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1. 发明授权

US09815842B2 Pyrazolo pyrimidine derivatives and their use as MALT1 inhibitors 有权
公开(公告)号：US09815842B2
公开(公告)日：2017-11-14
申请号：US15312321
申请日：2015-05-27
申请人： Carole Pissot Soldermann , Jean Quancard , Achim Schlapbach , Oliver Simic , Marina Tintelnot-Blomley , Thomas Zoller
发明人： Carole Pissot Soldermann , Jean Quancard , Achim Schlapbach , Oliver Simic , Marina Tintelnot-Blomley , Thomas Zoller
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61P35/00 , A61P29/00 , A61P9/00 , A61P35/02 , A61P35/04 , A61P19/02 , A61P11/06 , A61P11/08 , A61P9/08 , A61P11/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377
摘要： The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.

2. 发明申请

US20170121335A1 NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES AND THEIR USE AS MALT1 INHBITORS 有权
公开(公告)号：US20170121335A1
公开(公告)日：2017-05-04
申请号：US15312321
申请日：2015-05-27
申请人： Carole Pissot Soldermann , Jean Quancard , Achim Schlapbach , Oliver Simic , Marina Tintelnot-Bromley , Thomas Zoller
发明人： Carole Pissot Soldermann , Jean Quancard , Achim Schlapbach , Oliver Simic , Marina Tintelnot-Bromley , Thomas Zoller
IPC分类号： C07D487/04 , A61K31/5377 , A61K31/519
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377
摘要： The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.

3. 发明申请

US20100029636A1 Lck inhibitors 审中-公开
标题翻译： Lck抑制剂
公开(公告)号：US20100029636A1
公开(公告)日：2010-02-04
申请号：US12443229
申请日：2007-09-26
申请人： Peter Buehlmayer , Werner Breitenstein , Pascal Furet , Bernard Pirard , Anette von Matt , Thomas Zoller
发明人： Peter Buehlmayer , Werner Breitenstein , Pascal Furet , Bernard Pirard , Anette von Matt , Thomas Zoller
IPC分类号： A61K31/5377 , C07D487/04 , A61K31/4985 , C07D413/14 , A61P29/00
CPC分类号： C07D487/04
摘要： The invention relates to novel pyrazolo[1,5-A]pyrimidine compounds of Formula I in which all the variables are as defined in the specification; to their preparation and to their use as Lck kinase inhibitors.
摘要翻译：本发明涉及其中所有变量如说明书中所定义的式I的新型吡唑并[1,5-A]嘧啶化合物。用于制备和用作Lck激酶抑制剂。

4. 发明授权

US06412533B1 High transverse-curvature tire for two-wheeled vehicles including specified belt structure 有权
标题翻译：用于两轮车辆的高横向轮胎，包括特定的皮带结构
公开(公告)号：US06412533B1
公开(公告)日：2002-07-02
申请号：US09217912
申请日：1998-12-22
申请人： Giancarlo Armellin , Peter Kronthaler , Thomas Zoller
发明人： Giancarlo Armellin , Peter Kronthaler , Thomas Zoller
IPC分类号： B60C100
CPC分类号： B60C9/06 , B60C9/12 , B60C9/14 , B60C9/18 , B60C9/1821 , B60C9/2204 , B60C2009/1878 , B60C2009/2271 , B60C2200/10 , Y10T152/10513 , Y10T152/10864 , Y10T152/10873
摘要： A high transverse-curvature tire for two-wheeled vehicles includes a carcass structure, a belt structure, and a tread. The carcass structure includes at least two superimposed plies provided with reinforcing cords. The belt structure includes radially-outer and radially-inner layers. The reinforcing cords of each ply are essentially parallel to other reinforcing cords of that ply and are oriented along directions inclined with respect to an equatorial plane of the tire. The reinforcing cords of at least two adjacent superimposed plies are oriented in opposite directions with respect to the equatorial plane of the tire. The carcass structure includes at least one first sheet, located between the at least two superimposed plies, made of an elastomeric material incorporating fibrous reinforcing fillers. The radially-inner layer includes at least one second sheet made of an elastomeric material incorporating fibrous reinforcing fillers.
摘要翻译：用于两轮车辆的高横曲率轮胎包括胎体结构，带结构和胎面。胎体结构包括至少两个具有加强帘线的重叠帘布层。皮带结构包括径向外部和径向内层。每个帘布层的加强帘线基本上平行于该帘布层的其它加强帘线，并且沿着相对于轮胎的赤道平面倾斜的方向定向。至少两个相邻重叠层的加强帘线相对于轮胎的赤道平面在相反的方向上取向。胎体结构包括位于至少两个重叠层之间的至少一个第一片，由包含纤维增强填料的弹性体材料制成。径向内层包括由包含纤维增强填料的弹性体材料制成的至少一个第二片。

5. 发明申请

US20100099682A1 ACETYLENE DERIVATIVES 审中-公开
标题翻译：乙烯衍生物
公开(公告)号：US20100099682A1
公开(公告)日：2010-04-22
申请号：US12561390
申请日：2009-09-17
申请人： Ralf GLATTHAR , Thomas J. Troxler , Thomas Zoller , Joachim Nozulak
发明人： Ralf GLATTHAR , Thomas J. Troxler , Thomas Zoller , Joachim Nozulak
IPC分类号： A61K31/498 , C07D241/36 , A61K31/44 , C07D213/00 , C07D307/02 , A61K31/34 , A61K31/36 , C07D261/20 , C07D263/52 , C07C233/00 , A61K31/16 , A61K31/4196 , C07D249/08
CPC分类号： C07C235/54 , C07C233/22 , C07C233/23 , C07C233/74 , C07C235/14 , C07C235/36 , C07C235/78 , C07C237/38 , C07C317/44 , C07D233/90 , C07D249/08 , C07D249/10 , C07D307/68
摘要： The invention provides compounds of formula (I) wherein R1 represents hydrogen or alkyl; R2 represents an unsubstituted or substituted heterocycle or R2 represents an unsubstituted or substituted aryl; R3 represents alkyl or halogen; X represents a single bond or an alkandiyl-group, optionally interrupted by one or more oxygen atoms or carbonyl groups or carbonyloxy groups in free base or acid addition salt form, processes for their preparation and their use as pharmaceuticals.
摘要翻译：本发明提供式（I）化合物，其中R 1表示氢或烷基; R2表示未取代或取代的杂环，或者R2表示未取代或取代的芳基; R3表示烷基或卤素; X代表单键或烷二基，任选地被一个或多个氧原子或游离碱或酸加成盐形式的羰基或羰基氧基中断，其制备及其用作药物。

6. 发明申请

US20080269250A1 Pyrrolidine and Piperidine Acetylene Derivatives for Use as Mglur5 Antagonists 审中-公开
标题翻译：吡咯烷和哌啶乙炔衍生物，用作Mglur5拮抗剂
公开(公告)号：US20080269250A1
公开(公告)日：2008-10-30
申请号：US11816853
申请日：2006-02-20
申请人： Ralf Glatthar , Thomas J. Troxler , Thomas Zoller , Joachim Nozulak
发明人： Ralf Glatthar , Thomas J. Troxler , Thomas Zoller , Joachim Nozulak
IPC分类号： A61K31/497 , C07D405/02 , A61K31/4525 , C07D401/02 , A61K31/4545 , C07D401/04 , A61K31/444 , C07D403/02
CPC分类号： C07D471/04 , C07D211/48 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D413/06
摘要： The invention provides compounds of formula (I) wherein the substituents are as defined in the description, processes and intermediates for their preparation and their use as pharmaceuticals.
摘要翻译：本发明提供了式（I）化合物，其中取代基如本说明书中所定义，其制备方法和中间体及其作为药物的用途。

7. 发明申请

US20080214673A1 Acetylene Derivatives 失效
标题翻译：乙炔衍生物
公开(公告)号：US20080214673A1
公开(公告)日：2008-09-04
申请号：US11912626
申请日：2006-04-24
申请人： Ralf Glatthar , Thomas J. Troxler , Thomas Zoller , Joachim Nozulak
发明人： Ralf Glatthar , Thomas J. Troxler , Thomas Zoller , Joachim Nozulak
IPC分类号： A61K31/167 , C07C233/00 , A61P25/00
CPC分类号： C07C235/54 , C07C233/22 , C07C233/23 , C07C233/74 , C07C235/14 , C07C235/36 , C07C235/78 , C07C237/38 , C07C317/44 , C07D233/90 , C07D249/08 , C07D249/10 , C07D307/68
摘要： The invention provides compounds of formula (I) wherein R1 represents hydrogen or alkyl; R2 represents an unsubstituted or substituted heterocycle or R2 represents an unsubstituted or substituted aryl; R3 represents alkyl or halogen; X represents a single bond or an alkandiyl-group, optionally interrupted by one or more oxygen atoms or carbonyl groups or carbonyloxy groups in free base or acid addition salt form, processes for their preparation and their use as pharmaceuticals.
摘要翻译：本发明提供式（I）化合物，其中R 1表示氢或烷基; R 2表示未取代或取代的杂环，或者R 2表示未取代或取代的芳基; R 3表示烷基或卤素; X代表单键或烷二基，任选地被一个或多个氧原子或游离碱或酸加成盐形式的羰基或羰基氧基中断，其制备及其用作药物。

8. 发明授权

US06699343B2 Method of manufacturing a high transverse-curvature motor-bike tire 失效
标题翻译：制造高横曲率自行车轮胎的方法
公开(公告)号：US06699343B2
公开(公告)日：2004-03-02
申请号：US10119842
申请日：2002-04-11
申请人： Giancarlo Armellin , Peter Kronthaler , Thomas Zoller
发明人： Giancarlo Armellin , Peter Kronthaler , Thomas Zoller
IPC分类号： B29D3008
CPC分类号： B60C9/1821 , B60C9/12 , B60C9/14 , B60C9/18 , B60C9/2204 , B60C2009/2271 , Y10T152/10513 , Y10T152/10783
摘要： A method of manufacturing a high transverse-curvature motor-bike tire includes the steps of providing a carcass structure on a main assembly drum, providing at least one strip made of an elastomeric material incorporating a plurality of reinforcing cords on a comb-like drum, radially expanding radially-mobile sectors associated with the drum, circumferentially winding at least one inextensible cord on the at least one strip to form circumferential coils and to define a belt structure, circumferentially associating a tread around the belt structure, and associating the belt structure, together with the tread, around the carcass structure. The at least one cord is wound on the at least one strip at a substantially-null angle with respect to the equatorial plane of the drum according to a winding direction adapted to compression-stress, at least during initial winding, elastomeric material portions interposed between consecutive reinforcing cords incorporated in the at least one strip.
摘要翻译：制造高横曲率摩托车自行车轮胎的方法包括以下步骤：在主组件滚筒上设置胎体结构，在梳状滚筒上提供由弹性体材料制成的弹性体材料制成的至少一个条带，与鼓相关联的径向扩张的可径向移动的扇区，在至少一个条上周向缠绕至少一个不可延伸的绳索，以形成周向线圈并且限定带结构，使胎面围绕带结构周向地相关联，以及将带结构，与胎面一起，围绕胴体结构。根据适于压缩应力的卷绕方向，至少一条绳索相对于滚筒的赤道面以基本上为零的角度卷绕在至少一个条上，至少在初始卷绕期间，介于连续的增强帘线结合在至少一个条带中。

9. 发明授权

US06691755B2 High transverse-curvature tire for two-wheeled vehicles including specified belt structure 有权
标题翻译：用于两轮车辆的高横向轮胎，包括特定的皮带结构
公开(公告)号：US06691755B2
公开(公告)日：2004-02-17
申请号：US10162746
申请日：2002-06-06
申请人： Giancarlo Armellin , Peter Kronthaler , Thomas Zoller
发明人： Giancarlo Armellin , Peter Kronthaler , Thomas Zoller
IPC分类号： B60C100
CPC分类号： B60C9/06 , B60C9/12 , B60C9/14 , B60C9/18 , B60C9/1821 , B60C9/2204 , B60C2009/1878 , B60C2009/2271 , B60C2200/10 , Y10T152/10513 , Y10T152/10864 , Y10T152/10873
摘要： A high transverse-curvature tire for two-wheeled vehicles includes a carcass structure, a belt structure, and tread. The carcass structure includes at least two superimposed plies provided with reinforcing cords. The belt structure includes radially-outer and radially-inner layers. Each ply's reinforcing cords are essentially parallel to other reinforcing cords of that ply and are oriented along directions inclined with respect to an equatorial plane of the tire. The reinforcing cords of at least two adjacent plies are oriented in opposite directions with respect to the equatorial plane. The carcass structure includes at least one first sheet, located between the at least two plies, made of an elastomeric material incorporating fibrous reinforcing fillers. The plurality of circumferential coils are distributed with a constant density throughout an axial development of the belt structure. The radially-inner layer includes at least one second sheet made of an elastomeric material incorporating fibrous reinforcing fillers.
摘要翻译：用于两轮车辆的高横曲率轮胎包括胎体结构，带结构和胎面。胎体结构包括至少两个具有加强帘线的重叠帘布层。皮带结构包括径向外部和径向内层。每个帘布层的加强帘线基本上平行于该帘布层的其它加强帘线，并且沿着相对于轮胎的赤道平面倾斜的方向定向。至少两个相邻层的加强帘线相对于赤道面相反的方向定向。胎体结构包括位于至少两层之间的至少一个第一片，其由包含纤维增强填料的弹性体材料制成。多个周向线圈在带结构的整个轴向展开期间以恒定的密度分布。径向内层包括由包含纤维增强填料的弹性体材料制成的至少一个第二片。

10. 发明授权

US06397911B1 High transverse-curvature motor-bike tire 失效
标题翻译：高横弯自行车轮胎
公开(公告)号：US06397911B1
公开(公告)日：2002-06-04
申请号：US09218362
申请日：1998-12-22
申请人： Giancarlo Armellin , Peter Kronthaler , Thomas Zoller
发明人： Giancarlo Armellin , Peter Kronthaler , Thomas Zoller
IPC分类号： B60C100
CPC分类号： B60C9/1821 , B60C9/12 , B60C9/14 , B60C9/18 , B60C9/2204 , B60C2009/2271 , Y10T152/10513 , Y10T152/10783
摘要： A high transverse-curvature tire for two wheeled-vehicles comprises a carcass structure, a belt structure including radially-inner and radially-outer layers, and a tread. The radially-inner layer comprises at least one strip made of an elastomeric material incorporating a plurality of reinforcing cords essentially parallel to one another and oriented along directions inclined with respect to the equatorial plane of the tire. The radially-outer layer includes a plurality of circumferential coils, axially arranged side-by-side, of at least one circumferentially-inextensible cord wound at a substantially null angle with respect to the equatorial plane of the tire according to a winding direction adapted to compression-stress elastomeric material portions interposed between consecutive reinforcing cords incorporated in the at least one strip of the radially-inner layer.
摘要翻译：用于两轮车辆的高横曲率轮胎包括胎体结构，包括径向内径和径向外层的带结构和胎面。径向内层包括由弹性体材料制成的至少一个带，该弹性体材料包括基本上彼此平行并且相对于轮胎的赤道平面倾斜的方向定向的多个加强帘线。径向外层包括沿轴向方向并排布置的至少一个沿圆周不可伸展的帘线的多个圆周线圈，其相对于轮胎的赤道平面基本上为空角，根据适于压缩应力弹性体材料部分介于连接在径向内层的至少一个条带中的连续增强帘线之间。

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