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2. 发明授权

US5891196A Method for actively binding heparin to crosslinked biological tissues 失效
标题翻译：肝素与交联生物组织积极结合的方法
公开(公告)号：US5891196A
公开(公告)日：1999-04-06
申请号：US843504
申请日：1997-04-16
申请人： Catherine Ting Lee , Jun Yang
发明人： Catherine Ting Lee , Jun Yang
IPC分类号： A61L33/10 , A61L33/00 , A61L17/00
CPC分类号： A61L33/0029 , A61L33/0011 , Y10S514/822
摘要： Methods for binding heparin to biological or synthetic materials which are to be implanted within a mammalian body. In instances where connective tissue proteins or other components of the material having adequate carboxyl groups present thereon, the method comprises a) contacting the material with a carboxyl-activating agent, b) contacting the material with a polyamine compound to form amide-bound polyarnine side chains at the sites of the previously activated carboxyl groups, and c) contacting the material with heparin such that heparin will become bound to the amino groups on the polyamine side chains. In other applications wherein the connective tissue proteins or other molecular entities of the material are devoid of or deficient in carboxyl groups, the method will comprise a) contacting the material with a carboxyl-activating agent in combination with a polyamine compound which has functional carboxyl groups thereon such that at least some of the functional carboxyl groups of the polyamine compound will become activated and will react with some of the amino groups on the polyamine compounds to form a polyamine network interlocked within the molecular structure of the material, and b) contacting the material with heparin such that heparin will become bound to amino groups on the polyamine network.
摘要翻译：将肝素结合到植入哺乳动物体内的生物或合成材料的方法。在结缔组织蛋白质或具有足够羧基的物质的其它成分存在于其上的情况下，该方法包括：a）使材料与羧基活化剂接触，b）使该材料与多胺化合物接触以形成酰胺键结的聚胺一侧链在先前活化的羧基的位点，和c）使该材料与肝素接触，使得肝素将结合到多胺侧链上的氨基。在其中所述材料的结缔组织蛋白质或其它分子实体缺乏或缺乏羧基的其它应用中，所述方法将包括：a）使所述材料与羧基活化剂与具有官能羧基的多胺化合物组合使得多胺化合物的至少一些官能羧基将被活化并将与多胺化合物上的一些氨基发生反应以形成在该材料的分子结构内互锁的多胺网络，以及b）使材料与肝素，使肝素将结合到多胺网络上的氨基。

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