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1. 发明授权

US06241751B1 Defibrillator with impedance-compensated energy delivery 有权
标题翻译：具有阻抗补偿能量输送的除颤器
公开(公告)号：US06241751B1
公开(公告)日：2001-06-05
申请号：US09299455
申请日：1999-04-22
申请人： Carlton B. Morgan , Bradford E. Gliner , Kent W. Leyde , Thomas D. Lyster
发明人： Carlton B. Morgan , Bradford E. Gliner , Kent W. Leyde , Thomas D. Lyster
IPC分类号： A61N139
CPC分类号： A61N1/3943 , A61N1/39
摘要： A defibrillator having an energy storage capacitor network with multiple configurations selected according to patient impedance and desired energy level for delivery of an impedance-compensated defibrillation pulse is provided. The set of configurations may include series, parallel, and series/parallel combinations of energy storage capacitors within the energy storage capacitor network. The impedance-compensated defibrillation pulse may be delivered over an expanded range of energy levels while limiting the peak current to levels that are safe for the patient using configurations tailored for lower impedance patients and limiting the range of defibrillation pulse durations and providing adequate current levels for higher impedance patients. Configurations of the energy storage capacitor network may be readily added to extend the range of energy levels well above 200 joules.
摘要翻译：提供一种除颤器，其具有根据患者阻抗选择的多种配置的能量存储电容器网络和用于递送阻抗补偿除颤脉冲的期望能量水平。该组配置可以包括能量存储电容器网络内的能量存储电容器的串联，并联和串联/并联组合。阻抗补偿的除颤脉冲可以在能量水平的扩展范围内递送，同时将峰值电流限制到对于患者使用适合于较低阻抗患者的配置的安全性的水平，并且限制除颤脉冲持续时间的范围并提供足够的电流水平阻力较高的患者。可以容易地添加能量存储电容器网络的配置以扩展远高于200焦耳的能量范围。

2. 发明授权

US06374137B1 Method and apparatus for reducing defibrillation energy 失效
标题翻译：降低除颤能量的方法和装置
公开(公告)号：US06374137B1
公开(公告)日：2002-04-16
申请号：US09417269
申请日：1999-10-13
申请人： Carlton B. Morgan , Bradford E. Gliner , Dawn Jorgenson , Kent W. Leyde
发明人： Carlton B. Morgan , Bradford E. Gliner , Dawn Jorgenson , Kent W. Leyde
IPC分类号： A61N139
CPC分类号： A61N1/3937 , A61N1/3931
摘要： An energy reduction unit is removably connectable to an external defibrillator to reduce the defibrillation energy delivered by the defibrillator to a patient. Use of the energy reduction unit is particularly suited to defibrillating pediatric patients (infants and children under 8) with an automatic or semi-automatic external defibrillator (AED). In one embodiment, the energy reduction unit includes an attenuator which partially dissipates energy produced by the AED. The attenuator is advantageously designed to present an impedance to the AED which, when connected to the patient, is approximately equal to the patient's impedance. The energy reduction unit may include a presence-detect function which enables the defibrillator to modify analysis of ECG signals to account for differences heart rhythms of pediatric and adult patients. In a second embodiment, the energy reduction unit includes an energy control modifier circuit which affects the charging operations performed internal to the AED. Other than being attached to the defibrillation equipment, the energy reduction unit does not otherwise change how an operator uses the equipment.
摘要翻译：能量减少单元可拆卸地连接到外部除颤器，以减少除颤器向患者传递的除颤能量。能量减少装置的使用特别适用于使用自动或半自动外部除颤器（AED）除纤维化的儿科患者（8岁以下的婴儿和8岁以下的儿童）。在一个实施例中，能量减少单元包括部分耗散由AED产生的能量的衰减器。衰减器有利地被设计成向AED呈现阻抗，其在连接到患者时大致等于患者的阻抗。能量减少单元可以包括存在检测功能，其使除颤器能够修改ECG信号的分析，以解决儿科和成人患者的心律的差异。在第二实施例中，能量减少单元包括影响在AED内部执行的充电操作的能量控制修正器电路。除了附着到除颤设备之外，能量减少单元不会改变操作者如何使用设备。

3. 发明授权

US6134468A Method and apparatus for reducing defibrillation energy 失效
公开(公告)号：US6134468A
公开(公告)日：2000-10-17
申请号：US113803
申请日：1998-07-09
申请人： Carlton B. Morgan , Bradford E. Gliner , Dawn Jorgenson , Kent W. Leyde
发明人： Carlton B. Morgan , Bradford E. Gliner , Dawn Jorgenson , Kent W. Leyde
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3931
摘要： An energy reduction unit is removably connectable to an external defibrillator to reduce the defibrillation energy delivered by the defibrillator to a patient. Use of the energy reduction unit is particularly suited to defibrillating pediatric patients (infants and children under 8) with an automatic or semi-automatic external defibrillator (AED). In one embodiment, the energy reduction unit includes an attenuator which partially dissipates energy produced by the AED. The attenuator is advantageously designed to present an impedance to the AED which, when connected to the patient, is approximately equal to the patient's impedance. The energy reduction unit may include a presence-detect function which enables the defibrillator to modify analysis of ECG signals to account for differences heart rhythms of pediatric and adult patients. In a second embodiment, the energy reduction unit includes an energy control modifier circuit which affects the charging operations performed internal to the AED. Other than being attached to the defibrillation equipment, the energy reduction unit does not otherwise change how an operator uses the equipment.

4. 发明授权

US5593427A Electrotherapy method 失效
标题翻译：电疗法
公开(公告)号：US5593427A
公开(公告)日：1997-01-14
申请号：US601617
申请日：1996-02-14
申请人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
发明人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3906 , A61N1/3912
摘要： This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient. In a third aspect of the invention, the first phase ends when the first phase amplitude drops below a threshold value or when the first phase duration reaches a threshold time value, whichever comes first, as might occur with a low to average impedance patient. This method and apparatus of altering the delivered biphasic pulse thereby compensates for patient impedance differences by changing the nature of the delivered electrotherapeutic pulse, resulting in a smaller, more efficient and less expensive defibrillator.
摘要翻译：本发明提供一种外部除颤器和除颤方法，其自动补偿用于除颤和心脏复律的电疗脉冲递送中的患者对患者的阻抗差异。在优选实施例中，除颤器具有能够通过患者身上的电极排出的能量源，以提供双相电压或电流脉冲。在本发明的一个方面，第一和第二相位持续时间和初始第一相位振幅是预定值。在本发明的第二方面中，如果在预定的第一相位持续时间结束时脉冲的第一相位的幅度不能下降到阈值，则脉冲的第一相位的持续时间可能会延长与高阻抗患者。在本发明的第三方面中，当第一相位幅度下降到低于阈值时或当第一相位持续时间达到阈值时间值（以先到者为准）时，第一相位结束，如同低平均阻抗患者可能发生的那样。改变输送的双相脉冲的这种方法和装置由此通过改变递送的电疗脉冲的性质来补偿患者的阻抗差异，导致更小，更有效和更便宜的除颤器。

5. 发明授权

US5749905A Electrotherapy method utilizing patient dependent electrical parameters 失效
标题翻译：使用患者依赖电参数的电疗方法
公开(公告)号：US5749905A
公开(公告)日：1998-05-12
申请号：US691755
申请日：1996-08-02
申请人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
发明人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3906 , A61N1/3912
摘要： This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient. In a third aspect of the invention, the first phase ends when the first phase amplitude drops below a threshold value or when the first phase duration reaches a threshold time value, whichever comes first, as might occur with a low to average impedance patient. This method and apparatus of altering the delivered biphasic pulse thereby compensates for patient impedance differences by changing the nature of the delivered electrotherapeutic pulse, resulting in a smaller, more efficient and less expensive defibrillator.
摘要翻译：本发明提供一种外部除颤器和除颤方法，其自动补偿用于除颤和心脏复律的电疗脉冲递送中的患者对患者的阻抗差异。在优选实施例中，除颤器具有能够通过患者身上的电极排出的能量源，以提供双相电压或电流脉冲。在本发明的一个方面，第一和第二相位持续时间和初始第一相位振幅是预定值。在本发明的第二方面中，如果脉冲的第一相位的幅度在预定的第一相位持续时间结束时不能下降到阈值，则脉冲的第一相位的持续时间可能会延长与高阻抗患者。在本发明的第三方面中，当第一相位幅度下降到低于阈值时或当第一相位持续时间达到阈值时间值（以先到者为准）时，第一相位结束，如同低平均阻抗患者可能发生的那样。改变输送的双相脉冲的这种方法和装置由此通过改变递送的电疗脉冲的性质来补偿患者的阻抗差异，导致更小，更有效和更便宜的除颤器。

6. 发明授权

US5749904A Electrotherapy method utilizing patient dependent electrical parameters 失效
标题翻译：使用患者依赖电参数的电疗方法
公开(公告)号：US5749904A
公开(公告)日：1998-05-12
申请号：US690529
申请日：1996-07-31
申请人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
发明人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3906 , A61N1/3912
摘要： The invention provides a method for delivering electrotherapy to a patient through electrodes connected to a plurality of capacitors, including the steps of discharging at least one of the capacitors across the electrodes to deliver electrical energy to the patient, monitoring a patient-dependent electrical parameter (such as voltage, current or charge) during the discharging step, and adjusting energy delivered to the patient based on a value of the electrical parameter. The adjusting step may include selecting a serial or parallel arrangement for the capacitors based on a value of the electrical parameter. In another embodiment, the invention provides a method for delivering electrotherapy to a patient through electrodes connectable to a plurality of capacitors including the steps of discharging at least one of the capacitors across the electrodes to deliver electrical energy to the patient in a waveform having at least a first phase and a second phase, monitoring a patient-dependent electrical parameter (such as voltage, current or charge) during the discharging step, and modifying second phase initial voltage based on a value of the electrical parameter. The adjusting step may include selecting a serial or a parallel arrangement for the capacitors based on a value of the electrical parameter.
摘要翻译：本发明提供了一种通过连接到多个电容器的电极向患者传送电疗的方法，包括以下步骤：将电极中的至少一个放电到电极以将电能传递给患者，监测患者依赖的电参数（例如电压，电流或电荷），以及基于电参数的值来调节递送给患者的能量。调整步骤可以包括基于电参数的值来选择用于电容器的串行或并行布置。在另一个实施例中，本发明提供了一种通过可连接到多个电容器的电极向患者传送电疗的方法，包括以下步骤：跨过电极放电电容器中的至少一个电容器，以至少具有至少一个波形的电波第一阶段和第二阶段，在放电步骤期间监测与患者相关的电参数（例如电压，电流或电荷），以及基于电参数的值修改第二相初始电压。调整步骤可以包括基于电参数的值来选择用于电容器的串行或并行布置。

7. 发明授权

US5620470A Electrotherapy method 失效
公开(公告)号：US5620470A
公开(公告)日：1997-04-15
申请号：US653386
申请日：1996-05-24
申请人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
发明人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3906 , A61N1/3912
摘要： This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient. In a third aspect of the invention, the first phase ends when the first phase amplitude drops below a threshold value or when the first phase duration reaches a threshold time value, whichever comes first, as might occur with a low to average impedance patient. This method and apparatus of altering the delivered biphasic pulse thereby compensates for patient impedance differences by changing the nature of the delivered electrotherapeutic pulse, resulting in a smaller, more efficient and less expensive defibrillator.

8. 发明授权

US06671547B2 Adaptive analysis method for an electrotherapy device and apparatus 有权
公开(公告)号：US06671547B2
公开(公告)日：2003-12-30
申请号：US09879057
申请日：2001-06-13
申请人： Thomas D. Lyster , Carlton B. Morgan , Gust H. Bardy , Bradford E. Gliner
发明人： Thomas D. Lyster , Carlton B. Morgan , Gust H. Bardy , Bradford E. Gliner
IPC分类号： A61N139
CPC分类号： A61N1/3925
摘要： An electrotherapy device including at least one sensor operable to sense at least one physiological parameter of a patient. A controller is operably connected to the at least one sensor operable to receive signals from the at least one sensor corresponding to the at least one physiological parameter. Memory is operable to store computer-programming code executed by the controller. The programming code includes decision-making criteria operable to adapt a patient treatment in response changes to the detected at least one physiological parameter. At least one pair of electrodes is operably connected to the controller and operable to administer the treatment to the patient.

9. 发明授权

US5803927A Electrotherapy method and apparatus for external defibrillation 失效
标题翻译：用于外部除颤的电疗方法和装置
公开(公告)号：US5803927A
公开(公告)日：1998-09-08
申请号：US824713
申请日：1997-02-19
申请人： David Cameron , Thomas D. Lyster , Daniel J. Powers , Bradford E. Gliner , Clinton S. Cole , Carlton B. Morgan
发明人： David Cameron , Thomas D. Lyster , Daniel J. Powers , Bradford E. Gliner , Clinton S. Cole , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3906 , A61N1/3912
摘要： An electrotherapy method and apparatus for delivering a multiphasic waveform from an energy source to a patient. The preferred embodiment of the method comprises the steps of charging the energy source to an initial level; discharging the energy source across the electrodes to deliver electrical energy to the patient in a multiphasic waveform; monitoring a patient-dependent electrical parameter during the discharging step; shaping the waveform of the delivered electrical energy based on a value of the monitored electrical parameter, wherein the relative duration of the phases of the multiphasic waveform is dependent on the value of the monitored electrical parameter. The preferred apparatus comprises an energy source; two electrodes adapted to make electrical contact with a patient; a connecting mechanism forming an electrical circuit with the energy source and the electrodes when the electrodes are attached to a patient; and a controller operating the connecting mechanism to deliver electrical energy from the energy source to the electrodes in a multiphasic waveform the relative phase durations of which are based on an electrical parameter monitored during delivery of the electrical energy. The preferred defibrillator apparatus weighs less than 4 pounds and has a volume less than 150 cubic inches, and most preferably, weighs approximately three pounds or less and has a volume of approximately 141 cu.in.
摘要翻译：一种用于将多相波形从能量源递送到患者的电疗方法和装置。该方法的优选实施例包括以下步骤：将能源充电至初始水平; 通过电极排出能量源，以多相波形向患者输送电能; 在放电步骤期间监测与患者相关的电参数; 基于所监测的电参数的值对输送的电能的波形进行整形，其中多相波形的相位的相对持续时间取决于被监测的电参数的值。优选的装置包括能源; 两个电极，适于与患者进行电接触; 当电极附接到患者时，形成与能量源和电极的电路的连接机构; 以及控制器，其操作所述连接机构，以多相波形将能量从所述能量源传递到所述电极，所述多相波形的相对相位持续时间基于在所述电能传递期间监测的电参数。优选的除颤器装置重量小于4磅，体积小于150立方英寸，最优选重约3磅或更小，体积约为141立方英寸。

10. 发明授权

US5776166A Method for applying a multiphasic waveform 失效
标题翻译：应用多相波形的方法
公开(公告)号：US5776166A
公开(公告)日：1998-07-07
申请号：US803095
申请日：1997-02-20
申请人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
发明人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3906 , A61N1/3912
摘要： This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient. In a third aspect of the invention, the first phase ends when the first phase amplitude drops below a threshold value or when the first phase duration reaches a threshold time value, whichever comes first, as might occur with a low to average impedance patient. This method and apparatus of altering the delivered biphasic pulse thereby compensates for patient impedance differences by changing the nature of the delivered electrotherapeutic pulse, resulting in a smaller, more efficient and less expensive defibrillator.
摘要翻译：本发明提供一种外部除颤器和除颤方法，其自动补偿用于除颤和心脏复律的电疗脉冲递送中的患者对患者的阻抗差异。在优选实施例中，除颤器具有能够通过患者身上的电极排出的能量源，以提供双相电压或电流脉冲。在本发明的一个方面，第一和第二相位持续时间和初始第一相位振幅是预定值。在本发明的第二方面中，如果脉冲的第一相位的幅度在预定的第一相位持续时间结束时不能下降到阈值，则脉冲的第一相位的持续时间可能会延长与高阻抗患者。在本发明的第三方面中，当第一相位幅度下降到低于阈值时或当第一相位持续时间达到阈值时间值（以先到者为准）时，第一相位结束，如同低平均阻抗患者可能发生的那样。改变输送的双相脉冲的这种方法和装置由此通过改变递送的电疗脉冲的性质来补偿患者的阻抗差异，导致更小，更有效和更便宜的除颤器。

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