器和其他医疗和非医疗装置一起使用的紧凑型电子模块以及这种模块的制造/组装。组件和电路设计采用独特的再分配技术和附件方法。许多组件设计和封装配置使电子模块的体积效率最大化。还包括改进的工艺和系统，能够制造和组装这些紧凑型封装。

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