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1. 发明申请

US20070015689A1 Complexation of metal ions with polypeptides 审中-公开
标题翻译：金属离子与多肽的络合
公开(公告)号：US20070015689A1
公开(公告)日：2007-01-18
申请号：US11471984
申请日：2006-06-21
申请人： Catherine Rohloff , Guohua Chen , Zhongli Ding , Stephen Berry , Latha Narayanan , Michael Desjardin
发明人： Catherine Rohloff , Guohua Chen , Zhongli Ding , Stephen Berry , Latha Narayanan , Michael Desjardin
IPC分类号： A61K38/27
CPC分类号： A61K47/32 , A61K9/0019 , A61K9/1617 , A61K9/1623 , A61K9/1688 , A61K38/27 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/26 , A61K47/34 , A61K47/44
摘要： Formulations and methods are provided for improving the stability upon exposure to aqueous media of polypeptides present in non-aqueous suspension vehicles. In particular aspects of the invention, formulations are provided that comprise a complex of a metal ion and a polypeptide suspended in a non-aqueous, biocompatible suspension vehicle. Aggregation of individual polypeptide molecules is reduced when aqueous media is introduced to such formulations, serving to stabilize the polypeptide.
摘要翻译：提供了制备和方法，用于提高暴露于存在于非水悬浮载体中的多肽的水性介质时的稳定性。在本发明的特定方面，提供了包含悬浮在非水生物相容性悬浮载体中的金属离子和多肽的复合物的制剂。当将水性介质引入这种制剂用于稳定多肽时，单个多肽分子的聚集被降低。

2. 发明申请

US20120122782A1 COMPLEXATION OF METAL IONS WITH POLYPEPTIDES 审中-公开
标题翻译：金属离子与多糖的复合
公开(公告)号：US20120122782A1
公开(公告)日：2012-05-17
申请号：US13301739
申请日：2011-11-21
申请人： Catherine M. Rohloff , Guohua Chen , Zhongli Ding , Stephen Andrew Berry , Latha Pisharody Narayanan , Michael Desjardin
发明人： Catherine M. Rohloff , Guohua Chen , Zhongli Ding , Stephen Andrew Berry , Latha Pisharody Narayanan , Michael Desjardin
IPC分类号： A61K38/27 , A61P5/06 , A61K38/02
CPC分类号： A61K47/32 , A61K9/0019 , A61K9/1617 , A61K9/1623 , A61K9/1688 , A61K38/27 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/26 , A61K47/34 , A61K47/44
摘要： Formulations and methods are provided for improving the stability upon exposure to aqueous media of polypeptides present in non-aqueous suspension vehicles. In particular aspects of the invention, formulations are provided that comprise a complex of a metal ion and a polypeptide suspended in a non-aqueous, biocompatible suspension vehicle. Aggregation of individual polypeptide molecules is reduced when aqueous media is introduced to such formulations, serving to stabilize the polypeptide.
摘要翻译：提供了制备和方法，用于提高暴露于存在于非水悬浮载体中的多肽的水性介质时的稳定性。在本发明的特定方面，提供了包含悬浮在非水生物相容性悬浮载体中的金属离子和多肽的复合物的制剂。当将水性介质引入这种制剂用于稳定多肽时，单个多肽分子的聚集被降低。

3. 发明申请

US20070178159A1 In-Situ Forming Porous Scaffold 审中-公开
标题翻译：原位成型多孔脚手架
公开(公告)号：US20070178159A1
公开(公告)日：2007-08-02
申请号：US11623819
申请日：2007-01-17
申请人： Guohua Chen , Zhongli Ding , Johanna Bentz , Paul Houston , Ling-Ling Kang
发明人： Guohua Chen , Zhongli Ding , Johanna Bentz , Paul Houston , Ling-Ling Kang
IPC分类号： A61K38/20 , A61K38/19 , A61K38/18 , A61K9/14
CPC分类号： A61L27/56 , A61K38/1841 , A61K38/27 , A61L27/227 , A61L27/44 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2300/604 , A61L2430/02 , A61L2430/06 , C08L67/04
摘要： A composition includes a viscous gel formed from a combination of a biodegradable polymer and a biocompatible solvent. The composition also includes a hydrophilic porogen, which may be incorporated in the viscous gel. The composition may form a porous scaffold in situ.
摘要翻译：组合物包括由可生物降解的聚合物和生物相容性溶剂的组合形成的粘性凝胶。该组合物还包括亲水致孔剂，其可以结合到粘性凝胶中。组合物可原位形成多孔支架。

4. 发明授权

US08898150B1 Collecting image search event information 有权
标题翻译：收集图像搜索事件信息
公开(公告)号：US08898150B1
公开(公告)日：2014-11-25
申请号：US13608278
申请日：2012-09-10
申请人： Michihiro Kuramochi , James M. Synge , Zhongli Ding
发明人： Michihiro Kuramochi , James M. Synge , Zhongli Ding
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30265 , G06F17/30864
摘要： Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for collecting and compiling information regarding search operations. In one aspect, a query log that stores search event data items for identifiers is accessed. A proper subset of the search event data items is identified, the proper subset of search event data items being search event data items for search events related to an image search. A proper subset of the identifiers is identified, the proper subset of identifiers being identifiers associated with a search event data item for a search event related to an image search. For each identifier of the proper subset of identifiers, an image search session data object is generated using the proper subset of search event data items.
摘要翻译：方法，系统和装置，包括在计算机存储介质上编码的计算机程序，用于收集和编译关于搜索操作的信息。一方面，存储用于存储用于标识符的搜索事件数据项的查询日志。识别搜索事件数据项的适当子集，搜索事件数据项的正确子集是与图像搜索相关的搜索事件的搜索事件数据项。标识符的适当子集被识别，标识符的正确子集是与用于与图像搜索相关的搜索事件的搜索事件数据项相关联的标识符。对于标识符的正确子集的每个标识符，使用搜索事件数据项的适当子集来生成图像搜索会话数据对象。

5. 发明授权

US08719452B1 Correction of client-assigned timestamps 有权
标题翻译：更正客户端分配的时间戳
公开(公告)号：US08719452B1
公开(公告)日：2014-05-06
申请号：US13194892
申请日：2011-07-29
申请人： Zhongli Ding , Dragan Zivkovic
发明人： Zhongli Ding , Dragan Zivkovic
IPC分类号： G06F15/16
CPC分类号： G06F11/3476 , G06F2201/835 , G06F2201/86 , H04N21/4344
摘要： Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for correcting client-assigned timestamps. In one aspect, a method includes receiving, by one or more servers, a data packet that includes (i) data referencing one or more client-side events, (ii) data referencing a respective time that a client has assigned to each event, and (iii) data referencing a transmission time that the client has assigned to the data packet. The method also includes assigning, by the one or more servers, a receipt time to the data packet, and comparing, by the one or more servers, the transmission time that the client has assigned to the data packet to the receipt time that the one or more servers have assigned to the data packet, to determine a time correction factor.
摘要翻译：方法，系统和装置，包括在计算机存储介质上编码的计算机程序，用于校正客户端分配的时间戳。一方面，一种方法包括由一个或多个服务器接收包括（i）参考一个或多个客户端事件的数据的数据分组，（ii）参考客户端分配给每个事件的相应时间的数据，和（iii）参考客户端已经分配给数据分组的传输时间的数据。所述方法还包括由所述一个或多个服务器向所述数据分组分配接收时间，并且由所述一个或多个服务器将所述客户端已经分配给所述数据分组的传输时间与所述接收时间进行比较，或更多的服务器分配给数据包，以确定时间校正因子。

6. 发明申请

US20150172150A1 ASYNCHRONOUS AND SYNCHRONOUS RESOURCE LINKS 有权
标题翻译：非同步和同步资源链接
公开(公告)号：US20150172150A1
公开(公告)日：2015-06-18
申请号：US13222941
申请日：2011-08-31
申请人： Zhongli Ding , Dragan Zivkovic
发明人： Zhongli Ding , Dragan Zivkovic
IPC分类号： H04L12/26 , H04L29/06 , H04L29/08
CPC分类号： H04L67/1095 , G06F17/30861 , H04L43/10 , H04L63/101 , H04L67/02 , H04L67/22 , H04L67/42
摘要： Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for providing asynchronous and synchronous links to resources. According to one example implementation, a method includes receiving a request for a resource, identifying resources to be referenced by the requested resource, and identifying one or more of the referenced resources that are associated with client-side click tracking, and one or more of the referenced resources that are associated with server-side click tracking. The method also includes providing the requested resource. The provided resource includes one or more client-side click tracking links to the referenced resources that are associated with client-side click tracking, and one or more server-side click tracking links to the referenced resources that are associated with server-side click tracking.
摘要翻译：方法，系统和装置，包括在计算机存储介质上编码的计算机程序，用于向资源提供异步和同步链路。根据一个示例实现，一种方法包括接收对资源的请求，识别由所请求的资源引用的资源，以及识别与客户端点击跟踪相关联的所引用的资源中的一个或多个，以及一个或多个与服务器端点击跟踪相关联的引用资源。该方法还包括提供所请求的资源。所提供的资源包括与客户端点击跟踪相关联的引用资源的一个或多个客户端点击跟踪链接以及与服务器端点击跟踪相关联的所引用资源的一个或多个服务器端点击跟踪链接。

7. 发明申请

US20050158379A1 Minimization of drug oxidation in drug irradiated excipients formulations 失效
标题翻译：药物辐射赋形剂制剂中药物氧化的最小化
公开(公告)号：US20050158379A1
公开(公告)日：2005-07-21
申请号：US10986922
申请日：2004-11-12
申请人： Zhongli Ding , Lothar Kleiner
发明人： Zhongli Ding , Lothar Kleiner
IPC分类号： A61K9/16 , A61K9/20 , A61K31/355 , A61K38/20 , A61K38/21 , A61K38/24 , A61K38/47 , A61K47/12 , A61K48/00
CPC分类号： A61K47/12 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1694 , A61K31/355 , A61K47/32 , A61K47/34
摘要： This invention relates to compositions and methods for preventing oxidation of beneficial agents.
摘要翻译：本发明涉及防止有益剂氧化的组合物和方法。

8. 发明授权

US09432482B2 Asynchronous and synchronous resource links 有权
标题翻译：异步和同步资源链接
公开(公告)号：US09432482B2
公开(公告)日：2016-08-30
申请号：US13222941
申请日：2011-08-31
申请人： Zhongli Ding , Dragan Zivkovic
发明人： Zhongli Ding , Dragan Zivkovic
IPC分类号： G06F15/173 , H04L29/06 , H04L29/08 , G06F17/30 , H04L12/26
CPC分类号： H04L67/1095 , G06F17/30861 , H04L43/10 , H04L63/101 , H04L67/02 , H04L67/22 , H04L67/42
摘要： Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for providing asynchronous and synchronous links to resources. According to one example implementation, a method includes receiving a request for a resource, identifying resources to be referenced by the requested resource, and identifying one or more of the referenced resources that are associated with client-side click tracking, and one or more of the referenced resources that are associated with server-side click tracking. The method also includes providing the requested resource. The provided resource includes one or more client-side click tracking links to the referenced resources that are associated with client-side click tracking, and one or more server-side click tracking links to the referenced resources that are associated with server-side click tracking.
摘要翻译：方法，系统和装置，包括在计算机存储介质上编码的计算机程序，用于向资源提供异步和同步链路。根据一个示例实现，一种方法包括接收对资源的请求，识别所请求的资源引用的资源，以及识别与客户端点击跟踪相关联的所引用的资源中的一个或多个，以及一个或多个与服务器端点击跟踪相关联的引用资源。该方法还包括提供所请求的资源。所提供的资源包括与客户端点击跟踪相关联的引用资源的一个或多个客户端点击跟踪链接以及与服务器端点击跟踪相关联的所引用资源的一个或多个服务器端点击跟踪链接。

9. 发明申请

US20150163116A1 CLIENT-SIDE CLICK TRACKING 审中-公开
标题翻译：客户端点击跟踪
公开(公告)号：US20150163116A1
公开(公告)日：2015-06-11
申请号：US13194875
申请日：2011-07-29
申请人： Zhongli Ding , Dragan Zivkovic
发明人： Zhongli Ding , Dragan Zivkovic
IPC分类号： H04L12/26 , G06F15/173
CPC分类号： H04L43/10 , G06F16/958 , H04L43/0876 , H04L67/22
摘要： Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing client-side click tracking. In one aspect, a method includes receiving, by a client, a resource from one or more servers. The resource includes (i) a link, (ii) click tracking code, and (iii) local storage monitoring code. The method includes invoking, by the client, the click tracking code and the local storage monitoring code, detecting, by the invoked click tracking code, a selection of the link, and generating, by the invoked click tracking code, a representation of the selection of the link. The method includes storing, by the invoked click tracking code, the representation of the selection of the link in a local storage on the client, determining, by the invoked local storage monitoring code, to communicate the representation of the selection of the link; and communicating, by the invoked local storage monitoring code, the representation of the selection of the link to the one or more servers.
摘要翻译：方法，系统和装置，包括在计算机存储介质上编码的计算机程序，用于执行客户端点击跟踪。一方面，一种方法包括由客户端从一个或多个服务器接收资源。资源包括（i）链接，（ii）点击跟踪代码和（iii）本地存储监控代码。该方法包括由客户端调用点击跟踪代码和本地存储监控代码，通过调用的点击跟踪代码来检测链接的选择，以及通过调用的点击跟踪代码生成所述选择的表示的链接。该方法包括通过被调用的点击跟踪代码来存储在客户机上的本地存储器中的链接选择的表示，通过调用的本地存储监视代码来确定链接的选择的表示; 并且通过被调用的本地存储监视代码来传送对一个或多个服务器的链接的选择的表示。

10. 发明申请

US20080063626A1 MINIMIZATION OF DRUG OXIDATION IN DRUG IRRADIATED EXCIPIENTS FORMULATIONS 审中-公开
标题翻译：药物滥用药物制剂中药物最小化
公开(公告)号：US20080063626A1
公开(公告)日：2008-03-13
申请号：US11940085
申请日：2007-11-14
申请人： Zhongli Ding , Lothar Kleiner
发明人： Zhongli Ding , Lothar Kleiner
IPC分类号： A61K31/135 , A61K31/20 , A61K31/40 , A61K31/44 , A61K31/495 , A61K31/51 , A61K31/519 , A61K31/522 , A61K31/54 , A61K31/56 , A61K31/70 , A61K38/00 , A61K38/21 , A61K39/395 , A61K45/00 , A61K47/00 , A61K47/30 , A61P43/00
CPC分类号： A61K47/12 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1694 , A61K31/355 , A61K47/32 , A61K47/34
摘要： This invention relates to compositions and methods for preventing oxidation of beneficial agents that comprise at least one beneficial agent and an excipient, wherein the excipient has been irradiated and annealed.
摘要翻译：本发明涉及用于防止包含至少一种有益剂和赋形剂的有益剂的氧化的组合物和方法，其中所述赋形剂已被照射和退火。

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