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1. 发明授权

US06882883B2 Implantable medical device (IMD) system configurable to subject a patient to a stress test and to detect myocardial ischemia within the patient 有权
标题翻译：可植入医疗装置（IMD）系统可配置为使患者进行压力测试并检测患者内的心肌缺血
公开(公告)号：US06882883B2
公开(公告)日：2005-04-19
申请号：US09945195
申请日：2001-08-31
申请人： Catherine R. Condie , Robert W. Stadler , Lee Stylos
发明人： Catherine R. Condie , Robert W. Stadler , Lee Stylos
IPC分类号： A61B5/0472 , A61N1/362 , A61N1/372
CPC分类号： A61B5/4884 , A61B5/0472 , A61N1/362
摘要： Various implantable medical devices (IMDs) are disclosed for implantation in a patient. The IMD includes pacing circuitry configured to selectively produce pacing pulses at a programmable pacing rate. In one embodiment, the IMD is configurable to subject a patient to a stress test. The IMD may be configurable to subject the patient to the stress test at the time specified by stored timing information, or in response to a signal (e.g., from a patient activator). Another embodiment of the implantable medical device (IMD) includes sensor circuitry, a memory for storing data, and a control unit. The sensor circuitry produces sensor data relating to cardiac condition. The control unit is configurable to store the sensor data in the memory until a trigger signal is received. Methods are described for performing a stress test in a patient with an IMD, and for subsequently reproducing cardiac operational states.
摘要翻译：公开了用于植入患者体内的各种植入式医疗装置（IMD）。 IMD包括起搏电路，其配置成以可编程起搏速率选择性地产生起搏脉冲。在一个实施例中，IMD可配置为使患者进行压力测试。 IMD可以被配置为使患者在由存储的定时信息指定的时间或者响应于信号（例如来自患者激活器）的时间对患者进行压力测试。可植入医疗装置（IMD）的另一实施例包括传感器电路，用于存储数据的存储器和控制单元。传感器电路产生有关心脏状况的传感器数据。控制单元可配置为将传感器数据存储在存储器中，直到接收到触发信号。描述了用于在具有IMD的患者中进行压力测试并且随后再现心脏操作状态的方法。

2. 发明授权

US06731983B2 Pacemaker having adaptive arrhythmia detection windows 有权
标题翻译：起搏器具有适应性心律失常检测窗口
公开(公告)号：US06731983B2
公开(公告)日：2004-05-04
申请号：US10082981
申请日：2002-02-25
申请人： James H. Ericksen , Robert A. Betzold , Catherine R. Condie , Jeffrey M. Gillberg , Robert W. Stadler , John C. Stroebel , Troy E. Jackson
发明人： James H. Ericksen , Robert A. Betzold , Catherine R. Condie , Jeffrey M. Gillberg , Robert W. Stadler , John C. Stroebel , Troy E. Jackson
IPC分类号： A61N136
CPC分类号： A61N1/3622 , A61N1/3682
摘要： A device-implemented software system operates a detection window and adjusts PAV as needed after confirming the presence or detection of evidence of an arrhythmia. The detection window is monitored based on a preferred length. If the detection window is shorter than required, intervals are adjusted for a specific pacing rate. Further, the software system provides means for selecting detection over pacing based on an analysis of a preferred length in the presence of evidence of an arrhythmia.
摘要翻译：设备实现的软件系统在确认存在或检测到心律失常的证据之后，根据需要操作检测窗口并调整PAV。基于优选的长度来监视检测窗口。如果检测窗口比要求短，则根据特定的起搏速度对间隔进行调整。此外，软件系统提供了在存在心律失常证据的情况下基于优选长度的分析来选择起搏检测的手段。

3. 发明授权

US08229560B2 System and method of using AV conduction timing 有权
标题翻译：使用AV导通定时的系统和方法
公开(公告)号：US08229560B2
公开(公告)日：2012-07-24
申请号：US13078536
申请日：2011-04-01
申请人： Catherine R. Condie
发明人： Catherine R. Condie
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61B5/0468 , A61N1/3682
摘要： In an implantable medical device that provides atrial and ventricular pacing in an atrial-based pacing mode, longer periods of time are permitted for intrinsic AV conduction to occur. By monitoring the patient's AV delay under these circumstances, useful information is obtained that can be correlated to other patient conditions or symptoms.
摘要翻译：在以心房起搏模式提供心房和心室起搏的植入式医疗装置中，允许发生固有AV传导的较长时间段。通过在这些情况下监测患者的AV延迟，获得可以与其他患者状况或症状相关的有用信息。

4. 发明授权

US09532828B2 System and method for adaptive RF ablation 有权
标题翻译：自适应射频消融的系统和方法
公开(公告)号：US09532828B2
公开(公告)日：2017-01-03
申请号：US13096236
申请日：2011-04-28
申请人： Catherine R. Condie , Marshall L. Sherman , Kathryn E. Kasischke , Timothy J. Corvi , Aaron R. Strunk
发明人： Catherine R. Condie , Marshall L. Sherman , Kathryn E. Kasischke , Timothy J. Corvi , Aaron R. Strunk
IPC分类号： A61B18/18 , A61B18/14 , A61B18/12 , A61B18/00
CPC分类号： A61B18/14 , A61B18/1206 , A61B18/1492 , A61B2018/0016 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/00577 , A61B2018/00642 , A61B2018/00648 , A61B2018/00678 , A61B2018/00702 , A61B2018/00714 , A61B2018/00726 , A61B2018/00779 , A61B2018/00791 , A61B2090/065
摘要： A medical method, device, and system are provided, including advancing an ablation element of a medical device into contact with tissue to be treated, selecting a power level of energy to ablate the tissue, delivering energy at the selected power level to the ablation element, determining whether the ablation element is in continuous contact with the tissue, and reducing the selected power level when the ablation element ceases to be in continuous contact with the tissue.
摘要翻译：提供了一种医疗方法，装置和系统，包括使医疗装置的消融元件与待治疗组织接触，选择能量消耗组织的能量水平，将所选功率水平的能量输送到消融元件确定消融元件是否与组织连续接触，以及当消融元件停止与组织连续接触时降低所选择的功率水平。

5. 发明授权

US09504518B2 System and method for adaptive RF ablation 有权
标题翻译：自适应射频消融的系统和方法
公开(公告)号：US09504518B2
公开(公告)日：2016-11-29
申请号：US13096255
申请日：2011-04-28
申请人： Catherine R. Condie , Marshall L. Sherman , Kathryn E. Kasischke , Timothy J. Corvi , Aaron R. Strunk
发明人： Catherine R. Condie , Marshall L. Sherman , Kathryn E. Kasischke , Timothy J. Corvi , Aaron R. Strunk
IPC分类号： A61B18/18 , A61B18/14 , A61B18/12 , A61B18/00
CPC分类号： A61B18/14 , A61B18/1206 , A61B18/1492 , A61B2018/0016 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/00577 , A61B2018/00642 , A61B2018/00648 , A61B2018/00678 , A61B2018/00702 , A61B2018/00714 , A61B2018/00726 , A61B2018/00779 , A61B2018/00791 , A61B2090/065
摘要： A medical method, device, and system are provided, including advancing an ablation element of a medical device into contact with tissue to be treated, selecting a power level of energy to ablate the tissue, delivering energy at the selected power level to the ablation element, determining whether the ablation element is in continuous contact with the tissue, and reducing the selected power level when the ablation element ceases to be in continuous contact with the tissue.
摘要翻译：提供了一种医疗方法，装置和系统，包括使医疗装置的消融元件与待治疗组织接触，选择能量消耗组织的能量水平，将所选功率水平的能量输送到消融元件确定消融元件是否与组织连续接触，以及当消融元件停止与组织连续接触时降低所选择的功率水平。

6. 发明授权

US09060778B2 Intermittent short circuit detection on a multi-electrode catheter 有权
标题翻译：多电极导管间歇性短路检测
公开(公告)号：US09060778B2
公开(公告)日：2015-06-23
申请号：US13456592
申请日：2012-04-26
申请人： Catherine R. Condie , Marshall L. Sherman
发明人： Catherine R. Condie , Marshall L. Sherman
IPC分类号： A61B18/18 , A61B18/12 , A61B18/00 , A61B18/14
CPC分类号： A61B18/1233 , A61B18/1492 , A61B2018/00267 , A61B2018/00345 , A61B2018/00351 , A61B2018/00577 , A61B2018/00642 , A61B2018/00654 , A61B2018/00672 , A61B2018/00708 , A61B2018/00875 , A61B2018/00898 , A61B2018/1435
摘要： A method and system for detecting a short circuit during a radiofrequency ablation procedure. The method includes measuring an impedance of a pair of electrodes coupled to a treatment assembly of a medical device. Radiofrequency ablation energy is transmitted between the pair of electrodes. The transmission of radiofrequency ablation energy between the pair of electrodes is terminated when after a predetermined period of time the measured impedance in either of the electrodes in the pair of electrodes is below a predetermined threshold impedance value. An alert is generated indicating a short circuit between the pair of electrodes.
摘要翻译：一种用于在射频消融过程中检测短路的方法和系统。该方法包括测量耦合到医疗装置的治疗组件的一对电极的阻抗。射频消融能量在一对电极之间传输。当在一对电极中的任一个电极中的测量阻抗低于预定阈值阻抗值的预定时间段之后，终止一对电极之间的射频消融能量的传输。产生指示该对电极之间的短路的警报。

7. 发明授权

US09044245B2 Multipolarity epicardial radiofrequency ablation 有权
标题翻译：多极性心外膜射频消融
公开(公告)号：US09044245B2
公开(公告)日：2015-06-02
申请号：US12984675
申请日：2011-01-05
申请人： Catherine R. Condie , Sarah E. Ahlberg
发明人： Catherine R. Condie , Sarah E. Ahlberg
IPC分类号： A61B18/18 , A61B18/14 , A61B18/00
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00267 , A61B2018/00363 , A61B2018/00577 , A61B2018/00821 , A61B2018/1407 , A61B2018/1467 , A61B2218/002
摘要： A method of ablating an epicardial tissue region, including positioning a medical device adjacent the epicardial tissue region, the medical device having a first electrode, a second electrode, and a third electrode located in between the first and second electrodes; delivering an irrigation fluid to the tissue region; and ablating at least a portion of the tissue region by sequentially activating the third electrode in a monopolar radiofrequency delivery mode and activating the first and second electrodes in a bipolar radiofrequency delivery mode.
摘要翻译：一种消融心外膜组织区域的方法，包括定位邻近心外膜组织区域的医疗装置，所述医疗装置具有位于第一和第二电极之间的第一电极，第二电极和第三电极; 向组织区域输送冲洗流体; 以及通过以单极射频递送模式顺序启动所述第三电极并且以双极射频递送模式激活所述第一和第二电极，从而消融所述组织区域的至少一部分。

8. 发明授权

US5902325A Method and apparatus for detecting cardiac capture 失效
标题翻译：用于检测心脏捕获的方法和装置
公开(公告)号：US5902325A
公开(公告)日：1999-05-11
申请号：US126469
申请日：1998-07-30
申请人： Catherine R. Condie , Daniel J. Baxter , William J. Combs , Daniel J. Greeninger , Karen J. Kleckner , H. Toby Markowitz , John C. Stroebel , John D. Wahlstrand
发明人： Catherine R. Condie , Daniel J. Baxter , William J. Combs , Daniel J. Greeninger , Karen J. Kleckner , H. Toby Markowitz , John C. Stroebel , John D. Wahlstrand
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/36521 , A61N1/3712 , A61N1/3714
摘要： A method and apparatus for automatic determination of a pacemaker patient's pacing stimulation threshold. Circuitry is provided in a pacemaker for obtaining a signal reflecting cardiac impedance, which is known to reliably reflect certain aspects of cardiac function. Circuitry is also provided for monitoring the cardiac impedance waveform during a predetermined capture detect window following delivery of stimulating pulses. One or more values are derived which characterize the morphology of the impedance waveform during the capture detect window associated with each stimulation pulse delivered. These values are compared to predetermined control values in order to assess whether a stimulation pulse has achieved cardiac capture. The assessment of whether cardiac capture has been achieved is also based partly upon the conventional sensing of atrial and/or ventricular cardiac signals occurring during the capture detect window. In one embodiment of the invention, the control values against which impedance waveform characterization values are compared are obtained by delivering a series of stimulation pulses having sufficient energy to ensure that capture is achieved, and by monitoring the impedance waveform during delivery of these pulses.
摘要翻译：一种用于自动确定起搏器患者起搏刺激阈值的方法和装置。在起搏器中提供电路以获得反映心脏阻抗的信号，这已知可靠地反映心脏功能的某些方面。还提供电路用于在传送刺激脉冲之后的预定捕获检测窗口期间监测心脏阻抗波形。导出一个或多个值，其表征在与递送的每个刺激脉冲相关联的捕获检测窗口期间阻抗波形的形态。将这些值与预定的控制值进行比较，以便评估刺激脉冲是否已经实现心脏捕获。是否已经实现心脏捕获的评估也部分地基于在捕获检测窗口期间发生的心房和/或心室心脏信号的常规感测。在本发明的一个实施例中，通过递送具有足够能量的一系列刺激脉冲来确定阻抗波形表征值被比较的控制值，以确保实现捕获，并且通过在传送这些脉冲期间监视阻抗波形来获得。

9. 发明申请

US20120209127A1 METHOD AND APPARATUS TO DETECT AND MONITOR THE FREQUENCY OF OBSTRUCTIVE SLEEP APNEA 有权
标题翻译：检测和监测阻塞性睡眠呼吸暂停频率的方法和装置
公开(公告)号：US20120209127A1
公开(公告)日：2012-08-16
申请号：US13456568
申请日：2012-04-26
申请人： Donald N. Jensen , Catherine R. Condie , Yong K. Cho
发明人： Donald N. Jensen , Catherine R. Condie , Yong K. Cho
IPC分类号： A61B5/0205 , A61B5/0464
CPC分类号： A61B5/0538 , A61B5/04 , A61B5/0809 , A61B5/1118 , A61B5/4818
摘要： The present invention provides a method and apparatus for detecting and monitoring obstructive sleep apnea. The apparatus measures sinus tachycardia and a change in the atrial-ventricular conduction, and includes a controller for receiving the measurement of the sinus tachycardia and the change in the atrial-ventricular conduction to detect obstructive sleep apnea based upon the sinus tachycardia and the change in the atrial-ventricular conduction.
摘要翻译：本发明提供一种用于检测和监测阻塞性睡眠呼吸暂停的方法和装置。该装置测量窦性心动过速和心房 - 心室传导的变化，并且包括用于接收窦性心动过速的测量和心房 - 心室传导的变化的控制器，以基于窦性心动过速和变化来检测阻塞性睡眠呼吸暂停心房传导。

10. 发明授权

US08187200B2 Method and apparatus to detect and monitor the frequency of obstructive sleep apnea 有权
标题翻译：检测和监测阻塞性睡眠呼吸暂停频率的方法和装置
公开(公告)号：US08187200B2
公开(公告)日：2012-05-29
申请号：US12369899
申请日：2009-02-12
申请人： Donald N. Jensen , Catherine R. Condie , Yong Kyun Cho
发明人： Donald N. Jensen , Catherine R. Condie , Yong Kyun Cho
IPC分类号： A61B5/085
CPC分类号： A61B5/0538 , A61B5/04 , A61B5/0809 , A61B5/1118 , A61B5/4818
摘要： The present invention provides a method and apparatus for detecting and monitoring obstructive sleep apnea. The apparatus includes an intracardiac impedance sensor to measure intracardiac impedance, a movement sensor to measure an amount of movement of a patient, and a controller operatively coupled to said intracardiac impedance sensor and said movement sensor, said controller adapted to receive at least one of an intracardiac impedance and the amount of movement of the patient and detect obstructive sleep apnea based upon said intracardiac impedance and said movement.
摘要翻译：本发明提供一种用于检测和监测阻塞性睡眠呼吸暂停的方法和装置。该装置包括用于测量心内阻抗的心内阻抗传感器，用于测量患者的移动量的运动传感器以及可操作地耦合到所述心内阻抗传感器和所述运动传感器的控制器，所述控制器适于接收至少一个心内阻抗和患者的运动量，并且基于所述心内阻塞和所述移动来检测阻塞性睡眠呼吸暂停。

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