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1. 发明申请

US20140223602A1 ENZYMES FOR THE TREATMENT OF LIGNOCELLULOSICS, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：用于治疗细胞凋亡的酶，编码其核酸的酶及其制备和使用它们的方法
公开(公告)号：US20140223602A1
公开(公告)日：2014-08-07
申请号：US14039968
申请日：2013-09-27
申请人： Cathy Chang , Justin T. Stege , Nahla M. Aboushadi , Gordana Djordjevic , Ellen G. Burke , Peter Luginbuhl , Mark Dycaico , Toby H. Richardson , John Poland , Hefner Ying , Stacy M. Miles
发明人： Cathy Chang , Justin T. Stege , Nahla M. Aboushadi , Gordana Djordjevic , Ellen G. Burke , Peter Luginbuhl , Mark Dycaico , Toby H. Richardson , John Poland , Hefner Ying , Stacy M. Miles
IPC分类号： C12P19/14 , C12P19/02 , C12P7/04 , C12N9/42
CPC分类号： C12P19/14 , C12N9/2437 , C12N9/2445 , C12P7/04 , C12P19/02 , C12Y302/01021 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： The invention provides polypeptides having a lignocellulolytic activity, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a β-xylosidase), an arabinofuranosidase, and/or a glucose oxidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides that can enzymatically process (hydrolyze) sugarcane bagasse, i.e., for sugarcane bagasse degradation, or for biomass processing, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention.
摘要翻译：本发明提供具有木质纤维素分解活性的多肽，例如糖基水解酶，纤维素酶，内切葡聚糖酶，纤维二糖水解酶，β-葡糖苷酶，木聚糖酶，甘露聚糖酶，木糖苷酶（例如，α-氧化酶），阿拉伯呋喃糖苷酶，和/或葡萄糖氧化酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明提供了可以酶促加工（水解）甘蔗渣，即甘蔗渣降解或用于生物量加工的多肽，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。在一个实施方案中，本发明提供本发明的多肽的耐热性和耐热性形式。

2. 发明申请

US20100189706A1 ENZYMES FOR THE TREATMENT OF LIGNOCELLULOSICS, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：用于治疗细胞凋亡的酶，编码其核酸的酶及其制备和使用它们的方法
公开(公告)号：US20100189706A1
公开(公告)日：2010-07-29
申请号：US12525303
申请日：2008-01-30
申请人： Cathy Chang , Justin T. Stege , Nahla Aboushadi , Gordana Djordjevic , Ellen Burke , Peter Luginbuhl , Mark Dycaico , Toby Richardson , John Poland , Ying Hefner , Stacy Marie Miles
发明人： Cathy Chang , Justin T. Stege , Nahla Aboushadi , Gordana Djordjevic , Ellen Burke , Peter Luginbuhl , Mark Dycaico , Toby Richardson , John Poland , Ying Hefner , Stacy Marie Miles
IPC分类号： A61K38/44 , A61K38/46 , C12N11/16 , A23L1/28 , C12P21/06 , C12P19/34 , C12P7/04 , C12P7/16 , C12P7/06 , C12N11/14 , C12N11/00 , C12N11/08 , C12N9/00 , C12N9/02 , C12N9/10 , C12N9/42 , C12N5/10 , C12N1/21 , C12N1/15 , C12N1/19 , C12N15/63 , C12P1/00 , D21C3/00 , C40B40/06 , C40B40/10 , C11D7/42 , C07K16/00 , C07H21/04 , A01K67/00 , A01H5/00
CPC分类号： C12P19/14 , C12N9/2437 , C12N9/2445 , C12P7/04 , C12P19/02 , C12Y302/01021 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： The invention provides polypeptides having a lignocellulolytic activity, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a β-xylosidase), an arabinofuranosidase, and/or a glucose oxidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides that can enzymatically process (hydrolyze) sugarcane bagasse, i.e., for sugarcane bagasse degradation, or for biomass processing, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts; for example, the invention provides a multi-enzyme system that can hydrolyze polysaccharides in a bagasse component of sugarcane processed in sugar mills. The invention provides enzymes for the bioconversion of lignocellulosic residues into fermentable sugars; and these sugars can be used as a chemical feedstock for the production of ethanol and fuels, including biofuels such as bioethanol, biopropanol, biobutanol and biodiesels.
摘要翻译：本发明提供具有木质纤维素分解活性的多肽，例如糖基水解酶，纤维素酶，内切葡聚糖酶，纤维二糖水解酶，β-葡糖苷酶，木聚糖酶，甘露聚糖酶，木糖苷酶（例如，α-氧化酶），阿拉伯呋喃糖苷酶，和/或葡萄糖氧化酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明提供了可以酶促加工（水解）甘蔗渣，即甘蔗渣降解或用于生物量加工的多肽，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。在一个实施方案中，本发明提供本发明的多肽的耐热性和耐热性形式。本发明的多肽可用于各种药物，农业和工业环境; 例如，本发明提供了一种可以在糖厂加工的甘蔗的蔗渣组分中水解多糖的多酶体系。本发明提供用于将木质纤维素残基生物转化成可发酵糖的酶; 并且这些糖可以用作生产乙醇和燃料的化学原料，包括生物燃料如生物乙醇，生物丙醇，生物丁醇和生物柴油。

3. 发明授权

US09234216B2 Variant CBH I polypeptides 有权
标题翻译：变体CBH I多肽
公开(公告)号：US09234216B2
公开(公告)日：2016-01-12
申请号：US13824315
申请日：2011-10-06
申请人： Justin T. Stege , Alexander Varvak , John Poland , Chris S. Lyon , Shaun Healey , Peter Luginbuhl
发明人： Justin T. Stege , Alexander Varvak , John Poland , Chris S. Lyon , Shaun Healey , Peter Luginbuhl
IPC分类号： C12P7/14 , C12N9/42 , C12P19/02 , C12P19/14
CPC分类号： C12P7/14 , C12N9/2437 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： In alternative embodiments, the invention provides polypeptides having a lignocellulolytic (lignocellulosic) activity, e.g., a ligninolytic and cellulolytic activity, including, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase (cbhl) (e.g., an exo-cellobiohydrolase, e.g., having an “exo” activity that can processively release cellobiose units β-1,4 glucose-glucose disaccharide), a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a (β-xylosidase) and/or an arabinofuranosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides and nucleic acids of the invention are used in a variety of pharmaceutical, agricultural and industrial contexts; for example, as enzymes for the bioconversion of a biomass, e.g., lignocellulosic residues, into fermentable sugars, where in one aspect these sugars are used as a chemical feedstock for the production of ethanol and fuels, e.g., biofuels, e.g., synthetic liquid or gas fuels, including ethanol, methanol and the like.
摘要翻译：在替代实施方案中，本发明提供具有木质纤维素分解（木质纤维素）活性的多肽，例如木质素分解和纤维素分解活性，包括例如糖基水解酶，纤维素酶，内切葡聚糖酶，纤维二糖水解酶（cbhl）（例如，外切纤维二糖水解酶例如具有可以逐步释放纤维二糖单元和-1,4葡萄糖 - 葡萄糖二糖的“外显子”活性，β-葡糖苷酶，木聚糖酶，甘露聚糖，木糖苷酶（例如，（β-谷氨酸）和/或阿拉伯呋喃糖苷酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法在一个实施方案中，本发明提供了本发明的多肽的热稳定性和耐热性形式，使用本发明的多肽和核酸在各种制药，农业和工业环境中;例如，作为生物质生物转化的酶，例如木质纤维素残基，i 在一方面，这些糖用作生产乙醇和燃料的化学原料，例如生物燃料，例如合成液体或气体燃料，包括乙醇，甲醇等。

4. 发明授权

US09096871B2 Variant CBH I polypeptides with reduced product inhibition 有权
标题翻译：具有减少的产物抑制的变体CBH I多肽
公开(公告)号：US09096871B2
公开(公告)日：2015-08-04
申请号：US13824317
申请日：2011-10-06
申请人： Justin T. Stege , Alexander Varvak , John Poland , Chris S. Lyon , Shaun Healey , Peter Luginbuhl
发明人： Justin T. Stege , Alexander Varvak , John Poland , Chris S. Lyon , Shaun Healey , Peter Luginbuhl
IPC分类号： C12N9/42 , C12P7/14 , C12P19/02 , C12P19/14
CPC分类号： C12P7/14 , C12N9/2437 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： The present disclosure relates to variant CBH I polypeptides that have reduced product inhibition, and compositions, e.g., cellulase compositions, comprising variant CBH I polypeptides. The variant CBH I polypeptides and related compositions can be used in variety of agricultural and industrial applications. The present disclosure further relates to nucleic acids encoding variant CBH I polypeptides and host cells that recombinantly express the variant CBH I polypeptides.
摘要翻译：本公开涉及具有降低的产物抑制的变体CBH I多肽，以及包含变体CBH I多肽的组合物，例如纤维素酶组合物。变体CBH I多肽和相关组合物可用于各种农业和工业应用。本公开还涉及编码变体CBH I多肽的核酸和重组表达变体CBH I多肽的宿主细胞。

5. 发明申请

US20130203128A1 VARIANT CBH I POLYPEPTIDES 有权
标题翻译：变种CBH多糖
公开(公告)号：US20130203128A1
公开(公告)日：2013-08-08
申请号：US13824315
申请日：2011-10-06
申请人： Justin T. Stege , Alexander Varvak , John Poland , Chris S. Lyon , Shaun Healey , Peter Luginbuhl
发明人： Justin T. Stege , Alexander Varvak , John Poland , Chris S. Lyon , Shaun Healey , Peter Luginbuhl
IPC分类号： C12N9/42 , C12P19/02
CPC分类号： C12P7/14 , C12N9/2437 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： In alternative embodiments, the invention provides polypeptides having a lignocellulolytic (lignocellulosic) activity, e.g., a ligninolytic and cellulolytic activity, including, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase (cbhl) (e.g., an exo-cellobiohydrolase, e.g., having an “exo” activity that can processively release cellobiose units β-1,4 glucose-glucose disaccharide), a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a (β-xylosidase) and/or an arabinofuranosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides and nucleic acids of the invention are used in a variety of pharmaceutical, agricultural and industrial contexts; for example, as enzymes for the bioconversion of a biomass, e.g., lignocellulosic residues, into fermentable sugars, where in one aspect these sugars are used as a chemical feedstock for the production of ethanol and fuels, e.g., biofuels, e.g., synthetic liquid or gas fuels, including ethanol, methanol and the like.
摘要翻译：在替代实施方案中，本发明提供具有木质纤维素分解（木质纤维素）活性的多肽，例如木质素分解和纤维素分解活性，包括例如糖基水解酶，纤维素酶，内切葡聚糖酶，纤维二糖水解酶（cbhl）（例如，外切纤维二糖水解酶例如，具有可以逐步释放纤维二糖单位β-1,4葡萄糖 - 葡萄糖二糖的“外部”活性），β-葡糖苷酶，木聚糖酶，甘露聚糖，木糖苷酶（例如（β-木糖苷酶）和/ 或阿拉伯呋喃糖苷酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法在一个实施方案中，本发明提供了本发明的多肽的耐热和耐热形式。本发明的多肽和核酸用于各种制药，农业和工业环境;例如，作为生物质生物转化的酶，例如木质纤维素残基，转化为Fe 可再生糖，其中一方面，这些糖被用作用于生产乙醇和燃料的化学原料，例如生物燃料，例如合成液体或气体燃料，包括乙醇，甲醇等。

6. 发明授权

US08343747B2 Amylases and glucoamylases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：淀粉酶和葡糖淀粉酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US08343747B2
公开(公告)日：2013-01-01
申请号：US12520523
申请日：2007-12-21
申请人： Ellen G. Burke , Michelle H. Cayouette , Cathy Chang , Majid Ghassemian , Uvini Gunavardena , Geoff Hazlewood , Peter Luginbuhl , Aron Silverston , Malgorzata Slupska , Yan Zhang
发明人： Ellen G. Burke , Michelle H. Cayouette , Cathy Chang , Majid Ghassemian , Uvini Gunavardena , Geoff Hazlewood , Peter Luginbuhl , Aron Silverston , Malgorzata Slupska , Yan Zhang
IPC分类号： C12N9/34 , C12N9/26 , C12N15/00 , C12N1/20 , C12N15/82 , C12P21/06 , C12P19/34 , C07H21/04 , C07K1/00
CPC分类号： C12N9/96 , C12N9/2408 , C12N9/2414 , C12N9/2425 , C12N9/2428 , Y02E50/16 , Y02E50/17
摘要： In one aspect, the invention is directed to polypeptides having an amylase and/or glucoamylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of polysaccharide, oligosaccharide or starch into sugars. In one aspect, the invention provides delayed release compositions comprising an desired ingredient coated by a latex polymer coating. In alternative embodiments, enzymes are used to make biofuels, e.g., ethanol, butanol, propanol, or a gasoline-ethanol mix, including a bioethanol, biopropanol, biobutanol, or a biodiesel, or for any form of fuel or biomass processing.
摘要翻译：一方面，本发明涉及具有淀粉酶和/或葡糖淀粉酶活性的多肽，编码多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明的多肽可用作淀粉酶，例如α-淀粉酶，以催化多糖，寡糖或淀粉水解成糖。一方面，本发明提供包含通过胶乳聚合物涂层涂覆的所需成分的延迟释放组合物。在替代实施方案中，酶用于制备生物燃料，例如乙醇，丁醇，丙醇或汽油 - 乙醇混合物，包括生物乙醇，生物丙醇，生物丁醇或生物柴油，或用于任何形式的燃料或生物质处理。

7. 发明授权

US08168201B2 Vaccines 有权
标题翻译：疫苗
公开(公告)号：US08168201B2
公开(公告)日：2012-05-01
申请号：US11696131
申请日：2007-04-03
申请人： Leslie Hickle , Abraham Anderson , Robert C. Brown , Paul Budworth , Gordana Djordjevic , Scott Kroken , Peter Luginbuhl , Toby Richardson , Genevieve Hansen
发明人： Leslie Hickle , Abraham Anderson , Robert C. Brown , Paul Budworth , Gordana Djordjevic , Scott Kroken , Peter Luginbuhl , Toby Richardson , Genevieve Hansen
IPC分类号： A61K39/295 , A61K48/00 , A61K39/02 , C12N15/117 , A61K38/00
CPC分类号： A61K39/385 , A61K39/012 , A61K39/08 , A61K2039/552 , A61K2039/55516 , A61K2039/6037 , A61K2039/6075 , C07K2319/55 , C12N2720/10034 , C12N2760/18434 , C12N2770/20034 , Y02A50/489
摘要： The present invention relates to compositions for inducing immune responses, including an antigen and a promiscuous T-cell epitope. Also provided are methods of inducing immune responses in hosts, comprising administering compositions comprising antigens and promiscuous T-cell epitopes to the host.
摘要翻译：本发明涉及用于诱导免疫应答的组合物，包括抗原和混杂T细胞表位。还提供了在宿主中诱导免疫应答的方法，包括向宿主施用包含抗原和混杂的T细胞表位的组合物。

8. 发明申请

US20070286871A1 VACCINES 有权
标题翻译：疫苗
公开(公告)号：US20070286871A1
公开(公告)日：2007-12-13
申请号：US11696131
申请日：2007-04-03
申请人： Leslie Hickle , Abraham Anderson , Robert Brown , Paul Budworth , Gordana Djordjevic , Scott Kroken , Peter Luginbuhl , Toby Richardson , Genevieve Hansen
发明人： Leslie Hickle , Abraham Anderson , Robert Brown , Paul Budworth , Gordana Djordjevic , Scott Kroken , Peter Luginbuhl , Toby Richardson , Genevieve Hansen
IPC分类号： A61K39/295 , A61K39/116 , C07H21/04
CPC分类号： A61K39/385 , A61K39/012 , A61K39/08 , A61K2039/552 , A61K2039/55516 , A61K2039/6037 , A61K2039/6075 , C07K2319/55 , C12N2720/10034 , C12N2760/18434 , C12N2770/20034 , Y02A50/489
摘要： The present invention relates to compositions for inducing immune responses, including an antigen and a promiscuous T-cell epitope. Also provided are methods of inducing immune responses in hosts, comprising administering compositions comprising antigens and promiscuous T-cell epitopes to the host.
摘要翻译：本发明涉及用于诱导免疫应答的组合物，包括抗原和混杂T细胞表位。还提供了在宿主中诱导免疫应答的方法，包括向宿主施用包含抗原和混杂的T细胞表位的组合物。

9. 发明申请

US20100095390A1 Aldolases, Nucleic Acids Encoding Them and Methods for Making and Using Them 有权
标题翻译：醛缩酶，编码它们的核酸及其制备和使用方法
公开(公告)号：US20100095390A1
公开(公告)日：2010-04-15
申请号：US12281052
申请日：2007-03-07
申请人： David P. Weiner , Lishan Zhao , Peter Luginbuhl , Ellen Burke , Toby H. Richardson , Paula M. Hicks
发明人： David P. Weiner , Lishan Zhao , Peter Luginbuhl , Ellen Burke , Toby H. Richardson , Paula M. Hicks
IPC分类号： C12N9/88 , C07H21/04 , C07H21/00 , C12N15/74 , C12N5/07 , C12N5/04 , C12N1/15 , C12N1/21 , A01K67/033 , A01H5/00 , C12N9/24 , C07K16/00 , C12P21/00 , C07K7/08 , C07K14/00 , A61K38/47 , C12P1/00 , C12P13/14 , C07C205/01 , A61P35/00 , A23K1/00
CPC分类号： C12N9/88 , A01K2217/05 , A61K38/00 , C07K2317/92 , C12N9/1022 , C12N15/8243 , C12P17/10 , C12Y401/03016 , C12Y401/03017 , Y02E50/16 , Y02E50/17
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.
摘要翻译：本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，包括耐热和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。根据本发明的多肽可以用于各种药物，农业和工业环境。在一些实施方案中，本发明提供了可用于制备R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的多肽和生物合成途径，例如R ，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，例如R，R和S，R构型及其盐。

10. 发明授权

US08541220B2 Isomerases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：异构酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US08541220B2
公开(公告)日：2013-09-24
申请号：US12810067
申请日：2008-12-22
申请人： David P. Weiner , Ellen G. Burke , Peter Luginbuhl , Analia Bueno , Joslin M. Cuenca , Mervyn L. De Souza , Sherry Kollmann
发明人： David P. Weiner , Ellen G. Burke , Peter Luginbuhl , Analia Bueno , Joslin M. Cuenca , Mervyn L. De Souza , Sherry Kollmann
IPC分类号： C12N9/90 , C12N9/88 , C12N9/48 , C12N9/42 , C12N9/16 , C02F3/34 , A62D3/00 , C07H21/04 , C07K1/00 , A21D2/00 , A23L1/10 , D21C3/20
CPC分类号： C12N9/90 , A01K67/0275 , A01K2217/05 , A01K2227/10 , A23G3/366 , A23G4/123 , A23G4/14 , A23K20/189 , A23L29/06 , A23V2002/00 , A61K38/00 , A61K38/52 , C12Q1/533 , C12Y501/00 , C12Y501/01
摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.
摘要翻译：本发明一般涉及酶，编码酶的多核苷酸，这种多核苷酸和多肽的用途，更具体地涉及具有异构酶活性的酶，例如消旋酶活性，例如氨基酸消旋酶活性，丙氨酸消旋酶活性和/或差向异构酶活性，和/或催化分子内原子的重新排列，催化一种异构体转化为另一种异构体，催化光学活性底物转化为光学无活性的外消旋体，催化底物对映异构体的相互转化，催化立体化学在仅具有一个不对称中心的底物中的不对称碳原子周围反转，催化具有多于一个不对称中心的底物中不对称碳原子周围的构型的立体化学反转，和/或催化氨基酸的外消旋化。因此，本发明提供了用于生产药物组合物，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂的酶，组合物，药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和洗涤剂，其包含根据本发明的多肽或多核苷酸。

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