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1. 发明申请

US20080293696A1 2-Aminoarylcarboxamides Useful as Cancer Chemotherapeutic Agents 审中-公开
标题翻译：用作癌症化学治疗剂的2-氨基芳基羧酰胺
公开(公告)号：US20080293696A1
公开(公告)日：2008-11-27
申请号：US11630850
申请日：2005-06-23
申请人： Catherine Brennan , Julie A. Dixon , William J. Scott , Aniko Redman , Benjamin D. Jones , Barton Phillips , Philip Wickens , Istvan Enyedy , Ellalahewage Kumarasinghe , Charles Kreiman , Jacques Dumas , Uday Khire , Chih-Yuan Chuang , Harold C.E. Kluender , Zhenqiu Hong , Lei Wang , Donald Bierer
发明人： Catherine Brennan , Julie A. Dixon , William J. Scott , Aniko Redman , Benjamin D. Jones , Barton Phillips , Philip Wickens , Istvan Enyedy , Ellalahewage Kumarasinghe , Charles Kreiman , Jacques Dumas , Uday Khire , Chih-Yuan Chuang , Harold C.E. Kluender , Zhenqiu Hong , Lei Wang , Donald Bierer
IPC分类号： A61K31/55 , C07D405/12 , A61K31/4433 , A61K31/444 , A61P35/00 , C07D405/14 , A61K31/506
CPC分类号： C07D319/08
摘要： A compound having the formula (1) in which the ring containing E is a phenyl, a pyridine, or a pyrimidine. In formula (1) the symbol A represents wherein the group R4 represents halogen, CF3, or H, provided that the maximum number of CF3 groups on any A is 2, and the maximum number of hydrogens on A is 2 for the A groups which together with the carbon atoms to which they are attached form 6-membered rings, and the maximum number of hydrogens on A is 1 for the A group which together with the carbon atoms to which it is attached forms a 5-membered ring. Z represents N or CH when E forms a phenyl ring, and represents CH when E forms a pyridine or pyrimidine. The groups R1, R2 and R3 and the subscripts a, b, and d are as defined in the text and claims. Pharmaceutical compositions containing a compound of formula (1) and methods of treating cancer using compounds of formula (1) are also disclosed and claimed.
摘要翻译：具有式（1）的化合物，其中含有E的环是苯基，吡啶或嘧啶。在式（1）中，符号A表示其中基团R 4表示卤素，CF 3或H，条件是任何A上的CF 3基团的最大数目为2，并且A组中的最大氢数为2，与它们连接的碳原子一起形成6元环，并且对于与连接的碳原子一起形成5元环的A基团，A上的最大氢数为1。当E形成苯环时，Z表示N或CH，当E形成吡啶或嘧啶时，Z表示CH。基团R1，R2和R3以及下标a，b和d如本文和权利要求中所定义。还公开并要求保护含有式（1）化合物的药物组合物和使用式（1）化合物治疗癌症的方法。

2. 发明授权

US08143393B2 Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis 有权
公开(公告)号：US08143393B2
公开(公告)日：2012-03-27
申请号：US12085880
申请日：2006-12-01
申请人： Julie A. Dixon , Barton Phillips , Furahi Achebe , Harold C. E. Kluender , Jason Newcom , Kyle Parcella , Steven Magnuson , Zhenqiu Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler , Stephen O'Connor
发明人： Julie A. Dixon , Barton Phillips , Furahi Achebe , Harold C. E. Kluender , Jason Newcom , Kyle Parcella , Steven Magnuson , Zhenqiu Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler , Stephen O'Connor
IPC分类号： C07D487/04 , C07D417/02 , C07D413/02 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.

3. 发明授权

US08129379B2 Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis 有权
标题翻译：用于治疗高增殖性疾病和与血管发生相关的疾病的取代的4-氨基吡咯并三嗪衍生物
公开(公告)号：US08129379B2
公开(公告)日：2012-03-06
申请号：US12552923
申请日：2009-09-02
申请人： Julie A. Dixon , Barton Phillips , Furahi Achebe , Harold C. E. Kluender , Jason Newcom , Kyle Parcella , Steven Magnuson , Zhenqiu Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler , Stephen O'Connor
发明人： Julie A. Dixon , Barton Phillips , Furahi Achebe , Harold C. E. Kluender , Jason Newcom , Kyle Parcella , Steven Magnuson , Zhenqiu Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler , Stephen O'Connor
IPC分类号： A61K31/53 , A61P35/00 , C07D487/04 , C07D417/02 , C07D413/02
CPC分类号： C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要翻译：本发明涉及新颖的吡咯并三嗪化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用于治疗高增殖和/或血管生成障碍，作为唯一试剂或与其它活性成分组合的用途。

4. 发明申请

US20100179125A1 SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS 有权
标题翻译：取代的4-氨基吡咯烷酮衍生物有助于治疗与增殖性疾病有关的高血压病和疾病
公开(公告)号：US20100179125A1
公开(公告)日：2010-07-15
申请号：US12552923
申请日：2009-09-02
申请人： Julie A. Dixon , Barton Phillips , Furahi Achebe , Harold C. E. Kluender , Jason Newcom , Kyle Parcella , Steven Magnuson , Zhenqiu Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler , Stephen O'Connor
发明人： Julie A. Dixon , Barton Phillips , Furahi Achebe , Harold C. E. Kluender , Jason Newcom , Kyle Parcella , Steven Magnuson , Zhenqiu Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler , Stephen O'Connor
IPC分类号： A61K31/53 , C07D487/04 , A61K31/5377 , A61K31/541 , A61K31/553 , A61P35/00 , C12N5/00
CPC分类号： C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要翻译：本发明涉及新颖的吡咯并三嗪化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用于治疗高增殖和/或血管生成障碍，作为唯一试剂或与其它活性成分组合的用途。

5. 发明申请

US20120165314A1 SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS 有权
标题翻译：取代的4-氨基吡咯烷酮衍生物有助于治疗与增殖性疾病有关的高血压病和疾病
公开(公告)号：US20120165314A1
公开(公告)日：2012-06-28
申请号：US13414392
申请日：2012-03-07
申请人： Julie Dixon , Barton Phillips , Yamin Wang , Tindy Li , Kyle Parcella , Jason Newcom , Harold C.E. Kluender , Zhenqiu Hong , Brent Chandler , Zhonghua Zhang , Steven Magnuson , Kristen M. Allegue , Zheng Liu
发明人： Julie Dixon , Barton Phillips , Yamin Wang , Tindy Li , Kyle Parcella , Jason Newcom , Harold C.E. Kluender , Zhenqiu Hong , Brent Chandler , Zhonghua Zhang , Steven Magnuson , Kristen M. Allegue , Zheng Liu
IPC分类号： A61K31/53 , A61P35/00 , A61K31/541 , A61K31/553 , C07D487/04 , A61K31/5377
CPC分类号： C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译：本发明涉及新颖的吡唑并三嗪化合物，含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性障碍和疾病的用途。

6. 发明授权

US08829185B2 Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis 有权
标题翻译：用于治疗高增殖性疾病和与血管发生相关的疾病的取代的4-氨基吡咯并三嗪衍生物
公开(公告)号：US08829185B2
公开(公告)日：2014-09-09
申请号：US13414392
申请日：2012-03-07
申请人： Julie A. Dixon , Steven Magnuson , Barton Phillips , Yamin Wang , Tindy Li , Kyle Parcella , Jason Newcom , Harold C. E. Kluender , Zhenqiu Hong , Brent Chandler , Zhonghua Zhang , Kristen M. Allegue , Zhen Liu
发明人： Julie A. Dixon , Steven Magnuson , Barton Phillips , Yamin Wang , Tindy Li , Kyle Parcella , Jason Newcom , Harold C. E. Kluender , Zhenqiu Hong , Brent Chandler , Zhonghua Zhang , Kristen M. Allegue , Zhen Liu
IPC分类号： C07D487/04 , C07D417/02 , C07D413/02 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译：本发明涉及新颖的吡唑并三嗪化合物，含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性障碍和疾病的用途。

7. 发明申请

US20090281079A1 Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated With Angiogenesis 有权
标题翻译：用于治疗与血管发生相关的超增殖性疾病和疾病的替代的4-氨基 - 吡咯并嗪衍生物
公开(公告)号：US20090281079A1
公开(公告)日：2009-11-12
申请号：US12085879
申请日：2006-11-30
申请人： Julie Dixon , Steven Magnuson , Barton Phillips , Yamin Wang , Tandy Li , Kyle Parcella , Jason Newcom , Harold Kluender , Zhenqiu Hong , Brent Chandler , Zhonghua Zhang , Kristen Allegue , Zheng Liu
发明人： Julie Dixon , Steven Magnuson , Barton Phillips , Yamin Wang , Tandy Li , Kyle Parcella , Jason Newcom , Harold Kluender , Zhenqiu Hong , Brent Chandler , Zhonghua Zhang , Kristen Allegue , Zheng Liu
IPC分类号： A61K31/553 , C07D487/04 , A61K31/53 , A61K31/5377 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译：本发明涉及新颖的吡唑并三嗪化合物，含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性障碍和疾病的用途。

8. 发明授权

US08133995B2 Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis 有权
标题翻译：用于治疗高增殖性疾病和与血管发生相关的疾病的取代的4-氨基吡咯并三嗪衍生物
公开(公告)号：US08133995B2
公开(公告)日：2012-03-13
申请号：US12085879
申请日：2006-11-30
申请人： Julie Dixon , Steven Magnuson , Barton Phillips , Yamin Wang , Tandy Li , Kyle Parcella , Jason Newcom , Harold Kluender , Zhenqiu Hong , Brent Chandler , Zhonghua Zhang , Kristen Allegue , Zheng Liu
发明人： Julie Dixon , Steven Magnuson , Barton Phillips , Yamin Wang , Tandy Li , Kyle Parcella , Jason Newcom , Harold Kluender , Zhenqiu Hong , Brent Chandler , Zhonghua Zhang , Kristen Allegue , Zheng Liu
IPC分类号： C07D487/04 , C07D417/02 , C07D413/02 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译：本发明涉及新颖的吡唑并三嗪化合物，含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性障碍和疾病的用途。

9. 发明授权

US08415367B2 Pyrimidinylpiperidinyloxypyridinone analogues as GPR119 modulators 有权
标题翻译：嘧啶基哌啶氧基吡啶酮类似物作为GPR119调节剂
公开(公告)号：US08415367B2
公开(公告)日：2013-04-09
申请号：US13080758
申请日：2011-04-06
申请人： Dean Wacker , Stephen O'Connor , Zhenqiu Hong
发明人： Dean Wacker , Stephen O'Connor , Zhenqiu Hong
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D401/14
摘要： Novel compounds of structure Formula I: or an enantiomer, a diastereomer, or a pharmaceutically acceptable salt thereof, wherein n1, R1, R2, R3 and R4 are defined herein, are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR119 G protein-coupled receptor modulator therapy. Thus, the disclosure also concerns compositions comprising these novel compounds and methods of treating diseases or conditions related to the activity of the GPR119 G protein-coupled receptor by using any of these novel compounds or a composition comprising any of such novel compounds.
摘要翻译：提供结构式I的新型化合物或其对映异构体，非对映异构体或其药学上可接受的盐，其中n1，R1，R2，R3和R4如本文所定义，其是GPR119G蛋白偶联受体调节剂。 GPR119 G蛋白偶联受体调节剂可用于治疗，预防或减缓需要GPR119 G蛋白偶联受体调节剂治疗的疾病进展。因此，本公开还涉及包含这些新化合物的组合物以及通过使用任何这些新化合物或包含任何这些新化合物的组合物来治疗与GPR119G蛋白偶联受体的活性有关的疾病或病症的方法。

10. 发明申请

US20110251221A1 PYRIMIDINYLPIPERIDINYLOXYPYRIDINONE ANALOGUES AS GPR119 MODULATORS 有权
标题翻译： PYRIMIDINYLPIPERIDINYLOXYPYRIDINONE ANALOGUES作为GPR119调制器
公开(公告)号：US20110251221A1
公开(公告)日：2011-10-13
申请号：US13080758
申请日：2011-04-06
申请人： Dean Wacker , Stephen O'Connor , Zhenqiu Hong
发明人： Dean Wacker , Stephen O'Connor , Zhenqiu Hong
IPC分类号： A61K31/506 , A61P3/06 , A61P3/10 , C07D401/14
CPC分类号： C07D401/14
摘要： Novel compounds of structure Formula I: or an enantiomer, a diastereomer, or a pharmaceutically acceptable salt thereof, wherein n1, R1, R2, R3 and R4 are defined herein, are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR119 G protein-coupled receptor modulator therapy. Thus, the disclosure also concerns compositions comprising these novel compounds and methods of treating diseases or conditions related to the activity of the GPR119 G protein-coupled receptor by using any of these novel compounds or a composition comprising any of such novel compounds.
摘要翻译：提供结构式I的新型化合物或其对映异构体，非对映异构体或其药学上可接受的盐，其中n1，R1，R2，R3和R4如本文所定义，其是GPR119G蛋白偶联受体调节剂。 GPR119 G蛋白偶联受体调节剂可用于治疗，预防或减缓需要GPR119 G蛋白偶联受体调节剂治疗的疾病进展。因此，本公开还涉及包含这些新化合物的组合物以及通过使用任何这些新化合物或包含任何这些新化合物的组合物来治疗与GPR119G蛋白偶联受体的活性有关的疾病或病症的方法。

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