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1. 发明申请

US20090152756A1 Phase Transition Pharmaceutical Mold For Producing Pellets For Injection Device 审中-公开
标题翻译：相转移用于生产注射装置的颗粒的药物模具
公开(公告)号：US20090152756A1
公开(公告)日：2009-06-18
申请号：US11954890
申请日：2007-12-12
申请人： Cesario Dos Santos , Michael Morelli
发明人： Cesario Dos Santos , Michael Morelli
IPC分类号： B29C39/02 , B29C33/02 , B29C33/20
CPC分类号： A61F9/0017
摘要： A mold assembly includes a mold base plate and a mold. The mold base plate has a bottom plate located in a recess. The mold can be inserted into and removed from the recess and is located on top of the bottom plate. The mold has a first section that is separable from a second section. When the first section and the second section are located adjacent to each other in the recess, a plurality of cavities is formed, each cavity for receiving a quantity of a drug and compound mixture when the mold base plate and mold are at a temperature other than room temperature
摘要翻译：模具组件包括模具底板和模具。模具基板具有位于凹部中的底板。模具可以插入凹槽中并从凹槽移除并位于底板的顶部。模具具有可与第二部分分离的第一部分。当第一部分和第二部分在凹部中彼此相邻地设置时，形成多个空腔，每个腔体用于在模具底板和模具处于不同于温度的温度下接收一定量的药物和复合混合物室内温度

2. 发明授权

US07815603B2 Ophthalmic injection method 有权
标题翻译：眼睛注射法
公开(公告)号：US07815603B2
公开(公告)日：2010-10-19
申请号：US11832333
申请日：2007-08-01
申请人： Bruno Dacquay , Cesario Dos Santos , James Foster , Robert Sanchez
发明人： Bruno Dacquay , Cesario Dos Santos , James Foster , Robert Sanchez
IPC分类号： A61M37/00
CPC分类号： A61F9/0017 , A61M1/1058 , A61M5/14244 , A61M5/1452 , A61M5/14546 , A61M5/14566 , A61M5/31511 , A61M5/445 , A61M5/484 , A61M2005/14268 , A61M2205/3331 , A61M2205/3569 , A61M2205/6018 , A61M2205/8206 , A61M2205/8243 , A61M2205/8262 , A61M2209/086 , A61M2210/0612
摘要： A method of delivering a substance into an eye includes recognizing a connection between a tip segment and a limited reuse assembly; receiving dosage information from the tip segment; activating a temperature control device to alter a temperature of a substance to be delivered into an eye; receiving temperature information from a thermal sensor; using the temperature information to control the temperature control device; receiving an input indicating that the substance is to be delivered; and based on the dosage information, controlling an actuator to move a plunger to deliver the substance.
摘要翻译：将物质输送到眼睛中的方法包括识别尖端段和有限重复使用组件之间的连接; 从尖端段接收剂量信息; 激活温度控制装置以改变要输送到眼睛中的物质的温度; 从热传感器接收温度信息; 使用温度信息控制温度控制装置; 接收指示物质被输送的输入; 并且基于剂量信息，控制致动器以移动柱塞以输送物质。

3. 发明授权

US07811252B2 Dosage control device 有权
标题翻译：用量控制装置
公开(公告)号：US07811252B2
公开(公告)日：2010-10-12
申请号：US11688573
申请日：2007-03-20
申请人： Bruno Dacquay , Cesario Dos Santos , Casey Lind
发明人： Bruno Dacquay , Cesario Dos Santos , Casey Lind
IPC分类号： A61M5/00
CPC分类号： A61M5/14224 , A61F9/0017 , A61M5/20 , A61M5/31525 , A61M5/31546 , A61M2205/0244 , A61M2205/3368 , A61M2205/3653 , A61M2205/6018 , A61M2210/0612 , Y10S128/01
摘要： An injection device includes a dispensing chamber, a plunger, a controller, a memory device resistant to sterilization, and a housing at least partially enclosing the dispensing chamber and the plunger. The dispensing chamber has an inner surface and an outer surface. The inner surface defines a cavity for receiving a quantity of a substance. The plunger is engaged with the inner surface of the dispensing chamber, is capable of sliding in the cavity of the dispensing chamber, and is fluidly sealed to the inner surface of the dispensing chamber. The controller controls the operation of the injection device. The controller reads dosage data from the memory device and operates the injection device to deliver a dosage corresponding to the dosage data.
摘要翻译：注射装置包括分配室，柱塞，控制器，耐灭菌的存储装置，以及至少部分地包围分配腔和柱塞的壳体。分配室具有内表面和外表面。内表面限定用于接收一定量的物质的空腔。柱塞与分配室的内表面接合，能够在分配室的空腔中滑动，并且流体地密封到分配室的内表面。控制器控制注射装置的操作。控制器从存储装置读取剂量数据，并操作注射装置以递送对应于剂量数据的剂量。

4. 发明申请

US20090152750A1 Vacuum Drug Pellet Molding 审中-公开
标题翻译：真空药丸成型
公开(公告)号：US20090152750A1
公开(公告)日：2009-06-18
申请号：US11955035
申请日：2007-12-12
申请人： Cesario Dos Santos
发明人： Cesario Dos Santos
IPC分类号： B29C44/42 , B29C44/22
CPC分类号： B65B1/26 , A61F9/0017
摘要： A mold apparatus includes a container, a temperature control device, a distribution manifold, a plurality of dispensers, a mold, a bottom plate for the mold, and a vacuum chamber. The temperature control device at least partially surrounds the container. The distribution manifold is located downstream from the container. The plurality of dispensers are coupled to the distribution manifold. The mold has a plurality of cavities for receiving a mixture from the plurality of dispensers. The bottom plate is located on a bottom surface of the mold. The vacuum chamber keeps the container, distribution manifold, plurality of dispensers and mold in a vacuum. A drug and compound mixture are brought to a temperature other than room temperature and dispensed into the mold under a vacuum to form pellets.
摘要翻译：模具装置包括容器，温度控制装置，分配歧管，多个分配器，模具，用于模具的底板以及真空室。温度控制装置至少部分地围绕容器。分配歧管位于容器的下游。多个分配器联接到分配歧管。模具具有多个用于从多个分配器接收混合物的空腔。底板位于模具的底表面上。真空室将容器，分配歧管，多个分配器和模具保持在真空中。使药物和复合混合物达到室温以外的温度，并在真空下分配到模具中以形成颗粒。

5. 发明申请

US20090036846A1 Ophthalmic Injection System 有权
标题翻译：眼科注射系统
公开(公告)号：US20090036846A1
公开(公告)日：2009-02-05
申请号：US11832301
申请日：2007-08-01
申请人： Bruno Dacquay , Cesario Dos Santos , James Foster , Casey Lind , Raffi Pinedjian , Robert Sanchez
发明人： Bruno Dacquay , Cesario Dos Santos , James Foster , Casey Lind , Raffi Pinedjian , Robert Sanchez
IPC分类号： A61M35/00 , A61B5/00
CPC分类号： A61F9/0017 , A61M5/20 , A61M5/31525 , A61M2205/0244 , A61M2205/3306 , A61M2205/3317 , A61M2205/3368 , A61M2210/0612
摘要： An ophthalmic injection system has a tip segment attachable to and removable from a limited reuse assembly. The tip segment has a dispensing chamber housing, a plunger, a needle, a temperature control device, a thermal sensor, and a first housing at least partially enclosing the dispensing chamber housing, the temperature control device and the plunger. The limited reuse assembly has an actuator with a shaft, a power source for providing power to the actuator, a controller for controlling the actuator, a mechanical linkage interface, and a second housing at least partially enclosing the power source, the controller, and the actuator. The mechanical linkage interface is coupled to the actuator shaft and has a mating surface on one end. The substance is injected after the temperature of the substance is altered.
摘要翻译：眼科注射系统具有可附接到有限再利用组件并且可从有限再利用组件移除的尖端段。尖端段具有分配室壳体，柱塞，针，温度控制装置，热传感器和至少部分地包围分配腔室壳体，温度控制装置和柱塞的第一壳体。有限再利用组件具有致动器，其具有轴，用于向致动器提供动力的动力源，用于控制致动器的控制器，机械联动接口以及至少部分地包围动力源的控制器和控制器执行器。机械联动接口联接到致动器轴并且在一端具有配合表面。物质在物质温度变化后注射。

6. 发明申请

US20080125712A1 Ophthalmic injection system 审中-公开
标题翻译：眼科注射系统
公开(公告)号：US20080125712A1
公开(公告)日：2008-05-29
申请号：US11527245
申请日：2006-09-26
申请人： Bruno Dacquay , James Foster , Mark Hopkins , Lamar Kirchhevel , Cesario Dos Santos , Salomon Valencia
发明人： Bruno Dacquay , James Foster , Mark Hopkins , Lamar Kirchhevel , Cesario Dos Santos , Salomon Valencia
IPC分类号： A61M5/155
CPC分类号： A61M5/14526 , A61F9/0017 , A61M5/14566 , A61M5/172 , A61M5/44 , A61M2005/5026 , A61M2209/01 , A61M2210/0612
摘要： An ophthalmic injection system is disclosed. The system has a dispensing member, a plunger, an actuation chamber, a lock mechanism, a lock stop, a port, a source of pressurized gas, and a shaft. The lock mechanism travels in the actuation chamber in an axial direction toward and away from a distal end of the dispensing member. The lock stop is located on the inner surface of the actuation chamber. The lock stop is engageable with the lock mechanism such that when the lock mechanism travels in the axial direction toward the distal end of the dispensing member to a first position located on a distal side of the lock stop, the lock mechanism cannot travel in a reverse direction away from the distal end of the dispensing member to a location on a proximal side of the lock stop.
摘要翻译：公开了一种眼科注射系统。该系统具有分配构件，柱塞，致动室，锁定机构，锁定止动件，端口，加压气体源和轴。锁定机构在致动室中沿轴向方向行进并远离分配构件的远端。锁定止动件位于致动室的内表面上。锁定止动件可与锁定机构接合，使得当锁定机构沿着轴向方向朝向分配构件的远端行进到位于锁定止挡件的远侧上的第一位置时，锁定机构不能相反地行进远离分配构件的远端的方向到锁止止动件的近侧上的位置。

7. 发明授权

US09782541B2 Temperature control device and thermal sensor assembly for medical device 有权
公开(公告)号：US09782541B2
公开(公告)日：2017-10-10
申请号：US12444000
申请日：2007-10-01
申请人： Cesario Dos Santos , Robert J. Sanchez, Jr.
发明人： Cesario Dos Santos , Robert J. Sanchez, Jr.
IPC分类号： A61M5/145 , A61M5/142 , A61M5/20 , A61F9/00 , A61M5/31 , A61M5/44 , A61M5/315 , A61M5/14
CPC分类号： A61M5/20 , A61F9/0017 , A61M5/1413 , A61M5/14244 , A61M5/14526 , A61M5/14546 , A61M5/14566 , A61M5/3129 , A61M5/31511 , A61M5/445 , A61M2005/14268 , A61M2205/3368 , A61M2205/3653 , A61M2205/50 , A61M2205/6027 , A61M2205/8206 , A61M2210/0612
摘要： A dispensing assembly has a dispensing chamber housing, a temperature control device, a thermal sensor, and an interface. The dispensing chamber housing has an inner surface, an outer surface, and a wall thickness. The inner surface partially defines a dispensing chamber for receiving a quantity of a substance. The temperature control device at least partially surrounds the dispensing chamber housing. The temperature control device alters a temperature of a substance in the dispensing chamber. The temperature control device and the thermal sensor are located on a substrate. The substrate is wrapped around an exterior surface of the dispensing chamber housing. The interface is connected to the temperature control device and the thermal sensor. An interface connector is connected to the interface. The distance between the temperature control device and the thermal sensor is approximately equal to the wall thickness of the dispensing chamber housing.

8. 发明申请

US20100211044A1 BATTERY OPERATED SURGICAL HAND PIECE WITH DISPOSABLE END 有权
标题翻译：电池操作手术手柄与可切换的末端
公开(公告)号：US20100211044A1
公开(公告)日：2010-08-19
申请号：US12443898
申请日：2007-10-09
申请人： Bruno Dacquay , Casey Lind , Cesario Dos Santos , Paul R. Hallen
发明人： Bruno Dacquay , Casey Lind , Cesario Dos Santos , Paul R. Hallen
IPC分类号： A61M5/142 , A61M5/172
CPC分类号： A61M5/14224 , A61F9/0017 , A61M5/20 , A61M5/31525 , A61M5/31546 , A61M2205/0244 , A61M2205/3368 , A61M2205/3653 , A61M2205/6018 , A61M2210/0612 , Y10S128/01
摘要： The present invention is an ophthalmic injection system with a limited reuse assembly and a tip segment. The tip segment is connectable to and removable from the limited reuse assembly. The tip segment includes a dispensing chamber, a plunger, and a housing. The dispensing chamber holds a quantity of a substance to be injected into an eye. The proximate end of the plunger has a first mechanical linkage interface. The limited reuse assembly of the ophthalmic injection system has a power source, a controller, a motor, a second mechanical linkage interface located on an end of the motor shaft; and a second housing. The first mechanical linkage interface is mateable with the second mechanical linkage interface such that when the tip segment is connected to the limited reuse assembly, the first mechanical linkage interface mates with the second mechanical linkage interface so that motion of the shaft results in motion of the plunger.
摘要翻译：本发明是具有有限再利用组件和尖端部分的眼科注射系统。尖端段可连接到有限再利用组件并且从可重复使用组件移除。尖端段包括分配室，柱塞和壳体。分配室保持一定量的待注入眼睛的物质。柱塞的近端具有第一机械连杆接口。眼注射系统的有限再利用组件具有位于电动机轴的端部上的动力源，控制器，电动机，第二机械连杆接口; 和第二壳体。第一机械联动接口可与第二机械连杆接口相配合，使得当末端段连接到有限再利用组件时，第一机械连杆接口与第二机械连杆接口配合，使得轴的运动导致柱塞。

9. 发明申请

US20100057003A1 Drug Heating Cycle Limiter For Injection Device 审中-公开
标题翻译：用于注射装置的药物加热循环限制器
公开(公告)号：US20100057003A1
公开(公告)日：2010-03-04
申请号：US12444011
申请日：2007-10-09
申请人： Cesario Dos Santos
发明人： Cesario Dos Santos
IPC分类号： A61M5/44 , B67D7/82 , A61F7/12
CPC分类号： A61M5/20 , A61F9/0017 , A61M5/1413 , A61M5/14244 , A61M5/14526 , A61M5/14546 , A61M5/14566 , A61M5/3129 , A61M5/31511 , A61M5/445 , A61M2005/14268 , A61M2205/3368 , A61M2205/3653 , A61M2205/50 , A61M2205/6027 , A61M2205/8206 , A61M2210/0612
摘要： An injection assembly includes a dispensing chamber housing, a temperature control device, a thermal sensor, a switch, and a controller. The dispensing chamber housing has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for receiving a quantity of a substance. The temperature control device at least partially surrounds the dispensing chamber housing and alters a temperature of a substance in the dispensing chamber. The thermal sensor is located near the temperature control device and reads a temperature near the temperature control device. The switch is coupled to the temperature control device. The controller controls the temperature control device and the switch such that a first voltage is applied to the temperature control device until the temperature control device reaches a desired temperature, and a second voltage is applied to the temperature control device thereafter to maintain the temperature control device at the desired temperature.
摘要翻译：注射组件包括分配腔室，温度控制装置，热传感器，开关和控制器。分配腔室具有内表面和外表面。内表面部分地限定用于接收一定量的物质的分配室。温度控制装置至少部分地围绕分配腔室并改变分配室中物质的温度。热传感器位于温度控制装置附近，读取温度控制装置附近的温度。开关连接到温度控制装置。控制器控制温度控制装置和开关，使得第一电压被施加到温度控制装置，直到温度控制装置达到期望的温度，并且之后将第二电压施加到温度控制装置以维持温度控制装置在所需温度下。

10. 发明申请

US20100030157A1 Drug Retention Cap 审中-公开
标题翻译：药物保留上限
公开(公告)号：US20100030157A1
公开(公告)日：2010-02-04
申请号：US12364004
申请日：2009-02-02
申请人： Cesario Dos Santos , Robert J. Sanchez, JR.
发明人： Cesario Dos Santos , Robert J. Sanchez, JR.
IPC分类号： A61M5/31 , A61B19/02
CPC分类号： A61M5/3202 , A61M2005/311
摘要： A drug retention cap has a cap section and a drug retention pin. The cap section has a generally dome-shaped top end and a cylindrical portion extending downward from the generally dome-shaped top end. The top end of the cap section is closed, and the bottom end is open. The open bottom end is configured to receive a needle of a drug delivery device. The drug retention pin extends from near the apex of the dome-shaped top end downward toward the open bottom end. The drug retention pin is configured to fit inside a hollow needle.
摘要翻译：药物保持帽具有帽部分和药物保持针。盖部分具有大致圆顶形的顶端和从大致圆顶形的顶端向下延伸的圆柱形部分。盖部分的顶端封闭，底端打开。打开的底端构造成接收药物递送装置的针。药物保持销从圆顶状顶端的顶点附近向下朝向开放的底端延伸。药物保持销被配置成装配在中空针内。

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